AR063211A1 - Derivados de 3-(piridin-3-il)acrilamida y 3-(piridin-3-il)propionamida, un metodo para su preparacion, una composicion farmaceutica que los comprende y su uso en la fabricacion de medicamentos para el tratamiento de enfermedades asociadas con el receptor vaniloide. - Google Patents
Derivados de 3-(piridin-3-il)acrilamida y 3-(piridin-3-il)propionamida, un metodo para su preparacion, una composicion farmaceutica que los comprende y su uso en la fabricacion de medicamentos para el tratamiento de enfermedades asociadas con el receptor vaniloide.Info
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- AR063211A1 AR063211A1 ARP070103317A ARP070103317A AR063211A1 AR 063211 A1 AR063211 A1 AR 063211A1 AR P070103317 A ARP070103317 A AR P070103317A AR P070103317 A ARP070103317 A AR P070103317A AR 063211 A1 AR063211 A1 AR 063211A1
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- halogen
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Abstract
Sales farmacéuticamente aceptables, como antagonistas del receptor vaniloide (receptor vaniloide 1; VR1; TRPV1); una composicion farmacéutica que las contiene y su uso en la fabricacion de medicamentos para prevenir o tratar una enfermedad como el dolor, migrana, artralgia, neuralgia, neuropatías, lesion nerviosa, trastorno cutáneo, hipersensibilidad de la vejiga urinaria, síndrome de intestino irritable, incontinencia fecal, trastorno respiratorio, irritacion de la piel, ojos o membrana mucosa, ulcera del estomago y duodeno, enfermedades inflamatorias, enfermedad auditiva, enfermedad cardíaca y otras, Se provee además un método para su preparacion. Reivindicacion 1: Un compuesto de la formula (1), su isomero, o una de sus sales farmacéuticamente aceptables: en donde: X es CR11=CR12, o C:::C; en donde, R11 y R12, si están presentes, son independientemente hidrogeno, halogeno o alquilo C1-5; Z es N; Y es CR6; R1 es hidrogeno, halogeno o alquilo C1-5; R2, R3, R4, y R5 son independientemente hidrogeno, halogeno, nitro, ciano, alquilo C1-5, alcoxi C1-5, haloalquilo C1-5, alquenilo C2-5, alquinilo C2-5, carboxi, alcoxicarbonilo C1-5 o alquiltio C1-5; R6 es hidroxi, halogeno, nitro, carboxi, alquil C1-10, alcoxilo C1-10, alquenilo C2-10, alquinilo C2-10, alquil C1-10tio, alquil C1-10sulfonilo, alquil C1-10carbonilo, alcoxilo C1-10carbonilo, alquenilo C2-10oxi, alcoxi C1-5-alcoxi C1-5, alcoxi C1-5-alcoxi C1-5-alquilo C1-5, piperidilo, piperacinilo, alcoxi C1-5-alquil C1-5amino, alquil C1-10amino, di(alquil C1-10)amino, cicloalquil C3-8 , cicloalquil C3-8 amino, cicloalcoxi C3-8, oxacicloalquiloxi C3-8, N-alcoxi C1-5-alquilC1-5-N-alquilC1-5amino, N-cicloalquil C3-8-N-alquil C1-5amino, N-aril-N-alquil C1-5amino, preferiblemente N-fenil-N-alquil C1-5amino, arilo, preferiblemente fenilo, arilamino, preferiblemente fenilamino, aritio, preferiblemente fenitio, heteroarilo, preferiblemente piridinilo o tienilo, heteroarilamino, ariloxi, preferiblemente fenoxi, heteroariloxi, preferiblemente piridiniloxi, pirrolidinilo o morfoIinilo, R8 y R9 son independientemente hidrogeno, hidroxi, halogeno, nitro, carboxi, alquil C1-10, alcoxilo C1-10, alquenilo C2-10, alquinilo C2-10, alquil C1-10tio, alquil C1- 10sulfonilo, alquil C1-10carbonilo, alcoxilo C1-10carbonilo, alquenilo C2-10oxi, alcoxi C1-5-alcoxi C1-5, alcoxi C1-5-alcoxi C1-5-alquilo C1-5, piperidilo, piperacinilo, alcoxi C1-5-alquil C1-5amino, alquil C1-10amino, di(alquil C1-10)amino, cicloalquil C3-8 , cicloalquil C3-8 amino, cicloalcoxi C3-8, oxacicloalquiloxi C3-8, N-alcoxi C1-5-alquilC1-5-N-alquilC1-5amino, N-cicloalquil C3-8-N-alquil C1-5amino, N-aril-N-alquil C1-5amino, preferiblemente N-fenil-N-alquil C1-5amino, arilo, preferiblemente fenilo, arilamino, preferiblemente fenilamino, aritio, preferiblemente fenitio, heteroarilo, preferiblemente piridinilo o tienilo, heteroarilamino, ariloxi, preferiblemente fenoxi, heteroariloxi, preferiblemente piridiniloxi, pirrolidinilo o morfoIinilo, en donde: cada alquilo, alquenilo y alquinilo, también como parte de un grupo tal como en alcoxi, alquilsulfonilo, alquilcarbonilo, alquilamino o alqueniloxi, puede estar independientemente sustituido o no sustituido con uno o más sustituyentes seleccionados de entre halogeno, hidroxilo, alcoxi C1-5 sustituido o no sustituido con una funcionalidad halo, cicloalquilo C3-8 que puede estar sustituido o no sustituido con uno o dos radicales halogeno y/o grupos metilo, alquilamino C1-5 sustituido o no sustituido con una funcionalidad halo, fenilo que puede estar sustituido o no sustituido con uno o más sustituyentes seleccionados de halogeno, alquil C1-3 no sustituido, o haloalquilo C1-3, o di(C1-5)alquilamino sustituido o no sustituido con funcionalidad halo, cada arilo o heteroarilo, también parte de un grupo tal como en arilamino, ariloxi, heteroarilamino o heteroariloxi, puede estar independientemente sustituido o no sustituido con uno o más sustituyentes seleccionados de halogeno, alquilo C1-5 no sustituido, alcoxi C1-5 no sustituido o haloalquilo C1-5, cada cicloalquilo, también como parte de un grupo tal como en el cicloalcoxi o cicloalquilamino, puede estar sustituido o no sustituido con uno o más grupos alquilo C1-3 sustituidos o no sustituidos con funcionalidad halo, hidroximetilo, hidroxi, metoxi o amino, y cada piperacinilo, piperidilo, morfolinilo y pirrolidinilo puede estar sustituido o no sustituido con uno o más grupos alquilo C1-3 sustituidos o no sustituidos con funcionalidad halo, hidroxialquilo C1-3, alcoxi C1-3, alcoxi C1-3carbonilo, o hidroxilo; R7 es haloalquilo C1-5; y R10 es alquilo C1-5, haloalquilo C1-5, o alquenilo C2-5. Reivindicacion 47: Un proceso para la elaboracion de un compuesto representado por la formula (3) que comprende la reaccion de un compuesto representado por la formula (4); con un compuesto representado por la formula (5); en donde: R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 y R12 son como los descritos en una cualquiera de las reivindicaciones precedentes. Reivindicacion 49: Un compuesto de la formula (6) en donde W es hidrogeno o fluoro; R1 es hidrogeno o alquilo C1-3, preferiblemente metilo; y R10 es alquilo C1-3, alquenilo C2-3 o haloalquilo C1-3, preferiblemente metilo; con tal que si R1 es hidrogeno y R10 es metilo, entonces W es fluoro.
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EP06015724A EP1882687A1 (en) | 2006-07-27 | 2006-07-27 | Heterocyclic compounds useful as vanilloid receptor antagonists and pharmaceutical compositions containing the same |
EP06020620 | 2006-09-29 | ||
EP07004194 | 2007-02-28 | ||
US89397407P | 2007-03-09 | 2007-03-09 |
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ARP070103317A AR063211A1 (es) | 2006-07-27 | 2007-07-26 | Derivados de 3-(piridin-3-il)acrilamida y 3-(piridin-3-il)propionamida, un metodo para su preparacion, una composicion farmaceutica que los comprende y su uso en la fabricacion de medicamentos para el tratamiento de enfermedades asociadas con el receptor vaniloide. |
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US (1) | US7858621B2 (es) |
EP (1) | EP2054411B1 (es) |
JP (1) | JP5254228B2 (es) |
KR (1) | KR101410318B1 (es) |
AR (1) | AR063211A1 (es) |
AU (1) | AU2007277519B2 (es) |
CA (1) | CA2658925C (es) |
MX (1) | MX2009000925A (es) |
PL (1) | PL2054411T3 (es) |
WO (1) | WO2008013414A1 (es) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102007017884A1 (de) * | 2007-04-13 | 2008-10-16 | Grünethal GmbH | Neue Vanilloid-Rezeptor Liganden und ihre Verwendung zur Herstellung von Arzneimitteln |
EP2238105B1 (en) * | 2008-01-28 | 2014-04-16 | Amorepacific Corporation | Novel compounds as vanilloid receptor antagonists |
CA2842364A1 (en) * | 2011-07-29 | 2013-02-07 | Karyopharm Therapeutics, Inc. | Nuclear transport modulators and uses thereof |
DK3333164T3 (da) | 2011-07-29 | 2023-09-18 | Karyopharm Therapeutics Inc | Hydrazide containing nuclear transport modulators and uses thereof |
WO2013102145A1 (en) | 2011-12-28 | 2013-07-04 | Global Blood Therapeutics, Inc. | Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation |
CN104135859B (zh) | 2011-12-28 | 2017-06-27 | 全球血液疗法公司 | 取代的苯甲醛化合物及其用于增加组织氧合的方法 |
LT2858991T (lt) | 2012-05-09 | 2018-11-26 | Biogen Ma Inc. | Branduolinio transporto moduliatoriai ir jų panaudojimas |
CN104884426A (zh) * | 2012-12-28 | 2015-09-02 | 日本脏器制药株式会社 | 肉桂酰胺衍生物 |
US8952171B2 (en) | 2013-03-15 | 2015-02-10 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US9604999B2 (en) | 2013-03-15 | 2017-03-28 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US9802900B2 (en) | 2013-03-15 | 2017-10-31 | Global Blood Therapeutics, Inc. | Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin |
US20140274961A1 (en) | 2013-03-15 | 2014-09-18 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US9422279B2 (en) | 2013-03-15 | 2016-08-23 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
US9458139B2 (en) | 2013-03-15 | 2016-10-04 | Global Blood Therapeutics, Inc. | Compounds and uses thereof for the modulation of hemoglobin |
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KR102545732B1 (ko) | 2013-06-21 | 2023-06-20 | 카리오팜 쎄라퓨틱스, 인코포레이티드 | 핵수송 조절인자 및 이의 용도 |
EP2818461A1 (en) | 2013-06-26 | 2014-12-31 | Lonza Ltd | Method for preparation of 6-trifluoromethylpyridine-3-carboxylic acid derivatives from 4,4,4-trifluoro-3-oxobutanoyl chloride |
EP2821398A1 (en) | 2013-07-03 | 2015-01-07 | Lonza Ltd | Method for preparation of 6-trifluoromethylpyridine-3-carboxylic acid derivatives from 4,4,4-trifluoro-3-aminobutanoates |
EP2821399A1 (en) | 2013-07-04 | 2015-01-07 | Lonza Ltd | Method for preparation of 6-trifluoromethylpyridine-3-carboxylic acid derivatives from 4,4,4-trifluoro-3-oxobutanoyl chloride |
CN105492427B (zh) | 2013-07-19 | 2016-12-14 | 隆萨有限公司 | 由三氟乙酰乙酸制备6‑三氟甲基吡啶‑3‑羧酸衍生物的方法 |
EA201992707A1 (ru) | 2013-11-18 | 2020-06-30 | Глобал Блад Терапьютикс, Инк. | Соединения и их применения для модуляции гемоглобина |
DK3102208T4 (da) | 2014-02-07 | 2024-08-26 | Global Blood Therapeutics Inc | Krystallinsk polymorph af den frie base af 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyd |
MX2016017019A (es) | 2014-06-26 | 2017-05-12 | Lonza Ag | Metodo para la preparacion de 4-alcoxi-1,1,1-trifluorobut-3-en-2-o nas de 1,1,1 trifluoroacetona. |
CN107072992B (zh) | 2014-08-15 | 2020-03-10 | 卡尔约药物治疗公司 | 赛灵克斯的多晶型物 |
WO2016133317A1 (ko) * | 2015-02-17 | 2016-08-25 | (주)아모레퍼시픽 | N-[4-(1-아미노에틸)-페닐]-술폰아미드 유도체의 카이랄 분할 방법 |
KR20160101554A (ko) | 2015-02-17 | 2016-08-25 | (주)아모레퍼시픽 | N-[4-(1-아미노에틸)-페닐]-메탄술폰아미드 유도체의 카이랄 분할 방법 |
MA41841A (fr) | 2015-03-30 | 2018-02-06 | Global Blood Therapeutics Inc | Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs |
KR102359436B1 (ko) * | 2015-06-05 | 2022-02-09 | (주)아모레퍼시픽 | 메틸 2-프로필-6-(트리플루오로메틸) 니코티네이트의 제조방법 |
KR102287585B1 (ko) * | 2015-06-30 | 2021-08-10 | (주)아모레퍼시픽 | N-(4-아세틸-2,6-디플루오로페닐)메탄술폰아미드의 제조방법 |
EP3383392A1 (en) | 2015-12-04 | 2018-10-10 | Global Blood Therapeutics, Inc. | Dosing regimens for 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde |
WO2017117535A1 (en) | 2015-12-31 | 2017-07-06 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
WO2017117529A1 (en) | 2015-12-31 | 2017-07-06 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
KR102565407B1 (ko) * | 2016-01-04 | 2023-08-10 | (주)아모레퍼시픽 | 극성 비양자성 용매를 이용한 n-[4-(1-아미노에틸)-페닐]-술폰아미드 유도체의 카이랄 분할 방법 |
TWI752307B (zh) | 2016-05-12 | 2022-01-11 | 美商全球血液治療公司 | 新穎化合物及製造化合物之方法 |
KR102599958B1 (ko) * | 2016-09-28 | 2023-11-09 | (주)아모레퍼시픽 | (r)-n-[4-(1-아미노-에틸)-2,6-다이플루오로-페닐]-메테인설폰아마이드의 제조방법 |
TWI778983B (zh) | 2016-10-12 | 2022-10-01 | 美商全球血液治療公司 | 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑 |
WO2018098472A1 (en) | 2016-11-28 | 2018-05-31 | Karyopharm Therapeutics Inc. | Crm1 inhibitors for treating epilepsy |
KR102587339B1 (ko) | 2016-12-22 | 2023-10-12 | (주)아모레퍼시픽 | N-[4-(1-아미노-에틸)-2,6-다이플루오로-페닐]-메테인설폰아마이드의 거울상 이성질체들의 라세미화 방법 |
KR102540472B1 (ko) * | 2017-08-11 | 2023-06-08 | (주)아모레퍼시픽 | (r)-n-[1-(3,5-다이플루오로-4-메테인설폰일아미노-페닐)-에틸]-3-(2-프로필-6-트라이플루오로메틸-피리딘-3-일)-아크릴아마이드를 함유하는 약학 조성물 |
KR102587300B1 (ko) * | 2017-08-31 | 2023-10-12 | (주)아모레퍼시픽 | 아토피피부염 예방 또는 치료용 조성물 |
WO2019045215A1 (ko) * | 2017-08-31 | 2019-03-07 | (주)아모레퍼시픽 | 수면장애 예방 또는 치료용 조성물 |
KR102587297B1 (ko) | 2017-08-31 | 2023-10-12 | (주)아모레퍼시픽 | 수면장애 예방 또는 치료용 조성물 |
KR102518632B1 (ko) * | 2018-04-18 | 2023-04-06 | (주)아모레퍼시픽 | (r)-n-[1-(3,5-다이플루오로-4-메테인설폰일아미노-페닐)-에틸]-3-(2-프로필-6-트라이플루오로메틸-피리딘-3-일)-아크릴아마이드를 함유하는 약학 조성물 |
EP3860975B1 (en) | 2018-10-01 | 2023-10-18 | Global Blood Therapeutics, Inc. | Modulators of hemoglobin for the treatment of sickle cell disease |
KR20200053746A (ko) | 2018-11-09 | 2020-05-19 | (주)아모레퍼시픽 | 졸-겔 조성물 |
CA3152770A1 (en) * | 2019-08-30 | 2021-03-04 | National University Of Singapore | N-(2-aminophenyl)-prop-2-enamide derivatives, and uses thereof in the treatment of cancer |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE328868T1 (de) | 2000-08-21 | 2006-06-15 | Pacific Corp | Neue (thio)harnstoffverbindungen und arzneimittelkompositionen, die diese enthalten |
CN100439332C (zh) * | 2000-08-21 | 2008-12-03 | 株式会社太平洋 | 硫脲衍生物以及包含该衍生物的药物组合物 |
TWI283665B (en) * | 2001-09-13 | 2007-07-11 | Smithkline Beecham Plc | Novel urea compound, pharmaceutical composition containing the same and its use |
CA2468544A1 (en) * | 2001-12-10 | 2003-06-19 | Amgen Inc. | Vanilloid receptor ligands |
KR100707123B1 (ko) * | 2003-07-02 | 2007-04-16 | 그뤼넨탈 게엠베하 | 바닐로이드 수용체의 길항제로서 강력한 진통효과를나타내는 4-(메틸설포닐아미노)페닐 동족체 및 이를함유하는 약학적 조성물 |
CA2542494A1 (en) * | 2003-10-15 | 2005-05-06 | Bayer Healthcare Ag | Tetrahydro-naphthalene and urea derivatives |
CN101087771A (zh) * | 2004-11-10 | 2007-12-12 | 辉瑞大药厂 | 经取代n-磺酰基氨基苄基-2-苯氧基乙酰胺化合物 |
KR20070085957A (ko) * | 2004-11-10 | 2007-08-27 | 화이자 인코포레이티드 | 치환된 n-설폰일아미노벤질-2-페녹시 아세트아마이드화합물 |
ATE443056T1 (de) | 2005-03-10 | 2009-10-15 | Pfizer | Substituierte n-sulfonylaminophenylethyl-2- phenoxyacetamidverbindungen |
WO2006098554A1 (en) | 2005-03-16 | 2006-09-21 | Amorepacific Corporation | Novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and a pharmaceutical composition containing the same |
CN101160285A (zh) | 2005-03-17 | 2008-04-09 | 辉瑞大药厂 | 适用于治疗疼痛的n-(n-磺酰氨基甲基)环丙烷甲酰胺衍生物 |
JP5159604B2 (ja) | 2005-03-19 | 2013-03-06 | アモーレパシフィック コーポレイション | バニロイド受容体拮抗薬としての新規な化合物、その異性体又はその薬剤学的に許容される塩、及びこれを含む医薬組成物 |
WO2007133637A2 (en) * | 2006-05-10 | 2007-11-22 | Renovis, Inc. | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same |
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