ECSP10010303A - (dihidro)pirrolo[2,1-a]isoquinolinas - Google Patents

(dihidro)pirrolo[2,1-a]isoquinolinas

Info

Publication number
ECSP10010303A
ECSP10010303A EC2010010303A ECSP10010303A ECSP10010303A EC SP10010303 A ECSP10010303 A EC SP10010303A EC 2010010303 A EC2010010303 A EC 2010010303A EC SP10010303 A ECSP10010303 A EC SP10010303A EC SP10010303 A ECSP10010303 A EC SP10010303A
Authority
EC
Ecuador
Prior art keywords
isoquinolinas
pirrolo
dihidro
isoquinoline
dihydropyrrolo
Prior art date
Application number
EC2010010303A
Other languages
English (en)
Inventor
Cornelis Marius Timmers
Willem Frederik Johan Karstens
Hubert Jan Jozef Loozen
Der Veen Lars Anders Van
Rijn Rachel Deborah Van
Original Assignee
Organon Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Nv filed Critical Organon Nv
Publication of ECSP10010303A publication Critical patent/ECSP10010303A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Reproductive Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La invención se refiere a derivados de 5,6-dihidropirrolo[2,1-a]isoquinolina y pirrolo[2,1-a]isoquinolina de acuerdo con la Fórmula general I o una sal farmacéuticamente aceptable de los mismos. Los compuestos pueden usarse para el tratamiento de la infertilidad.
EC2010010303A 2008-02-08 2010-06-23 (dihidro)pirrolo[2,1-a]isoquinolinas ECSP10010303A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08151199 2008-02-08

Publications (1)

Publication Number Publication Date
ECSP10010303A true ECSP10010303A (es) 2010-07-30

Family

ID=39516937

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2010010303A ECSP10010303A (es) 2008-02-08 2010-06-23 (dihidro)pirrolo[2,1-a]isoquinolinas

Country Status (27)

Country Link
US (1) US8394789B2 (es)
EP (1) EP2252611B1 (es)
JP (1) JP5620823B2 (es)
KR (1) KR101586870B1 (es)
CN (1) CN102216297B (es)
AR (1) AR070345A1 (es)
AT (1) ATE527260T1 (es)
AU (1) AU2009211296B2 (es)
BR (1) BRPI0906937A2 (es)
CA (1) CA2713173C (es)
CL (1) CL2009000281A1 (es)
CO (1) CO6241120A2 (es)
DK (1) DK2252611T3 (es)
EC (1) ECSP10010303A (es)
ES (1) ES2373022T3 (es)
HK (1) HK1150597A1 (es)
HR (1) HRP20110942T1 (es)
IL (1) IL206378A0 (es)
MX (1) MX2010008717A (es)
NZ (1) NZ587164A (es)
PE (1) PE20091413A1 (es)
PL (1) PL2252611T3 (es)
PT (1) PT2252611E (es)
RU (1) RU2495037C2 (es)
SI (1) SI2252611T1 (es)
TW (1) TW200944523A (es)
WO (1) WO2009098283A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI461426B (zh) * 2009-05-27 2014-11-21 Merck Sharp & Dohme （二氫）咪唑並異〔５，１－ａ〕喹啉類
US8071587B2 (en) 2009-05-27 2011-12-06 N. V. Organon (Dihydro)imidazoiso[5,1-A]quinolines
WO2011061318A1 (en) 2009-11-23 2011-05-26 N.V. Organon Heterocylic compounds as antagonists of the orexin receptors
US20120174381A1 (en) 2011-01-10 2012-07-12 David Messick Apparatus and method for frame crimping
WO2012112956A2 (en) * 2011-02-19 2012-08-23 The Broad Institute, Inc Compounds and methods for targeting leukemic stem cells
JP5947898B2 (ja) * 2011-09-22 2016-07-06 メルク・シャープ・エンド・ドーム・ベー・フェー Ｆｓｈ受容体アンタゴニスト
PL2796460T3 (pl) * 2011-12-21 2018-12-31 Jiangsu Hengrui Medicine Co. Ltd. Sześcioczłonowa pirolowa heteroarylowa pochodna pierścieniowa, sposób jej otrzymywania i zastosowania medyczne
CN102718695B (zh) * 2012-06-25 2014-04-02 华东师范大学 一种氮杂双环[3.3.0]辛烷衍生物的合成方法
PT2925745T (pt) 2012-11-29 2018-08-08 Chemocentryx Inc Antagonistas de cxcr7
RU2550366C1 (ru) * 2014-05-22 2015-05-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Российский университет дружбы народов" (РУДН) СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ 5,6-ДИГИДРОПИРРОЛО[2,1-a]ИЗОХИНОЛИНОВ
BR112021011222A2 (pt) * 2018-12-12 2021-08-24 Chemocentryx, Inc. Inibidores de cxcr7 para o tratamento de câncer
CN110540519B (zh) * 2019-09-05 2022-12-02 宁波大学 一种1,6-烯炔类化合物与酮类化合物的自由基环化反应方法
CN113999103A (zh) * 2021-11-26 2022-02-01 八叶草健康产业研究院(厦门)有限公司 一种α-羟基-环丁烷甲酸的制备方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8718980D0 (en) * 1987-08-11 1987-09-16 May & Baker Ltd Compositions of matter
DE4343649A1 (de) * 1993-12-21 1995-06-22 Boehringer Ingelheim Kg Neue Pyridazino[4',5':3,4]pyrrolo-[2,1-a]isochinoline und deren Verwendung für die Herstellung von pharmazeutischen Zubereitungen
FR2761358B1 (fr) * 1997-03-27 1999-05-07 Adir Nouveaux composes de n-aryl piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
ATE329911T1 (de) * 1998-08-07 2006-07-15 Applied Research Systems Fsh mimetika zur behandlung von infertilität
WO2000048144A1 (fr) 1999-02-15 2000-08-17 Medailles Souvenirs Dispositif de personnalisation et de distribution de medailles
AU2001278006A1 (en) 2000-07-27 2002-02-13 Smithkline Beecham Corporation Agonists of follicle stimulating hormone activity
US6930114B2 (en) * 2000-12-13 2005-08-16 Bayer Pharmaceuticals Corporation Pyrrolo (2.1a)dihydroisoquinolines and their use as phosphodiesterase 10a inhibitors
US8058441B2 (en) 2001-07-02 2011-11-15 N.V. Organon Tetrahydroquinoline derivatives
US20030236276A1 (en) 2001-08-06 2003-12-25 Ulrich Niewohner Pyrrolo[2.1-a]isoquinoline derivatives
WO2003014115A1 (en) 2001-08-06 2003-02-20 Bayer Aktiengesellschaft 3-substituted pyrrolo (2.1-a) isoquinoline derivatives
AU2002366362A1 (en) * 2001-12-18 2003-06-30 Bayer Aktiengesellschaft 2-substituted pyrrolo(2.1-a)isoquinolines against cancer
EP1542993B1 (en) * 2002-09-20 2012-12-19 Merck Serono SA Piperazine derivatives and methods of use
CA2530114A1 (en) 2003-06-30 2005-01-13 Altana Pharma Ag Pyrrolo-dihydroisoquinoline derivatives as pde10 inhibitors
UA86591C2 (ru) * 2003-06-30 2009-05-12 Алтана Фарма Аг Пирролодигидроизохинолины как ингибиторы pde10, фармацевтическая композиция на их основе
US20080004263A1 (en) 2004-03-04 2008-01-03 Santora Vincent J Ligands of Follicle Stimulating Hormone Receptor and Methods of Use Thereof
JP2008526817A (ja) 2005-01-12 2008-07-24 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規のピロロジヒドロイソキノリン
EP1838707B1 (en) 2005-01-12 2009-04-29 Nycomed GmbH Novel pyrrolodihydroisoquinolines as pde10 inhibitors
UA92007C2 (ru) 2005-05-04 2010-09-27 Н.В. Органон Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодности
UA92008C2 (en) 2005-05-04 2010-09-27 Н.В. Органон 4-PHENYL-5-OXO-l,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY
CN101171234B (zh) 2005-05-04 2011-11-16 欧加农股份有限公司 二氢吡啶衍生物
UA92009C2 (ru) 2005-05-04 2010-09-27 Н.В. Органон Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодия

Also Published As

Publication number Publication date
HK1150597A1 (es) 2012-01-06
DK2252611T3 (da) 2012-01-30
IL206378A0 (en) 2010-12-30
CN102216297A (zh) 2011-10-12
PE20091413A1 (es) 2009-09-23
MX2010008717A (es) 2010-09-24
CL2009000281A1 (es) 2009-06-26
CA2713173A1 (en) 2009-08-13
RU2010136057A (ru) 2012-03-20
EP2252611A1 (en) 2010-11-24
CA2713173C (en) 2016-04-19
BRPI0906937A2 (pt) 2016-04-19
RU2495037C2 (ru) 2013-10-10
NZ587164A (en) 2011-06-30
KR101586870B1 (ko) 2016-01-19
SI2252611T1 (sl) 2012-02-29
JP5620823B2 (ja) 2014-11-05
JP2011511041A (ja) 2011-04-07
CO6241120A2 (es) 2011-01-20
AU2009211296B2 (en) 2014-01-30
KR20100124279A (ko) 2010-11-26
ATE527260T1 (de) 2011-10-15
CN102216297B (zh) 2014-06-25
AU2009211296A1 (en) 2009-08-13
AR070345A1 (es) 2010-03-31
PT2252611E (pt) 2011-12-20
PL2252611T3 (pl) 2012-03-30
WO2009098283A1 (en) 2009-08-13
HRP20110942T1 (hr) 2012-01-31
TW200944523A (en) 2009-11-01
US8394789B2 (en) 2013-03-12
US20110039832A1 (en) 2011-02-17
EP2252611B1 (en) 2011-10-05
ES2373022T3 (es) 2012-01-30

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