BRPI0514077A - derivados de benzilóxi como inibidores de maob - Google Patents

derivados de benzilóxi como inibidores de maob

Info

Publication number
BRPI0514077A
BRPI0514077A BRPI0514077-3A BRPI0514077A BRPI0514077A BR PI0514077 A BRPI0514077 A BR PI0514077A BR PI0514077 A BRPI0514077 A BR PI0514077A BR PI0514077 A BRPI0514077 A BR PI0514077A
Authority
BR
Brazil
Prior art keywords
lower alkyl
inhibitors
maob inhibitors
benzyloxy derivatives
benzyloxy
Prior art date
Application number
BRPI0514077-3A
Other languages
English (en)
Inventor
Rosa Maria Rodriguez-Sarmiento
Wolfgang Wostl
Rene Wyler
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BRPI0514077A publication Critical patent/BRPI0514077A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

DERIVADOS DE BENZILóXI COMO INIBIDORES DE MAOB. A presente invenção refere-se a compostos da fórmula geral (I); em que R¬ ¬ é halogênio; R¬ ¬ é -C(O)NH~ 2~, -C(NH~ 2~)=N-OH, -C(O)CH~ 2~Br,-C(O)N(CH~ 3~)OCH~ 3~ ou alquil -C(O)-inferior, ou é um grupo heteroarila de 5 membros, contendo 2 ou 3 heteroátomos, selecionado do grupo consistindo em N, O ou S, opcionalmente substituído por R¬ ¬, em que R¬ ¬ é alquila inferior,-NRR" ou -C(O)R; R é NR<39>R", alquila inferior, ou alcóxi inferior; R<39>/R" são independentemente hidrogênio ou alquila inferior; bem como seus sais farmaceuticamente aceitáveis para o tratamento de doenças, que são mediadas por inibidores de monoamina oxidase B, por exemplo, doença de Alzheimer e demência senil.
BRPI0514077-3A 2004-08-02 2005-07-27 derivados de benzilóxi como inibidores de maob BRPI0514077A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04103710 2004-08-02
PCT/EP2005/008143 WO2006013049A2 (en) 2004-08-02 2005-07-27 Benzyloxy derivatives as maob inhibitors

Publications (1)

Publication Number Publication Date
BRPI0514077A true BRPI0514077A (pt) 2008-05-27

Family

ID=35456889

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0514077-3A BRPI0514077A (pt) 2004-08-02 2005-07-27 derivados de benzilóxi como inibidores de maob

Country Status (17)

Country Link
US (1) US7456210B2 (pt)
EP (1) EP1776337A2 (pt)
JP (1) JP4629105B2 (pt)
CN (1) CN100560566C (pt)
AR (1) AR050193A1 (pt)
AU (1) AU2005268894B2 (pt)
BR (1) BRPI0514077A (pt)
CA (1) CA2575018A1 (pt)
HK (1) HK1108432A1 (pt)
IL (1) IL180791A0 (pt)
MX (1) MX2007001169A (pt)
NO (1) NO20070972L (pt)
NZ (1) NZ552649A (pt)
RU (1) RU2378270C2 (pt)
TW (1) TWI291349B (pt)
WO (1) WO2006013049A2 (pt)
ZA (1) ZA200700537B (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7501528B2 (en) * 2005-03-15 2009-03-10 Hoffmann-La Roche Inc. Method for preparing enantiomerically pure 4-pyrrolidino phenylbenzyl ether derivatives
KR101220182B1 (ko) * 2009-02-25 2013-01-11 에스케이바이오팜 주식회사 치환된 아졸 유도체 화합물, 이를 포함하는 약제학적 조성물 및 이를 이용한 파킨슨씨 병 치료방법
JP6454349B2 (ja) * 2013-12-26 2019-01-16 武田薬品工業株式会社 モノアシルグリセロールリパーゼ（ｍａｇｌ）阻害剤としての４−（ピペラジン−１−イル）−ピロリジン−２−オン化合物
CN110240557B (zh) * 2018-03-08 2023-05-09 广东东阳光药业有限公司 吡咯烷酰胺衍生物及其用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2500450A1 (fr) * 1981-02-25 1982-08-27 Delalande Sa Nouveaux derives aminomethyl-5 oxazolidiniques, leur procede de preparation et leur application en therapeutique
US5679715A (en) 1995-06-07 1997-10-21 Harris; Richard Y. Method for treating multiple sclerosis
JP3258027B2 (ja) 1996-03-15 2002-02-18 サマーセット・ファーマシューティカルズ・インコーポレイテッド セレジリン投与による末梢ニューロパシーの予防および治療方法
WO2001034172A2 (en) 1999-11-05 2001-05-17 Vela Pharmaceuticals Inc. Methods and compositions for treating reward deficiency syndrome
PA8583001A1 (es) * 2002-09-20 2004-04-23 Hoffmann La Roche Derivados de 4-pirrolidino-fenil-bencil eter como inhibidores de mao-b

Also Published As

Publication number Publication date
IL180791A0 (en) 2007-06-03
US7456210B2 (en) 2008-11-25
CN1993319A (zh) 2007-07-04
AR050193A1 (es) 2006-10-04
EP1776337A2 (en) 2007-04-25
AU2005268894A1 (en) 2006-02-09
TWI291349B (en) 2007-12-21
CN100560566C (zh) 2009-11-18
WO2006013049A2 (en) 2006-02-09
TW200612912A (en) 2006-05-01
JP4629105B2 (ja) 2011-02-09
JP2008508335A (ja) 2008-03-21
RU2378270C2 (ru) 2010-01-10
AU2005268894B2 (en) 2010-12-16
WO2006013049A3 (en) 2006-06-22
NZ552649A (en) 2010-05-28
MX2007001169A (es) 2007-03-12
US20060025599A1 (en) 2006-02-02
CA2575018A1 (en) 2006-02-09
HK1108432A1 (en) 2008-05-09
RU2007103236A (ru) 2008-09-10
ZA200700537B (en) 2008-05-28
NO20070972L (no) 2007-02-28

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: NAO APRESENTADA A GUIA DE CUMPRIMENTO DE EXIGENCIA. REFERENTE A 7A ANUIDADE.