ATE504580T1 - Malonsäureamidderivate als inhibitoren von g- sekretase zur behandlung von alzheimer-krankheit - Google Patents
Malonsäureamidderivate als inhibitoren von g- sekretase zur behandlung von alzheimer-krankheitInfo
- Publication number
- ATE504580T1 ATE504580T1 AT05811672T AT05811672T ATE504580T1 AT E504580 T1 ATE504580 T1 AT E504580T1 AT 05811672 T AT05811672 T AT 05811672T AT 05811672 T AT05811672 T AT 05811672T AT E504580 T1 ATE504580 T1 AT E504580T1
- Authority
- AT
- Austria
- Prior art keywords
- secretase
- alzheimer
- inhibitors
- disease
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04106395 | 2004-12-08 | ||
| EP05100816 | 2005-02-07 | ||
| PCT/EP2005/012834 WO2006061136A2 (en) | 2004-12-08 | 2005-12-01 | Malonamide derivatives as inhibitors of gamma-secretase for the treatment of alzheimer’s disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE504580T1 true ATE504580T1 (de) | 2011-04-15 |
Family
ID=36293585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05811672T ATE504580T1 (de) | 2004-12-08 | 2005-12-01 | Malonsäureamidderivate als inhibitoren von g- sekretase zur behandlung von alzheimer-krankheit |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7211573B2 (de) |
| EP (1) | EP1828151B1 (de) |
| JP (1) | JP4979590B2 (de) |
| KR (1) | KR100890678B1 (de) |
| CN (1) | CN101072760B (de) |
| AR (1) | AR053987A1 (de) |
| AT (1) | ATE504580T1 (de) |
| AU (1) | AU2005313582B8 (de) |
| BR (1) | BRPI0518615A2 (de) |
| CA (1) | CA2589196A1 (de) |
| DE (1) | DE602005027388D1 (de) |
| DK (1) | DK1828151T3 (de) |
| IL (1) | IL183293A0 (de) |
| MX (1) | MX2007006504A (de) |
| NO (1) | NO20072609L (de) |
| NZ (1) | NZ555184A (de) |
| PL (1) | PL1828151T3 (de) |
| PT (1) | PT1828151E (de) |
| RU (1) | RU2402538C2 (de) |
| TW (1) | TWI349005B (de) |
| WO (1) | WO2006061136A2 (de) |
| ZA (1) | ZA200705018B (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007299129A1 (en) * | 2006-09-20 | 2008-03-27 | F. Hoffmann-La Roche Ag | 4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepine derivatives |
| JP2010517954A (ja) * | 2007-02-02 | 2010-05-27 | エフ．ホフマン−ラ ロシュ アーゲー | ６−オキソ−６，７−ジヒドロ−５Ｈ−ジベンゾ［ｂ，ｄ］アゼピン−７−イル誘導体 |
| KR20140007979A (ko) * | 2008-01-11 | 2014-01-20 | 에프. 호프만-라 로슈 아게 | 암 치료를 위한 감마-세크레타제 저해제의 용도 |
| US8741889B2 (en) * | 2008-01-11 | 2014-06-03 | Hoffmann-La Roche Inc | Method of treating non-small cell lung cancer and colon cancer with gamma-secretase inhibitor |
| WO2016198366A1 (en) | 2015-06-11 | 2016-12-15 | F. Hoffmann-La Roche Ag | Targeted notch pathway inhibitors |
| CA3079786A1 (en) | 2017-10-24 | 2019-05-02 | The Broad Institute, Inc. | 4h-pyrrolo[3,2-c]pyridin-4-one derivatives |
| JP7279073B2 (ja) * | 2018-11-07 | 2023-05-22 | 中外製薬株式会社 | Ｏ－置換セリン誘導体の製造方法 |
| US12403135B2 (en) | 2019-04-24 | 2025-09-02 | Bayer Aktiengesellschaft | 4H-pyrrolo[3,2-c]pyridin-4-one derivatives |
| US20240307362A1 (en) | 2019-04-24 | 2024-09-19 | Bayer Aktiengesellschaft | 4H-PYRROLO[3,2-c]PYRIDIN-4-ONE COMPOUNDS |
| CN114127064B (zh) | 2019-04-24 | 2023-12-26 | 拜耳股份有限公司 | 4H-吡咯并[3,2-c]吡啶-4-酮化合物 |
| CN112300019A (zh) * | 2019-07-31 | 2021-02-02 | 华东师范大学 | 一种邻乙酰氨基苯丁酸类化合物的制备方法 |
| EP4126861B1 (de) | 2020-03-31 | 2025-06-18 | Bayer Aktiengesellschaft | 3-(anilino)-2-[3-(3-alkoxy-pyridin-4-yl]-1,5,6,7-tetrahydro-4h-pyrrolo[3,2-c]pyridin-4-on-derivate als egfr inhibitoren zur behandlung von krebs |
| CR20230440A (es) | 2021-03-09 | 2023-10-26 | Basf Se | Malonamidas y su uso como herbicidas |
| WO2023025855A1 (en) * | 2021-08-25 | 2023-03-02 | Basf Se | Herbicidal malonamides |
