AR056943A1 - DERIVADOS DE AMIDAS, ISoMEROS DE LOS MISMOS O LAS SALES FARMACÉUTICAMENTE ACEPTABLES DE LOS MISMOS COMO EL ANTAGONISTA DEL RECEPTOR VANILOIDE Y LAS COMPOSICIONES FARMACÉUTICAS QUE CONTIENEN LOS MISMOS - Google Patents

DERIVADOS DE AMIDAS, ISoMEROS DE LOS MISMOS O LAS SALES FARMACÉUTICAMENTE ACEPTABLES DE LOS MISMOS COMO EL ANTAGONISTA DEL RECEPTOR VANILOIDE Y LAS COMPOSICIONES FARMACÉUTICAS QUE CONTIENEN LOS MISMOS

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Publication number
AR056943A1
AR056943A1 ARP060101058A ARP060101058A AR056943A1 AR 056943 A1 AR056943 A1 AR 056943A1 AR P060101058 A ARP060101058 A AR P060101058A AR P060101058 A ARP060101058 A AR P060101058A AR 056943 A1 AR056943 A1 AR 056943A1
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Argentina
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alkyl
same
hydrogen
alkylsulfonyl
halo
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ARP060101058A
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Amorepacific Corp
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Publication of AR056943A1 publication Critical patent/AR056943A1/es

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
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Abstract

REIVINDICACIoN 1.- Un compuesto de la formula (1), un isomero y/o una sal farmacéuticamente aceptable del mismo; donde X es CR11=CR12, o C=C, donde, R11 y R12 son independientemente hidrogeno, halogeno, C1-C5 alquilo, o fenilo; R1 y R2 son independientemente hidrogeno, carboxi, C1-C5 alquilo, halogeno, nitro, C1-C5 alcoxi, halo (C1-C5) alquilo, C1-C5 alquilcarbonilo, C1-C5 alquilcarbonilamino, C1-C5 alquilsulfonilamino, fenilsulfonilamino, C1-C5 alquiltio, C1-C5 alquilsulfonilo, o C1- C5 alcoxicarbonilo; R3 es hidrogeno, C1-C5 alquilo, C1-C5 alcoxi, o halo (C1-C5) alquilo; R4, R5, R6, R7 y R8 son independientemente hidrogeno, carboxi, C1-C5 alquilo, nitro, C2-C5 alquenilo, C1-C5 alcoxi, C2-C5 alquinilo, halo (C1-C5) alquilo, C1- C5 alquiltio, C1-C5 alquilsulfonilo, C1-C5 alquil carbonilo, C1-C5 alcoxicarbonilo, fenilo, o halogeno, donde, fenilo puede estar no substituido o substituido con uno o más substituyentes seleccionados de carboxi, C1-C5 alquilo, halogeno, nitro, C2- C5 alquenilo, C1-C5 alcoxi, halo (C1-C5) alquilo, C1-C5 alquil carbonilo, C1-C5 alquiltio, C1-C5 alquilsulfonilo, o C1-C5 alcoxi carbonilo; R9 es C1-C5 alquilsulfonilo o C2-C5 alquenilsulfonilo; y R10 es hidrogeno; excepto que si R3 es diferente de hidrogeno, entonces R11 y R12 no son simultáneamente hidrogeno. Los isomeros de los mismos o a las sales farmacéuticamente aceptables de los mismos como el antagonista del receptor vaniloide (Receptor Vaniloide 1; VR1; TRPV1); y una composicion farmacéutica que contiene a los mismos. La presente invencion proporciona una composicion farmacéutica para prevenir o tratar una enfermedad tal como el dolor, migrana, astralgia, neuralgia, neuropatías, herida en los nervios, desordenes de la piel, hipersensibilidad de la vejiga urinaria, síndrome del intestino irritable, urgencia fecal, un desorden respiratorio, irritacion de la piel, membrana del ojo o mucosa, ulcera duodenal-estomacal, enfermedades inflamatorias, enfermedad del oído y enfermedad del corazon.
ARP060101058A 2005-03-19 2006-03-17 DERIVADOS DE AMIDAS, ISoMEROS DE LOS MISMOS O LAS SALES FARMACÉUTICAMENTE ACEPTABLES DE LOS MISMOS COMO EL ANTAGONISTA DEL RECEPTOR VANILOIDE Y LAS COMPOSICIONES FARMACÉUTICAS QUE CONTIENEN LOS MISMOS AR056943A1 (es)

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KR20050022986 2005-03-19
US66326905P 2005-03-21 2005-03-21

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AR056943A1 true AR056943A1 (es) 2007-11-07

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ARP060101059A AR053561A1 (es) 2005-03-19 2006-03-17 Compuestos novedosos, isomeros de los mismos o las sales farmaceuticamente aceptables de los mismos como el antagonista del receptor vaniloide y las composiciones farmaceuticas que contienen los mismos
ARP060101058A AR056943A1 (es) 2005-03-19 2006-03-17 DERIVADOS DE AMIDAS, ISoMEROS DE LOS MISMOS O LAS SALES FARMACÉUTICAMENTE ACEPTABLES DE LOS MISMOS COMO EL ANTAGONISTA DEL RECEPTOR VANILOIDE Y LAS COMPOSICIONES FARMACÉUTICAS QUE CONTIENEN LOS MISMOS

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US (2) US7763657B2 (es)
EP (2) EP1861357B1 (es)
JP (2) JP5159604B2 (es)
KR (2) KR101304981B1 (es)
AR (2) AR053561A1 (es)
AU (2) AU2006225496A1 (es)
BR (2) BRPI0608714A2 (es)
CA (2) CA2601871A1 (es)
EA (2) EA200702020A1 (es)
IL (2) IL185892A0 (es)
MX (2) MX2007011466A (es)
NO (2) NO20075353L (es)
TW (2) TW200716522A (es)
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EA200702020A1 (ru) * 2005-03-19 2008-02-28 Эморпасифик Корпорейшн Новые соединения, их изомеры или фармацевтически приемлемые соли в качестве антагонистов ваниллоидных рецепторов и содержащие их фармацевтические композиции
KR101410318B1 (ko) 2006-07-27 2014-06-27 (주)아모레퍼시픽 바닐로이드 수용체 길항제로서의 신규 화합물, 그의 이성질체, 또는 약제학적으로 허용가능한 그의 염, 및 이를함유하는 약제학적 조성물
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