CY1122024T1 - Ενωσεις αναστολης σηματοδοτησης μονοπατιου notch - Google Patents

Ενωσεις αναστολης σηματοδοτησης μονοπατιου notch

Info

Publication number
CY1122024T1
CY1122024T1 CY20191100776T CY191100776T CY1122024T1 CY 1122024 T1 CY1122024 T1 CY 1122024T1 CY 20191100776 T CY20191100776 T CY 20191100776T CY 191100776 T CY191100776 T CY 191100776T CY 1122024 T1 CY1122024 T1 CY 1122024T1
Authority
CY
Cyprus
Prior art keywords
notch pathway
pathway signaling
inhibiting compounds
hair cells
signaling inhibiting
Prior art date
Application number
CY20191100776T
Other languages
English (en)
Inventor
Julia Marie Clay
Albert Edge
Philip Arthur Hipskind
John C. GILL
Bharvin Kumar Patel
Helmuth Hendrikus Gerardus Van Es
Aaron D. WROBLESKI
Gaiying ZHAO
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of CY1122024T1 publication Critical patent/CY1122024T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Η παρούσα εφεύρεση παρέχει τις παρακάτω ενώσεις, ή φαρμακευτικώς αποδεκτά άλατα αυτών, και φαρμακευτικές συνθέσεις που περιέχουν τις εν λόγω ενώσεις χρήσιμες ως αναστολείς σηματοδότησης μονοπατιού Notch για τη θεραπεία κατονομαζόμενων καρκίνων, νευροαισθητικής απώλειας ακοής που προκαλείται από απώλεια ακουστικών τριχωτών κυττάρων, και την επαγωγή παραγωγής ακουστικών τριχωτών κυττάρων.
CY20191100776T 2015-07-07 2019-07-23 Ενωσεις αναστολης σηματοδοτησης μονοπατιου notch CY1122024T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562189393P 2015-07-07 2015-07-07
PCT/US2016/040612 WO2017007702A1 (en) 2015-07-07 2016-07-01 Notch pathway signaling inhibitor compounds

Publications (1)

Publication Number Publication Date
CY1122024T1 true CY1122024T1 (el) 2020-10-14

Family

ID=56507825

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20191100776T CY1122024T1 (el) 2015-07-07 2019-07-23 Ενωσεις αναστολης σηματοδοτησης μονοπατιου notch

Country Status (42)

Country Link
US (1) US10450317B2 (el)
EP (1) EP3319967B1 (el)
JP (1) JP6571214B2 (el)
KR (1) KR102078946B1 (el)
CN (1) CN107849054B (el)
AR (1) AR105080A1 (el)
AU (1) AU2016289822B2 (el)
CA (1) CA2987431C (el)
CL (1) CL2018000007A1 (el)
CO (1) CO2018000224A2 (el)
CR (2) CR20170598A (el)
CY (1) CY1122024T1 (el)
DK (1) DK3319967T3 (el)
DO (1) DOP2018000005A (el)
EA (1) EA032634B1 (el)
EC (1) ECSP18000042A (el)
ES (1) ES2735139T3 (el)
HK (1) HK1247187B (el)
HR (1) HRP20191175T1 (el)
HU (1) HUE044666T2 (el)
IL (1) IL255726B (el)
JO (1) JO3491B1 (el)
LT (1) LT3319967T (el)
MA (1) MA42399B1 (el)
MD (1) MD3319967T2 (el)
ME (1) ME03495B (el)
MX (1) MX2017016555A (el)
MY (1) MY197519A (el)
NZ (1) NZ737322A (el)
PE (1) PE20180412A1 (el)
PH (1) PH12018500047B1 (el)
PL (1) PL3319967T3 (el)
PT (1) PT3319967T (el)
RS (1) RS59115B1 (el)
SI (1) SI3319967T1 (el)
SV (1) SV2017005597A (el)
TN (1) TN2017000495A1 (el)
TR (1) TR201908683T4 (el)
TW (1) TWI625332B (el)
UA (1) UA120539C2 (el)
WO (1) WO2017007702A1 (el)
ZA (1) ZA201707858B (el)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3491B1 (ar) 2015-07-07 2020-07-05 Audion Therapeutics مركبات مثبطة لإشارات مسار notch
KR20190024983A (ko) 2016-06-29 2019-03-08 오토노미, 인코포레이티드 트리글리세라이드 귀 제제 및 이의 용도
US11253193B2 (en) * 2016-11-08 2022-02-22 Cochlear Limited Utilization of vocal acoustic biomarkers for assistive listening device utilization
JP6904612B2 (ja) 2016-12-16 2021-07-21 パイプライン セラピューティクス， インコーポレイテッド 蝸牛シナプス障害を処置する方法
AU2018237987B2 (en) * 2017-03-24 2021-01-21 Novartis Ag Isoxazole carboxamide compounds and uses thereof
US11117932B2 (en) * 2018-07-20 2021-09-14 The Hong Kong Polytechnic University Peptides for specific inhibition of Jag 1-Notch 1 pathway
MA53645A (fr) * 2018-09-21 2021-12-29 Novartis Ag Composés d'isoxazole carboxamide et leurs utilisations
CA3114113A1 (en) 2018-10-02 2020-04-09 Frequency Therapeutics, Inc. Pharmaceutical compositions and methods related to otic therapeutic agents
US20220008433A1 (en) * 2018-11-30 2022-01-13 Massachusetts Eye And Ear Infirmary Inhibition of Lysine Demethylase 1 (Lsd1) Induces Differentiation of Hair Cells
CN114340611A (zh) 2019-04-08 2022-04-12 频率医疗公司 用于治疗听力损失的chir99021和丙戊酸的组合
US20230118097A1 (en) * 2020-01-22 2023-04-20 Beth Israel Deaconess Medical Center, Inc. Biomarkers for placenta accreta spectrum (pas) disorders
WO2023200017A1 (en) * 2022-04-11 2023-10-19 Prism BioLab Co., Ltd. Novel seven-membered ring-fused compounds

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8673634B2 (en) 2003-11-13 2014-03-18 Massachusetts Eye & Ear Infirmary Method for the treatment of hearing loss
CN101410378B (zh) 2006-03-27 2012-12-05 霍夫曼-拉罗奇有限公司 作为γ分泌酶抑制剂的丙二酰胺衍生物
CA2714370C (en) 2008-02-07 2017-05-02 Massachusetts Eye & Ear Infirmary Compounds that enhance atoh-1 expression
US8648119B2 (en) 2008-05-23 2014-02-11 Otonomy, Inc. Controlled release immunomodulator compositions and methods for the treatment of otic disorders
CA2743436C (en) 2008-11-24 2017-10-31 Massachusetts Eye & Ear Infirmary Pathways to generate hair cells
US9125894B2 (en) 2010-10-06 2015-09-08 Massachusetts Eye & Ear Infirmary Methods for promoting reinnervation of auditory hair cells
JO3148B1 (ar) * 2011-07-27 2017-09-20 Lilly Co Eli مركب مثبط لإشارات مسار notch
US8716229B2 (en) 2011-11-09 2014-05-06 Massachusetts Eye & Ear Infirmary Osteoprotegerin in neuroprotection
WO2014039781A1 (en) * 2012-09-07 2014-03-13 Massachusetts Eye & Ear Infirmary Treating hearing loss
AU2013337422A1 (en) 2012-11-02 2015-05-07 Genesys Research Institute Compositions and methods for auditory therapy
JO3491B1 (ar) 2015-07-07 2020-07-05 Audion Therapeutics مركبات مثبطة لإشارات مسار notch
JP6904612B2 (ja) * 2016-12-16 2021-07-21 パイプライン セラピューティクス， インコーポレイテッド 蝸牛シナプス障害を処置する方法

Also Published As

Publication number Publication date
HK1247187B (zh) 2020-01-10
JO3491B1 (ar) 2020-07-05
LT3319967T (lt) 2019-08-12
UA120539C2 (uk) 2019-12-26
KR20180011314A (ko) 2018-01-31
ECSP18000042A (es) 2018-03-31
CL2018000007A1 (es) 2018-06-29
US20180148456A1 (en) 2018-05-31
MD3319967T2 (ro) 2019-11-30
PL3319967T3 (pl) 2019-10-31
CR20170598A (es) 2018-03-20
TW201712016A (zh) 2017-04-01
PT3319967T (pt) 2019-07-29
JP6571214B2 (ja) 2019-09-04
CN107849054B (zh) 2020-04-28
HRP20191175T1 (hr) 2019-10-04
CO2018000224A2 (es) 2018-04-10
CN107849054A (zh) 2018-03-27
ME03495B (me) 2020-01-20
ZA201707858B (en) 2020-01-29
CA2987431C (en) 2019-11-26
AU2016289822B2 (en) 2018-07-26
NZ737322A (en) 2019-05-31
US10450317B2 (en) 2019-10-22
SV2017005597A (es) 2019-04-04
MA42399A (fr) 2018-05-16
EA201792478A1 (ru) 2018-06-29
CR20220368A (es) 2022-08-23
MX2017016555A (es) 2018-11-09
JP2018520157A (ja) 2018-07-26
MY197519A (en) 2023-06-19
HUE044666T2 (hu) 2019-11-28
WO2017007702A1 (en) 2017-01-12
EP3319967B1 (en) 2019-05-22
IL255726A (en) 2018-01-31
IL255726B (en) 2020-10-29
TN2017000495A1 (en) 2019-04-12
SI3319967T1 (sl) 2019-08-30
DK3319967T3 (da) 2019-07-22
CA2987431A1 (en) 2017-01-12
AR105080A1 (es) 2017-09-06
ES2735139T3 (es) 2019-12-16
EA032634B1 (ru) 2019-06-28
TWI625332B (zh) 2018-06-01
PH12018500047A1 (en) 2018-07-09
AU2016289822A1 (en) 2017-11-30
TR201908683T4 (tr) 2019-07-22
KR102078946B1 (ko) 2020-02-19
EP3319967A1 (en) 2018-05-16
DOP2018000005A (es) 2018-10-31
PH12018500047B1 (en) 2018-07-09
RS59115B1 (sr) 2019-09-30
MA42399B1 (fr) 2019-08-30
PE20180412A1 (es) 2018-03-01

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