AR105080A1 - Compuestos inhibidores de la señalización de la vía de notch - Google Patents
Compuestos inhibidores de la señalización de la vía de notchInfo
- Publication number
- AR105080A1 AR105080A1 ARP160101848A ARP160101848A AR105080A1 AR 105080 A1 AR105080 A1 AR 105080A1 AR P160101848 A ARP160101848 A AR P160101848A AR P160101848 A ARP160101848 A AR P160101848A AR 105080 A1 AR105080 A1 AR 105080A1
- Authority
- AR
- Argentina
- Prior art keywords
- pharmaceutically acceptable
- signaling
- loss
- inhibiting compounds
- hair cells
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente solicitud proporciona compuestos, o una sal farmacéuticamente aceptable de estos y una composición farmacéutica que contiene dichos compuestos o una sal farmacéuticamente aceptable de esta, útil como un inhibidor de la señalización de la vía Notch para el tratamiento de los cánceres nombrados, pérdida de audición neurosensorial causada por la pérdida de células ciliadas auditivas e inducción de la generación de células ciliadas auditivas. Reivindicación 1: Un compuesto de la estructura de fórmula (1), 4,4,4-trifluoro-N-((2S)-1-((9-metoxi-3,3dimetil-5-oxo-2,3,5,6-tetrahidro-1H-benzo[f]pirrolo[1,2-a]azepin-6-il)amino)-1-oxopropan-2-il)butanamida, uno de sus isómeros puro en forma sustancialmente diastereomérica o una sal farmacéuticamente aceptable de cualquiera de los anteriores.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562189393P | 2015-07-07 | 2015-07-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR105080A1 true AR105080A1 (es) | 2017-09-06 |
Family
ID=56507825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP160101848A AR105080A1 (es) | 2015-07-07 | 2016-06-21 | Compuestos inhibidores de la señalización de la vía de notch |
Country Status (42)
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI625332B (zh) | 2015-07-07 | 2018-06-01 | 美國禮來大藥廠 | 刻痕（ｎｏｔｃｈ）路徑傳訊抑制化合物 |
| JP7033789B2 (ja) | 2016-06-29 | 2022-03-11 | オトノミー，インク． | トリグリセリド耳用製剤とその使用 |
| US11253193B2 (en) * | 2016-11-08 | 2022-02-22 | Cochlear Limited | Utilization of vocal acoustic biomarkers for assistive listening device utilization |
| CA3047096A1 (en) | 2016-12-16 | 2018-06-21 | Pipeline Therapeutics, Inc. | Methods of treating cochlear synaptopathy |
| WO2018172997A1 (en) * | 2017-03-24 | 2018-09-27 | Novartis Ag | Isoxazole carboxamide compounds and uses thereof |
| CN113227128A (zh) * | 2018-07-20 | 2021-08-06 | 香港理工大学 | 针对抑制jag1-notch1信号通路的肽 |
| BR112021005263A2 (pt) * | 2018-09-21 | 2021-06-15 | Novartis Ag | compostos de isoxazol carboxamida e usos dos mesmos |
| CA3114113A1 (en) | 2018-10-02 | 2020-04-09 | Frequency Therapeutics, Inc. | Pharmaceutical compositions and methods related to otic therapeutic agents |
| WO2020112883A1 (en) * | 2018-11-30 | 2020-06-04 | Massachusetts Eye And Ear Infirmary | Inhibition of lysine demethylase 1 (lsd1) induces differentiation of hair cells |
| BR112021020141A2 (pt) | 2019-04-08 | 2021-12-21 | Frequency Therapeutics Inc | Combinação de chir99021 e ácido valpróico para tratamento de perda auditiva |
| WO2021150672A2 (en) * | 2020-01-22 | 2021-07-29 | Beth Israel Deaconess Medical Center, Inc. | Biomarkers for placenta accreta spectrum (pas) disorders |
| WO2023200017A1 (en) * | 2022-04-11 | 2023-10-19 | Prism BioLab Co., Ltd. | Novel seven-membered ring-fused compounds |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8673634B2 (en) | 2003-11-13 | 2014-03-18 | Massachusetts Eye & Ear Infirmary | Method for the treatment of hearing loss |
| CN101410378B (zh) | 2006-03-27 | 2012-12-05 | 霍夫曼-拉罗奇有限公司 | 作为γ分泌酶抑制剂的丙二酰胺衍生物 |
| WO2009100438A2 (en) | 2008-02-07 | 2009-08-13 | Massachusetts Eye & Ear Infirmary | Compounds that enhance atoh-1 expression |
| US8648119B2 (en) | 2008-05-23 | 2014-02-11 | Otonomy, Inc. | Controlled release immunomodulator compositions and methods for the treatment of otic disorders |
