PT2069374E - Solvatos cristalinos de derivados de (1s)-1,5-anidro-1-c-(3- ((fenil)metil)fenil)-d-glucitol com álcoois como inibidores de sglt2 para o tratamento de diabetes - Google Patents

Solvatos cristalinos de derivados de (1s)-1,5-anidro-1-c-(3- ((fenil)metil)fenil)-d-glucitol com álcoois como inibidores de sglt2 para o tratamento de diabetes Download PDF

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Publication number
PT2069374E
PT2069374E PT77844991T PT07784499T PT2069374E PT 2069374 E PT2069374 E PT 2069374E PT 77844991 T PT77844991 T PT 77844991T PT 07784499 T PT07784499 T PT 07784499T PT 2069374 E PT2069374 E PT 2069374E
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PT
Portugal
Prior art keywords
phenyl
anhydro
diabetes
alcohols
methyl
Prior art date
Application number
PT77844991T
Other languages
English (en)
Inventor
Jack Z Gougoutas
Chiajen Lai
Hildegard Lobinger
Srividya Ramakrishnan
Prashant P Deshpande
Jeffrey T Bien
Chenchi Wang
Peter Riebel
John Anthony Grosso
Alexandra A Nirschl
Janak Singh
John D Dimarco
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38581970&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2069374(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PT2069374E publication Critical patent/PT2069374E/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/207—Cyclohexane rings not substituted by nitrogen atoms, e.g. kasugamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/04—Carbocyclic radicals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
PT77844991T 2006-06-28 2007-06-21 Solvatos cristalinos de derivados de (1s)-1,5-anidro-1-c-(3- ((fenil)metil)fenil)-d-glucitol com álcoois como inibidores de sglt2 para o tratamento de diabetes PT2069374E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81711806P 2006-06-28 2006-06-28
US11/765,481 US7919598B2 (en) 2006-06-28 2007-06-20 Crystal structures of SGLT2 inhibitors and processes for preparing same

Publications (1)

Publication Number Publication Date
PT2069374E true PT2069374E (pt) 2014-10-30

Family

ID=38581970

Family Applications (1)

Application Number Title Priority Date Filing Date
PT77844991T PT2069374E (pt) 2006-06-28 2007-06-21 Solvatos cristalinos de derivados de (1s)-1,5-anidro-1-c-(3- ((fenil)metil)fenil)-d-glucitol com álcoois como inibidores de sglt2 para o tratamento de diabetes

Country Status (33)

Country Link
US (3) US7919598B2 (pt)
EP (4) EP2069374B2 (pt)
JP (6) JP5313889B2 (pt)
KR (1) KR101493102B1 (pt)
CN (2) CN103145773B (pt)
AR (1) AR061730A1 (pt)
AU (1) AU2007265246B2 (pt)
BR (3) BR122017021516B8 (pt)
CA (3) CA2653344C (pt)
CL (1) CL2007001915A1 (pt)
CO (1) CO6160299A2 (pt)
CY (1) CY1115738T1 (pt)
DK (1) DK2069374T4 (pt)
EA (4) EA028259B1 (pt)
ES (3) ES2769130T3 (pt)
HK (1) HK1127359A1 (pt)
HR (1) HRP20141007T4 (pt)
IL (5) IL195882A (pt)
MX (3) MX367155B (pt)
MY (2) MY173930A (pt)
NO (2) NO346828B1 (pt)
NZ (4) NZ589202A (pt)
PE (2) PE20120776A1 (pt)
PH (1) PH12012500168B1 (pt)
PL (1) PL2069374T5 (pt)
PT (1) PT2069374E (pt)
RS (1) RS53638B2 (pt)
SG (2) SG172741A1 (pt)
SI (1) SI2069374T2 (pt)
TW (4) TWI466876B (pt)
UA (1) UA96765C2 (pt)
WO (1) WO2008002824A1 (pt)
ZA (1) ZA200810475B (pt)

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CN104829572B (zh) 2014-02-10 2019-01-04 江苏豪森药业集团有限公司 达格列净新晶型及其制备方法

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