DK1828151T3 - Malonamidderivater som inhibitorer af gamma-sekretase til behandlingen af alzheimer's sygdom - Google Patents
Malonamidderivater som inhibitorer af gamma-sekretase til behandlingen af alzheimer's sygdomInfo
- Publication number
- DK1828151T3 DK1828151T3 DK05811672.4T DK05811672T DK1828151T3 DK 1828151 T3 DK1828151 T3 DK 1828151T3 DK 05811672 T DK05811672 T DK 05811672T DK 1828151 T3 DK1828151 T3 DK 1828151T3
- Authority
- DK
- Denmark
- Prior art keywords
- alzheimer
- inhibitors
- disease
- treatment
- gamma secretase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04106395 | 2004-12-08 | ||
| EP05100816 | 2005-02-07 | ||
| PCT/EP2005/012834 WO2006061136A2 (en) | 2004-12-08 | 2005-12-01 | Malonamide derivatives as inhibitors of gamma-secretase for the treatment of alzheimer’s disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1828151T3 true DK1828151T3 (da) | 2011-05-16 |
Family
ID=36293585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK05811672.4T DK1828151T3 (da) | 2004-12-08 | 2005-12-01 | Malonamidderivater som inhibitorer af gamma-sekretase til behandlingen af alzheimer's sygdom |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7211573B2 (da) |
| EP (1) | EP1828151B1 (da) |
| JP (1) | JP4979590B2 (da) |
| KR (1) | KR100890678B1 (da) |
| CN (1) | CN101072760B (da) |
| AR (1) | AR053987A1 (da) |
| AT (1) | ATE504580T1 (da) |
| AU (1) | AU2005313582B8 (da) |
| BR (1) | BRPI0518615A2 (da) |
| CA (1) | CA2589196A1 (da) |
| DE (1) | DE602005027388D1 (da) |
| DK (1) | DK1828151T3 (da) |
| HK (1) | HK1114840A1 (da) |
| IL (1) | IL183293A0 (da) |
| MX (1) | MX2007006504A (da) |
| NO (1) | NO20072609L (da) |
| NZ (1) | NZ555184A (da) |
| PL (1) | PL1828151T3 (da) |
| PT (1) | PT1828151E (da) |
| RU (1) | RU2402538C2 (da) |
| TW (1) | TWI349005B (da) |
| WO (1) | WO2006061136A2 (da) |
| ZA (1) | ZA200705018B (da) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5001372B2 (ja) | 2006-09-20 | 2012-08-15 | エフ．ホフマン−ラ ロシュ アーゲー | ４−オキソ−２，３，４，５−テトラヒドロ−ベンゾ［ｂ］［１，４］ジアゼピン誘導体 |
| CN101622232A (zh) * | 2007-02-02 | 2010-01-06 | 弗·哈夫曼-拉罗切有限公司 | 6-氧代-6,7-二氢-5h-二苯并[b,d]氮杂䓬-7-基衍生物 |
| US8741889B2 (en) * | 2008-01-11 | 2014-06-03 | Hoffmann-La Roche Inc | Method of treating non-small cell lung cancer and colon cancer with gamma-secretase inhibitor |
| US20090181944A1 (en) * | 2008-01-11 | 2009-07-16 | John Frederick Boylan | Method for cancer therapy |
| EP3307721B1 (en) | 2015-06-11 | 2020-06-17 | H. Hoffnabb-La Roche Ag | Targeted notch pathway inhibitors |
| EP3700904B1 (en) | 2017-10-24 | 2023-07-19 | Bayer AG | 4h-pyrrolo[3,2-c]pyridin-4-one derivatives |
| EP3878836A4 (en) * | 2018-11-07 | 2022-08-10 | Chugai Seiyaku Kabushiki Kaisha | PROCESS FOR THE PREPARATION OF O-SUBSTITUTED SERIN DERIVATIVES |
| CA3137610A1 (en) | 2019-04-24 | 2020-10-29 | Bayer Aktiengesellschaft | 4h-pyrrolo[3,2-c]pyridin-4-one compounds |
| JP2022532850A (ja) | 2019-04-24 | 2022-07-20 | バイエル・アクチエンゲゼルシヤフト | ４ｈ－ピロロ［３，２－ｃ］ピリジン－４－オン化合物 |
| CA3137611A1 (en) | 2019-04-24 | 2020-10-29 | Bayer Aktiengesellschaft | 4h-pyrrolo[3,2-c]pyridin-4-one derivatives |
| CN112300019A (zh) * | 2019-07-31 | 2021-02-02 | 华东师范大学 | 一种邻乙酰氨基苯丁酸类化合物的制备方法 |
| EP4126861A1 (en) | 2020-03-31 | 2023-02-08 | Bayer Aktiengesellschaft | 3-(anilino)-2-[3-(3-alkoxy-pyridin-4-yl]-1,5,6,7-tetrahydro-4h-pyrrolo[3,2-c]pyridin-4-one derivatives as egfr inhibitors for the treatment of cancer |
| JP2024508977A (ja) | 2021-03-09 | 2024-02-28 | ビーエーエスエフ ソシエタス・ヨーロピア | マロンアミド及び除草剤としてのその使用 |
| KR20240051210A (ko) * | 2021-08-25 | 2024-04-19 | 바스프 에스이 | 제초제 말론아미드 |
| WO2023031200A1 (en) * | 2021-08-31 | 2023-03-09 | Basf Se | Herbicidal malonamides containing a condensed ring system |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002241368A (ja) * | 1997-02-18 | 2002-08-28 | Shionogi & Co Ltd | 新規ベンゾラクタム誘導体およびそれを含有する医薬組成物 |
| WO1999067219A1 (en) * | 1998-06-22 | 1999-12-29 | Elan Pharmaceuticals, Inc. | Compounds for inhibiting beta-amyloid peptide release and/or its synthesis |
| GB0012671D0 (en) | 2000-05-24 | 2000-07-19 | Merck Sharp & Dohme | Therapeutic agents |
| DK1511718T3 (da) * | 2002-05-29 | 2009-06-22 | Hoffmann La Roche | N-acylaminobenzenderivater som selektive monoaminoxidase B-inhibitorer |
| TW200502221A (en) * | 2002-10-03 | 2005-01-16 | Astrazeneca Ab | Novel lactams and uses thereof |
| MXPA05008172A (es) | 2003-02-04 | 2005-10-05 | Hoffmann La Roche | Derivados de malonamida como inhibidores gamma-secretasa. |
| US7060698B2 (en) | 2003-05-19 | 2006-06-13 | Hoffmann-La Roche Inc. | Benzoxazepinone derivatives |
| NZ545538A (en) | 2003-09-09 | 2008-12-24 | Hoffmann La Roche | Malonamide derivatives blocking the activity of gama-secretase |
| DK1673347T3 (da) | 2003-10-06 | 2015-10-12 | Hoffmann La Roche | Substituerede dibenzo-azepin og benzo-diazepinderivater der er anvendelige som gamma-sekretaseinhibitorer |
-
2005
- 2005-11-30 US US11/289,176 patent/US7211573B2/en not_active Expired - Fee Related
- 2005-12-01 AT AT05811672T patent/ATE504580T1/de active
- 2005-12-01 WO PCT/EP2005/012834 patent/WO2006061136A2/en active Application Filing
- 2005-12-01 DE DE602005027388T patent/DE602005027388D1/de active Active
- 2005-12-01 KR KR1020077015604A patent/KR100890678B1/ko not_active IP Right Cessation
- 2005-12-01 JP JP2007544779A patent/JP4979590B2/ja not_active Expired - Fee Related
- 2005-12-01 CA CA002589196A patent/CA2589196A1/en not_active Abandoned
- 2005-12-01 NZ NZ555184A patent/NZ555184A/en not_active IP Right Cessation
- 2005-12-01 PL PL05811672T patent/PL1828151T3/pl unknown
- 2005-12-01 AU AU2005313582A patent/AU2005313582B8/en not_active Ceased
- 2005-12-01 RU RU2007120211/04A patent/RU2402538C2/ru not_active IP Right Cessation
- 2005-12-01 PT PT05811672T patent/PT1828151E/pt unknown
- 2005-12-01 MX MX2007006504A patent/MX2007006504A/es active IP Right Grant
- 2005-12-01 DK DK05811672.4T patent/DK1828151T3/da active
- 2005-12-01 CN CN2005800421635A patent/CN101072760B/zh not_active Expired - Fee Related
- 2005-12-01 EP EP05811672A patent/EP1828151B1/en active Active
- 2005-12-01 BR BRPI0518615-3A patent/BRPI0518615A2/pt not_active IP Right Cessation
- 2005-12-07 TW TW094143269A patent/TWI349005B/zh not_active IP Right Cessation
- 2005-12-07 AR ARP050105106A patent/AR053987A1/es unknown
-
2007
- 2007-05-17 IL IL183293A patent/IL183293A0/en unknown
- 2007-05-24 NO NO20072609A patent/NO20072609L/no not_active Application Discontinuation
- 2007-06-04 ZA ZA200705018A patent/ZA200705018B/xx unknown
-
2008
- 2008-04-29 HK HK08104728.3A patent/HK1114840A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006061136A2 (en) | 2006-06-15 |
| ZA200705018B (en) | 2010-04-28 |
| WO2006061136A3 (en) | 2006-08-03 |
| AR053987A1 (es) | 2007-05-30 |
| AU2005313582A1 (en) | 2006-06-15 |
| IL183293A0 (en) | 2007-09-20 |
| EP1828151B1 (en) | 2011-04-06 |
| JP2008522994A (ja) | 2008-07-03 |
| PT1828151E (pt) | 2011-06-16 |
| US20060122168A1 (en) | 2006-06-08 |
| KR100890678B1 (ko) | 2009-03-26 |
| US7211573B2 (en) | 2007-05-01 |
| DE602005027388D1 (de) | 2011-05-19 |
| CA2589196A1 (en) | 2006-06-15 |
| HK1114840A1 (en) | 2008-11-14 |
| NZ555184A (en) | 2010-01-29 |
| NO20072609L (no) | 2007-06-19 |
| TW200626568A (en) | 2006-08-01 |
| BRPI0518615A2 (pt) | 2008-11-25 |
| AU2005313582B8 (en) | 2011-06-16 |
| KR20070086979A (ko) | 2007-08-27 |
| RU2007120211A (ru) | 2009-01-20 |
| ATE504580T1 (de) | 2011-04-15 |
| EP1828151A2 (en) | 2007-09-05 |
| JP4979590B2 (ja) | 2012-07-18 |
| CN101072760A (zh) | 2007-11-14 |
| RU2402538C2 (ru) | 2010-10-27 |
| TWI349005B (en) | 2011-09-21 |
| AU2005313582B2 (en) | 2011-06-02 |
| MX2007006504A (es) | 2007-06-22 |
| CN101072760B (zh) | 2011-12-28 |
| AU2005313582A8 (en) | 2011-06-16 |
| PL1828151T3 (pl) | 2011-09-30 |
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