AR057887A1 - Composiciones y metodos de tratamiento de trastornos del snc - Google Patents

Composiciones y metodos de tratamiento de trastornos del snc

Info

Publication number
AR057887A1
AR057887A1 ARP060104925A ARP060104925A AR057887A1 AR 057887 A1 AR057887 A1 AR 057887A1 AR P060104925 A ARP060104925 A AR P060104925A AR P060104925 A ARP060104925 A AR P060104925A AR 057887 A1 AR057887 A1 AR 057887A1
Authority
AR
Argentina
Prior art keywords
substituted
unsubstituted
compound
treatment
branched
Prior art date
Application number
ARP060104925A
Other languages
English (en)
Inventor
Laurence Wu
Oren M Becker
Mercedes Lobera
Boaz Inbal
Dale S Dhanoa
Silvia Noiman
Yael Marantz
Dongli Chen
Alexander He
Original Assignee
Mohanty Pradyumna
Epix Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mohanty Pradyumna, Epix Pharm Inc filed Critical Mohanty Pradyumna
Publication of AR057887A1 publication Critical patent/AR057887A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Reivindicacion 1: Una composicion farmacéutica, caractetizada porque comprende - un primer compuesto que tiene la siguiente formula (1) en donde R1 puede ser alquilo (C1-8), ramificado o no ramificado; un anillo carbocíclico (C1-8) sustituido o no sustituido; haloalquilo ramificado o no ramificado, un anillo arilo o heteroarilo sustituido o no sustituido o un anillo (CH2)p-arilo o (CH2)p-heteroarilo sustituido o no susittuido, donde p es 1, 2, 3 o 4; R2 y R3, tomados juntos, forman un anillo de piperidina; pirrolidina, azepán, aziridina o azetidina sustituido o no sustituido; y n es 1, 2, 3, 4, 5 o 6; y sales y/o ésteres aceptables para uso farmacéutico del mismo, donde el primer compuesto está presente en una cantidad tal que si se administrara sola no mejora sustancialmente la memoria; y - un segundo compuesto que es un inhibidor de colinesterasa o acetilcolinesterasa y está presente en una cantidad tal que si se administrara sola no mejora sustancialmente la memoria. Moduladores de tienopiridinona del receptor 5-HT4, y en particular el uso de estos compuestos y sus composiciones farmacéuticas, por ejemplo, en el tratamiento, la modulacion y/o la prevencion de las afecciones fisiologicas asociadas con la accion de serotonina, tal como en el tratamiento del mal de Alzheimer, trastornos cognitivos, depresion y ansiedad.
ARP060104925A 2005-11-10 2006-11-09 Composiciones y metodos de tratamiento de trastornos del snc AR057887A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11/271,019 US7598265B2 (en) 2004-09-30 2005-11-10 Compositions and methods for treating CNS disorders

Publications (1)

Publication Number Publication Date
AR057887A1 true AR057887A1 (es) 2007-12-26

Family

ID=37946751

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060104925A AR057887A1 (es) 2005-11-10 2006-11-09 Composiciones y metodos de tratamiento de trastornos del snc

Country Status (17)

Country Link
US (2) US7598265B2 (es)
EP (1) EP1959954A2 (es)
JP (1) JP2009515877A (es)
KR (1) KR20080067001A (es)
CN (1) CN101340908A (es)
AR (1) AR057887A1 (es)
AU (1) AU2006315854A1 (es)
BR (1) BRPI0618493A2 (es)
CA (1) CA2629312C (es)
CR (1) CR10062A (es)
EA (1) EA200801302A1 (es)
IL (1) IL191168A0 (es)
MA (1) MA30037B1 (es)
NO (1) NO20082679L (es)
TW (1) TW200735868A (es)
WO (1) WO2007058805A2 (es)
ZA (1) ZA200804951B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050222175A1 (en) * 2004-03-31 2005-10-06 Dhanoa Dale S New piperidinylamino-thieno[2,3-D] pyrimidine compounds
US7612078B2 (en) * 2003-03-31 2009-11-03 Epix Delaware, Inc. Piperidinylamino-thieno[2,3-D] pyrimidine compounds
US7488736B2 (en) * 2004-05-17 2009-02-10 Epix Delaware, Inc. Thienopyridinone compounds and methods of treatment
US7598265B2 (en) * 2004-09-30 2009-10-06 Epix Delaware, Inc. Compositions and methods for treating CNS disorders
US7576211B2 (en) * 2004-09-30 2009-08-18 Epix Delaware, Inc. Synthesis of thienopyridinone compounds and related intermediates
US7407966B2 (en) * 2004-10-07 2008-08-05 Epix Delaware, Inc. Thienopyridinone compounds and methods of treatment
CA2595607C (en) 2005-01-25 2014-07-15 Epix Delaware, Inc. Substituted arylamine compounds and their use as 5-ht6 modulators
GB0526258D0 (en) * 2005-12-22 2006-02-01 Novartis Ag Organic compounds
WO2010065743A2 (en) * 2008-12-03 2010-06-10 Nanotherapeutics, Inc. Bicyclic compounds and methods of making and using same
JP2012523437A (ja) * 2009-04-13 2012-10-04 セラヴァンス， インコーポレーテッド 認知障害の治療のための５−ｈｔ４受容体アゴニスト化合物
US20230139125A1 (en) * 2021-02-04 2023-05-04 Richard Natrillo Dietary supplement for improving brain performance

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Also Published As

Publication number Publication date
US20110195953A1 (en) 2011-08-11
EA200801302A1 (ru) 2009-02-27
TW200735868A (en) 2007-10-01
EP1959954A2 (en) 2008-08-27
KR20080067001A (ko) 2008-07-17
ZA200804951B (en) 2009-04-29
AU2006315854A1 (en) 2007-05-24
NO20082679L (no) 2008-06-10
BRPI0618493A2 (pt) 2011-08-30
CR10062A (es) 2009-05-14
US20060234998A1 (en) 2006-10-19
CN101340908A (zh) 2009-01-07
IL191168A0 (en) 2008-12-29
CA2629312C (en) 2014-08-12
WO2007058805A2 (en) 2007-05-24
CA2629312A1 (en) 2007-05-24
JP2009515877A (ja) 2009-04-16
WO2007058805A3 (en) 2007-10-04
US7598265B2 (en) 2009-10-06
MA30037B1 (fr) 2008-12-01

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