PT1828151E - Derivados de malonamida como inibidores de gama-secretase para o tratamento da doença de alzheimer - Google Patents
Derivados de malonamida como inibidores de gama-secretase para o tratamento da doença de alzheimer Download PDFInfo
- Publication number
- PT1828151E PT1828151E PT05811672T PT05811672T PT1828151E PT 1828151 E PT1828151 E PT 1828151E PT 05811672 T PT05811672 T PT 05811672T PT 05811672 T PT05811672 T PT 05811672T PT 1828151 E PT1828151 E PT 1828151E
- Authority
- PT
- Portugal
- Prior art keywords
- secretase
- alzheimer
- gamma
- inhibitors
- disease
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04106395 | 2004-12-08 | ||
| EP05100816 | 2005-02-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1828151E true PT1828151E (pt) | 2011-06-16 |
Family
ID=36293585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT05811672T PT1828151E (pt) | 2004-12-08 | 2005-12-01 | Derivados de malonamida como inibidores de gama-secretase para o tratamento da doença de alzheimer |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7211573B2 (pt) |
| EP (1) | EP1828151B1 (pt) |
| JP (1) | JP4979590B2 (pt) |
| KR (1) | KR100890678B1 (pt) |
| CN (1) | CN101072760B (pt) |
| AR (1) | AR053987A1 (pt) |
| AT (1) | ATE504580T1 (pt) |
| AU (1) | AU2005313582B8 (pt) |
| BR (1) | BRPI0518615A2 (pt) |
| CA (1) | CA2589196A1 (pt) |
| DE (1) | DE602005027388D1 (pt) |
| DK (1) | DK1828151T3 (pt) |
| HK (1) | HK1114840A1 (pt) |
| IL (1) | IL183293A0 (pt) |
| MX (1) | MX2007006504A (pt) |
| NO (1) | NO20072609L (pt) |
| NZ (1) | NZ555184A (pt) |
| PL (1) | PL1828151T3 (pt) |
| PT (1) | PT1828151E (pt) |
| RU (1) | RU2402538C2 (pt) |
| TW (1) | TWI349005B (pt) |
| WO (1) | WO2006061136A2 (pt) |
| ZA (1) | ZA200705018B (pt) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101096476B1 (ko) | 2006-09-20 | 2011-12-20 | 에프. 호프만-라 로슈 아게 | 4-옥소-2,3,4,5-테트라히드로-벤조[ｂ][1,4]디아제핀 유도체 |
| EP2109604A1 (en) * | 2007-02-02 | 2009-10-21 | F. Hoffmann-Roche AG | 6-oxo-6,7-dihydro-5h-dibenzo[b,d]azepin-7-yl derivatives |
| EP2244713A1 (en) * | 2008-01-11 | 2010-11-03 | F. Hoffmann-La Roche AG | Use of a gamma-secretase inhibitor for treating cancer |
| US8741889B2 (en) * | 2008-01-11 | 2014-06-03 | Hoffmann-La Roche Inc | Method of treating non-small cell lung cancer and colon cancer with gamma-secretase inhibitor |
| JP6877365B2 (ja) | 2015-06-11 | 2021-05-26 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 標的化されたＮｏｔｃｈ経路阻害剤 |
| CA3079786A1 (en) | 2017-10-24 | 2019-05-02 | The Broad Institute, Inc. | 4h-pyrrolo[3,2-c]pyridin-4-one derivatives |
| US20220017456A1 (en) * | 2018-11-07 | 2022-01-20 | Chugai Seiyaku Kabushiki Kaisha | O-substituted serine derivative production method |
| TW202106683A (zh) | 2019-04-24 | 2021-02-16 | 德商拜耳廠股份有限公司 | 4H-吡咯并[3,2-c]吡啶-4-酮化合物 |
| WO2020216773A1 (en) | 2019-04-24 | 2020-10-29 | Bayer Aktiengesellschaft | 4h-pyrrolo[3,2-c]pyridin-4-one compounds |
| CA3137611A1 (en) | 2019-04-24 | 2020-10-29 | Bayer Aktiengesellschaft | 4h-pyrrolo[3,2-c]pyridin-4-one derivatives |
| CN112300019A (zh) * | 2019-07-31 | 2021-02-02 | 华东师范大学 | 一种邻乙酰氨基苯丁酸类化合物的制备方法 |
| CA3177214A1 (en) | 2020-03-31 | 2021-10-07 | Bayer Aktiengesellschaft | 3-(anilino)-2-[3-(3-alkoxy-pyridin-4-yl]-1,5,6,7-tetrahydro-4h-pyrrolo[3,2-c]pyridin-4-one derivatives as egfr inhibitors for the treatment of cancer |
| KR20230155446A (ko) | 2021-03-09 | 2023-11-10 | 바스프 에스이 | 말론아미드 및 제초제로서의 그의 용도 |
| AR126867A1 (es) * | 2021-08-25 | 2023-11-22 | Basf Se | Malonamidas herbicidas |
| AU2022339008A1 (en) * | 2021-08-31 | 2024-03-14 | Basf Se | Herbicidal malonamides containing a condensed ring system |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002241368A (ja) * | 1997-02-18 | 2002-08-28 | Shionogi & Co Ltd | 新規ベンゾラクタム誘導体およびそれを含有する医薬組成物 |
| WO1999067219A1 (en) * | 1998-06-22 | 1999-12-29 | Elan Pharmaceuticals, Inc. | Compounds for inhibiting beta-amyloid peptide release and/or its synthesis |
| GB0012671D0 (en) | 2000-05-24 | 2000-07-19 | Merck Sharp & Dohme | Therapeutic agents |
| ATE430726T1 (de) * | 2002-05-29 | 2009-05-15 | Hoffmann La Roche | N-acylamino-benzyletherderivate als selektive inhibitoren der monoaminoxidase b |
| TW200502221A (en) * | 2002-10-03 | 2005-01-16 | Astrazeneca Ab | Novel lactams and uses thereof |
| EP1592684B1 (en) | 2003-02-04 | 2008-07-30 | F. Hoffmann-La Roche Ag | Malonamide derivatives as gamma-secretase inhibitors |
| US7060698B2 (en) | 2003-05-19 | 2006-06-13 | Hoffmann-La Roche Inc. | Benzoxazepinone derivatives |
| PT1711470E (pt) | 2003-09-09 | 2009-05-21 | Hoffmann La Roche | Derivados de malonamida que bloqueiam a actividade de gama-secretase |
| MXPA06003870A (es) | 2003-10-06 | 2006-07-03 | Hoffmann La Roche | Derivados de dibenzo-azepina y benzo-diazepina substituidas utiles como inhibidores de gama-secretasa. |
-
2005
- 2005-11-30 US US11/289,176 patent/US7211573B2/en not_active Expired - Fee Related
- 2005-12-01 CA CA002589196A patent/CA2589196A1/en not_active Abandoned
- 2005-12-01 KR KR1020077015604A patent/KR100890678B1/ko not_active IP Right Cessation
- 2005-12-01 AU AU2005313582A patent/AU2005313582B8/en not_active Ceased
- 2005-12-01 CN CN2005800421635A patent/CN101072760B/zh not_active Expired - Fee Related
- 2005-12-01 BR BRPI0518615-3A patent/BRPI0518615A2/pt not_active IP Right Cessation
- 2005-12-01 WO PCT/EP2005/012834 patent/WO2006061136A2/en active Application Filing
- 2005-12-01 DK DK05811672.4T patent/DK1828151T3/da active
- 2005-12-01 JP JP2007544779A patent/JP4979590B2/ja not_active Expired - Fee Related
- 2005-12-01 EP EP05811672A patent/EP1828151B1/en active Active
- 2005-12-01 RU RU2007120211/04A patent/RU2402538C2/ru not_active IP Right Cessation
- 2005-12-01 PT PT05811672T patent/PT1828151E/pt unknown
- 2005-12-01 DE DE602005027388T patent/DE602005027388D1/de active Active
- 2005-12-01 NZ NZ555184A patent/NZ555184A/en not_active IP Right Cessation
- 2005-12-01 AT AT05811672T patent/ATE504580T1/de active
- 2005-12-01 PL PL05811672T patent/PL1828151T3/pl unknown
- 2005-12-01 MX MX2007006504A patent/MX2007006504A/es active IP Right Grant
- 2005-12-07 AR ARP050105106A patent/AR053987A1/es unknown
- 2005-12-07 TW TW094143269A patent/TWI349005B/zh not_active IP Right Cessation
-
2007
- 2007-05-17 IL IL183293A patent/IL183293A0/en unknown
- 2007-05-24 NO NO20072609A patent/NO20072609L/no not_active Application Discontinuation
- 2007-06-04 ZA ZA200705018A patent/ZA200705018B/xx unknown
-
2008
- 2008-04-29 HK HK08104728.3A patent/HK1114840A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PL1828151T3 (pl) | 2011-09-30 |
| NO20072609L (no) | 2007-06-19 |
| CN101072760A (zh) | 2007-11-14 |
| IL183293A0 (en) | 2007-09-20 |
| HK1114840A1 (en) | 2008-11-14 |
| TW200626568A (en) | 2006-08-01 |
| AU2005313582B8 (en) | 2011-06-16 |
| MX2007006504A (es) | 2007-06-22 |
| AR053987A1 (es) | 2007-05-30 |
| DE602005027388D1 (de) | 2011-05-19 |
| WO2006061136A3 (en) | 2006-08-03 |
| AU2005313582A8 (en) | 2011-06-16 |
| RU2007120211A (ru) | 2009-01-20 |
| JP4979590B2 (ja) | 2012-07-18 |
| EP1828151A2 (en) | 2007-09-05 |
| NZ555184A (en) | 2010-01-29 |
| DK1828151T3 (da) | 2011-05-16 |
| ATE504580T1 (de) | 2011-04-15 |
| US20060122168A1 (en) | 2006-06-08 |
| AU2005313582B2 (en) | 2011-06-02 |
| JP2008522994A (ja) | 2008-07-03 |
| CA2589196A1 (en) | 2006-06-15 |
| KR100890678B1 (ko) | 2009-03-26 |
| KR20070086979A (ko) | 2007-08-27 |
| TWI349005B (en) | 2011-09-21 |
| US7211573B2 (en) | 2007-05-01 |
| WO2006061136A2 (en) | 2006-06-15 |
| ZA200705018B (en) | 2010-04-28 |
| EP1828151B1 (en) | 2011-04-06 |
| RU2402538C2 (ru) | 2010-10-27 |
| BRPI0518615A2 (pt) | 2008-11-25 |
| AU2005313582A1 (en) | 2006-06-15 |
| CN101072760B (zh) | 2011-12-28 |
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