AR053987A1 - Derivados de malonamida. proceso de obtencion y composiciones farmaceuticas. - Google Patents
Derivados de malonamida. proceso de obtencion y composiciones farmaceuticas.Info
- Publication number
- AR053987A1 AR053987A1 ARP050105106A ARP050105106A AR053987A1 AR 053987 A1 AR053987 A1 AR 053987A1 AR P050105106 A ARP050105106 A AR P050105106A AR P050105106 A ARP050105106 A AR P050105106A AR 053987 A1 AR053987 A1 AR 053987A1
- Authority
- AR
- Argentina
- Prior art keywords
- lower alkyl
- halogen
- pharmaceutical compositions
- cycloalkyl
- hydroxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Proceso de obtencion y composiciones farmacéuticas que los comprenden. Reivindicacion 1: Compuestos de la formula general (1) en la que R es halogeno, alquilo inferior o trifluorometilo; R1 es H, alquilo inferior o alquilo inferior sustituido por halogeno o hidroxi o es alquenilo inferior, -(CH2)n-cicloalquilo, -(CH2)n-COR' o es bencilo opcionalmente sustituido por halogeno o R' es alcoxi inferior, hidroxi o amino; R2 es H, alquilo inferior, trifluorometilo o cicloalquilo; R3 es alquilo inferior o alquilo inferior sustituido por halogeno o es bencilo opcionalmente sustituido por dos átomos de halogeno o es -(CH2)n-cicloalquilo o -(CH2)n-piridinilo; X es -CH2-, -CH(R4)-, -C(alquilo inferior)2-, -C(halogeno)(alquilo inferior)- o - CH(R4)-O-; R4 es alquilo, alquilo inferior, alcoxi inferior, hidroxi o -CH2-2-[1,3]dioxalano-; n es 0, 1 o 2; a sales de adicion de ácido farmacéuticamente aceptables de los mismos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04106395 | 2004-12-08 | ||
| EP05100816 | 2005-02-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR053987A1 true AR053987A1 (es) | 2007-05-30 |
Family
ID=36293585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050105106A AR053987A1 (es) | 2004-12-08 | 2005-12-07 | Derivados de malonamida. proceso de obtencion y composiciones farmaceuticas. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7211573B2 (es) |
| EP (1) | EP1828151B1 (es) |
| JP (1) | JP4979590B2 (es) |
| KR (1) | KR100890678B1 (es) |
| CN (1) | CN101072760B (es) |
| AR (1) | AR053987A1 (es) |
| AT (1) | ATE504580T1 (es) |
| AU (1) | AU2005313582B8 (es) |
| BR (1) | BRPI0518615A2 (es) |
| CA (1) | CA2589196A1 (es) |
| DE (1) | DE602005027388D1 (es) |
| DK (1) | DK1828151T3 (es) |
| HK (1) | HK1114840A1 (es) |
| IL (1) | IL183293A0 (es) |
| MX (1) | MX2007006504A (es) |
| NO (1) | NO20072609L (es) |
| NZ (1) | NZ555184A (es) |
| PL (1) | PL1828151T3 (es) |
| PT (1) | PT1828151E (es) |
| RU (1) | RU2402538C2 (es) |
| TW (1) | TWI349005B (es) |
| WO (1) | WO2006061136A2 (es) |
| ZA (1) | ZA200705018B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2663240A1 (en) | 2006-09-20 | 2008-03-27 | F. Hoffmann-La Roche Ag | 4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepine derivatives |
| MX2009007864A (es) * | 2007-02-02 | 2009-07-31 | Hoffmann La Roche | Derivados de 6-oxo-6,7-dihidro-5h-dibenzo[b,d]azepin-7-ilo. |
| AU2009203776A1 (en) * | 2008-01-11 | 2009-07-16 | F. Hoffmann-La Roche Ag | Use of a gamma-secretase inhibitor for treating cancer |
| US8741889B2 (en) * | 2008-01-11 | 2014-06-03 | Hoffmann-La Roche Inc | Method of treating non-small cell lung cancer and colon cancer with gamma-secretase inhibitor |
| WO2016198366A1 (en) | 2015-06-11 | 2016-12-15 | F. Hoffmann-La Roche Ag | Targeted notch pathway inhibitors |
| EP3700904B1 (en) | 2017-10-24 | 2023-07-19 | Bayer AG | 4h-pyrrolo[3,2-c]pyridin-4-one derivatives |
| US20220017456A1 (en) * | 2018-11-07 | 2022-01-20 | Chugai Seiyaku Kabushiki Kaisha | O-substituted serine derivative production method |
| WO2020216773A1 (en) | 2019-04-24 | 2020-10-29 | Bayer Aktiengesellschaft | 4h-pyrrolo[3,2-c]pyridin-4-one compounds |
| CA3137611A1 (en) | 2019-04-24 | 2020-10-29 | Bayer Aktiengesellschaft | 4h-pyrrolo[3,2-c]pyridin-4-one derivatives |
| MA55751A (fr) | 2019-04-24 | 2022-03-02 | Bayer Ag | Composés de 4h-pyrrolo[3,2-c]pyridin-4-one |
| CN112300019A (zh) * | 2019-07-31 | 2021-02-02 | 华东师范大学 | 一种邻乙酰氨基苯丁酸类化合物的制备方法 |
| CA3177214A1 (en) | 2020-03-31 | 2021-10-07 | Bayer Aktiengesellschaft | 3-(anilino)-2-[3-(3-alkoxy-pyridin-4-yl]-1,5,6,7-tetrahydro-4h-pyrrolo[3,2-c]pyridin-4-one derivatives as egfr inhibitors for the treatment of cancer |
| AU2022234513A1 (en) | 2021-03-09 | 2023-09-21 | Basf Se | Malonamides and their use as herbicides |
| CR20240097A (es) * | 2021-08-25 | 2024-05-20 | Basf Se | Malonamidas herbicidas |
| WO2023031200A1 (en) * | 2021-08-31 | 2023-03-09 | Basf Se | Herbicidal malonamides containing a condensed ring system |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002241368A (ja) * | 1997-02-18 | 2002-08-28 | Shionogi & Co Ltd | 新規ベンゾラクタム誘導体およびそれを含有する医薬組成物 |
| AU4707999A (en) * | 1998-06-22 | 2000-01-10 | Elan Pharmaceuticals, Inc. | Compounds for inhibiting beta-amyloid peptide release and/or its synthesis |
| GB0012671D0 (en) | 2000-05-24 | 2000-07-19 | Merck Sharp & Dohme | Therapeutic agents |
| PL212708B1 (pl) * | 2002-05-29 | 2012-11-30 | Hoffmann La Roche | Pochodne N-acyloaminobenzenu, sposób ich wytwarzania, lek zawierajacy te pochodne i zastosowanie pochodnych N-acyloaminobenzenu |
| TW200502221A (en) * | 2002-10-03 | 2005-01-16 | Astrazeneca Ab | Novel lactams and uses thereof |
| BRPI0407262A (pt) | 2003-02-04 | 2006-01-31 | Hoffmann La Roche | Derivados de malonamida como inibidores gama-secretase |
| US7060698B2 (en) | 2003-05-19 | 2006-06-13 | Hoffmann-La Roche Inc. | Benzoxazepinone derivatives |
| EP1711470B1 (en) | 2003-09-09 | 2009-04-15 | F. Hoffmann-La Roche Ag | Malonamide derivatives blocking the activtiy of gamma-secretase |
| KR100867035B1 (ko) | 2003-10-06 | 2008-11-04 | 에프. 호프만-라 로슈 아게 | 감마-세크레타제 저해제로서 유용한 치환된다이벤조-아제핀 및 벤조-다이아제핀 유도체 |
-
2005
- 2005-11-30 US US11/289,176 patent/US7211573B2/en not_active Expired - Fee Related
- 2005-12-01 DE DE602005027388T patent/DE602005027388D1/de active Active
- 2005-12-01 AT AT05811672T patent/ATE504580T1/de active
- 2005-12-01 DK DK05811672.4T patent/DK1828151T3/da active
- 2005-12-01 CA CA002589196A patent/CA2589196A1/en not_active Abandoned
- 2005-12-01 MX MX2007006504A patent/MX2007006504A/es active IP Right Grant
- 2005-12-01 WO PCT/EP2005/012834 patent/WO2006061136A2/en active Application Filing
- 2005-12-01 AU AU2005313582A patent/AU2005313582B8/en not_active Ceased
- 2005-12-01 PL PL05811672T patent/PL1828151T3/pl unknown
- 2005-12-01 BR BRPI0518615-3A patent/BRPI0518615A2/pt not_active IP Right Cessation
- 2005-12-01 JP JP2007544779A patent/JP4979590B2/ja not_active Expired - Fee Related
- 2005-12-01 RU RU2007120211/04A patent/RU2402538C2/ru not_active IP Right Cessation
- 2005-12-01 NZ NZ555184A patent/NZ555184A/en not_active IP Right Cessation
- 2005-12-01 KR KR1020077015604A patent/KR100890678B1/ko not_active IP Right Cessation
- 2005-12-01 CN CN2005800421635A patent/CN101072760B/zh not_active Expired - Fee Related
- 2005-12-01 EP EP05811672A patent/EP1828151B1/en active Active
- 2005-12-01 PT PT05811672T patent/PT1828151E/pt unknown
- 2005-12-07 AR ARP050105106A patent/AR053987A1/es unknown
- 2005-12-07 TW TW094143269A patent/TWI349005B/zh not_active IP Right Cessation
-
2007
- 2007-05-17 IL IL183293A patent/IL183293A0/en unknown
- 2007-05-24 NO NO20072609A patent/NO20072609L/no not_active Application Discontinuation
- 2007-06-04 ZA ZA200705018A patent/ZA200705018B/xx unknown
-
2008
- 2008-04-29 HK HK08104728.3A patent/HK1114840A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008522994A (ja) | 2008-07-03 |
| MX2007006504A (es) | 2007-06-22 |
| NO20072609L (no) | 2007-06-19 |
| PL1828151T3 (pl) | 2011-09-30 |
| TW200626568A (en) | 2006-08-01 |
| EP1828151A2 (en) | 2007-09-05 |
| HK1114840A1 (en) | 2008-11-14 |
| US20060122168A1 (en) | 2006-06-08 |
| CN101072760A (zh) | 2007-11-14 |
| AU2005313582B2 (en) | 2011-06-02 |
| DE602005027388D1 (de) | 2011-05-19 |
| KR20070086979A (ko) | 2007-08-27 |
| EP1828151B1 (en) | 2011-04-06 |
| AU2005313582A8 (en) | 2011-06-16 |
| WO2006061136A3 (en) | 2006-08-03 |
| BRPI0518615A2 (pt) | 2008-11-25 |
| AU2005313582B8 (en) | 2011-06-16 |
| RU2402538C2 (ru) | 2010-10-27 |
| US7211573B2 (en) | 2007-05-01 |
| KR100890678B1 (ko) | 2009-03-26 |
| CA2589196A1 (en) | 2006-06-15 |
| ATE504580T1 (de) | 2011-04-15 |
| IL183293A0 (en) | 2007-09-20 |
| JP4979590B2 (ja) | 2012-07-18 |
| CN101072760B (zh) | 2011-12-28 |
| RU2007120211A (ru) | 2009-01-20 |
| NZ555184A (en) | 2010-01-29 |
| TWI349005B (en) | 2011-09-21 |
| DK1828151T3 (da) | 2011-05-16 |
| PT1828151E (pt) | 2011-06-16 |
| AU2005313582A1 (en) | 2006-06-15 |
| WO2006061136A2 (en) | 2006-06-15 |
| ZA200705018B (en) | 2010-04-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |