BRPI0811275B8 - derivado de 1,3-di-hidroimidazol-2-tiona como inibidor da dopamina-beta-hidroxilase, processo para a preparação do mesmo, composição farmacêutica, e, uso do mesmo - Google Patents
derivado de 1,3-di-hidroimidazol-2-tiona como inibidor da dopamina-beta-hidroxilase, processo para a preparação do mesmo, composição farmacêutica, e, uso do mesmoInfo
- Publication number
- BRPI0811275B8 BRPI0811275B8 BRPI0811275A BRPI0811275A BRPI0811275B8 BR PI0811275 B8 BRPI0811275 B8 BR PI0811275B8 BR PI0811275 A BRPI0811275 A BR PI0811275A BR PI0811275 A BRPI0811275 A BR PI0811275A BR PI0811275 B8 BRPI0811275 B8 BR PI0811275B8
- Authority
- BR
- Brazil
- Prior art keywords
- preparation
- dihydroimidazol
- dopamine
- beta
- pharmaceutical composition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0708818.0A GB0708818D0 (en) | 2007-05-08 | 2007-05-08 | Compounds |
GB0708818.0 | 2007-05-08 | ||
PCT/PT2008/000019 WO2008136695A1 (en) | 2007-05-08 | 2008-05-06 | 1, 3-dihydroimidazole- 2 -thione derivatives as inhibitors of dopamine-beta-hydroxylase |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0811275A2 BRPI0811275A2 (pt) | 2014-12-23 |
BRPI0811275B1 BRPI0811275B1 (pt) | 2020-01-07 |
BRPI0811275B8 true BRPI0811275B8 (pt) | 2021-05-25 |
Family
ID=38198874
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0811275A BRPI0811275B8 (pt) | 2007-05-08 | 2008-05-06 | derivado de 1,3-di-hidroimidazol-2-tiona como inibidor da dopamina-beta-hidroxilase, processo para a preparação do mesmo, composição farmacêutica, e, uso do mesmo |
Country Status (30)
Country | Link |
---|---|
US (5) | US8481582B2 (pt) |
EP (1) | EP2155731B1 (pt) |
JP (1) | JP5559677B2 (pt) |
KR (1) | KR101598482B1 (pt) |
CN (1) | CN101687858B (pt) |
AR (2) | AR066457A1 (pt) |
AT (1) | ATE499367T1 (pt) |
AU (1) | AU2008246443B2 (pt) |
BR (1) | BRPI0811275B8 (pt) |
CA (1) | CA2686387C (pt) |
CL (1) | CL2008001321A1 (pt) |
CY (1) | CY1111517T1 (pt) |
DE (1) | DE602008005141D1 (pt) |
DK (1) | DK2155731T3 (pt) |
ES (1) | ES2360841T3 (pt) |
GB (1) | GB0708818D0 (pt) |
HK (1) | HK1142898A1 (pt) |
HR (1) | HRP20110253T1 (pt) |
IL (1) | IL201921A (pt) |
MX (1) | MX2009012041A (pt) |
NO (1) | NO20093275L (pt) |
NZ (1) | NZ580962A (pt) |
PL (1) | PL2155731T3 (pt) |
RS (1) | RS51692B (pt) |
RU (1) | RU2501796C2 (pt) |
SI (1) | SI2155731T1 (pt) |
TW (1) | TWI458722B (pt) |
UA (1) | UA104844C2 (pt) |
WO (1) | WO2008136695A1 (pt) |
ZA (1) | ZA200908612B (pt) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0708818D0 (en) | 2007-05-08 | 2007-06-13 | Portela & Ca Sa | Compounds |
WO2012020742A1 (ja) * | 2010-08-10 | 2012-02-16 | 塩野義製薬株式会社 | 新規複素環誘導体およびそれらを含有する医薬組成物 |
BR112013015864B1 (pt) * | 2010-12-22 | 2021-11-09 | Bial - Portela & C.A., S.A. | Processo para purificar um composto de forma cristalina a de (r)-5-(2-benzilamino)etil)-1- (6,8-difluorocroman-3-il)-1h-imidazol-2(3h)-tiona |
EP2726454B1 (en) | 2011-06-29 | 2018-01-24 | Bial-Portela & CA, S.A. | Process |
TR201815850T4 (tr) * | 2012-11-14 | 2018-11-21 | Bial Portela & Ca Sa | Pulmoner arteryel hipertansiyonun ve akciğer hasarının tedavisinde kullanım için 1,3-dihidroimidazol-2-tion türevleri. |
CN103356671B (zh) * | 2013-06-24 | 2015-11-25 | 顾祥茂 | Houttuynoid C在制备治疗或预防慢性心衰的药物中的应用 |
GB201316410D0 (en) | 2013-09-13 | 2013-10-30 | Bial Portela & Ca Sa | Processes for preparing peripherally-selective inhibitors of dopamine-?-hydroxylase and intermediates for use therein |
JOP20190050A1 (ar) * | 2016-09-23 | 2019-03-20 | Bial Portela & C? S A | مثبطات دوبامين-b-هيدروكسيلاز تخترق حاجز المخ الدموي |
MX2020002696A (es) | 2017-09-13 | 2020-09-25 | Amgen Inc | Compuestos de bisamida que activan el sarcomero y sus usos. |
US11434242B2 (en) | 2017-12-04 | 2022-09-06 | Bial—Portela & Ca, S.A. | Dopamine-b-hydroxylase inhibitors |
GB201810395D0 (en) | 2018-06-25 | 2018-08-08 | Bial Portela & Ca Sa | Formulations comprising dopamine-beta-hydroxylase inhibitors and methods for their preparation |
GB201908044D0 (en) | 2019-06-05 | 2019-07-17 | Bial Portela & Ca Sa | Dopamine-B-Hydroxylase inhibitors |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4217347A (en) * | 1977-12-27 | 1980-08-12 | E. R. Squibb & Sons, Inc. | Method of treating hypertension and medicaments therefor |
US4962128A (en) * | 1989-11-02 | 1990-10-09 | Pfizer Inc. | Method of treating anxiety-related disorders using sertraline |
US5298497A (en) * | 1990-05-15 | 1994-03-29 | E. R. Squibb & Sons, Inc. | Method for preventing onset of hypertension employing a cholesterol lowering drug |
DE69531102T2 (de) | 1994-04-26 | 2004-04-29 | Roche Palo Alto Llc, Palo Alto | Benzocyclohexylimidazolthion-derivate |
AR032711A1 (es) * | 2001-02-21 | 2003-11-19 | Solvay Pharm Bv | Derivados de fenilpiperazina, un metodo para la preparacion de los mismos y una composicion farmaceutica que los contiene |
US7125904B2 (en) * | 2002-10-11 | 2006-10-24 | Portela & C.A., S.A. | Peripherally-selective inhibitors of dopamine-β-hydroxylase and method of their preparation |
GB2393958A (en) * | 2002-10-11 | 2004-04-14 | Portela & Ca Sa | Peripherally-selective imidazole inhibitors of dopamine-beta-hydroxylase |
GB0708818D0 (en) | 2007-05-08 | 2007-06-13 | Portela & Ca Sa | Compounds |
-
2007
- 2007-05-08 GB GBGB0708818.0A patent/GB0708818D0/en not_active Ceased
-
2008
- 2008-05-06 KR KR1020097025071A patent/KR101598482B1/ko active IP Right Grant
- 2008-05-06 MX MX2009012041A patent/MX2009012041A/es active IP Right Grant
- 2008-05-06 DE DE602008005141T patent/DE602008005141D1/de active Active
- 2008-05-06 AT AT08741778T patent/ATE499367T1/de active
- 2008-05-06 US US12/599,014 patent/US8481582B2/en active Active
- 2008-05-06 WO PCT/PT2008/000019 patent/WO2008136695A1/en active Application Filing
- 2008-05-06 RS RS20110165A patent/RS51692B/en unknown
- 2008-05-06 PL PL08741778T patent/PL2155731T3/pl unknown
- 2008-05-06 AU AU2008246443A patent/AU2008246443B2/en not_active Ceased
- 2008-05-06 CA CA2686387A patent/CA2686387C/en active Active
- 2008-05-06 JP JP2010507348A patent/JP5559677B2/ja not_active Expired - Fee Related
- 2008-05-06 EP EP08741778A patent/EP2155731B1/en active Active
- 2008-05-06 NZ NZ580962A patent/NZ580962A/en not_active IP Right Cessation
- 2008-05-06 UA UAA200912720A patent/UA104844C2/uk unknown
- 2008-05-06 DK DK08741778.8T patent/DK2155731T3/da active
- 2008-05-06 CN CN2008800151606A patent/CN101687858B/zh not_active Expired - Fee Related
- 2008-05-06 AR ARP080101912A patent/AR066457A1/es not_active Application Discontinuation
- 2008-05-06 ES ES08741778T patent/ES2360841T3/es active Active
- 2008-05-06 RU RU2009145270/04A patent/RU2501796C2/ru active
- 2008-05-06 BR BRPI0811275A patent/BRPI0811275B8/pt not_active IP Right Cessation
- 2008-05-06 SI SI200830191T patent/SI2155731T1/sl unknown
- 2008-05-07 TW TW097116854A patent/TWI458722B/zh not_active IP Right Cessation
- 2008-05-07 CL CL2008001321A patent/CL2008001321A1/es unknown
-
2009
- 2009-11-03 NO NO20093275A patent/NO20093275L/no not_active Application Discontinuation
- 2009-11-04 IL IL201921A patent/IL201921A/en active IP Right Grant
- 2009-12-04 ZA ZA2009/08612A patent/ZA200908612B/en unknown
-
2010
- 2010-09-29 HK HK10109325.5A patent/HK1142898A1/xx not_active IP Right Cessation
-
2011
- 2011-04-07 HR HR20110253T patent/HRP20110253T1/hr unknown
- 2011-04-26 CY CY20111100414T patent/CY1111517T1/el unknown
-
2013
- 2013-06-13 US US13/917,385 patent/US9630951B2/en active Active
-
2017
- 2017-03-09 US US15/454,201 patent/US20170369478A1/en not_active Abandoned
-
2018
- 2018-09-05 AR ARP180102520A patent/AR112789A2/es unknown
-
2019
- 2019-05-03 US US16/402,454 patent/US20190322648A1/en not_active Abandoned
-
2021
- 2021-05-10 US US17/315,791 patent/US20210261533A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0811275B8 (pt) | derivado de 1,3-di-hidroimidazol-2-tiona como inibidor da dopamina-beta-hidroxilase, processo para a preparação do mesmo, composição farmacêutica, e, uso do mesmo | |
BR0315143A (pt) | Composto, processo para a preparação dos (r) e (s) - enanciÈmeros individuais ou misturas de enanciÈmeros e sais farmaceuticamente aceitáveis de um composto, composição farmacêutica, e, uso de um composto | |
BRPI0507903A (pt) | derivados de quinazolina e composição farmacêutica compreendendo os mesmos | |
BRPI0713132B8 (pt) | compostos derivados de cinamoil-piperazina, método de preparação dos referidos compostos, composições farmacêuticas, seus usos como antagonistas de par-i e produtos | |
BRPI0716069A2 (pt) | composto, composiÇço farmacÊutica, e, mÉtodo para tratar um distérbio | |
BR0212378A (pt) | Inibidores de 17beta-hidroxiesteróide desidrogenase tipo 3 para o tratamento de doenças dependentes de androgênio | |
NO20080981L (no) | Nitrocatechol-derivater som COMT-inhibitorer | |
BRPI0914404A2 (pt) | "compostos, composição farmacêutica e método para tratar ou atenuar a gravidade de uma doença ou condição responsiva à inibição da atividade jak quinase em um paciente" | |
BR0316081A (pt) | Derivados de 2-piridona como inibidores de elastase de neutrófilo | |
BR0317435A (pt) | Derivados de pirimidina para o tratamento do crescimento celular anormal | |
BRPI0507495A (pt) | composto, composição farmacêutica, uso do composto método para o tratamento de distúrbios mediados por mglur5, e, método para inibir a ativação de receptores de mglur5 | |
UY27976A1 (es) | Piperazinas heterocíclicas sustituídas para el tratamiento de la esquizofrenia | |
EA200800172A1 (ru) | 2,4-диаминопиримидины как ингибиторы aurora | |
BRPI0515412A (pt) | composto, composição farmacêutica, e, uso de um composto ou uma composição farmacêutica | |
ME00962B (me) | Benzimidazolski derivati | |
TN2010000026A1 (fr) | Nouveaux derives de 6-triazolopyridazine-sulfanyl benzothiazole et benzimidazole, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de met | |
AR041298A1 (es) | Derivados de pirrolidona como inhibidores de maob | |
BR0315580A (pt) | Derivados de metileno uréia | |
BR112013001632A2 (pt) | composto, composição farmacêutica, método de inibir uma atividade uma jak quinase in vitro, uso de um composto, ou da composição farmacêutica, e, método de fabricar um composto | |
BR9911826A (pt) | Benzimidazóis, sua preparação e seu uso como composições farmacêutica | |
BRPI0406717A (pt) | Composto, composição farmacêutica que compreende o mesmo, método de tratamento de uma enfermidade em um mamìfero, utilização do composto e processo para a sua produção | |
AR043485A1 (es) | Derivados del 8'-piridinil-dihidrospiro-[cicloalquil]-pirimido[1,2a]pirimidin-6-ona y 8´-pirimidinil-dihidrospiro-[cicloalquil]-pirimido[1,2a]pirimidin-6-ona substituidos | |
BR0308338A (pt) | Derivados de nitrosodifenilamina e seu uso farmacêutico contra patologias de estresse oxidativo | |
BR112014001083A8 (pt) | composto, processo para a preparação de um composto, composição farmacêutica, método para o tratamento de doenças e uso de um composto | |
BR112022014480A2 (pt) | Compostos, composições farmacêutica, método para tratar um distúrbio em um paciente, usos de um composto e de uma composição farmacêutica e kit |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 07/01/2020, OBSERVADAS AS CONDICOES LEGAIS. |
|
B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 06/05/2008 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
|
B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 15A ANUIDADE. |
|
B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2721 DE 28-02-2023 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |