SI2252611T1 - (dihidro)pirolo(2,1-a)izokuinolini - Google Patents

(dihidro)pirolo(2,1-a)izokuinolini

Info

Publication number
SI2252611T1
SI2252611T1 SI200930133T SI200930133T SI2252611T1 SI 2252611 T1 SI2252611 T1 SI 2252611T1 SI 200930133 T SI200930133 T SI 200930133T SI 200930133 T SI200930133 T SI 200930133T SI 2252611 T1 SI2252611 T1 SI 2252611T1
Authority
SI
Slovenia
Prior art keywords
isoquinolines
pyrrolo
dihydro
Prior art date
Application number
SI200930133T
Other languages
English (en)
Inventor
Rijn Rachel Deborah Van
Hubert Jan Jozef Loozen
Cornelis Marius Timmers
Der Veen Lars Anders Van
Willem Frederik Johan Karstens
Original Assignee
Organon Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Nv filed Critical Organon Nv
Publication of SI2252611T1 publication Critical patent/SI2252611T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
SI200930133T 2008-02-08 2009-02-06 (dihidro)pirolo(2,1-a)izokuinolini SI2252611T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US2706208P 2008-02-08 2008-02-08
EP08151199 2008-02-08
PCT/EP2009/051366 WO2009098283A1 (en) 2008-02-08 2009-02-06 (dihydro)pyrrolo[2,1-a]isoquinolines
EP09708584A EP2252611B1 (en) 2008-02-08 2009-02-06 (dihydro)pyrrolo[2,1-a]isoquinolines

Publications (1)

Publication Number Publication Date
SI2252611T1 true SI2252611T1 (sl) 2012-02-29

Family

ID=39516937

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200930133T SI2252611T1 (sl) 2008-02-08 2009-02-06 (dihidro)pirolo(2,1-a)izokuinolini

Country Status (27)

Country Link
US (1) US8394789B2 (sl)
EP (1) EP2252611B1 (sl)
JP (1) JP5620823B2 (sl)
KR (1) KR101586870B1 (sl)
CN (1) CN102216297B (sl)
AR (1) AR070345A1 (sl)
AT (1) ATE527260T1 (sl)
AU (1) AU2009211296B2 (sl)
BR (1) BRPI0906937A2 (sl)
CA (1) CA2713173C (sl)
CL (1) CL2009000281A1 (sl)
CO (1) CO6241120A2 (sl)
DK (1) DK2252611T3 (sl)
EC (1) ECSP10010303A (sl)
ES (1) ES2373022T3 (sl)
HK (1) HK1150597A1 (sl)
HR (1) HRP20110942T1 (sl)
IL (1) IL206378A0 (sl)
MX (1) MX2010008717A (sl)
NZ (1) NZ587164A (sl)
PE (1) PE20091413A1 (sl)
PL (1) PL2252611T3 (sl)
PT (1) PT2252611E (sl)
RU (1) RU2495037C2 (sl)
SI (1) SI2252611T1 (sl)
TW (1) TW200944523A (sl)
WO (1) WO2009098283A1 (sl)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI461426B (zh) * 2009-05-27 2014-11-21 Merck Sharp & Dohme （二氫）咪唑並異〔５，１－ａ〕喹啉類
US8071587B2 (en) 2009-05-27 2011-12-06 N. V. Organon (Dihydro)imidazoiso[5,1-A]quinolines
EP2504316A1 (en) 2009-11-23 2012-10-03 MSD Oss B.V. Heterocylic compounds as antagonists of the orexin receptors
US20120174381A1 (en) 2011-01-10 2012-07-12 David Messick Apparatus and method for frame crimping
WO2012112956A2 (en) * 2011-02-19 2012-08-23 The Broad Institute, Inc Compounds and methods for targeting leukemic stem cells
US9127007B2 (en) 2011-09-22 2015-09-08 Merck Sharp & Dohme B.V. FSH receptor antagonists
AU2012357296B2 (en) * 2011-12-21 2017-04-13 Jiangsu Hengrui Medicine Co., Ltd. Pyrrole six-membered heteroaryl ring derivative, preparation method therefor, and medicinal uses thereof
CN102718695B (zh) * 2012-06-25 2014-04-02 华东师范大学 一种氮杂双环[3.3.0]辛烷衍生物的合成方法
WO2014085490A1 (en) 2012-11-29 2014-06-05 Chemocentryx, Inc. Cxcr7 antagonists
RU2550366C1 (ru) * 2014-05-22 2015-05-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Российский университет дружбы народов" (РУДН) СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ 5,6-ДИГИДРОПИРРОЛО[2,1-a]ИЗОХИНОЛИНОВ
CN113194956A (zh) 2018-12-12 2021-07-30 凯莫森特里克斯股份有限公司 用于癌症治疗的cxcr7抑制剂
CN110540519B (zh) * 2019-09-05 2022-12-02 宁波大学 一种1,6-烯炔类化合物与酮类化合物的自由基环化反应方法
CN113999103A (zh) * 2021-11-26 2022-02-01 八叶草健康产业研究院(厦门)有限公司 一种α-羟基-环丁烷甲酸的制备方法

Family Cites Families (21)

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GB8718980D0 (en) * 1987-08-11 1987-09-16 May & Baker Ltd Compositions of matter
DE4343649A1 (de) * 1993-12-21 1995-06-22 Boehringer Ingelheim Kg Neue Pyridazino[4',5':3,4]pyrrolo-[2,1-a]isochinoline und deren Verwendung für die Herstellung von pharmazeutischen Zubereitungen
FR2761358B1 (fr) * 1997-03-27 1999-05-07 Adir Nouveaux composes de n-aryl piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JP4511042B2 (ja) * 1998-08-07 2010-07-28 メルク セローノ ソシエテ アノニム 不妊症の治療のためのｆｓｈ模倣物
WO2000048144A1 (fr) 1999-02-15 2000-08-17 Medailles Souvenirs Dispositif de personnalisation et de distribution de medailles
JP2004505051A (ja) 2000-07-27 2004-02-19 スミスクライン　ビーチャム　コーポレーション 卵胞刺激ホルモン活性のアゴニスト
EP1347973A1 (en) * 2000-12-13 2003-10-01 Bayer Aktiengesellschaft Pyrrolo (2.1-a) dihydroisoquinolines and their use as phosphodiesterase 10a inhibitors
ES2260458T3 (es) 2001-07-02 2006-11-01 Akzo Nobel N.V. Derivados de tetrahidroquinolina.
WO2003014116A1 (en) 2001-08-06 2003-02-20 Bayer Corporation Pyrrolo[2.1-a]isoquinoline derivatives
WO2003014115A1 (en) 2001-08-06 2003-02-20 Bayer Aktiengesellschaft 3-substituted pyrrolo (2.1-a) isoquinoline derivatives
WO2003051877A1 (en) 2001-12-18 2003-06-26 Bayer Corporation 2-substituted pyrrolo[2.1-a]isoquinolines against cancer
ES2399047T3 (es) 2002-09-20 2013-03-25 Merck Serono Sa Derivados de piperazina y procedimiento de uso
EP1641794A1 (en) * 2003-06-30 2006-04-05 ALTANA Pharma AG Novel pyrrolodihydroisoquinolines useful in the treatment of cancer
WO2005002579A1 (en) 2003-06-30 2005-01-13 Altana Pharma Ag Pyrrolo-dihydroisoquinoline derivatives as pde10 inhibitors
WO2005087765A1 (en) 2004-03-04 2005-09-22 Arena Pharmaceuticals, Inc. Ligands of follicle stimulating hormone receptor and methods of use thereof
WO2006075012A2 (en) 2005-01-12 2006-07-20 Nycomed Gmbh Pyrrolodihydroisoquinolines as antiproliferative agents
US20080161338A1 (en) 2005-01-12 2008-07-03 Altana Pharma Ag Novel Pyrrolodihydroisoquinolines as Pde 10 Inhibitors
UA92007C2 (ru) 2005-05-04 2010-09-27 Н.В. Органон Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодности
UA92009C2 (ru) 2005-05-04 2010-09-27 Н.В. Органон Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодия
DK1879866T3 (da) 2005-05-04 2011-06-06 Organon Nv Dihydropyridinderivater
UA92008C2 (en) 2005-05-04 2010-09-27 Н.В. Органон 4-PHENYL-5-OXO-l,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY

Also Published As

Publication number Publication date
RU2495037C2 (ru) 2013-10-10
KR101586870B1 (ko) 2016-01-19
PT2252611E (pt) 2011-12-20
BRPI0906937A2 (pt) 2016-04-19
PE20091413A1 (es) 2009-09-23
ECSP10010303A (es) 2010-07-30
IL206378A0 (en) 2010-12-30
HRP20110942T1 (hr) 2012-01-31
ES2373022T3 (es) 2012-01-30
NZ587164A (en) 2011-06-30
CA2713173C (en) 2016-04-19
ATE527260T1 (de) 2011-10-15
AU2009211296B2 (en) 2014-01-30
CN102216297A (zh) 2011-10-12
CL2009000281A1 (es) 2009-06-26
DK2252611T3 (da) 2012-01-30
CO6241120A2 (es) 2011-01-20
US8394789B2 (en) 2013-03-12
TW200944523A (en) 2009-11-01
JP2011511041A (ja) 2011-04-07
EP2252611B1 (en) 2011-10-05
WO2009098283A1 (en) 2009-08-13
US20110039832A1 (en) 2011-02-17
KR20100124279A (ko) 2010-11-26
HK1150597A1 (sl) 2012-01-06
CA2713173A1 (en) 2009-08-13
CN102216297B (zh) 2014-06-25
AR070345A1 (es) 2010-03-31
AU2009211296A1 (en) 2009-08-13
RU2010136057A (ru) 2012-03-20
JP5620823B2 (ja) 2014-11-05
PL2252611T3 (pl) 2012-03-30
MX2010008717A (es) 2010-09-24
EP2252611A1 (en) 2010-11-24

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