AR056943A1 - DERIVADOS DE AMIDAS, ISoMEROS DE LOS MISMOS O LAS SALES FARMACÉUTICAMENTE ACEPTABLES DE LOS MISMOS COMO EL ANTAGONISTA DEL RECEPTOR VANILOIDE Y LAS COMPOSICIONES FARMACÉUTICAS QUE CONTIENEN LOS MISMOS - Google Patents

DERIVADOS DE AMIDAS, ISoMEROS DE LOS MISMOS O LAS SALES FARMACÉUTICAMENTE ACEPTABLES DE LOS MISMOS COMO EL ANTAGONISTA DEL RECEPTOR VANILOIDE Y LAS COMPOSICIONES FARMACÉUTICAS QUE CONTIENEN LOS MISMOS

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AR056943A1
AR056943A1 ARP060101058A ARP060101058A AR056943A1 AR 056943 A1 AR056943 A1 AR 056943A1 AR P060101058 A ARP060101058 A AR P060101058A AR P060101058 A ARP060101058 A AR P060101058A AR 056943 A1 AR056943 A1 AR 056943A1
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Argentina
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alkyl
same
hydrogen
alkylsulfonyl
halo
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ARP060101058A
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Amorepacific Corp
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Publication of AR056943A1 publication Critical patent/AR056943A1/es

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Abstract

REIVINDICACIoN 1.- Un compuesto de la formula (1), un isomero y/o una sal farmacéuticamente aceptable del mismo; donde X es CR11=CR12, o C=C, donde, R11 y R12 son independientemente hidrogeno, halogeno, C1-C5 alquilo, o fenilo; R1 y R2 son independientemente hidrogeno, carboxi, C1-C5 alquilo, halogeno, nitro, C1-C5 alcoxi, halo (C1-C5) alquilo, C1-C5 alquilcarbonilo, C1-C5 alquilcarbonilamino, C1-C5 alquilsulfonilamino, fenilsulfonilamino, C1-C5 alquiltio, C1-C5 alquilsulfonilo, o C1- C5 alcoxicarbonilo; R3 es hidrogeno, C1-C5 alquilo, C1-C5 alcoxi, o halo (C1-C5) alquilo; R4, R5, R6, R7 y R8 son independientemente hidrogeno, carboxi, C1-C5 alquilo, nitro, C2-C5 alquenilo, C1-C5 alcoxi, C2-C5 alquinilo, halo (C1-C5) alquilo, C1- C5 alquiltio, C1-C5 alquilsulfonilo, C1-C5 alquil carbonilo, C1-C5 alcoxicarbonilo, fenilo, o halogeno, donde, fenilo puede estar no substituido o substituido con uno o más substituyentes seleccionados de carboxi, C1-C5 alquilo, halogeno, nitro, C2- C5 alquenilo, C1-C5 alcoxi, halo (C1-C5) alquilo, C1-C5 alquil carbonilo, C1-C5 alquiltio, C1-C5 alquilsulfonilo, o C1-C5 alcoxi carbonilo; R9 es C1-C5 alquilsulfonilo o C2-C5 alquenilsulfonilo; y R10 es hidrogeno; excepto que si R3 es diferente de hidrogeno, entonces R11 y R12 no son simultáneamente hidrogeno. Los isomeros de los mismos o a las sales farmacéuticamente aceptables de los mismos como el antagonista del receptor vaniloide (Receptor Vaniloide 1; VR1; TRPV1); y una composicion farmacéutica que contiene a los mismos. La presente invencion proporciona una composicion farmacéutica para prevenir o tratar una enfermedad tal como el dolor, migrana, astralgia, neuralgia, neuropatías, herida en los nervios, desordenes de la piel, hipersensibilidad de la vejiga urinaria, síndrome del intestino irritable, urgencia fecal, un desorden respiratorio, irritacion de la piel, membrana del ojo o mucosa, ulcera duodenal-estomacal, enfermedades inflamatorias, enfermedad del oído y enfermedad del corazon.
ARP060101058A 2005-03-19 2006-03-17 DERIVADOS DE AMIDAS, ISoMEROS DE LOS MISMOS O LAS SALES FARMACÉUTICAMENTE ACEPTABLES DE LOS MISMOS COMO EL ANTAGONISTA DEL RECEPTOR VANILOIDE Y LAS COMPOSICIONES FARMACÉUTICAS QUE CONTIENEN LOS MISMOS AR056943A1 (es)

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KR20050022986 2005-03-19
US66326905P 2005-03-21 2005-03-21

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ARP060101059A AR053561A1 (es) 2005-03-19 2006-03-17 Compuestos novedosos, isomeros de los mismos o las sales farmaceuticamente aceptables de los mismos como el antagonista del receptor vaniloide y las composiciones farmaceuticas que contienen los mismos
ARP060101058A AR056943A1 (es) 2005-03-19 2006-03-17 DERIVADOS DE AMIDAS, ISoMEROS DE LOS MISMOS O LAS SALES FARMACÉUTICAMENTE ACEPTABLES DE LOS MISMOS COMO EL ANTAGONISTA DEL RECEPTOR VANILOIDE Y LAS COMPOSICIONES FARMACÉUTICAS QUE CONTIENEN LOS MISMOS

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US (2) US7763657B2 (es)
EP (2) EP1861357B1 (es)
JP (2) JP5159604B2 (es)
KR (2) KR101304981B1 (es)
AR (2) AR053561A1 (es)
AU (2) AU2006225496A1 (es)
BR (2) BRPI0608714A2 (es)
CA (2) CA2601871A1 (es)
EA (2) EA200702020A1 (es)
IL (2) IL185891A0 (es)
MX (2) MX2007011466A (es)
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CA2601871A1 (en) 2005-03-19 2006-09-28 Amorepacific Corporation Novel compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and pharmaceutical compositions containing the same
AU2007277519B2 (en) 2006-07-27 2011-12-22 Amorepacific Corporation Novel compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and pharmaceutical compositions containing the same
DE102007017884A1 (de) 2007-04-13 2008-10-16 Grünethal GmbH Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln
US20110160279A1 (en) * 2007-08-13 2011-06-30 Board Of Trustees Of Southern Illinois University METHODS FOR TREATMENT AND PREVENTION OF OTOTOXICITY BY siRNA
CN101925575B (zh) 2008-01-28 2014-06-18 株式会社爱茉莉太平洋 作为香草酸受体拮抗剂的化合物、其异构体或其药物学可接受的盐、及包含这些化合物的药物组合物
EP2484664B1 (en) * 2008-05-07 2013-09-04 Dainippon Sumitomo Pharma Co., Ltd. Cyclic amine-1-carboxylic acid ester derivative and pharmaceutical composition containing the same
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BRPI0608624A2 (pt) 2010-01-19
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IL185891A0 (en) 2008-02-09
EP1861357A4 (en) 2011-08-31
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US20090105258A1 (en) 2009-04-23
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AU2006225496A1 (en) 2006-09-28
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