CO5261624A1 - Novedosos derivados fenilheteroalquilamina, procesos para su preparacion, composiciones farmaceuticas que comprenden dichos derivados novedosos y su uso en terapia - Google Patents

Novedosos derivados fenilheteroalquilamina, procesos para su preparacion, composiciones farmaceuticas que comprenden dichos derivados novedosos y su uso en terapia

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Publication number
CO5261624A1
CO5261624A1 CO01013439A CO01013439A CO5261624A1 CO 5261624 A1 CO5261624 A1 CO 5261624A1 CO 01013439 A CO01013439 A CO 01013439A CO 01013439 A CO01013439 A CO 01013439A CO 5261624 A1 CO5261624 A1 CO 5261624A1
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Colombia
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derivatives
new
therapy
processes
preparation
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CO01013439A
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English (en)
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David Cheshire
Stephen Connolly
David Cox
Antonio Mete
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Astrazeneca Ab
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Publication of CO5261624A1 publication Critical patent/CO5261624A1/es

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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
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    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/20—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
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Abstract

Un compuesto de la fórmula (I) <EMI FILE="01013439_1" ID="1" IMF=JPEG >en donde: X y Y independientemente representan alquil C1 a 4, alcoxi C1 a 4, halógeno, CF3, OCF3, CN, C(CH, S(O)mCH3, S(O)pCF3, NO2 o NHCHO; m y p independientemente representan un entero 0, 1 o 2; Z representa H o fluoro; V representa O, S(O)n o NR3;W representa alquil C1 a 4, alquenil C2 a 4, alquinil C2 a 4, cicloalquil C3 a 6 o un anillo heterocíclico saturado de 4 a 8 miembros que incorpora un heteroátomo seleccionado entre O, S y N; cualquiera de dichos grupos siendo además opcionalmente substituido por alquil C1 a 4, alcoxi C1 a 4, alquiltio C1 a 4, cicloalquil C3 a 6, halógeno o fenil; dicho grupo fenil siendo opcionalmente substituido además por uno o más substituyentes seleccionados independientemente entre halógeno, alquil C1 a 4, alcoxi C1 a 4, CF3, OCF3, CN o NO2; R1 y R2 independientemente representan H, alquil C1 a 4 o cicloalquil C3 a 6; dicho grupo alquil siendo opcionalmente substituido por alcoxi C1 a 4, halógeno, hidroxi, NR6R7, fenil o un anillo heterocíclico saturado o aromático de cinco o seis miembros que contiene 1 a 3 heteroátomos independientemente seleccionados entre O, S y N; dicho fenil o anillo heterocíclico aromático siendo además opcionalmente substituido por halógeno, alquil C1 a 4, alcoxi C1 a 4, CF3, OCF3, CN o NO2; - 2 -o el grupo NR1R2 junto representa un anillo azacíclico saturado de 4 a 8 miembros que incorpora opcionalmente un heteroátomo adicional seleccionado entre O, S o NR6; dicho anillo siendo opcionalmente substituido por alquil C1 a 4, alcoxi C1 a 4 o OH; dicho grupo alquil siendo opcionalmente substituido por alcoxi C1 a 4, OH o NR7R8; R3 representa H o alquil C1 a 4; R4 y R5 independientemente representan H o alquil C1 a 4; R6 representa H o alquil C1 a 6; dicho grupo alquil siendo opcionalmente substituido por alcoxi C1 a 4, OH, NR9R10, fenil o un anillo heterocíclico saturado o aromático de cinco o seis miembros que contiene 1 a 3 heteroátomos independientemente seleccionados entre O, S y N; dicho fenil o anillo heterocíclico aromático siendo además opcionalmente substituido por halógeno, alquil C1 a 4, alcoxi C1 a 4, CF3, OCF3, CN o NO2; R7, R8, R9 y R10 independientemente representan H o alquil C1 a 4; n representa un entero 0, 1 o 2;. o una sal, enantiómero o racemato del mismo farmacéuticamente aceptable; con la condición de que cuando V representa 0; y R1 y R2 cada uno independientemente representan H o metil; y W representa cicloalquil C5 a 6; entonces por lo menos uno de X y Y no representan halógeno, alquil C1 a 4, C1 a 3 alcoxi o CF3.
CO01013439A 2000-02-23 2001-02-20 Novedosos derivados fenilheteroalquilamina, procesos para su preparacion, composiciones farmaceuticas que comprenden dichos derivados novedosos y su uso en terapia CO5261624A1 (es)

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GBGB0004152.5A GB0004152D0 (en) 2000-02-23 2000-02-23 Novel compounds

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US (1) US6900243B2 (es)
EP (1) EP1263715B1 (es)
JP (1) JP2003523993A (es)
AT (1) ATE265423T1 (es)
AU (1) AU2001234314A1 (es)
CO (1) CO5261624A1 (es)
DE (1) DE60103034T2 (es)
GB (1) GB0004152D0 (es)
WO (1) WO2001062714A1 (es)

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AR035700A1 (es) * 2001-05-08 2004-06-23 Astrazeneca Ab Derivados de arilheteroalquilamina, composicion farmaceutica, usos de estos derivados para la fabricacion de medicamentos, metodos de tratamiento, y proceso para la preparacion de estos derivados
SE0102640D0 (sv) 2001-07-31 2001-07-31 Astrazeneca Ab Novel compounds
EP1587781A1 (en) * 2002-11-05 2005-10-26 Eli Lilly And Company 3-aryloxy/thio-2,3-substituted propanamines and their use in inhibiting serotonin and norepinephrine reuptake
WO2004043904A1 (en) 2002-11-05 2004-05-27 Eli Lilly And Company 3-aryloxy/thio-3-substituted propanamines and their use in inhibiting serotonin and norephinephrine reuptake
SE0203304D0 (sv) * 2002-11-07 2002-11-07 Astrazeneca Ab Novel Coumpounds
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EP1263715A1 (en) 2002-12-11
DE60103034D1 (de) 2004-06-03
WO2001062714A1 (en) 2001-08-30
JP2003523993A (ja) 2003-08-12
GB0004152D0 (en) 2000-04-12
AU2001234314A1 (en) 2001-09-03
ATE265423T1 (de) 2004-05-15

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