HUP0303347A2 - (R)-2-aril-propionsav-omega-aminoalkilamidok mint polimorf magvú és egymagvú sejtek kemotaxisának inhibitorai, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents
(R)-2-aril-propionsav-omega-aminoalkilamidok mint polimorf magvú és egymagvú sejtek kemotaxisának inhibitorai, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0303347A2 HUP0303347A2 HU0303347A HUP0303347A HUP0303347A2 HU P0303347 A2 HUP0303347 A2 HU P0303347A2 HU 0303347 A HU0303347 A HU 0303347A HU P0303347 A HUP0303347 A HU P0303347A HU P0303347 A2 HUP0303347 A2 HU P0303347A2
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- hydrogen atom
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- 230000035605 chemotaxis Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 9
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 5
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 2
- 229910052717 sulfur Chemical group 0.000 abstract 2
- 125000004434 sulfur atom Chemical group 0.000 abstract 2
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- -1 N-(2-methoxyphenyl)piperazinyl group Chemical group 0.000 abstract 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000004419 alkynylene group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000005982 diphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000003367 polycyclic group Chemical group 0.000 abstract 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
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- C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/40—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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Abstract
A találmány szerinti vegyületek (I) általános képletében Ar jelentéseadott esetben szubsztituált arilcsoport, R jelentése hidrogénatom,alkilcsoport, alkenilcsoport vagy alkinilcsoport, amelyek adottesetben CO2R3 csoporttal szubsztituálva lehetnek, ahol R3 jelentésehidrogénatom, alkilcsoport vagy alkenilcsoport, X jelentése 1-6szénatomos egyenes vagy elágazó szénláncú alkiléncsoport, 4-6szénatomos alkeniléncsoport vagy 4-6 szénatomos alkiniléncsoport,amelyet adott esetben CO2R3 vagy CONHR4 csoporttal szubsztituálvalehetnek, ahol R4 jelentése hidrogénatom, 2-6 szénatomos egyenes vagyelágazó szénláncú alkilcsoport vagy OR3 csoport, R3 jelentése a fenti,(CH2)m-B-(CH2)n csoport, amely adott esetben fent definiált CO2R3 vagyCONHR4 csoporttal szubsztituálva lehet, ahol B jelentése oxigénatomvagy kénatom, m értéke 0, 2 vagy 3 és n értéke 2 vagy 3, vagy Bjelentése CO, SO vagy CONH csoport és m értéke 1-3, és n értéke 2 vagy3, vagy X jelentése a kapcsolódó omega-aminocsoport nitrogénatomjávalés az R1 csoporttal együtt 3-7 tagú nem aromás nitrogéntartalmúheterociklusos csoport, monociklusos csoport vagy policiklusoscsoport, amely a nitrogénatomon Rc csoportot hordoz, ahol Rc jelentésehidrogénatom, alkilcsoport, hidroxialkilcsoport, acilcsoport, adottesetben szubsztituált fenilcsoport vagy difenilmetilcsoport, Rl és R2jelentése egymástól függetlenül hidrogénatom, egyenes vagy elágazószénláncú alkilcsoport, amely adott esetben oxigénatomot vagykénatomot tartalmaz, cikloalkilcsoport, alkenilcsoport,alkinilcsoport, arilalkilcsoport vagy hidroxialkilcsoport, vagy R1 ésR2 jelentése a kapcsolódó nitrogénatommal együtt (II) általánosképletű 3-7 tagú nitrogéntartalmú heterociklusos csoport, ahol Yjelentése közvetlen kötés, CH2, O, S vagy N-Rc csoport, p értéke 0-3,vagy R1 jelentése a fenti és R2 jelentése (III) általános képletűcsoport, ahol Ra jelentése hidrogénatom, Rb jelentése hidrogénatom,hidroxilcsoport, alkilcsoport vagy NRdRe csoport, ahol Rd és Rejelentése egymástól függetlenül hidrogénatom, alkilcsoport vagyfenilcsoport, vagy Ra és Rb jelentése a kapcsolódó nitrogénatomokkalegyütt 5-7 tagú heterociklusos csoport, amely adott esetbenbenzolgyűrűvel, piridingyűrűvel vagy pirimidingyűrűvel fuzionálva van,azzal a megszorítással, hogy ha Ar jelentése 4-difenilcsoport és Xjelentése etiléncsoport vagy propiléncsoport, akkor R1 és R2 jelentéseetilcsoporttól eltérő, ha Ar jelentése 4-(2-fluor)difenilcsoport és Xjelentése CO2H csoporttal szubsztituált butiléncsoport, akkor Ra és Rbjelentése hidrogénatomtól eltérő, ha Ar jelentése fenilcsoport és Xjelentése butiléncsoport, akkor R1 és R2 jelentése a kapcsolódónitrogénatommal együtt N-(2-metoxifenil)piperazinilcsoporttól eltérő.A találmány kiterjed a fenti vegyületek előállítására és gyógyszerkénttörténő alkalmazására és a vegyületeket
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2001MI000395A ITMI20010395A1 (it) | 2001-02-27 | 2001-02-27 | Omega-amminoalchilammidi di acidi r-2-aril-propionici come inibitori della chemiotassi di cellule polimorfonucleate e mononucleate |
ITMI2001A000395 | 2001-02-27 | ||
PCT/EP2002/001974 WO2002068377A1 (en) | 2001-02-27 | 2002-02-25 | Omega-aminoalkylamides of r-2-aryl-propionic acids as inhibitors of the chemotaxis of polymorphonucleate and mononucleate cells |
Publications (3)
Publication Number | Publication Date |
---|---|
HUP0303347A2 true HUP0303347A2 (hu) | 2004-01-28 |
HUP0303347A3 HUP0303347A3 (en) | 2005-06-28 |
HU230832B1 HU230832B1 (hu) | 2018-07-30 |
Family
ID=11447032
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Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0303347A HU230832B1 (hu) | 2001-02-27 | 2002-02-25 | (R)-2-aril-propionsav-omega-aminoalkilamidok mint polimorf magvú és egymagvú sejtek kemotaxisának inhibitorai |
Country Status (28)
Country | Link |
---|---|
US (3) | US8288368B2 (hu) |
EP (1) | EP1366018B1 (hu) |
JP (1) | JP4267922B2 (hu) |
KR (1) | KR100890680B1 (hu) |
CN (1) | CN1538951B (hu) |
AU (1) | AU2002308305B2 (hu) |
BR (2) | BRPI0207664B1 (hu) |
CA (1) | CA2435687C (hu) |
CY (1) | CY1118047T1 (hu) |
CZ (1) | CZ304762B6 (hu) |
DK (1) | DK1366018T3 (hu) |
EE (1) | EE05327B1 (hu) |
ES (1) | ES2594614T3 (hu) |
HK (1) | HK1069815A1 (hu) |
HU (1) | HU230832B1 (hu) |
IL (1) | IL157560A0 (hu) |
IT (1) | ITMI20010395A1 (hu) |
LT (1) | LT1366018T (hu) |
MX (1) | MXPA03006786A (hu) |
NO (1) | NO331976B1 (hu) |
NZ (1) | NZ526923A (hu) |
PL (1) | PL211429B1 (hu) |
PT (1) | PT1366018T (hu) |
RU (1) | RU2272024C2 (hu) |
SI (1) | SI1366018T1 (hu) |
SK (1) | SK288422B6 (hu) |
WO (1) | WO2002068377A1 (hu) |
ZA (1) | ZA200305173B (hu) |
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2001
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2002
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2012
- 2012-10-15 US US13/652,199 patent/US9493402B2/en not_active Expired - Fee Related
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2016
- 2016-10-03 CY CY20161100975T patent/CY1118047T1/el unknown
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