NO20085169L - Krystallinske solvater og komplekser av (1S)-1,5-anhydro-L-C- (3-((fenyl)metyl)fenyl)-D-glucitol derivater med aminosyrer som SGLT2-inhibitorer for behandling av diabetes - Google Patents

Krystallinske solvater og komplekser av (1S)-1,5-anhydro-L-C- (3-((fenyl)metyl)fenyl)-D-glucitol derivater med aminosyrer som SGLT2-inhibitorer for behandling av diabetes

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Publication number
NO20085169L
NO20085169L NO20085169A NO20085169A NO20085169L NO 20085169 L NO20085169 L NO 20085169L NO 20085169 A NO20085169 A NO 20085169A NO 20085169 A NO20085169 A NO 20085169A NO 20085169 L NO20085169 L NO 20085169L
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NO
Norway
Prior art keywords
phenyl
diabetes
anhydro
complexes
methyl
Prior art date
Application number
NO20085169A
Other languages
English (en)
Other versions
NO346828B1 (no
Inventor
Janak Singh
Jack Z Gougoutas
Chiajen Lai
Hildegard Lobinger
Srividya Ramakrishnan
Prashant P Deshpande
Jeffrey T Bien
Chenchi Wang
Peter Riebel
John Anthony Grosso
Alexandra A Nirschi
John D Dimarco
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38581970&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20085169(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NO20085169L publication Critical patent/NO20085169L/no
Publication of NO346828B1 publication Critical patent/NO346828B1/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/207—Cyclohexane rings not substituted by nitrogen atoms, e.g. kasugamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/04—Carbocyclic radicals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Foreliggende oppfinnelse angår fysiske krystallstrukturer av en forbindelse med formel I: hvor R1, R2, R2a, R3 og R4 er som definert her, spesielt farmasøytiske preparater som inneholder strukturer av forbindelse I eller II, fremgangsmåter for fremstilling av disse, mellomprodukter som blir anvendt ved fremstillinga av disse, samt metoder for behandling av sykdommer, så som diabetes, ved anvendelse av slike strukturer.
NO20085169A 2006-06-28 2007-06-21 KRYSTALLINSK (S)-PROPYLENEGLYKOLSOLVAT AV 1-C-6-KLORO-4’-ETOKSYDIFENYLMETAN-3-YL-β-D-GLUCOPYRANOSE NO346828B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81711806P 2006-06-28 2006-06-28
US11/765,481 US7919598B2 (en) 2006-06-28 2007-06-20 Crystal structures of SGLT2 inhibitors and processes for preparing same
PCT/US2007/071749 WO2008002824A1 (en) 2006-06-28 2007-06-21 Crystalline solvates and complexes of (is) -1, 5-anhydro-l-c- (3- ( (phenyl) methyl) phenyl) -d-glucitol derivatives with amino acids as sglt2 inhibitors for the treatment of diabetes

Publications (2)

Publication Number Publication Date
NO20085169L true NO20085169L (no) 2009-01-20
NO346828B1 NO346828B1 (no) 2023-01-23

Family

ID=38581970

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20085169A NO346828B1 (no) 2006-06-28 2007-06-21 KRYSTALLINSK (S)-PROPYLENEGLYKOLSOLVAT AV 1-C-6-KLORO-4’-ETOKSYDIFENYLMETAN-3-YL-β-D-GLUCOPYRANOSE
NO20221233A NO347770B1 (no) 2006-06-28 2022-11-17 Krystallinske solvater og komplekser av (1S)-1,5-anhydro-L-C-(3-((fenyl)metyl)fenyl)-D-glucitol-derivater med aminosyrer som SGLT2-inhibitorer for behandling av diabetes

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20221233A NO347770B1 (no) 2006-06-28 2022-11-17 Krystallinske solvater og komplekser av (1S)-1,5-anhydro-L-C-(3-((fenyl)metyl)fenyl)-D-glucitol-derivater med aminosyrer som SGLT2-inhibitorer for behandling av diabetes

Country Status (33)

Country Link
US (3) US7919598B2 (no)
EP (4) EP2457918A3 (no)
JP (6) JP5313889B2 (no)
KR (1) KR101493102B1 (no)
CN (2) CN101479287B (no)
AR (1) AR061730A1 (no)
AU (1) AU2007265246B2 (no)
BR (3) BR122017015106B8 (no)
CA (3) CA2924318C (no)
CL (1) CL2007001915A1 (no)
CO (1) CO6160299A2 (no)
CY (1) CY1115738T1 (no)
DK (1) DK2069374T4 (no)
EA (4) EA018229B1 (no)
ES (3) ES2659862T3 (no)
HK (1) HK1127359A1 (no)
HR (1) HRP20141007T4 (no)
IL (5) IL195882A (no)
MX (3) MX367155B (no)
MY (2) MY173930A (no)
NO (2) NO346828B1 (no)
NZ (4) NZ589202A (no)
PE (2) PE20120776A1 (no)
PH (1) PH12012500168A1 (no)
PL (1) PL2069374T5 (no)
PT (1) PT2069374E (no)
RS (1) RS53638B2 (no)
SG (2) SG10201402181SA (no)
SI (1) SI2069374T2 (no)
TW (4) TWI519528B (no)
UA (1) UA96765C2 (no)
WO (1) WO2008002824A1 (no)
ZA (1) ZA200810475B (no)

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