AR060125A1 - Derivados de la malonamida - Google Patents
Derivados de la malonamidaInfo
- Publication number
- AR060125A1 AR060125A1 ARP070101236A ARP070101236A AR060125A1 AR 060125 A1 AR060125 A1 AR 060125A1 AR P070101236 A ARP070101236 A AR P070101236A AR P070101236 A ARP070101236 A AR P070101236A AR 060125 A1 AR060125 A1 AR 060125A1
- Authority
- AR
- Argentina
- Prior art keywords
- short chain
- chain alkyl
- hydrogen
- halogen
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente está relacionada con derivados de la malonamida de formula (1) en la que A1 es -CHR- o -C(O)-; A2 es -C(O)- y R2/R3 son independientemente entre sí hidrogeno, alquilo de cadena corta, halogeno, hidroxi o alcoxi de cadena corta; o A2 es - O-C(O)- y R2/R3 son independientemente entre sí hidrogeno o alquilo de cadena corta; R es hidrogeno o alquilo de cadena corta sustituido por halogeno; R1 es hidrogeno, alquilo de cadena corta o -(CH2)n-arilo, opcionalmente sustituido por halogeno; R4 es alquilo de cadena corta sustituido por halogeno; n es 0, 1 o 2; y con sales de adicion ácida farmacéuticamente aceptables, enantiomeros opticamente puros, racematos o mezclas diastereoméricas de los mismos para el tratamiento de la enfermedad de Alzheimer
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06111771 | 2006-03-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR060125A1 true AR060125A1 (es) | 2008-05-28 |
Family
ID=36843221
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070101236A AR060125A1 (es) | 2006-03-27 | 2007-03-26 | Derivados de la malonamida |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7425551B2 (es) |
| EP (1) | EP2018368B1 (es) |
| JP (1) | JP5129231B2 (es) |
| KR (1) | KR101169628B1 (es) |
| CN (1) | CN101410378B (es) |
| AR (1) | AR060125A1 (es) |
| AU (1) | AU2007229550B2 (es) |
| BR (1) | BRPI0709773B8 (es) |
| CA (1) | CA2645756C (es) |
| CL (1) | CL2007000789A1 (es) |
| ES (1) | ES2398531T3 (es) |
| IL (1) | IL194054A (es) |
| MX (1) | MX2008012136A (es) |
| NO (1) | NO20083917L (es) |
| RU (1) | RU2440342C2 (es) |
| TW (1) | TW200740760A (es) |
| WO (1) | WO2007110335A1 (es) |
| ZA (1) | ZA200808190B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010509235A (ja) * | 2006-11-03 | 2010-03-25 | ノースウェスタン ユニバーシティ | 多発性硬化症の治療 |
| JP2010517954A (ja) * | 2007-02-02 | 2010-05-27 | エフ．ホフマン−ラ ロシュ アーゲー | ６−オキソ−６，７−ジヒドロ−５Ｈ−ジベンゾ［ｂ，ｄ］アゼピン−７−イル誘導体 |
| FR2913886B1 (fr) | 2007-03-22 | 2012-03-02 | Guerbet Sa | Utilisation de nanoparticules metalliques dans le diagnostique de la maladie d'alzheimer |
| US8309299B2 (en) * | 2010-05-19 | 2012-11-13 | Hoffmann-La Roche Inc. | Combination therapy and method for assessing resistance to treatment |
| TWI530489B (zh) | 2011-03-22 | 2016-04-21 | 必治妥美雅史谷比公司 | 雙（氟烷基）－１，４－苯二氮呯酮化合物 |
| JO3148B1 (ar) | 2011-07-27 | 2017-09-20 | Lilly Co Eli | مركب مثبط لإشارات مسار notch |
| JO3491B1 (ar) | 2015-07-07 | 2020-07-05 | Audion Therapeutics | مركبات مثبطة لإشارات مسار notch |
| IL311001A (en) * | 2021-08-31 | 2024-04-01 | Basf Se | Herbicidal malonamides containing a compressed ring system |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004500419A (ja) * | 2000-04-11 | 2004-01-08 | デュポン ファーマシューティカルズ カンパニー | Ａβタンパク質産生阻害剤としての置換ラクタム |
| NZ516746A (en) * | 2000-06-01 | 2004-02-27 | Bristol Myers Squibb Pharma | Lactams substituted by cyclic succinates as inhibitors of A-beta protein production |
| TW200502221A (en) * | 2002-10-03 | 2005-01-16 | Astrazeneca Ab | Novel lactams and uses thereof |
| CA2514267C (en) | 2003-02-04 | 2011-05-17 | F. Hoffmann-La Roche Ag | Malonamide derivatives as gamma-secretase inhibitors |
| ATE428698T1 (de) * | 2003-09-09 | 2009-05-15 | Hoffmann La Roche | Die aktivität von gamma-secretase blockierende malonamidderivate |
| KR100867035B1 (ko) * | 2003-10-06 | 2008-11-04 | 에프. 호프만-라 로슈 아게 | 감마-세크레타제 저해제로서 유용한 치환된다이벤조-아제핀 및 벤조-다이아제핀 유도체 |
-
2007
- 2007-03-19 RU RU2008142361/04A patent/RU2440342C2/ru not_active IP Right Cessation
- 2007-03-19 CN CN2007800103966A patent/CN101410378B/zh active Active
- 2007-03-19 MX MX2008012136A patent/MX2008012136A/es active IP Right Grant
- 2007-03-19 KR KR1020087023614A patent/KR101169628B1/ko active IP Right Grant
- 2007-03-19 WO PCT/EP2007/052557 patent/WO2007110335A1/en active Application Filing
- 2007-03-19 CA CA2645756A patent/CA2645756C/en active Active
- 2007-03-19 AU AU2007229550A patent/AU2007229550B2/en active Active
- 2007-03-19 JP JP2009502013A patent/JP5129231B2/ja active Active
- 2007-03-19 EP EP07727035A patent/EP2018368B1/en active Active
- 2007-03-19 ES ES07727035T patent/ES2398531T3/es active Active
- 2007-03-19 BR BRPI0709773A patent/BRPI0709773B8/pt active IP Right Grant
- 2007-03-22 US US11/726,639 patent/US7425551B2/en active Active
- 2007-03-23 TW TW096110174A patent/TW200740760A/zh unknown
- 2007-03-26 CL CL2007000789A patent/CL2007000789A1/es unknown
- 2007-03-26 AR ARP070101236A patent/AR060125A1/es not_active Application Discontinuation
-
2008
- 2008-09-11 IL IL194054A patent/IL194054A/en active IP Right Grant
- 2008-09-15 NO NO20083917A patent/NO20083917L/no not_active Application Discontinuation
- 2008-09-23 ZA ZA200808190A patent/ZA200808190B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2398531T3 (es) | 2013-03-20 |
| KR101169628B1 (ko) | 2012-07-30 |
| ZA200808190B (en) | 2009-08-26 |
| IL194054A (en) | 2013-05-30 |
| EP2018368B1 (en) | 2012-12-05 |
| CL2007000789A1 (es) | 2008-01-18 |
| CN101410378B (zh) | 2012-12-05 |
| CN101410378A (zh) | 2009-04-15 |
| JP2009531369A (ja) | 2009-09-03 |
| BRPI0709773B1 (pt) | 2020-09-15 |
| TW200740760A (en) | 2007-11-01 |
| NO20083917L (no) | 2008-10-23 |
| RU2008142361A (ru) | 2010-05-10 |
| KR20080098441A (ko) | 2008-11-07 |
| WO2007110335A1 (en) | 2007-10-04 |
| BRPI0709773B8 (pt) | 2021-05-25 |
| RU2440342C2 (ru) | 2012-01-20 |
| CA2645756A1 (en) | 2007-10-04 |
| AU2007229550B2 (en) | 2012-03-08 |
| EP2018368A1 (en) | 2009-01-28 |
| BRPI0709773A2 (pt) | 2011-07-26 |
| US20070225273A1 (en) | 2007-09-27 |
| JP5129231B2 (ja) | 2013-01-30 |
| MX2008012136A (es) | 2008-10-03 |
| CA2645756C (en) | 2013-12-31 |
| US7425551B2 (en) | 2008-09-16 |
| AU2007229550A1 (en) | 2007-10-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |