NO20083917L - Malonamidderivater som gammasekretaseinhibitorer - Google Patents
Malonamidderivater som gammasekretaseinhibitorerInfo
- Publication number
- NO20083917L NO20083917L NO20083917A NO20083917A NO20083917L NO 20083917 L NO20083917 L NO 20083917L NO 20083917 A NO20083917 A NO 20083917A NO 20083917 A NO20083917 A NO 20083917A NO 20083917 L NO20083917 L NO 20083917L
- Authority
- NO
- Norway
- Prior art keywords
- lower alkyl
- halogen
- hydrogen
- gamma secretase
- secretase inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Oppfinnelsen angår malonamid-derivater med formel (I): I hvor A1 er -CHR- eller -C(O)-; A2 er -C(O)-, og R2/R3, uavhengig av hverandre, er hydrogen, lavere alkyl, halogen, hydroksy eller lavere alkoksy; eller A2 er -O-C(O)-, og R2/R3, uavhengig av hverandre, er hydrogen eller lavere alkyl; R er hydrogen eller lavere alkyl substituert med halogen; R1 er hydrogen, lavere alkyl eller -(CH2)n-aryl, eventuelt substituert med halogen; R4 er lavere alkyl substituert med halogen; n er 0, 1 eller 2; og farmasøytisk egnede syreaddisjonssalter, optisk rene enantiomerer, racemater eller diastereomere blandinger derav, for behandling av Alzheimers sykdom.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06111771 | 2006-03-27 | ||
| PCT/EP2007/052557 WO2007110335A1 (en) | 2006-03-27 | 2007-03-19 | Malonamide derivatives as gamma secretase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20083917L true NO20083917L (no) | 2008-10-23 |
Family
ID=36843221
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20083917A NO20083917L (no) | 2006-03-27 | 2008-09-15 | Malonamidderivater som gammasekretaseinhibitorer |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7425551B2 (no) |
| EP (1) | EP2018368B1 (no) |
| JP (1) | JP5129231B2 (no) |
| KR (1) | KR101169628B1 (no) |
| CN (1) | CN101410378B (no) |
| AR (1) | AR060125A1 (no) |
| AU (1) | AU2007229550B2 (no) |
| BR (1) | BRPI0709773B8 (no) |
| CA (1) | CA2645756C (no) |
| CL (1) | CL2007000789A1 (no) |
| ES (1) | ES2398531T3 (no) |
| IL (1) | IL194054A (no) |
| MX (1) | MX2008012136A (no) |
| NO (1) | NO20083917L (no) |
| RU (1) | RU2440342C2 (no) |
| TW (1) | TW200740760A (no) |
| WO (1) | WO2007110335A1 (no) |
| ZA (1) | ZA200808190B (no) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010509235A (ja) * | 2006-11-03 | 2010-03-25 | ノースウェスタン ユニバーシティ | 多発性硬化症の治療 |
| KR101150574B1 (ko) * | 2007-02-02 | 2012-05-30 | 에프. 호프만-라 로슈 아게 | 6-옥소-6,7-다이하이드로-5ｈ-다이벤조［ｂ,ｄ］아제핀-7-일 유도체 |
| FR2913886B1 (fr) | 2007-03-22 | 2012-03-02 | Guerbet Sa | Utilisation de nanoparticules metalliques dans le diagnostique de la maladie d'alzheimer |
| US8309299B2 (en) * | 2010-05-19 | 2012-11-13 | Hoffmann-La Roche Inc. | Combination therapy and method for assessing resistance to treatment |
| TWI530489B (zh) | 2011-03-22 | 2016-04-21 | 必治妥美雅史谷比公司 | 雙（氟烷基）－１，４－苯二氮呯酮化合物 |
| JO3148B1 (ar) | 2011-07-27 | 2017-09-20 | Lilly Co Eli | مركب مثبط لإشارات مسار notch |
| AR105080A1 (es) | 2015-07-07 | 2017-09-06 | Lilly Co Eli | Compuestos inhibidores de la señalización de la vía de notch |
| CN117881667A (zh) * | 2021-08-31 | 2024-04-12 | 巴斯夫欧洲公司 | 含有稠环系的除草剂丙二酰胺 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2404273A1 (en) * | 2000-04-11 | 2001-10-18 | Bristol-Myers Squibb Pharma Company | Substituted lactams as inhibitors of a.beta. protein production |
| EP1268450A1 (en) * | 2000-06-01 | 2003-01-02 | Bristol-Myers Squibb Pharma Company | Lactams substituted by cyclic succinates as inhibitors of a-beta protein production |
| TW200502221A (en) * | 2002-10-03 | 2005-01-16 | Astrazeneca Ab | Novel lactams and uses thereof |
| WO2004069826A1 (en) | 2003-02-04 | 2004-08-19 | F. Hoffmann-La Roche Ag | Malonamide derivatives as gamma-secretase inhibitors |
| MXPA06002562A (es) * | 2003-09-09 | 2006-06-20 | Hoffmann La Roche | Derivados de malonamida que bloquean la actividad de la gamma-secretasa. |
| HUE025548T2 (en) * | 2003-10-06 | 2016-02-29 | Hoffmann La Roche | Substituted dibenzo-azepine and benzodiazepine derivatives useful as gamma-secretase inhibitors |
-
2007
- 2007-03-19 ES ES07727035T patent/ES2398531T3/es active Active
- 2007-03-19 CA CA2645756A patent/CA2645756C/en active Active
- 2007-03-19 KR KR1020087023614A patent/KR101169628B1/ko active IP Right Grant
- 2007-03-19 EP EP07727035A patent/EP2018368B1/en active Active
- 2007-03-19 RU RU2008142361/04A patent/RU2440342C2/ru not_active IP Right Cessation
- 2007-03-19 CN CN2007800103966A patent/CN101410378B/zh active Active
- 2007-03-19 JP JP2009502013A patent/JP5129231B2/ja active Active
- 2007-03-19 AU AU2007229550A patent/AU2007229550B2/en active Active
- 2007-03-19 WO PCT/EP2007/052557 patent/WO2007110335A1/en active Application Filing
- 2007-03-19 MX MX2008012136A patent/MX2008012136A/es active IP Right Grant
- 2007-03-19 BR BRPI0709773A patent/BRPI0709773B8/pt active IP Right Grant
- 2007-03-22 US US11/726,639 patent/US7425551B2/en active Active
- 2007-03-23 TW TW096110174A patent/TW200740760A/zh unknown
- 2007-03-26 AR ARP070101236A patent/AR060125A1/es not_active Application Discontinuation
- 2007-03-26 CL CL2007000789A patent/CL2007000789A1/es unknown
-
2008
- 2008-09-11 IL IL194054A patent/IL194054A/en active IP Right Grant
- 2008-09-15 NO NO20083917A patent/NO20083917L/no not_active Application Discontinuation
- 2008-09-23 ZA ZA200808190A patent/ZA200808190B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101410378A (zh) | 2009-04-15 |
| CL2007000789A1 (es) | 2008-01-18 |
| BRPI0709773A2 (pt) | 2011-07-26 |
| BRPI0709773B1 (pt) | 2020-09-15 |
| AU2007229550B2 (en) | 2012-03-08 |
| AR060125A1 (es) | 2008-05-28 |
| TW200740760A (en) | 2007-11-01 |
| US7425551B2 (en) | 2008-09-16 |
| US20070225273A1 (en) | 2007-09-27 |
| JP5129231B2 (ja) | 2013-01-30 |
| CA2645756A1 (en) | 2007-10-04 |
| IL194054A (en) | 2013-05-30 |
| RU2440342C2 (ru) | 2012-01-20 |
| RU2008142361A (ru) | 2010-05-10 |
| CN101410378B (zh) | 2012-12-05 |
| MX2008012136A (es) | 2008-10-03 |
| ZA200808190B (en) | 2009-08-26 |
| KR101169628B1 (ko) | 2012-07-30 |
| CA2645756C (en) | 2013-12-31 |
| ES2398531T3 (es) | 2013-03-20 |
| EP2018368A1 (en) | 2009-01-28 |
| BRPI0709773B8 (pt) | 2021-05-25 |
| KR20080098441A (ko) | 2008-11-07 |
| JP2009531369A (ja) | 2009-09-03 |
| EP2018368B1 (en) | 2012-12-05 |
| AU2007229550A1 (en) | 2007-10-04 |
| WO2007110335A1 (en) | 2007-10-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |