US3674836A
(en)
|
1968-05-21 |
1972-07-04 |
Parke Davis & Co |
2,2-dimethyl-{11 -aryloxy-alkanoic acids and salts and esters thereof
|
US4027009A
(en)
|
1973-06-11 |
1977-05-31 |
Merck & Co., Inc. |
Compositions and methods for depressing blood serum cholesterol
|
JPS5612114B2
(en)
|
1974-06-07 |
1981-03-18 |
|
|
US4231938A
(en)
|
1979-06-15 |
1980-11-04 |
Merck & Co., Inc. |
Hypocholesteremic fermentation products and process of preparation
|
MX7065E
(en)
|
1980-06-06 |
1987-04-10 |
Sankyo Co |
A MICROBIOLOGICAL PROCEDURE FOR PREPARING DERIVATIVES OF ML-236B
|
US4450171A
(en)
|
1980-08-05 |
1984-05-22 |
Merck & Co., Inc. |
Antihypercholesterolemic compounds
|
US4448784A
(en)
|
1982-04-12 |
1984-05-15 |
Hoechst-Roussel Pharmaceuticals, Inc. |
1-(Aminoalkylphenyl and aminoalkylbenzyl)-indoles and indolines and analgesic method of use thereof
|
US4499289A
(en)
|
1982-12-03 |
1985-02-12 |
G. D. Searle & Co. |
Octahydronapthalenes
|
JPS6051189A
(en)
|
1983-08-30 |
1985-03-22 |
Sankyo Co Ltd |
Thiazolidine derivative and its preparation
|
CA1327360C
(en)
|
1983-11-14 |
1994-03-01 |
William F. Hoffman |
Oxo-analogs of mevinolin-like antihypercholesterolemic agents
|
US4613610A
(en)
|
1984-06-22 |
1986-09-23 |
Sandoz Pharmaceuticals Corp. |
Cholesterol biosynthesis inhibiting pyrazole analogs of mevalonolactone and its derivatives
|
US4686237A
(en)
|
1984-07-24 |
1987-08-11 |
Sandoz Pharmaceuticals Corp. |
Erythro-(E)-7-[3'-C1-3 alkyl-1'-(3",5"-dimethylphenyl)naphth-2'-yl]-3,5-dihydroxyhept-6-enoic acids and derivatives thereof
|
US4647576A
(en)
|
1984-09-24 |
1987-03-03 |
Warner-Lambert Company |
Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis
|
KR910003427B1
(en)
|
1984-12-04 |
1991-05-31 |
산도즈 파마슈티칼스 코포레이션 |
Process for preparing indene analogs of mevalonolactone and derivatives thereof
|
US4668794A
(en)
|
1985-05-22 |
1987-05-26 |
Sandoz Pharm. Corp. |
Intermediate imidazole acrolein analogs
|
EP0221025A1
(en)
|
1985-10-25 |
1987-05-06 |
Sandoz Ag |
Heterocyclic analogs of mevalonolactone and derivatives thereof, processes for their production and their use as pharmaceuticals
|
FR2596393B1
(en)
|
1986-04-01 |
1988-06-03 |
Sanofi Sa |
HYDROXY-3 DIHYDROXYOXOPHOSPHORIO-4 BUTANOIC ACID DERIVATIVES, THEIR PREPARATION PROCESS, THEIR USE AS MEDICAMENTS AND THE COMPOSITIONS CONTAINING THEM
|
DE3817375C2
(en)
|
1987-05-22 |
1997-04-30 |
Squibb & Sons Inc |
Phosphorus-containing HMG-CoA reductase inhibitors and their use
|
US4759923A
(en)
|
1987-06-25 |
1988-07-26 |
Hercules Incorporated |
Process for lowering serum cholesterol using poly(diallylmethylamine) derivatives
|
US4871721A
(en)
|
1988-01-11 |
1989-10-03 |
E. R. Squibb & Sons, Inc. |
Phosphorus-containing squalene synthetase inhibitors
|
US4924024A
(en)
|
1988-01-11 |
1990-05-08 |
E. R. Squibb & Sons, Inc. |