| JP5809061B2 (ja) | 2008-11-24 | 2015-11-10 | マサチューセッツ・アイ・アンド・イア・インファーマリー | 有毛細胞を産生するための経路 |
| WO2012047706A2 (en) | 2010-10-06 | 2012-04-12 | Massachusetts Eye & Ear Infirmary | Methods for promotiing reinnervation of auditory hair cells |
| AR087107A1 (es) * | 2011-07-27 | 2014-02-12 | Lilly Co Eli | Compuesto inhibidor de la señalizacion de la trayectoria notch |
| US8716229B2 (en) | 2011-11-09 | 2014-05-06 | Massachusetts Eye & Ear Infirmary | Osteoprotegerin in neuroprotection |
| EP3970725A1 (en) * | 2012-09-07 | 2022-03-23 | Massachusetts Eye & Ear Infirmary | A gamma secretase inhibitor for treating hearing loss |
| US20140134136A1 (en) | 2012-11-02 | 2014-05-15 | Massachusetts Eye And Ear Infirmary | Compositions and methods for auditory therapy |
| TWI625332B (zh) | 2015-07-07 | 2018-06-01 | 美國禮來大藥廠 | 刻痕（ｎｏｔｃｈ）路徑傳訊抑制化合物 |
| CA3047096A1 (en) * | 2016-12-16 | 2018-06-21 | Pipeline Therapeutics, Inc. | Methods of treating cochlear synaptopathy |
-
2016
- 2016-06-21 TW TW105119456A patent/TWI625332B/zh active
- 2016-06-21 AR ARP160101848A patent/AR105080A1/es active IP Right Grant
- 2016-06-21 JO JOP/2016/0125A patent/JO3491B1/ar active
- 2016-07-01 TN TNP/2017/000495A patent/TN2017000495A1/en unknown
- 2016-07-01 ES ES16741742T patent/ES2735139T3/es active Active
- 2016-07-01 PE PE2018000012A patent/PE20180412A1/es unknown
- 2016-07-01 MA MA42399A patent/MA42399B1/fr unknown
- 2016-07-01 CN CN201680039699.XA patent/CN107849054B/zh active Active
- 2016-07-01 ME MEP-2019-191A patent/ME03495B/me unknown
- 2016-07-01 PT PT16741742T patent/PT3319967T/pt unknown
- 2016-07-01 JP JP2017568395A patent/JP6571214B2/ja active Active
- 2016-07-01 NZ NZ737322A patent/NZ737322A/en unknown
- 2016-07-01 TR TR2019/08683T patent/TR201908683T4/tr unknown
- 2016-07-01 DK DK16741742.7T patent/DK3319967T3/da active
- 2016-07-01 CR CR20170598A patent/CR20170598A/es unknown
- 2016-07-01 CR CR20220368A patent/CR20220368A/es unknown
- 2016-07-01 SI SI201630270T patent/SI3319967T1/sl unknown
- 2016-07-01 US US15/736,345 patent/US10450317B2/en active Active
- 2016-07-01 EP EP16741742.7A patent/EP3319967B1/en active Active
- 2016-07-01 UA UAA201712094A patent/UA120539C2/uk unknown
- 2016-07-01 KR KR1020187000149A patent/KR102078946B1/ko active IP Right Grant
- 2016-07-01 AU AU2016289822A patent/AU2016289822B2/en active Active
- 2016-07-01 CA CA2987431A patent/CA2987431C/en active Active
- 2016-07-01 MD MDE20180506 patent/MD3319967T2/ro unknown
- 2016-07-01 PL PL16741742T patent/PL3319967T3/pl unknown
- 2016-07-01 EA EA201792478A patent/EA032634B1/ru not_active IP Right Cessation
- 2016-07-01 WO PCT/US2016/040612 patent/WO2017007702A1/en active Application Filing
- 2016-07-01 RS RS20190820A patent/RS59115B1/sr unknown
- 2016-07-01 HU HUE16741742 patent/HUE044666T2/hu unknown
- 2016-07-01 MX MX2017016555A patent/MX2017016555A/es active IP Right Grant
- 2016-07-01 MY MYPI2018700032A patent/MY197519A/en unknown
- 2016-07-01 LT LTEP16741742.7T patent/LT3319967T/lt unknown
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2017
- 2017-11-16 IL IL255726A patent/IL255726B/en active IP Right Grant
- 2017-11-20 ZA ZA2017/07858A patent/ZA201707858B/en unknown
- 2017-12-20 SV SV2017005597A patent/SV2017005597A/es unknown
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2018
- 2018-01-02 EC ECIEPI201842A patent/ECSP18000042A/es unknown
- 2018-01-02 CL CL2018000007A patent/CL2018000007A1/es unknown
- 2018-01-05 PH PH12018500047A patent/PH12018500047B1/en unknown
- 2018-01-05 DO DO2018000005A patent/DOP2018000005A/es unknown
- 2018-01-12 CO CONC2018/0000224A patent/CO2018000224A2/es unknown
- 2018-05-17 HK HK18106380.5A patent/HK1247187B/zh unknown
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2019
- 2019-06-28 HR HRP20191175TT patent/HRP20191175T1/hr unknown
- 2019-07-23 CY CY20191100776T patent/CY1122024T1/el unknown
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