JO3357B1 - مركبات إيميدازوبيروليدينون - Google Patents

مركبات إيميدازوبيروليدينون

Info

Publication number
JO3357B1
JO3357B1 JOP/2013/0025A JOP20130025A JO3357B1 JO 3357 B1 JO3357 B1 JO 3357B1 JO P20130025 A JOP20130025 A JO P20130025A JO 3357 B1 JO3357 B1 JO 3357B1
Authority
JO
Jordan
Prior art keywords
compounds
imidazopyrrolidinone
imidazopyrrolidinone compounds
adisorder
mdm4
Prior art date
Application number
JOP/2013/0025A
Other languages
English (en)
Inventor
Mao Liang
Vaupel Andrea
Schlabach Achim
Furet Pascal
Kallen Joerg
Mah Robert
Stutz Stefan
Guagnano Vito
Holzer Philipp
Masuya Keiichi
Liao Lv
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47997596&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JO3357(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of JO3357B1 publication Critical patent/JO3357B1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cosmetics (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

بتعلق الاختراع بمركبات إيميدازوبيروليدينون جديدة لها الصيغة (I) كما وصف هنا ، مستحضرات صيدلانية تتضمن تلك المركبات ، استخداماته و طرق استخدام تلك المركبات لمعالجة اضطراب أو مرض و الذي ينشأ عبر فاعلية MDM2 و / أو MDM4 و اتحادات تتضمن تلك المركبات.
JOP/2013/0025A 2012-01-26 2013-01-24 مركبات إيميدازوبيروليدينون JO3357B1 (ar)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261591001P 2012-01-26 2012-01-26
US201261669902P 2012-07-10 2012-07-10
CNPCT/CN2012/086703 2012-12-14

Publications (1)

Publication Number Publication Date
JO3357B1 true JO3357B1 (ar) 2019-03-13

Family

ID=47997596

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2013/0025A JO3357B1 (ar) 2012-01-26 2013-01-24 مركبات إيميدازوبيروليدينون

Country Status (44)

Country Link
US (2) US8815926B2 (ar)
EP (3) EP3272754B1 (ar)
JP (3) JP5865519B2 (ar)
KR (2) KR20160150292A (ar)
CN (1) CN104203952B (ar)
AP (1) AP2014007810A0 (ar)
AR (1) AR089807A1 (ar)
AU (1) AU2013213260B2 (ar)
BR (1) BR112014018475B1 (ar)
CA (1) CA2860951C (ar)
CL (1) CL2014001855A1 (ar)
CO (1) CO7010838A2 (ar)
CR (1) CR20140354A (ar)
CU (1) CU24336B1 (ar)
CY (1) CY1119058T1 (ar)
DK (1) DK2807164T3 (ar)
DO (1) DOP2014000170A (ar)
EA (2) EA201790134A3 (ar)
EC (1) ECSP14015553A (ar)
ES (2) ES2632430T3 (ar)
GE (1) GEP20166438B (ar)
GT (1) GT201400164A (ar)
HK (2) HK1198761A1 (ar)
HR (1) HRP20171005T1 (ar)
IL (1) IL233739A (ar)
JO (1) JO3357B1 (ar)
LT (1) LT2807164T (ar)
MA (1) MA35869B1 (ar)
MX (1) MX353315B (ar)
MY (1) MY177242A (ar)
NI (1) NI201400083A (ar)
NZ (1) NZ627277A (ar)
PE (1) PE20141655A1 (ar)
PH (1) PH12014501702A1 (ar)
PL (1) PL2807164T3 (ar)
PT (1) PT2807164T (ar)
RS (1) RS56197B1 (ar)
SG (1) SG11201403935VA (ar)
SI (1) SI2807164T1 (ar)
TN (1) TN2014000319A1 (ar)
TW (2) TWI579284B (ar)
UA (1) UA115231C2 (ar)
UY (1) UY34591A (ar)
WO (1) WO2013111105A1 (ar)

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