Phosphorus-containing squalene synthetase inhibitors, new intermediates and method
|
US5506219A
(en)
|
1988-08-29 |
1996-04-09 |
E. R. Squibb & Sons, Inc. |
Pyridine anchors for HMG-CoA reductase inhibitors
|
US5753675A
(en)
|
1989-03-03 |
1998-05-19 |
Novartis Pharmaceuticals Corporation |
Quinoline analogs of mevalonolactone and derivatives thereof
|
JPH035988A
(en)
|
1989-06-01 |
1991-01-11 |
Matsushita Electric Ind Co Ltd |
Dynamic memory
|
US5470845A
(en)
|
1992-10-28 |
1995-11-28 |
Bristol-Myers Squibb Company |
Methods of using α-phosphonosulfonate squalene synthetase inhibitors including the treatment of atherosclerosis and hypercholesterolemia
|
US5731292A
(en)
|
1992-11-12 |
1998-03-24 |
Tanabe Seiyaku Co., Ltd. |
Dihydrochalcone derivatives which are hypoglycemic agents
|
CA2102591C
(en)
|
1992-11-12 |
2000-12-26 |
Kenji Tsujihara |
Hypoglycemic agent
|
LT3300B
(en)
|
1992-12-23 |
1995-06-26 |
Schering Corp |
Combination of a cholesterol biosynhtesis inhibitor and a beta- lactam cholesterol absorbtion inhibitor
|
US5594016A
(en)
|
1992-12-28 |
1997-01-14 |
Mitsubishi Chemical Corporation |
Naphthalene derivatives
|
US5776983A
(en)
|
1993-12-21 |
1998-07-07 |
Bristol-Myers Squibb Company |
Catecholamine surrogates useful as β3 agonists
|
US5488064A
(en)
|
1994-05-02 |
1996-01-30 |
Bristol-Myers Squibb Company |
Benzo 1,3 dioxole derivatives
|
US5830873A
(en)
|
1994-05-11 |
1998-11-03 |
Tanabe Seiyaku Co., Ltd. |
Propiophenone derivative and a process for preparing the same
|
JP2814950B2
(en)
|
1994-05-11 |
1998-10-27 |
田辺製薬株式会社 |
Hypoglycemic agent
|
US5612359A
(en)
|
1994-08-26 |
1997-03-18 |
Bristol-Myers Squibb Company |
Substituted biphenyl isoxazole sulfonamides
|
US5491134A
(en)
|
1994-09-16 |
1996-02-13 |
Bristol-Myers Squibb Company |
Sulfonic, phosphonic or phosphiniic acid β3 agonist derivatives
|
US5541204A
(en)
|
1994-12-02 |
1996-07-30 |
Bristol-Myers Squibb Company |
Aryloxypropanolamine β 3 adrenergic agonists
|
US5698527A
(en)
|
1995-08-08 |
1997-12-16 |
Merck & Co., Inc. |
Steroidal glycosides as antihyperlipidemic agents
|
JP3006513B2
(en)
|
1995-11-07 |
2000-02-07 |
田辺製薬株式会社 |
Pharmaceutical composition
|
JP3065235B2
(en)
|
1995-11-07 |
2000-07-17 |
田辺製薬株式会社 |
Propiophenone derivatives and their production
|
JP3034192B2
(en)
|
1995-11-07 |
2000-04-17 |
田辺製薬株式会社 |
Propiophenone derivatives and their production
|
JP3059088B2
(en)
|
1995-11-07 |
2000-07-04 |
田辺製薬株式会社 |
Propiophenone derivatives and their production
|
US6236946B1
(en)
|
1995-12-13 |
2001-05-22 |
Thomas S. Scanlan |
Nuclear receptor ligands and ligand binding domains
|
US5770615A
(en)
|
1996-04-04 |
1998-06-23 |
Bristol-Myers Squibb Company |
Catecholamine surrogates useful as β3 agonists
|
DE19622222A1
(en)
|
1996-06-03 |
1997-12-04 |
Hoechst Ag |
Use of sodium=proton exchange inhibitor
|
WO1997048701A1
(en)
|
1996-06-20 |
1997-12-24 |
Pfizer Inc. |
4,1-benzoxazepines or 4,1-benzothiazepines and their use as squalene synthetase inhibitors
|
HRP970330B1
(en)
|
1996-07-08 |
2004-06-30 |
Bayer Ag |
Cycloalkano pyridines
|
DK0850948T3
(en)
|
1996-12-26 |
2002-07-29 |
Tanabe Seiyaku Co |
Propiophenone derivatives and process for their preparation
|
TW536540B
(en)
|
1997-01-30 |
2003-06-11 |
Bristol Myers Squibb Co |
Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe
|
JPH10245391A
(en)
|
1997-03-03 |
1998-09-14 |
Dainippon Ink & Chem Inc |
Diabetes therapeutic agent containing 7-glycosyloxybenzopyran derivative as active ingredient
|
GB9713739D0
(en)
|
1997-06-27 |
1997-09-03 |
Karobio Ab |
Thyroid receptor ligands
|
CZ302475B6
(en)
|
1997-10-08 |
2011-06-08 |
Sankyo Company Limited |
Substituted fused heterocyclic compounds
|
AU766219B2
(en)
|
1998-02-02 |
2003-10-09 |
1149336 Ontario Inc. |
Method of regulating glucose metabolism, and reagents related thereto
|
JP2002506075A
(en)
|
1998-03-09 |
2002-02-26 |
フォンダテッヒ・ベネルクス・ナムローゼ・フェンノートシャップ |
Serine peptidase modulator
|
DE19823831A1
(en)
|
1998-05-28 |
1999-12-02 |
Probiodrug Ges Fuer Arzneim |
New pharmaceutical use of isoleucyl thiazolidide and its salts
|
DE19828113A1
(en)
|
1998-06-24 |
2000-01-05 |
Probiodrug Ges Fuer Arzneim |
Prodrugs of Dipeptidyl Peptidase IV Inhibitors
|
DE19828114A1
(en)
|
1998-06-24 |
2000-01-27 |
Probiodrug Ges Fuer Arzneim |
Produgs of unstable inhibitors of dipeptidyl peptidase IV
|
PL203771B1
(en)
|
1998-07-06 |
2009-11-30 |
Bristol Myers Squibb Co |
Biphenylsulphonamide derivative as dual antagonist of angiotensin and endothelin receptors, method for production thereof the use of thereof and biphenyl derivative and benzene derivative
|
AU5612199A
(en)
|
1998-09-10 |
2000-04-03 |
Forbes Medi-Tech Inc. |
Compositions comprising one or more phytosterols, phytostanols or mixtures of both and one or more alpha, beta, delta, or gamma tocotrienols or derivatives thereof and use of the compositions in treating or preventing cardiovascular disease, its underlying conditions and other
|
US6147089A
(en)
|
1998-09-17 |
2000-11-14 |
Pfizer Inc. |
Annulated 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines
|
NZ511812A
(en)
|
1998-11-25 |
2003-11-28 |
Nutri Pharma As |
Method of lowering lipid, triglyceride, total cholesterol and LDL-cholesterol serum levels and increasing the HDL/LDL cholesterol ratio thereby treating cardiovascular disease
|
WO2000038722A1
(en)
|
1998-12-23 |
2000-07-06 |
G.D. Searle & Co. |
COMBINATIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS AND HMG CoA REDUCTASE INHIBITORS FOR CARDIOVASCULAR INDICATIONS
|
GB9828442D0
(en)
|
1998-12-24 |
1999-02-17 |
Karobio Ab |
Novel thyroid receptor ligands and method II
|
ES2261187T3
(en)
|
1999-02-24 |
2006-11-16 |
The Johns Hopkins University |
COMPOSITIONS AND METHODS TO MODULATE SERIOUS CHOLESTEROL.
|
US6548529B1
(en)
|
1999-04-05 |
2003-04-15 |
Bristol-Myers Squibb Company |
Heterocyclic containing biphenyl aP2 inhibitors and method
|
US6414002B1
(en)
|
1999-09-22 |
2002-07-02 |
Bristol-Myers Squibb Company |
Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
|
US6515117B2
(en)
*
|
1999-10-12 |
2003-02-04 |
Bristol-Myers Squibb Company |
C-aryl glucoside SGLT2 inhibitors and method
|
US6432156B1
(en)
|
1999-11-17 |
2002-08-13 |
The Homestead Corp. |
Method of coating materials and materials formed thereby
|
US6395767B2
(en)
|
2000-03-10 |
2002-05-28 |
Bristol-Myers Squibb Company |
Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method
|
US6683056B2
(en)
|
2000-03-30 |
2004-01-27 |
Bristol-Myers Squibb Company |
O-aryl glucoside SGLT2 inhibitors and method
|
US6555519B2
(en)
|
2000-03-30 |
2003-04-29 |
Bristol-Myers Squibb Company |
O-glucosylated benzamide SGLT2 inhibitors and method
|
EP1338603B1
(en)
|
2000-11-02 |
2010-01-20 |
Ajinomoto Co., Inc. |
Novel pyrazole derivatives and diabetes remedies containing the same
|
EP1392326B1
(en)
|
2001-04-04 |
2009-09-09 |
Ortho-McNeil-Janssen Pharmaceuticals, Inc. |
Combination therapy comprising glucose reabsorption inhibitors and retinoid-x receptor modulators
|
CA2444481A1
(en)
|
2001-04-11 |
2002-10-24 |
Bristol-Myers Squibb Company |
Amino acid complexes of c-aryl glucosides for treatment of diabetes and method
|
CA2672001A1
(en)
|
2001-04-27 |
2002-11-07 |
Ajinomoto Co., Inc. |
N-substituted pyrazole-o-glycoside derivatives and therapeutic agent for diabetes containing the same
|
EP1404215B1
(en)
|
2001-06-20 |
2007-08-15 |
Purdue Research Foundation |
Body-member-illuminating pressure cuff for use in optical noninvasive measurement of blood parameters
|
EP1489089A4
(en)
|
2002-03-22 |
2009-10-28 |
Kissei Pharmaceutical |
Crystals of glucopyranosyloxybenzyl benzene derivative
|
US7202350B2
(en)
|
2003-03-14 |
2007-04-10 |
Astellas Pharma Inc. |
C-glycoside derivatives and salts thereof
|
US7439232B2
(en)
|
2003-04-01 |
2008-10-21 |
Taisho Pharmaceutical Co., Ltd. |
Heteroaryl 5-thio-β-D-glucopyranoside derivatives and therapeutic agents for diabetes containing the same
|
JP2004359630A
(en)
|
2003-06-06 |
2004-12-24 |
Yamanouchi Pharmaceut Co Ltd |
Difluorodiphenylmethane derivative and its salt
|
AR045173A1
(en)
|
2003-08-01 |
2005-10-19 |
Tanabe Seiyaku Co |
COMPOUNDS THAT HAVE INHIBITORY ACTIVITY AGAINST TRANSPORTER OF GLUCOSE DEPENDENT ON SODIUM
|
UA86042C2
(en)
|
2003-08-01 |
2009-03-25 |
Янссен Фармацевтика Н.В. |
Substituted indazole-o-glucosides
|
US7375090B2
(en)
|
2003-08-26 |
2008-05-20 |
Boehringer Ingelheim International Gmbh |
Glucopyranosyloxy-pyrazoles, pharmaceutical compositions containing these compounds, the use thereof and processed for the preparation thereof
|
EA011158B1
(en)
|
2004-03-16 |
2009-02-27 |
Бёрингер Ингельхайм Интернациональ Гмбх |
Glucopyranosyl-substituted benzol derivatives, drugs containing said compounds, the use thereof and method for the production thereof
|
US7393836B2
(en)
|
2004-07-06 |
2008-07-01 |
Boehringer Ingelheim International Gmbh |
D-xylopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture
|
DE102004034690A1
(en)
|
2004-07-17 |
2006-02-02 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Methylidene-D-xylopyranosyl and oxo-D-xylopyranosyl-substituted phenyls, medicaments containing these compounds, their use and processes for their preparation
|
TW200606129A
(en)
|
2004-07-26 |
2006-02-16 |
Chugai Pharmaceutical Co Ltd |
Novel cyclohexane derivative, its prodrug, its salt and diabetic therapeutic agent containing the same
|
WO2006010557A1
(en)
|
2004-07-27 |
2006-02-02 |
Boehringer Ingelheim International Gmbh |
D-glucopyranosyl phenyl-substituted cyclene, medicaments containing these compounds, their use, and method for the production thereof
|
WO2006018150A1
(en)
|
2004-08-11 |
2006-02-23 |
Boehringer Ingelheim International Gmbh |
D-xylopyranosyl-phenyl-substituited cyclene, medicaments containing said compounds, use thereof and method for the production thereof
|
AR051446A1
(en)
|
2004-09-23 |
2007-01-17 |
Bristol Myers Squibb Co |
C-ARYL GLUCOSIDS AS SELECTIVE INHIBITORS OF GLUCOSE CONVEYORS (SGLT2)
|
JP2006117651A
(en)
|
2004-09-27 |
2006-05-11 |
Taisho Pharmaceut Co Ltd |
Sglt2 activity inhibitor
|
MX2007003785A
(en)
|
2004-09-29 |
2007-07-12 |
Kissei Pharmaceutical |
1-( ??-d-glycopyranosyl)-3-substituted nitrogenous heterocyclic compound, medicinal composition containing the same, and medicinal use thereof.
|
DE102004048388A1
(en)
|
2004-10-01 |
2006-04-06 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
D-pyranosyl-substituted phenyls, pharmaceutical compositions containing them, their use and processes for their preparation
|
DE102004058449A1
(en)
|
2004-12-03 |
2006-06-14 |
Merck Patent Gmbh |
tetrahydropyran
|
TW200637869A
(en)
|
2005-01-28 |
2006-11-01 |
Chugai Pharmaceutical Co Ltd |
The spiroketal derivatives and the use as therapeutical agent for diabetes of the same
|
KR20080102395A
(en)
*
|
2006-02-15 |
2008-11-25 |
베링거 인겔하임 인터내셔날 게엠베하 |
Glycopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture
|
US7919598B2
(en)
|
2006-06-28 |
2011-04-05 |
Bristol-Myers Squibb Company |
Crystal structures of SGLT2 inhibitors and processes for preparing same
|
US7910747B2
(en)
|
2006-07-06 |
2011-03-22 |
Bristol-Myers Squibb Company |
Phosphonate and phosphinate pyrazolylamide glucokinase activators
|
US7569590B2
(en)
|
2006-09-19 |
2009-08-04 |
Bristol-Myers Squibb Company |
Use of thianecarboxamides as dgat inhibitors
|
AU2010212867B2
(en)
*
|
2009-02-13 |
2013-05-16 |
Boehringer Ingelheim International Gmbh |
Pharmaceutical composition comprising a SGLT2 inhibitor, a DPP-IV inhibitor and optionally a further antidiabetic agent and uses thereof
|
CA2812016A1
(en)
|
2013-04-05 |
2014-10-05 |
Boehringer Ingelheim International Gmbh |
Pharmaceutical composition, methods for treating and uses thereof
|
ES2950384T3
(en)
*
|
2014-02-28 |
2023-10-09 |
Boehringer Ingelheim Int |
Medical use of a DPP-4 inhibitor
|
RS58274B1
(en)
|
2014-06-30 |
2019-03-29 |
Astrazeneca Ab |
Benzoxazinone amides as mineralocorticoid receptor modulators
|
JP7161405B2
(en)
|
2016-03-16 |
2022-10-26 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Pharmaceutical composition containing empagliflozin and its use
|
WO2018043463A1
(en)
|
2016-08-30 |
2018-03-08 |
国立大学法人新潟大学 |
Drug for removing aged cells
|
WO2018142422A1
(en)
|
2017-02-02 |
2018-08-09 |
Indoco Remedies Limited |
Process for the preparation of dapagliflozin
|
KR101943382B1
(en)
|
2017-09-19 |
2019-01-29 |
오토텔릭바이오 주식회사 |
A pharmaceutical composition comprising SGLT-2 inhibitor and angiotensin receptor blocker
|
EA202190226A1
(en)
|
2018-07-19 |
2021-06-16 |
Астразенека Аб |
METHODS FOR TREATMENT OF HFpEF USING DAPAGLIFLOSIN AND COMPOSITIONS CONTAINING IT
|
US10973836B2
(en)
|
2019-08-30 |
2021-04-13 |
Astrazeneca Ab |
Methods of treating heart failure with reduced ejection fraction
|