NO20072609L - Malonamid-derivater - Google Patents
Malonamid-derivaterInfo
- Publication number
- NO20072609L NO20072609L NO20072609A NO20072609A NO20072609L NO 20072609 L NO20072609 L NO 20072609L NO 20072609 A NO20072609 A NO 20072609A NO 20072609 A NO20072609 A NO 20072609A NO 20072609 L NO20072609 L NO 20072609L
- Authority
- NO
- Norway
- Prior art keywords
- lower alkyl
- halogen
- hydroxy
- substituted
- cycloalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
I Oppfinnelsen angår forbindelser med den generelle formel I hvor R er halogen, lavere alkyl eller lavere alkyl substituert med halogen; R1 er hydrogen, lavere alkyl eller lavere alkyl substituert med halogen eller hydroksy eller er lavere alkenyl, -(CH2)n-cykloalkyl, -(CH2)n-COR' eller er benzyl, eventuelt substituert med halogen eller er -(CH2)n-morfolinyl; R' er lavere alkoksy, hydroksy eller amino; R2 er hydrogen, lavere alkyl eller di-lavere alkyl, lavere alkyl substituert med halogen eller hydroksy eller er benzyl eller cykloalkyl; R3 er lavere alkyl eller lavere alkyl substituert med halogen eller er benzyl, eventuelt substituert med to halogenatomer eller er -(CH2)n-cykloalkyl eller -(CH2)n-pyridinyl; X er -CR4R4'- eller - CR4R4'-O-; R4/R4' er uavhengig av hverandre hydrogen, halogen, lavere alkyl, lavere alkoksy, hydroksy eller -CH2-2-[1,3]dioksalan-; n er 0, 1 eller 2; farmasøytisk egnede syreaddisjonssalter derav og alle former av optisk rene enantiomerer, racemater eller diastereomerer og diastereomer-blandinger derav for behandling av Alzheimer's sykdom.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04106395 | 2004-12-08 | ||
| EP05100816 | 2005-02-07 | ||
| PCT/EP2005/012834 WO2006061136A2 (en) | 2004-12-08 | 2005-12-01 | Malonamide derivatives as inhibitors of gamma-secretase for the treatment of alzheimer’s disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20072609L true NO20072609L (no) | 2007-06-19 |
Family
ID=36293585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20072609A NO20072609L (no) | 2004-12-08 | 2007-05-24 | Malonamid-derivater |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US7211573B2 (no) |
| EP (1) | EP1828151B1 (no) |
| JP (1) | JP4979590B2 (no) |
| KR (1) | KR100890678B1 (no) |
| CN (1) | CN101072760B (no) |
| AR (1) | AR053987A1 (no) |
| AT (1) | ATE504580T1 (no) |
| AU (1) | AU2005313582B8 (no) |
| BR (1) | BRPI0518615A2 (no) |
| CA (1) | CA2589196A1 (no) |
| DE (1) | DE602005027388D1 (no) |
| DK (1) | DK1828151T3 (no) |
| HK (1) | HK1114840A1 (no) |
| IL (1) | IL183293A0 (no) |
| MX (1) | MX2007006504A (no) |
| NO (1) | NO20072609L (no) |
| NZ (1) | NZ555184A (no) |
| PL (1) | PL1828151T3 (no) |
| PT (1) | PT1828151E (no) |
| RU (1) | RU2402538C2 (no) |
| TW (1) | TWI349005B (no) |
| WO (1) | WO2006061136A2 (no) |
| ZA (1) | ZA200705018B (no) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5001372B2 (ja) * | 2006-09-20 | 2012-08-15 | エフ．ホフマン−ラ ロシュ アーゲー | ４−オキソ−２，３，４，５−テトラヒドロ−ベンゾ［ｂ］［１，４］ジアゼピン誘導体 |
| JP2010517954A (ja) * | 2007-02-02 | 2010-05-27 | エフ．ホフマン−ラ ロシュ アーゲー | ６−オキソ−６，７−ジヒドロ−５Ｈ−ジベンゾ［ｂ，ｄ］アゼピン−７−イル誘導体 |
| US8741889B2 (en) * | 2008-01-11 | 2014-06-03 | Hoffmann-La Roche Inc | Method of treating non-small cell lung cancer and colon cancer with gamma-secretase inhibitor |
| MA33076B1 (fr) * | 2008-01-11 | 2012-03-01 | Hoffmann La Roche | Utilisation d'un inhibiteur de la gamma-secretase pour le traitement du cancer |
| JP6877365B2 (ja) | 2015-06-11 | 2021-05-26 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 標的化されたＮｏｔｃｈ経路阻害剤 |
| US11339157B1 (en) | 2017-10-24 | 2022-05-24 | Bayer Aktiengesellschaft | 4H-pyrrolo[3,2-c]pyridin-4-one derivatives |
| EP3878836A4 (en) * | 2018-11-07 | 2022-08-10 | Chugai Seiyaku Kabushiki Kaisha | PROCESS FOR THE PREPARATION OF O-SUBSTITUTED SERIN DERIVATIVES |
| JP2022532850A (ja) | 2019-04-24 | 2022-07-20 | バイエル・アクチエンゲゼルシヤフト | ４ｈ－ピロロ［３，２－ｃ］ピリジン－４－オン化合物 |
| WO2020216774A1 (en) | 2019-04-24 | 2020-10-29 | Bayer Aktiengesellschaft | 4h-pyrrolo[3,2-c]pyridin-4-one derivatives |
| CA3137610A1 (en) | 2019-04-24 | 2020-10-29 | Bayer Aktiengesellschaft | 4h-pyrrolo[3,2-c]pyridin-4-one compounds |
| CN112300019A (zh) * | 2019-07-31 | 2021-02-02 | 华东师范大学 | 一种邻乙酰氨基苯丁酸类化合物的制备方法 |
| WO2021198020A1 (en) | 2020-03-31 | 2021-10-07 | Bayer Aktiengesellschaft | 3-(anilino)-2-[3-(3-alkoxy-pyridin-4-yl]-1,5,6,7-tetrahydro-4h-pyrrolo[3,2-c]pyridin-4-one derivatives as egfr inhibitors for the treatment of cancer |
| EP4305020A1 (en) | 2021-03-09 | 2024-01-17 | Basf Se | Malonamides and their use as herbicides |
| KR20240051210A (ko) * | 2021-08-25 | 2024-04-19 | 바스프 에스이 | 제초제 말론아미드 |
| CN117881667A (zh) * | 2021-08-31 | 2024-04-12 | 巴斯夫欧洲公司 | 含有稠环系的除草剂丙二酰胺 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002241368A (ja) * | 1997-02-18 | 2002-08-28 | Shionogi & Co Ltd | 新規ベンゾラクタム誘導体およびそれを含有する医薬組成物 |
| JP2002518481A (ja) * | 1998-06-22 | 2002-06-25 | エラン ファーマシューティカルズ，インコーポレイテッド | β−アミロイドペプチドの放出および／またはその合成を阻害するための化合物 |
| GB0012671D0 (en) | 2000-05-24 | 2000-07-19 | Merck Sharp & Dohme | Therapeutic agents |
| MXPA04011594A (es) * | 2002-05-29 | 2005-03-07 | Hoffmann La Roche | Derivados n-acilaminobenceno como inhibidores selectivos de monoamino oxidasa b. |
| TW200502221A (en) * | 2002-10-03 | 2005-01-16 | Astrazeneca Ab | Novel lactams and uses thereof |
| ATE402934T1 (de) | 2003-02-04 | 2008-08-15 | Hoffmann La Roche | Malonamidderivate als gamma-secretaseinhibitoren |
| US7060698B2 (en) | 2003-05-19 | 2006-06-13 | Hoffmann-La Roche Inc. | Benzoxazepinone derivatives |
| EP1711470B1 (en) | 2003-09-09 | 2009-04-15 | F. Hoffmann-La Roche Ag | Malonamide derivatives blocking the activtiy of gamma-secretase |
| KR100884872B1 (ko) | 2003-10-06 | 2009-02-23 | 에프. 호프만-라 로슈 아게 | 감마-세크레타제 저해제로서 유용한 치환된다이벤조-아제핀 및 벤조-다이아제핀 유도체 |
-
2005
- 2005-11-30 US US11/289,176 patent/US7211573B2/en not_active Expired - Fee Related
- 2005-12-01 MX MX2007006504A patent/MX2007006504A/es active IP Right Grant
- 2005-12-01 KR KR1020077015604A patent/KR100890678B1/ko not_active IP Right Cessation
- 2005-12-01 DK DK05811672.4T patent/DK1828151T3/da active
- 2005-12-01 BR BRPI0518615-3A patent/BRPI0518615A2/pt not_active IP Right Cessation
- 2005-12-01 PL PL05811672T patent/PL1828151T3/pl unknown
- 2005-12-01 AT AT05811672T patent/ATE504580T1/de active
- 2005-12-01 CN CN2005800421635A patent/CN101072760B/zh not_active Expired - Fee Related
- 2005-12-01 CA CA002589196A patent/CA2589196A1/en not_active Abandoned
- 2005-12-01 AU AU2005313582A patent/AU2005313582B8/en not_active Ceased
- 2005-12-01 JP JP2007544779A patent/JP4979590B2/ja not_active Expired - Fee Related
- 2005-12-01 DE DE602005027388T patent/DE602005027388D1/de active Active
- 2005-12-01 EP EP05811672A patent/EP1828151B1/en active Active
- 2005-12-01 RU RU2007120211/04A patent/RU2402538C2/ru not_active IP Right Cessation
- 2005-12-01 NZ NZ555184A patent/NZ555184A/en not_active IP Right Cessation
- 2005-12-01 WO PCT/EP2005/012834 patent/WO2006061136A2/en active Application Filing
- 2005-12-01 PT PT05811672T patent/PT1828151E/pt unknown
- 2005-12-07 AR ARP050105106A patent/AR053987A1/es unknown
- 2005-12-07 TW TW094143269A patent/TWI349005B/zh not_active IP Right Cessation
-
2007
- 2007-05-17 IL IL183293A patent/IL183293A0/en unknown
- 2007-05-24 NO NO20072609A patent/NO20072609L/no not_active Application Discontinuation
- 2007-06-04 ZA ZA200705018A patent/ZA200705018B/xx unknown
-
2008
- 2008-04-29 HK HK08104728.3A patent/HK1114840A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20070086979A (ko) | 2007-08-27 |
| DK1828151T3 (da) | 2011-05-16 |
| AU2005313582A1 (en) | 2006-06-15 |
| PL1828151T3 (pl) | 2011-09-30 |
| JP4979590B2 (ja) | 2012-07-18 |
| RU2402538C2 (ru) | 2010-10-27 |
| KR100890678B1 (ko) | 2009-03-26 |
| IL183293A0 (en) | 2007-09-20 |
| TWI349005B (en) | 2011-09-21 |
| CN101072760A (zh) | 2007-11-14 |
| US7211573B2 (en) | 2007-05-01 |
| BRPI0518615A2 (pt) | 2008-11-25 |
| US20060122168A1 (en) | 2006-06-08 |
| AU2005313582A8 (en) | 2011-06-16 |
| CN101072760B (zh) | 2011-12-28 |
| EP1828151B1 (en) | 2011-04-06 |
| HK1114840A1 (en) | 2008-11-14 |
| JP2008522994A (ja) | 2008-07-03 |
| ATE504580T1 (de) | 2011-04-15 |
| CA2589196A1 (en) | 2006-06-15 |
| DE602005027388D1 (de) | 2011-05-19 |
| TW200626568A (en) | 2006-08-01 |
| AR053987A1 (es) | 2007-05-30 |
| RU2007120211A (ru) | 2009-01-20 |
| PT1828151E (pt) | 2011-06-16 |
| AU2005313582B2 (en) | 2011-06-02 |
| AU2005313582B8 (en) | 2011-06-16 |
| NZ555184A (en) | 2010-01-29 |
| WO2006061136A3 (en) | 2006-08-03 |
| EP1828151A2 (en) | 2007-09-05 |
| WO2006061136A2 (en) | 2006-06-15 |
| ZA200705018B (en) | 2010-04-28 |
| MX2007006504A (es) | 2007-06-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |