PT1828151E - Derivados de malonamida como inibidores de gama-secretase para o tratamento da doença de alzheimer - Google Patents
Derivados de malonamida como inibidores de gama-secretase para o tratamento da doença de alzheimer Download PDFInfo
- Publication number
- PT1828151E PT1828151E PT05811672T PT05811672T PT1828151E PT 1828151 E PT1828151 E PT 1828151E PT 05811672 T PT05811672 T PT 05811672T PT 05811672 T PT05811672 T PT 05811672T PT 1828151 E PT1828151 E PT 1828151E
- Authority
- PT
- Portugal
- Prior art keywords
- secretase
- alzheimer
- gamma
- inhibitors
- disease
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04106395 | 2004-12-08 | ||
| EP05100816 | 2005-02-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1828151E true PT1828151E (pt) | 2011-06-16 |
Family
ID=36293585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT05811672T PT1828151E (pt) | 2004-12-08 | 2005-12-01 | Derivados de malonamida como inibidores de gama-secretase para o tratamento da doença de alzheimer |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7211573B2 (pt) |
| EP (1) | EP1828151B1 (pt) |
| JP (1) | JP4979590B2 (pt) |
| KR (1) | KR100890678B1 (pt) |
| CN (1) | CN101072760B (pt) |
| AR (1) | AR053987A1 (pt) |
| AT (1) | ATE504580T1 (pt) |
| AU (1) | AU2005313582B8 (pt) |
| BR (1) | BRPI0518615A2 (pt) |
| CA (1) | CA2589196A1 (pt) |
| DE (1) | DE602005027388D1 (pt) |
| DK (1) | DK1828151T3 (pt) |
| HK (1) | HK1114840A1 (pt) |
| IL (1) | IL183293A0 (pt) |
| MX (1) | MX2007006504A (pt) |
| NO (1) | NO20072609L (pt) |
| NZ (1) | NZ555184A (pt) |
| PL (1) | PL1828151T3 (pt) |
| PT (1) | PT1828151E (pt) |
| RU (1) | RU2402538C2 (pt) |
| TW (1) | TWI349005B (pt) |
| WO (1) | WO2006061136A2 (pt) |
| ZA (1) | ZA200705018B (pt) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2069317A2 (en) | 2006-09-20 | 2009-06-17 | F. Hoffmann-Roche AG | 4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]diazepine derivatives |
| KR101150574B1 (ko) * | 2007-02-02 | 2012-05-30 | 에프. 호프만-라 로슈 아게 | 6-옥소-6,7-다이하이드로-5ｈ-다이벤조［ｂ,ｄ］아제핀-7-일 유도체 |
| CA2710913A1 (en) * | 2008-01-11 | 2009-07-16 | F. Hoffmann-La Roche Ag | Use of a gamma-secretase inhibitor for treating cancer |
| US8741889B2 (en) * | 2008-01-11 | 2014-06-03 | Hoffmann-La Roche Inc | Method of treating non-small cell lung cancer and colon cancer with gamma-secretase inhibitor |
| WO2016198366A1 (en) | 2015-06-11 | 2016-12-15 | F. Hoffmann-La Roche Ag | Targeted notch pathway inhibitors |
| US11339157B1 (en) | 2017-10-24 | 2022-05-24 | Bayer Aktiengesellschaft | 4H-pyrrolo[3,2-c]pyridin-4-one derivatives |
| EP3878836A4 (en) * | 2018-11-07 | 2022-08-10 | Chugai Seiyaku Kabushiki Kaisha | PROCESS FOR THE PREPARATION OF O-SUBSTITUTED SERIN DERIVATIVES |
| US20240307362A1 (en) | 2019-04-24 | 2024-09-19 | Bayer Aktiengesellschaft | 4H-PYRROLO[3,2-c]PYRIDIN-4-ONE COMPOUNDS |
| CA3137611A1 (en) | 2019-04-24 | 2020-10-29 | Bayer Aktiengesellschaft | 4h-pyrrolo[3,2-c]pyridin-4-one derivatives |
| SG11202111304UA (en) | 2019-04-24 | 2021-11-29 | Bayer Ag | 4h-pyrrolo[3,2-c]pyridin-4-one compounds |
| CN112300019A (zh) * | 2019-07-31 | 2021-02-02 | 华东师范大学 | 一种邻乙酰氨基苯丁酸类化合物的制备方法 |
| CA3177214A1 (en) | 2020-03-31 | 2021-10-07 | Bayer Aktiengesellschaft | 3-(anilino)-2-[3-(3-alkoxy-pyridin-4-yl]-1,5,6,7-tetrahydro-4h-pyrrolo[3,2-c]pyridin-4-one derivatives as egfr inhibitors for the treatment of cancer |
| CR20230440A (es) | 2021-03-09 | 2023-10-26 | Basf Se | Malonamidas y su uso como herbicidas |
| AR126867A1 (es) * | 2021-08-25 | 2023-11-22 | Basf Se | Malonamidas herbicidas |
| CN117881667A (zh) * | 2021-08-31 | 2024-04-12 | 巴斯夫欧洲公司 | 含有稠环系的除草剂丙二酰胺 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002241368A (ja) * | 1997-02-18 | 2002-08-28 | Shionogi & Co Ltd | 新規ベンゾラクタム誘導体およびそれを含有する医薬組成物 |
| AU4707999A (en) * | 1998-06-22 | 2000-01-10 | Elan Pharmaceuticals, Inc. | Compounds for inhibiting beta-amyloid peptide release and/or its synthesis |
| GB0012671D0 (en) | 2000-05-24 | 2000-07-19 | Merck Sharp & Dohme | Therapeutic agents |
| JP4223003B2 (ja) * | 2002-05-29 | 2009-02-12 | エフ．ホフマン−ラ ロシュ アーゲー | 選択的モノアミンオキシダーゼｂインヒビターとしてのｎ−アシルアミノベンゼン誘導体 |
| TW200502221A (en) * | 2002-10-03 | 2005-01-16 | Astrazeneca Ab | Novel lactams and uses thereof |
| WO2004069826A1 (en) | 2003-02-04 | 2004-08-19 | F. Hoffmann-La Roche Ag | Malonamide derivatives as gamma-secretase inhibitors |
| US7060698B2 (en) | 2003-05-19 | 2006-06-13 | Hoffmann-La Roche Inc. | Benzoxazepinone derivatives |
| MXPA06002562A (es) | 2003-09-09 | 2006-06-20 | Hoffmann La Roche | Derivados de malonamida que bloquean la actividad de la gamma-secretasa. |
| HUE025548T2 (en) | 2003-10-06 | 2016-02-29 | Hoffmann La Roche | Substituted dibenzo-azepine and benzodiazepine derivatives useful as gamma-secretase inhibitors |
-
2005
- 2005-11-30 US US11/289,176 patent/US7211573B2/en not_active Expired - Fee Related
- 2005-12-01 KR KR1020077015604A patent/KR100890678B1/ko not_active IP Right Cessation
- 2005-12-01 PL PL05811672T patent/PL1828151T3/pl unknown
- 2005-12-01 PT PT05811672T patent/PT1828151E/pt unknown
- 2005-12-01 NZ NZ555184A patent/NZ555184A/en not_active IP Right Cessation
- 2005-12-01 BR BRPI0518615-3A patent/BRPI0518615A2/pt not_active IP Right Cessation
- 2005-12-01 EP EP05811672A patent/EP1828151B1/en active Active
- 2005-12-01 DK DK05811672.4T patent/DK1828151T3/da active
- 2005-12-01 CA CA002589196A patent/CA2589196A1/en not_active Abandoned
- 2005-12-01 MX MX2007006504A patent/MX2007006504A/es active IP Right Grant
- 2005-12-01 JP JP2007544779A patent/JP4979590B2/ja not_active Expired - Fee Related
- 2005-12-01 DE DE602005027388T patent/DE602005027388D1/de active Active
- 2005-12-01 AU AU2005313582A patent/AU2005313582B8/en not_active Ceased
- 2005-12-01 CN CN2005800421635A patent/CN101072760B/zh not_active Expired - Fee Related
- 2005-12-01 WO PCT/EP2005/012834 patent/WO2006061136A2/en active Application Filing
- 2005-12-01 AT AT05811672T patent/ATE504580T1/de active
- 2005-12-01 RU RU2007120211/04A patent/RU2402538C2/ru not_active IP Right Cessation
- 2005-12-07 AR ARP050105106A patent/AR053987A1/es unknown
- 2005-12-07 TW TW094143269A patent/TWI349005B/zh not_active IP Right Cessation
-
2007
- 2007-05-17 IL IL183293A patent/IL183293A0/en unknown
- 2007-05-24 NO NO20072609A patent/NO20072609L/no not_active Application Discontinuation
- 2007-06-04 ZA ZA200705018A patent/ZA200705018B/xx unknown
-
2008
- 2008-04-29 HK HK08104728.3A patent/HK1114840A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005313582B2 (en) | 2011-06-02 |
| JP2008522994A (ja) | 2008-07-03 |
| MX2007006504A (es) | 2007-06-22 |
| NO20072609L (no) | 2007-06-19 |
| TW200626568A (en) | 2006-08-01 |
| DK1828151T3 (da) | 2011-05-16 |
| AR053987A1 (es) | 2007-05-30 |
| JP4979590B2 (ja) | 2012-07-18 |
| DE602005027388D1 (de) | 2011-05-19 |
| RU2007120211A (ru) | 2009-01-20 |
| RU2402538C2 (ru) | 2010-10-27 |
| ATE504580T1 (de) | 2011-04-15 |
| AU2005313582B8 (en) | 2011-06-16 |
| AU2005313582A8 (en) | 2011-06-16 |
| WO2006061136A3 (en) | 2006-08-03 |
| AU2005313582A1 (en) | 2006-06-15 |
| CN101072760B (zh) | 2011-12-28 |
| TWI349005B (en) | 2011-09-21 |
| PL1828151T3 (pl) | 2011-09-30 |
| KR100890678B1 (ko) | 2009-03-26 |
| US7211573B2 (en) | 2007-05-01 |
| CN101072760A (zh) | 2007-11-14 |
| NZ555184A (en) | 2010-01-29 |
| HK1114840A1 (en) | 2008-11-14 |
| IL183293A0 (en) | 2007-09-20 |
| CA2589196A1 (en) | 2006-06-15 |
| WO2006061136A2 (en) | 2006-06-15 |
| ZA200705018B (en) | 2010-04-28 |
| EP1828151A2 (en) | 2007-09-05 |
| BRPI0518615A2 (pt) | 2008-11-25 |
| US20060122168A1 (en) | 2006-06-08 |
| KR20070086979A (ko) | 2007-08-27 |
| EP1828151B1 (en) | 2011-04-06 |
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