MX2007006504A - Derivados de malonamida como inhibidores de gamma-secretasa para el tratamiento de la enfermedad de alzheimer. - Google Patents
Derivados de malonamida como inhibidores de gamma-secretasa para el tratamiento de la enfermedad de alzheimer.Info
- Publication number
- MX2007006504A MX2007006504A MX2007006504A MX2007006504A MX2007006504A MX 2007006504 A MX2007006504 A MX 2007006504A MX 2007006504 A MX2007006504 A MX 2007006504A MX 2007006504 A MX2007006504 A MX 2007006504A MX 2007006504 A MX2007006504 A MX 2007006504A
- Authority
- MX
- Mexico
- Prior art keywords
- lower alkyl
- halogen
- hydroxy
- alzheimer
- disease
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La invencion se refiere a compuestos de la formula general en donde R es halogeno, alquilo inferior o alquilo inferior sustituido por halogeno; R1 es hidrogeno, alquilo inferior o alquilo inferior sustituido por halogeno o hidroxi o es alquenilo inferior, -(CH2)n-cicloalquilo, -(CH2)n-COR?? o es bencilo opcionalmente sustituido por halogeno o es -(CH2)n-morfolinilo; R?? es alcoxi inferior, hidroxi o amino, R2 es hidrogeno, alquilo inferior o di-(alquilo inferior), alquilo inferior sustituido por halogeno o hidroxi o es bencilo o cicloalquilo; R3 es alquilo inferior o alquilo inferior sustituido por halogeno o es bencilo opcionalmente sustituido por dos atomos de halogeno o es -(CH2)n-cicloalquilo o -(CH2)n-piridinilo; X es -CR4R4??- o -CR4R4??-O-; R4/R4?? con independencia entre si son hidrogeno, halogeno, alquilo inferior, alcoxi inferior, hidroxi o -CH2-2-[1,3]dioxalan-; n es 0,1 o 2; a sales de adicion de acido farmaceuticamente aceptables de los mismos y a todas las formas de enantiomeros opticamente puros, racematos o diaestereomeros y mezclas de diaestereomeros de los mismos, para el tratamiento de la enfermedad de Alzheimer.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04106395 | 2004-12-08 | ||
| EP05100816 | 2005-02-07 | ||
| PCT/EP2005/012834 WO2006061136A2 (en) | 2004-12-08 | 2005-12-01 | Malonamide derivatives as inhibitors of gamma-secretase for the treatment of alzheimer’s disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2007006504A true MX2007006504A (es) | 2007-06-22 |
Family
ID=36293585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2007006504A MX2007006504A (es) | 2004-12-08 | 2005-12-01 | Derivados de malonamida como inhibidores de gamma-secretasa para el tratamiento de la enfermedad de alzheimer. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7211573B2 (es) |
| EP (1) | EP1828151B1 (es) |
| JP (1) | JP4979590B2 (es) |
| KR (1) | KR100890678B1 (es) |
| CN (1) | CN101072760B (es) |
| AR (1) | AR053987A1 (es) |
| AT (1) | ATE504580T1 (es) |
| AU (1) | AU2005313582B8 (es) |
| BR (1) | BRPI0518615A2 (es) |
| CA (1) | CA2589196A1 (es) |
| DE (1) | DE602005027388D1 (es) |
| DK (1) | DK1828151T3 (es) |
| HK (1) | HK1114840A1 (es) |
| IL (1) | IL183293A0 (es) |
| MX (1) | MX2007006504A (es) |
| NO (1) | NO20072609L (es) |
| NZ (1) | NZ555184A (es) |
| PL (1) | PL1828151T3 (es) |
| PT (1) | PT1828151E (es) |
| RU (1) | RU2402538C2 (es) |
| TW (1) | TWI349005B (es) |
| WO (1) | WO2006061136A2 (es) |
| ZA (1) | ZA200705018B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007299129A1 (en) * | 2006-09-20 | 2008-03-27 | F. Hoffmann-La Roche Ag | 4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepine derivatives |
| AU2008209861B2 (en) | 2007-02-02 | 2012-08-09 | F. Hoffmann-La Roche Ag | 6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl derivatives |
| US8741889B2 (en) * | 2008-01-11 | 2014-06-03 | Hoffmann-La Roche Inc | Method of treating non-small cell lung cancer and colon cancer with gamma-secretase inhibitor |
| EP2244713A1 (en) * | 2008-01-11 | 2010-11-03 | F. Hoffmann-La Roche AG | Use of a gamma-secretase inhibitor for treating cancer |
| WO2016198366A1 (en) | 2015-06-11 | 2016-12-15 | F. Hoffmann-La Roche Ag | Targeted notch pathway inhibitors |
| CA3079786A1 (en) | 2017-10-24 | 2019-05-02 | The Broad Institute, Inc. | 4h-pyrrolo[3,2-c]pyridin-4-one derivatives |
| EP3878836A4 (en) * | 2018-11-07 | 2022-08-10 | Chugai Seiyaku Kabushiki Kaisha | PROCESS FOR THE PREPARATION OF O-SUBSTITUTED SERIN DERIVATIVES |
| US20220378762A1 (en) | 2019-04-24 | 2022-12-01 | Bayer Aktiengesellschaft | 4h-pyrrolo[3,2-c]pyridin-4-one derivatives |
| CN117946100A (zh) | 2019-04-24 | 2024-04-30 | 拜耳股份有限公司 | 4H-吡咯并[3,2-c]吡啶-4-酮化合物 |
| WO2020216773A1 (en) | 2019-04-24 | 2020-10-29 | Bayer Aktiengesellschaft | 4h-pyrrolo[3,2-c]pyridin-4-one compounds |
| CN112300019A (zh) * | 2019-07-31 | 2021-02-02 | 华东师范大学 | 一种邻乙酰氨基苯丁酸类化合物的制备方法 |
| WO2021198020A1 (en) | 2020-03-31 | 2021-10-07 | Bayer Aktiengesellschaft | 3-(anilino)-2-[3-(3-alkoxy-pyridin-4-yl]-1,5,6,7-tetrahydro-4h-pyrrolo[3,2-c]pyridin-4-one derivatives as egfr inhibitors for the treatment of cancer |
| AU2022234513A1 (en) | 2021-03-09 | 2023-09-21 | Basf Se | Malonamides and their use as herbicides |
| KR20240051210A (ko) * | 2021-08-25 | 2024-04-19 | 바스프 에스이 | 제초제 말론아미드 |
| KR20240054320A (ko) * | 2021-08-31 | 2024-04-25 | 바스프 에스이 | 축합된 고리계를 함유하는 제초성 말론아미드 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002241368A (ja) * | 1997-02-18 | 2002-08-28 | Shionogi & Co Ltd | 新規ベンゾラクタム誘導体およびそれを含有する医薬組成物 |
| WO1999067219A1 (en) * | 1998-06-22 | 1999-12-29 | Elan Pharmaceuticals, Inc. | Compounds for inhibiting beta-amyloid peptide release and/or its synthesis |
| GB0012671D0 (en) | 2000-05-24 | 2000-07-19 | Merck Sharp & Dohme | Therapeutic agents |
| SI1511718T1 (sl) * | 2002-05-29 | 2009-08-31 | Hoffmann La Roche | Derivati n-acilaminobenzena kot selektivni inhibitorji monoaminske oksidaze b |
| TW200502221A (en) * | 2002-10-03 | 2005-01-16 | Astrazeneca Ab | Novel lactams and uses thereof |
| ES2311795T3 (es) | 2003-02-04 | 2009-02-16 | F. Hoffmann-La Roche Ag | Derivados de malonamida como inhibidores de gamma-secretasa. |
| US7060698B2 (en) | 2003-05-19 | 2006-06-13 | Hoffmann-La Roche Inc. | Benzoxazepinone derivatives |
| KR20070087233A (ko) | 2003-09-09 | 2007-08-27 | 에프. 호프만-라 로슈 아게 | 감마-세크리테이즈의 활성을 차단하는 말론아미드 유도체 |