| EP4396173A1 (de) * | 2021-08-31 | 2024-07-10 | Basf Se | Herbizide malonamide mit einem kondensierten ringsystem |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL72523A (en) * | 1983-08-12 | 1988-06-30 | Takeda Chemical Industries Ltd | 3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine derivatives,their production and pharmaceutical compositions containing them |
| JP2002241368A (ja) * | 1997-02-18 | 2002-08-28 | Shionogi & Co Ltd | 新規ベンゾラクタム誘導体およびそれを含有する医薬組成物 |
| WO1999067219A1 (en) * | 1998-06-22 | 1999-12-29 | Elan Pharmaceuticals, Inc. | Compounds for inhibiting beta-amyloid peptide release and/or its synthesis |
| GB0012671D0 (en) | 2000-05-24 | 2000-07-19 | Merck Sharp & Dohme | Therapeutic agents |
| PT1511718E (pt) * | 2002-05-29 | 2009-06-12 | Hoffmann La Roche | Derivados de n-acilaminobenzeno como inibidores selectivos de monoamina-oxidase b |
| TW200502221A (en) * | 2002-10-03 | 2005-01-16 | Astrazeneca Ab | Novel lactams and uses thereof |
| KR100810810B1 (ko) | 2003-02-04 | 2008-03-06 | 에프. 호프만-라 로슈 아게 | 감마-세크레타제 억제제로서 말론아마이드 유도체 |
| US7060698B2 (en) | 2003-05-19 | 2006-06-13 | Hoffmann-La Roche Inc. | Benzoxazepinone derivatives |
| EA009940B1 (ru) | 2003-09-09 | 2008-04-28 | Ф. Хоффманн-Ля Рош Аг | ПРОИЗВОДНЫЕ МАЛОНАМИДА, БЛОКИРУЮЩИЕ АКТИВНОСТЬ γ-СЕКРЕТАЗЫ |
| CN1894217B (zh) | 2003-10-06 | 2011-09-21 | 弗·哈夫曼-拉罗切有限公司 | 用作γ-分泌酶抑制剂的取代的二苯并氮杂*和苯并二氮杂* |
-
2005
- 2005-11-30 US US11/289,176 patent/US7211573B2/en not_active Expired - Fee Related
- 2005-12-01 AU AU2005313582A patent/AU2005313582B8/en not_active Ceased
- 2005-12-01 CA CA002589196A patent/CA2589196A1/en not_active Abandoned
- 2005-12-01 AT AT05811672T patent/ATE504580T1/de active
- 2005-12-01 PT PT05811672T patent/PT1828151E/pt unknown
- 2005-12-01 DK DK05811672.4T patent/DK1828151T3/da active
- 2005-12-01 JP JP2007544779A patent/JP4979590B2/ja not_active Expired - Fee Related
- 2005-12-01 CN CN2005800421635A patent/CN101072760B/zh not_active Expired - Fee Related
- 2005-12-01 MX MX2007006504A patent/MX2007006504A/es active IP Right Grant
- 2005-12-01 DE DE602005027388T patent/DE602005027388D1/de not_active Expired - Lifetime
- 2005-12-01 PL PL05811672T patent/PL1828151T3/pl unknown
- 2005-12-01 WO PCT/EP2005/012834 patent/WO2006061136A2/en not_active Ceased
- 2005-12-01 RU RU2007120211/04A patent/RU2402538C2/ru not_active IP Right Cessation
- 2005-12-01 KR KR1020077015604A patent/KR100890678B1/ko not_active Expired - Fee Related
- 2005-12-01 EP EP05811672A patent/EP1828151B1/de not_active Expired - Lifetime
- 2005-12-01 BR BRPI0518615-3A patent/BRPI0518615A2/pt not_active IP Right Cessation
- 2005-12-01 NZ NZ555184A patent/NZ555184A/en not_active IP Right Cessation
- 2005-12-07 TW TW094143269A patent/TWI349005B/zh not_active IP Right Cessation
- 2005-12-07 AR ARP050105106A patent/AR053987A1/es unknown
-
2007
- 2007-05-17 IL IL183293A patent/IL183293A0/en unknown
- 2007-05-24 NO NO20072609A patent/NO20072609L/no not_active Application Discontinuation
- 2007-06-04 ZA ZA200705018A patent/ZA200705018B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008522994A (ja) | 2008-07-03 |
| US7211573B2 (en) | 2007-05-01 |
| PT1828151E (pt) | 2011-06-16 |
| CA2589196A1 (en) | 2006-06-15 |
| TWI349005B (en) | 2011-09-21 |
| EP1828151A2 (de) | 2007-09-05 |
| BRPI0518615A2 (pt) | 2008-11-25 |
| NO20072609L (no) | 2007-06-19 |
| KR100890678B1 (ko) | 2009-03-26 |
| WO2006061136A3 (en) | 2006-08-03 |
| CN101072760A (zh) | 2007-11-14 |
| HK1114840A1 (en) | 2008-11-14 |
| PL1828151T3 (pl) | 2011-09-30 |
| AU2005313582B8 (en) | 2011-06-16 |
| RU2007120211A (ru) | 2009-01-20 |
| AU2005313582B2 (en) | 2011-06-02 |
| NZ555184A (en) | 2010-01-29 |
| CN101072760B (zh) | 2011-12-28 |
| US20060122168A1 (en) | 2006-06-08 |
| JP4979590B2 (ja) | 2012-07-18 |
| MX2007006504A (es) | 2007-06-22 |
| RU2402538C2 (ru) | 2010-10-27 |
| DK1828151T3 (da) | 2011-05-16 |
| IL183293A0 (en) | 2007-09-20 |
| KR20070086979A (ko) | 2007-08-27 |
| TW200626568A (en) | 2006-08-01 |
| AU2005313582A8 (en) | 2011-06-16 |
| WO2006061136A2 (en) | 2006-06-15 |
| ZA200705018B (en) | 2010-04-28 |
| EP1828151B1 (de) | 2011-04-06 |
| DE602005027388D1 (de) | 2011-05-19 |
| AR053987A1 (es) | 2007-05-30 |
| AU2005313582A1 (en) | 2006-06-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE550338T1 (de) | Spiropiperidininhibitoren von beta-secretase zur behandlung von alzheimer-krankheit | |
| ATE457989T1 (de) | Bi- und trizyklische substituierte phenyl- methanone als inhibitoren von glycin-i (glyt-1)- transportern zur behandlung der alzheimer- krankheit | |
| DE60303238D1 (de) | Pyrimidin-Essigsäure Derivate geeignet zur Behandlung von CRTH2-bedingten Krankheiten | |
| DE602005005810D1 (de) | Verwendung von substituierten chinolin-derivaten zur behandlung von arzneimittelresistenten mycobakteriellen erkrankungen | |
| DE602005007717D1 (de) | Imidazolverbindungen zur behandlung von neurodegenerativen erkrankungen | |
| DE602005023172D1 (de) | Hydantoinderivate zur behandlung von entzündlichen erkrankungen | |
| DE602005022113D1 (de) | Phenyl)methanon-derivate als glycin-transporter 1 (glyt-1) hemmer zur behandlung von neurologischen und neuropsychiatrischen erkrankungen | |
| ATE369333T1 (de) | Sulfonamidderivate zur behandlung von krankheiten | |
| DE602004028763D1 (de) | Te zur behandlung von virenerkrankungen | |
| ATE519488T1 (de) | Aminopyrazin-analoga zur behandlung von glaukomen und anderen durch rho-kinase verursachten krankheiten | |
| ATE447559T1 (de) | 4-(phenylamino)-6-oxo-1,6-dihydropyridazine-3- carboxamid derivate als mek inhibitoren zur behandlung von hyperproliferativen erkrankungen | |
| ATE476414T1 (de) | Biphenyloxyessigsäurederivate zur behandlung von atemwegserkrankungen | |
| DE602005026984D1 (de) | Chinolin-derivate zur behandlung von latenter tuberkulose | |
| ATE375977T1 (de) | Sulfonamidderivate zur behandlung von krankheiten | |
| ATE506951T1 (de) | Als inhibitoren von beta-secretase aktive tertiäre carbinamine mit substituierten heterocyclen zur behandlung der alzheimer- krankheit | |
| ATE534633T1 (de) | Indazolderivate zur behandlung von hsp90- induzierten krankheiten | |
| DE602005017503D1 (de) | Biphenyloxyessigsäure - derivate zur behandlung von atemwegserkränkungen | |
| ATE538651T1 (de) | Spiropiperidininhibitoren von beta-secretase zur behandlung von alzheimer-krankheit | |
| ZA200705018B (en) | Malonamide derivatives as inhibitors of gamma-secretase for the treatment of Alzheimer's disease | |
| ATE429218T1 (de) | Pinolensäure zur behandlung von übergewicht | |
| EP1965827A4 (de) | Behandlung von entmyelinisierenden erkrankungen | |
| DE602004006118D1 (de) | 2,3,4,5-TETRAHYDROBENZOiFöi1,4öOXAZEPIN-5-CARBONSÄUREAMID DERIVATE ALS GAMMA-SECRETASE INHIBITOREN ZUR BEHANDLUNG VON ALZHEIMER | |
| DE602004022035D1 (de) | Verwendung von pthalide derivativen zur behandlung | |
| ATE525355T1 (de) | 1-ä(4-äbenzoyl(methyl)aminoü-3- (phenyl)butylüazetidinderivate zur behandlung von gastrointestinalen erkrankungen 1 | |
| ATE538796T1 (de) | Piperidin- und pyrrolidin-beta-secretase-hemmer zur behandlung von alzheimer-krankheit |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1828151 Country of ref document: EP |