NO20093275L - 1,3-Dihydroimidazol-2-thione derivater som inhibitorer av dopamin-beta-hydroksylase - Google Patents
1,3-Dihydroimidazol-2-thione derivater som inhibitorer av dopamin-beta-hydroksylaseInfo
- Publication number
- NO20093275L NO20093275L NO20093275A NO20093275A NO20093275L NO 20093275 L NO20093275 L NO 20093275L NO 20093275 A NO20093275 A NO 20093275A NO 20093275 A NO20093275 A NO 20093275A NO 20093275 L NO20093275 L NO 20093275L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- dihydroimidazole
- hydroxylase
- inhibitors
- enantiomers
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Forbindelser av formel I og en framgangsmåte for framstilling av disse, er beskrevet: hvor R1, R2 og R3 er like eller forskjellige og betegner hydrogener, halogener, alkyl, nitro, amino, alkylkarbonylamino, alkylamino eller dialkylamino-gruppe; R4 betegner -alkyl-aryl eller -alkyl-heteroaryl; X betegner CH2, oksygenatom eller svovelatom, n er 2 eller 3; inkludert de individuelle (R)- og (S)- enantiomerene eller blandinger av enantiomerene derav; og inkludert farmasøytisk akseptable salter og estere av disse. Forbindelsene har potensielt verdifulle farmasøytiske egenskaper for behandling av hjerte- og karsykdommer så som hypertensjon og kronisk hjertesvikt.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0708818.0A GB0708818D0 (en) | 2007-05-08 | 2007-05-08 | Compounds |
PCT/PT2008/000019 WO2008136695A1 (en) | 2007-05-08 | 2008-05-06 | 1, 3-dihydroimidazole- 2 -thione derivatives as inhibitors of dopamine-beta-hydroxylase |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20093275L true NO20093275L (no) | 2010-02-04 |
Family
ID=38198874
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20093275A NO20093275L (no) | 2007-05-08 | 2009-11-03 | 1,3-Dihydroimidazol-2-thione derivater som inhibitorer av dopamin-beta-hydroksylase |
Country Status (30)
Country | Link |
---|---|
US (5) | US8481582B2 (no) |
EP (1) | EP2155731B1 (no) |
JP (1) | JP5559677B2 (no) |
KR (1) | KR101598482B1 (no) |
CN (1) | CN101687858B (no) |
AR (2) | AR066457A1 (no) |
AT (1) | ATE499367T1 (no) |
AU (1) | AU2008246443B2 (no) |
BR (1) | BRPI0811275B8 (no) |
CA (1) | CA2686387C (no) |
CL (1) | CL2008001321A1 (no) |
CY (1) | CY1111517T1 (no) |
DE (1) | DE602008005141D1 (no) |
DK (1) | DK2155731T3 (no) |
ES (1) | ES2360841T3 (no) |
GB (1) | GB0708818D0 (no) |
HK (1) | HK1142898A1 (no) |
HR (1) | HRP20110253T1 (no) |
IL (1) | IL201921A (no) |
MX (1) | MX2009012041A (no) |
NO (1) | NO20093275L (no) |
NZ (1) | NZ580962A (no) |
PL (1) | PL2155731T3 (no) |
RS (1) | RS51692B (no) |
RU (1) | RU2501796C2 (no) |
SI (1) | SI2155731T1 (no) |
TW (1) | TWI458722B (no) |
UA (1) | UA104844C2 (no) |
WO (1) | WO2008136695A1 (no) |
ZA (1) | ZA200908612B (no) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0708818D0 (en) | 2007-05-08 | 2007-06-13 | Portela & Ca Sa | Compounds |
EP2604260B1 (en) * | 2010-08-10 | 2017-05-10 | Shionogi&Co., Ltd. | Novel heterocyclic derivatives and pharmaceutical composition containing same |
PT2655363T (pt) * | 2010-12-22 | 2017-07-13 | Bial-Portela & Ca S A | Formas cristalinas e processos para a sua preparação |
WO2013002660A2 (en) | 2011-06-29 | 2013-01-03 | BIAL - PORTELA & Cª, S.A. | Process |
SI2919780T1 (sl) * | 2012-11-14 | 2018-12-31 | Bial - Portela & Ca., S.A. | Derivati 1,3-dihidroimidazol-2-tiona za uporabo v zdravljenju pljučne arterijske hipertenzije in poškodbe pljuč |
CN103356671B (zh) * | 2013-06-24 | 2015-11-25 | 顾祥茂 | Houttuynoid C在制备治疗或预防慢性心衰的药物中的应用 |
GB201316410D0 (en) * | 2013-09-13 | 2013-10-30 | Bial Portela & Ca Sa | Processes for preparing peripherally-selective inhibitors of dopamine-?-hydroxylase and intermediates for use therein |
JOP20190049A1 (ar) * | 2016-09-23 | 2019-03-20 | Bial Portela & C? S A | مثبطات دوبامين-b-هيدروكسيلاز |
CN111601798B (zh) | 2017-09-13 | 2023-08-11 | 美国安进公司 | 双酰胺肌节活化化合物及其用途 |
WO2019112457A1 (en) | 2017-12-04 | 2019-06-13 | BIAL - PORTELA & Cª, S.A. | Dopamine-β-hydroxylase inhibitors |
GB201810395D0 (en) * | 2018-06-25 | 2018-08-08 | Bial Portela & Ca Sa | Formulations comprising dopamine-beta-hydroxylase inhibitors and methods for their preparation |
GB201908044D0 (en) | 2019-06-05 | 2019-07-17 | Bial Portela & Ca Sa | Dopamine-B-Hydroxylase inhibitors |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4217347A (en) * | 1977-12-27 | 1980-08-12 | E. R. Squibb & Sons, Inc. | Method of treating hypertension and medicaments therefor |
US4962128A (en) * | 1989-11-02 | 1990-10-09 | Pfizer Inc. | Method of treating anxiety-related disorders using sertraline |
US5298497A (en) * | 1990-05-15 | 1994-03-29 | E. R. Squibb & Sons, Inc. | Method for preventing onset of hypertension employing a cholesterol lowering drug |
ES2201104T3 (es) * | 1994-04-26 | 2004-03-16 | Roche Palo Alto Llc | Derivados de benzociclohexilimidazoltiona. |
AR032711A1 (es) * | 2001-02-21 | 2003-11-19 | Solvay Pharm Bv | Derivados de fenilpiperazina, un metodo para la preparacion de los mismos y una composicion farmaceutica que los contiene |
US7125904B2 (en) * | 2002-10-11 | 2006-10-24 | Portela & C.A., S.A. | Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation |
GB2393958A (en) * | 2002-10-11 | 2004-04-14 | Portela & Ca Sa | Peripherally-selective imidazole inhibitors of dopamine-beta-hydroxylase |
GB0708818D0 (en) | 2007-05-08 | 2007-06-13 | Portela & Ca Sa | Compounds |
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2007
- 2007-05-08 GB GBGB0708818.0A patent/GB0708818D0/en not_active Ceased
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2008
- 2008-05-06 MX MX2009012041A patent/MX2009012041A/es active IP Right Grant
- 2008-05-06 CA CA2686387A patent/CA2686387C/en active Active
- 2008-05-06 AU AU2008246443A patent/AU2008246443B2/en not_active Ceased
- 2008-05-06 DE DE602008005141T patent/DE602008005141D1/de active Active
- 2008-05-06 EP EP08741778A patent/EP2155731B1/en active Active
- 2008-05-06 UA UAA200912720A patent/UA104844C2/uk unknown
- 2008-05-06 BR BRPI0811275A patent/BRPI0811275B8/pt not_active IP Right Cessation
- 2008-05-06 JP JP2010507348A patent/JP5559677B2/ja not_active Expired - Fee Related
- 2008-05-06 WO PCT/PT2008/000019 patent/WO2008136695A1/en active Application Filing
- 2008-05-06 SI SI200830191T patent/SI2155731T1/sl unknown
- 2008-05-06 US US12/599,014 patent/US8481582B2/en active Active
- 2008-05-06 AT AT08741778T patent/ATE499367T1/de active
- 2008-05-06 DK DK08741778.8T patent/DK2155731T3/da active
- 2008-05-06 AR ARP080101912A patent/AR066457A1/es not_active Application Discontinuation
- 2008-05-06 ES ES08741778T patent/ES2360841T3/es active Active
- 2008-05-06 RS RS20110165A patent/RS51692B/en unknown
- 2008-05-06 RU RU2009145270/04A patent/RU2501796C2/ru active
- 2008-05-06 PL PL08741778T patent/PL2155731T3/pl unknown
- 2008-05-06 CN CN2008800151606A patent/CN101687858B/zh not_active Expired - Fee Related
- 2008-05-06 KR KR1020097025071A patent/KR101598482B1/ko active IP Right Grant
- 2008-05-06 NZ NZ580962A patent/NZ580962A/en not_active IP Right Cessation
- 2008-05-07 CL CL2008001321A patent/CL2008001321A1/es unknown
- 2008-05-07 TW TW097116854A patent/TWI458722B/zh not_active IP Right Cessation
-
2009
- 2009-11-03 NO NO20093275A patent/NO20093275L/no not_active Application Discontinuation
- 2009-11-04 IL IL201921A patent/IL201921A/en active IP Right Grant
- 2009-12-04 ZA ZA2009/08612A patent/ZA200908612B/en unknown
-
2010
- 2010-09-29 HK HK10109325.5A patent/HK1142898A1/xx not_active IP Right Cessation
-
2011
- 2011-04-07 HR HR20110253T patent/HRP20110253T1/hr unknown
- 2011-04-26 CY CY20111100414T patent/CY1111517T1/el unknown
-
2013
- 2013-06-13 US US13/917,385 patent/US9630951B2/en active Active
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2017
- 2017-03-09 US US15/454,201 patent/US20170369478A1/en not_active Abandoned
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2018
- 2018-09-05 AR ARP180102520A patent/AR112789A2/es unknown
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2019
- 2019-05-03 US US16/402,454 patent/US20190322648A1/en not_active Abandoned
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2021
- 2021-05-10 US US17/315,791 patent/US20210261533A1/en not_active Abandoned
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FC2A | Withdrawal, rejection or dismissal of laid open patent application |