| US7166587B2 (en) | 2003-10-06 | 2007-01-23 | Hoffmann-La Roche Inc. | Carbamic acid alkyl ester derivatives |
-
2005
- 2005-11-30 US US11/289,176 patent/US7211573B2/en not_active Expired - Fee Related
- 2005-12-01 RU RU2007120211/04A patent/RU2402538C2/ru not_active IP Right Cessation
- 2005-12-01 DE DE602005027388T patent/DE602005027388D1/de active Active
- 2005-12-01 AU AU2005313582A patent/AU2005313582B8/en not_active Ceased
- 2005-12-01 PL PL05811672T patent/PL1828151T3/pl unknown
- 2005-12-01 EP EP05811672A patent/EP1828151B1/en active Active
- 2005-12-01 WO PCT/EP2005/012834 patent/WO2006061136A2/en active Application Filing
- 2005-12-01 PT PT05811672T patent/PT1828151E/pt unknown
- 2005-12-01 MX MX2007006504A patent/MX2007006504A/es active IP Right Grant
- 2005-12-01 AT AT05811672T patent/ATE504580T1/de active
- 2005-12-01 BR BRPI0518615-3A patent/BRPI0518615A2/pt not_active IP Right Cessation
- 2005-12-01 JP JP2007544779A patent/JP4979590B2/ja not_active Expired - Fee Related
- 2005-12-01 CN CN2005800421635A patent/CN101072760B/zh not_active Expired - Fee Related
- 2005-12-01 DK DK05811672.4T patent/DK1828151T3/da active
- 2005-12-01 CA CA002589196A patent/CA2589196A1/en not_active Abandoned
- 2005-12-01 KR KR1020077015604A patent/KR100890678B1/ko not_active IP Right Cessation
- 2005-12-01 NZ NZ555184A patent/NZ555184A/en not_active IP Right Cessation
- 2005-12-07 TW TW094143269A patent/TWI349005B/zh not_active IP Right Cessation
- 2005-12-07 AR ARP050105106A patent/AR053987A1/es unknown
-
2007
- 2007-05-17 IL IL183293A patent/IL183293A0/en unknown
- 2007-05-24 NO NO20072609A patent/NO20072609L/no not_active Application Discontinuation
- 2007-06-04 ZA ZA200705018A patent/ZA200705018B/xx unknown
-
2008
- 2008-04-29 HK HK08104728.3A patent/HK1114840A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE602005027388D1 (de) | 2011-05-19 |
| US20060122168A1 (en) | 2006-06-08 |
| EP1828151A2 (en) | 2007-09-05 |
| WO2006061136A2 (en) | 2006-06-15 |
| ZA200705018B (en) | 2010-04-28 |
| KR100890678B1 (ko) | 2009-03-26 |
| RU2402538C2 (ru) | 2010-10-27 |
| RU2007120211A (ru) | 2009-01-20 |
| JP2008522994A (ja) | 2008-07-03 |
| ATE504580T1 (de) | 2011-04-15 |
| IL183293A0 (en) | 2007-09-20 |
| PL1828151T3 (pl) | 2011-09-30 |
| CN101072760B (zh) | 2011-12-28 |
| CA2589196A1 (en) | 2006-06-15 |
| CN101072760A (zh) | 2007-11-14 |
| AU2005313582A1 (en) | 2006-06-15 |
| US7211573B2 (en) | 2007-05-01 |
| JP4979590B2 (ja) | 2012-07-18 |
| NZ555184A (en) | 2010-01-29 |
| AU2005313582A8 (en) | 2011-06-16 |
| WO2006061136A3 (en) | 2006-08-03 |
| AU2005313582B8 (en) | 2011-06-16 |
| PT1828151E (pt) | 2011-06-16 |
| NO20072609L (no) | 2007-06-19 |
| TWI349005B (en) | 2011-09-21 |
| KR20070086979A (ko) | 2007-08-27 |
| BRPI0518615A2 (pt) | 2008-11-25 |
| TW200626568A (en) | 2006-08-01 |
| EP1828151B1 (en) | 2011-04-06 |
| AU2005313582B2 (en) | 2011-06-02 |
| AR053987A1 (es) | 2007-05-30 |
| DK1828151T3 (da) | 2011-05-16 |
| HK1114840A1 (en) | 2008-11-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |