BR0315143A - Composto, processo para a preparação dos (r) e (s) - enanciÈmeros individuais ou misturas de enanciÈmeros e sais farmaceuticamente aceitáveis de um composto, composição farmacêutica, e, uso de um composto - Google Patents

Composto, processo para a preparação dos (r) e (s) - enanciÈmeros individuais ou misturas de enanciÈmeros e sais farmaceuticamente aceitáveis de um composto, composição farmacêutica, e, uso de um composto

Info

Publication number
BR0315143A
BR0315143A BR0315143-3A BR0315143A BR0315143A BR 0315143 A BR0315143 A BR 0315143A BR 0315143 A BR0315143 A BR 0315143A BR 0315143 A BR0315143 A BR 0315143A
Authority
BR
Brazil
Prior art keywords
compound
preparation
enantiomers
mixtures
pharmaceutically acceptable
Prior art date
Application number
BR0315143-3A
Other languages
English (en)
Other versions
BRPI0315143B8 (pt
BRPI0315143B1 (pt
Inventor
David Alexander Learmonth
Patricio Manuel Vieira A Silva
Alexander Beliaev
Original Assignee
Portela & Ca Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0223719A external-priority patent/GB2393958A/en
Application filed by Portela & Ca Sa filed Critical Portela & Ca Sa
Publication of BR0315143A publication Critical patent/BR0315143A/pt
Publication of BRPI0315143B1 publication Critical patent/BRPI0315143B1/pt
Publication of BRPI0315143B8 publication Critical patent/BRPI0315143B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/695—Silicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"COMPOSTO, PROCESSO PARA A PREPARAçãO DOS (R) E (S) ENANCIÈMEROS INDIVIDUAIS OU MISTURAS DE ENANCIÈMEROS E SAIS FARMACEUTICAMENTE ACEITáVEIS DE UM COMPOSTO, COMPOSIçãO FARMACêUTICA, E, USO DE UM COMPOSTO". São descritos compostos da fórmula (I) e um método para a sua preparação, em que X é CH~ 2~,O e S, e n é 1,2 ou 3, com a condição de que se X for CH~ 2~, n não é 1. Os compostos possuem propriedades farmacêuticas potencialmente valiosas para o tratamento de distúrbios cardiovasculares, tais como hipertensão e falha cardíaca.
BRPI0315143A 2002-10-11 2003-10-10 composto, composição farmacêutica, e, uso de um composto BRPI0315143B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0223719A GB2393958A (en) 2002-10-11 2002-10-11 Peripherally-selective imidazole inhibitors of dopamine-beta-hydroxylase
GB0224306A GB2394223B (en) 2002-10-11 2002-10-18 Peripherally-selective inhibitors of dopamine-beta-hydroxylase and method of their preparation
PCT/GB2003/004430 WO2004033447A1 (en) 2002-10-11 2003-10-10 Imidazole derivatives and their use as peripherally-selective inhibitors of dopamine-beta-hydroxylase

Publications (3)

Publication Number Publication Date
BR0315143A true BR0315143A (pt) 2005-08-16
BRPI0315143B1 BRPI0315143B1 (pt) 2017-02-14
BRPI0315143B8 BRPI0315143B8 (pt) 2021-05-25

Family

ID=32031889

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0315143A BRPI0315143B8 (pt) 2002-10-11 2003-10-10 composto, composição farmacêutica, e, uso de um composto

Country Status (13)

Country Link
US (2) US7125904B2 (pt)
EP (5) EP1908759B1 (pt)
JP (1) JP4620464B2 (pt)
KR (1) KR101155159B1 (pt)
AU (1) AU2003271945B2 (pt)
BR (1) BRPI0315143B8 (pt)
CA (1) CA2501819C (pt)
GB (2) GB2432158B (pt)
MX (1) MXPA05003847A (pt)
PL (1) PL218537B1 (pt)
PT (1) PT103029B (pt)
RU (1) RU2332416C2 (pt)
WO (1) WO2004033447A1 (pt)

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GB0600709D0 (en) * 2006-01-13 2006-02-22 Portela & Ca Sa Drug combinations
GB0610804D0 (en) * 2006-05-31 2006-07-12 Portela & Ca Sa New crystal forms
AU2007331340A1 (en) 2006-12-12 2008-06-19 Bial-Portela & Ca, S.A. Catalytic process for asymmetric hydrogenation
GB0700635D0 (en) * 2007-01-12 2007-02-21 Portela & Ca Sa Therapy
GB0701966D0 (en) * 2007-02-01 2007-03-14 Portela & Ca Sa Process
US20100093817A1 (en) * 2007-02-01 2010-04-15 Bial - Portela & Ca S.A. Compounds
GB0701965D0 (en) * 2007-02-01 2007-03-14 Portela & Ca Sa Process
US20100105748A1 (en) * 2007-03-16 2010-04-29 David Weinshenker Methods and compositions for treatment of drug addiction
GB0708818D0 (en) 2007-05-08 2007-06-13 Portela & Ca Sa Compounds
GB0709695D0 (en) * 2007-05-21 2007-06-27 Portela & Ca Sa Process
TW200927740A (en) * 2007-11-13 2009-07-01 Bial Portela & Ca Sa Process
EP2231648A1 (en) * 2007-12-05 2010-09-29 BIAL - Portela & Ca., S.A. New salts and crystal forms
AR070841A1 (es) * 2008-03-13 2010-05-05 Bial Portela & Ca Sa Proceso de hidrogenacion catalitica asimetrica
US8313984B2 (en) * 2008-03-19 2012-11-20 Ati Technologies Ulc Die substrate with reinforcement structure
PT2297042E (pt) 2008-03-19 2013-10-10 Bial Portela & Ca Sa Hidrogenação catalítica assimétrica
AR071632A1 (es) 2008-05-06 2010-06-30 Bial Portela & Ca Sa Proceso catalitico para hidrogenacion asimetrica en la sintesis de inhibidores de la dopamina-beta-hidroxilasa"
WO2010054401A1 (en) * 2008-11-10 2010-05-14 Alnylam Pharmaceuticals, Inc. Novel lipids and compositions for the delivery of therapeutics
JP5574480B2 (ja) * 2009-03-12 2014-08-20 国立大学法人高知大学 アミノ基含有アセトン誘導体、及びそれを用いた炭素−炭素結合形成方法
TWI507462B (zh) * 2010-01-25 2015-11-11 羅門哈斯電子材料有限公司 包含有含氮化合物之光阻
ES2632351T3 (es) * 2010-12-22 2017-09-12 Bial-Portela & Ca, S.A. Formas cristalinas y procedimientos para su preparación
US9346751B2 (en) 2011-06-29 2016-05-24 Bial-Portela & Ca, S.A. Process for preparing 1, 3-Dihydroimidazole-2-Thione Derivatives
WO2013134047A2 (en) 2012-03-07 2013-09-12 The Mclean Hospital Corporation Aminoquinoline derivatives and uses thereof
CN105025895B (zh) * 2012-11-14 2019-02-26 比亚尔-波特拉&Ca有限公司 用于治疗肺动脉高压和肺损伤的1,3-二氢咪唑-2-硫酮衍生物
GB201316410D0 (en) 2013-09-13 2013-10-30 Bial Portela & Ca Sa Processes for preparing peripherally-selective inhibitors of dopamine-?-hydroxylase and intermediates for use therein
JOP20190050A1 (ar) * 2016-09-23 2019-03-20 Bial Portela & C? S A مثبطات دوبامين-b-هيدروكسيلاز تخترق حاجز المخ الدموي
AU2018379646A1 (en) * 2017-12-04 2020-06-11 BIAL - PORTELA & Cª, S.A. Dopamine-B-hydroxylase inhibitors
GB201810395D0 (en) 2018-06-25 2018-08-08 Bial Portela & Ca Sa Formulations comprising dopamine-beta-hydroxylase inhibitors and methods for their preparation
WO2020123699A1 (en) * 2018-12-11 2020-06-18 The Trustees Of Columbia University In The City Of New York Compounds and compositions that cause mycn and/or cmyc degradation and methods of use thereof
GB201908044D0 (en) 2019-06-05 2019-07-17 Bial Portela & Ca Sa Dopamine-B-Hydroxylase inhibitors

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Also Published As

Publication number Publication date
AU2003271945A1 (en) 2004-05-04
EP1908760B1 (en) 2011-04-13
RU2005114021A (ru) 2005-11-10
EP1911757B1 (en) 2011-03-02
KR20050057647A (ko) 2005-06-16
EP1911757B8 (en) 2011-05-25
EP1908760A1 (en) 2008-04-09
CA2501819A1 (en) 2004-04-22
EP1908759A3 (en) 2008-04-16
EP1408038B1 (en) 2008-08-06
JP2006507261A (ja) 2006-03-02
EP1408038A3 (en) 2004-04-21
CA2501819C (en) 2012-09-04
EP1908759B1 (en) 2012-03-21
GB2432158B (en) 2007-06-27
KR101155159B1 (ko) 2012-06-11
RU2332416C2 (ru) 2008-08-27
US20040142996A1 (en) 2004-07-22
PL376224A1 (en) 2005-12-27
US7259271B2 (en) 2007-08-21
GB0702981D0 (en) 2007-03-28
EP1408038A2 (en) 2004-04-14
BRPI0315143B8 (pt) 2021-05-25
EP1914233B1 (en) 2011-03-02
EP1908759A2 (en) 2008-04-09
GB0702982D0 (en) 2007-03-28
PT103029B (pt) 2005-05-31
WO2004033447A1 (en) 2004-04-22
EP1914233B8 (en) 2011-04-13
US7125904B2 (en) 2006-10-24
GB2432159B (en) 2007-06-27
PL218537B1 (pl) 2014-12-31
GB2432158A (en) 2007-05-16
EP1911757A2 (en) 2008-04-16
AU2003271945B2 (en) 2009-12-17
BRPI0315143B1 (pt) 2017-02-14
MXPA05003847A (es) 2005-06-22
GB2432159A (en) 2007-05-16
EP1911757A3 (en) 2008-05-28
PT103029A (pt) 2004-05-31
US20070015730A1 (en) 2007-01-18
JP4620464B2 (ja) 2011-01-26
EP1914233A1 (en) 2008-04-23

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B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]
B16C Correction of notification of the grant [chapter 16.3 patent gazette]

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B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 20A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2743 DE 01-08-2023 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.