EA201891644A1 - Антибактериальные соединения и их применение - Google Patents

Антибактериальные соединения и их применение

Info

Publication number
EA201891644A1
EA201891644A1 EA201891644A EA201891644A EA201891644A1 EA 201891644 A1 EA201891644 A1 EA 201891644A1 EA 201891644 A EA201891644 A EA 201891644A EA 201891644 A EA201891644 A EA 201891644A EA 201891644 A1 EA201891644 A1 EA 201891644A1
Authority
EA
Eurasian Patent Office
Prior art keywords
antibacterial
connections
application
tuberculosis
compounds
Prior art date
Application number
EA201891644A
Other languages
English (en)
Inventor
Анна Мария Аптон
Кристофер Блэр Купер
Кунрад Йозел Лодевейк Марсел
Жером Эмиль Жорж Гиймон
Вальтер Марсель Матильда Ван Ден Брук
Брайан Десмонд Палмер
Чжэнькунь Ма
Original Assignee
Зе Глобал Эллайенс Фо Тб Драг Девелопмент, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Зе Глобал Эллайенс Фо Тб Драг Девелопмент, Инк. filed Critical Зе Глобал Эллайенс Фо Тб Драг Девелопмент, Инк.
Publication of EA201891644A1 publication Critical patent/EA201891644A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

Настоящее изобретение относится к соединениям формулы (I)включая любые его стереохимически изомерные формы, или его фармацевтически приемлемым солям для лечения туберкулеза.
EA201891644A 2016-03-07 2017-03-07 Антибактериальные соединения и их применение EA201891644A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662304661P 2016-03-07 2016-03-07
PCT/US2017/021031 WO2017155909A1 (en) 2016-03-07 2017-03-07 Antibacterial compounds and uses thereof

Publications (1)

Publication Number Publication Date
EA201891644A1 true EA201891644A1 (ru) 2019-04-30

Family

ID=59790723

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201891644A EA201891644A1 (ru) 2016-03-07 2017-03-07 Антибактериальные соединения и их применение

Country Status (12)

Country Link
US (2) US10508097B2 (ru)
EP (2) EP4148053A1 (ru)
JP (3) JP6997095B2 (ru)
KR (2) KR102480410B1 (ru)
CN (1) CN109069514B (ru)
AU (2) AU2017229128B2 (ru)
BR (2) BR122023025283A2 (ru)
CA (2) CA3226824A1 (ru)
EA (1) EA201891644A1 (ru)
ES (1) ES2934785T3 (ru)
WO (1) WO2017155909A1 (ru)
ZA (1) ZA201805523B (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109069514B (zh) * 2016-03-07 2023-12-29 结核病药物开发全球联盟公司 抗菌化合物及其用途
CN108929310A (zh) * 2018-06-29 2018-12-04 湖南华腾制药有限公司 一种二芳基喹啉衍生物的制备方法
CN108707138A (zh) * 2018-06-29 2018-10-26 湖南华腾制药有限公司 一种二芳基喹啉衍生物的制备方法
CN108689998A (zh) * 2018-06-29 2018-10-23 湖南华腾制药有限公司 一种二芳基喹啉衍生物的制备方法
CN108840857A (zh) * 2018-07-10 2018-11-20 湖南华腾制药有限公司 一种喹啉衍生物的制备方法
WO2020047596A1 (en) * 2018-09-04 2020-03-12 Monash University Antibacterial compounds and methods of use
CN109535068B (zh) * 2018-12-26 2022-07-29 中国药科大学 吡啶取代查尔酮类化合物或其可药用的盐及其制备方法和用途
WO2021057190A1 (zh) * 2019-09-29 2021-04-01 上海阳帆医药科技有限公司 喹啉类化合物、其制备方法和用途

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DK2301544T3 (da) * 2002-07-25 2013-01-02 Janssen Pharmaceutica Nv Quinolinderivater som mellemprodukter til mykobakterielle inhibitorer
MXPA06013888A (es) 2004-05-28 2007-01-26 Janssen Pharmaceutica Nv Uso de derivados de quinolina sustituidos para el tratamiento de enfermedades micobacterianas resistentes a los farmacos.
EE05394B1 (et) 2004-12-24 2011-04-15 Janssen Pharmaceutica N.V. Kinoliinihendid kasutamiseks latentse tuberkuloosi ravis
JP2006182755A (ja) 2004-12-24 2006-07-13 Janssen Pharmaceut Nv 潜伏性結核の処置
PT1888604E (pt) * 2005-05-25 2012-05-28 Janssen Pharmaceutica Nv Processo para preparar (alfa s, beta r)-6-bromo-alfa-[2- (dimetilamino)etil]-2-metoxi-alfa-1-naftalenil-beta-fenil- 3-quinolinoetanol
JP5349730B2 (ja) 2005-06-09 2013-11-20 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 抗バクテリア剤としてのキノリン誘導体
JO2837B1 (en) * 2005-08-03 2014-09-15 جانسن فارمسيتكا ان في Quinoline derivatives acting as antibacterial agents
JO2684B1 (en) 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان في Quinoline antibacterial derivatives
JO3271B1 (ar) * 2006-12-06 2018-09-16 Janssen Pharmaceutica Nv مشتقات الكوينولين المضادة للجراثيم
JO2970B1 (en) 2006-12-06 2016-03-15 جانسين فارماسوتيكا ان. في Quinoline antibacterial derivatives
SI2195311T1 (sl) 2007-08-17 2011-07-29 Actelion Pharmaceuticals Ltd Derivati piridina kot modulatorji receptorja s1p1/edg1
WO2009083553A1 (en) 2007-12-31 2009-07-09 Rheoscience A/S Azine compounds as glucokinase activators
CA2711912A1 (en) * 2008-01-14 2009-07-23 Jyoti Chattopadhyaya Quinoline, naphthalene and conformationally constrained quinoline or naphthalene derivates as anti-mycobacterial agents
UA103634C2 (en) 2008-09-26 2013-11-11 Берингер Ингельхайм Интернациональ Гмбх Azaindazole compounds as ccr1 receptor antagonists
EP2375899B1 (en) 2009-01-12 2015-02-25 Array Biopharma Inc. Piperidine-containing compounds and use thereof in the treatment of diabetes
WO2010100475A1 (en) 2009-03-02 2010-09-10 Astrazeneca Ab Hydroxamic acid derivatives as gram-negative antibacterial agents
ES2576491T3 (es) * 2012-04-27 2016-07-07 Janssen Pharmaceutica, N.V. Derivados de quinolina antibacterianos
US9572809B2 (en) * 2012-07-18 2017-02-21 Spero Trinem, Inc. Combination therapy to treat Mycobacterium diseases
BR112017000764B1 (pt) 2014-07-14 2022-07-12 Shanghai Jia Tan Pharmatech Co. Ltd. Composto, método para preparar o composto e uso do composto
CN109069514B (zh) * 2016-03-07 2023-12-29 结核病药物开发全球联盟公司 抗菌化合物及其用途

Also Published As

Publication number Publication date
KR102355154B1 (ko) 2022-01-26
BR122023025283A2 (pt) 2024-02-20
AU2017229128B2 (en) 2022-04-07
US10508097B2 (en) 2019-12-17
ZA201805523B (en) 2019-11-27
AU2022204071B2 (en) 2023-11-23
EP4148053A1 (en) 2023-03-15
US20200039955A1 (en) 2020-02-06
KR20180119663A (ko) 2018-11-02
CN109069514A (zh) 2018-12-21
KR102480410B1 (ko) 2022-12-22
BR112018067922B1 (pt) 2024-02-06
US10981891B2 (en) 2021-04-20
JP2021191769A (ja) 2021-12-16
AU2017229128A1 (en) 2018-09-06
EP3426255A4 (en) 2019-08-21
US20190071417A1 (en) 2019-03-07
EP3426255A1 (en) 2019-01-16
WO2017155909A1 (en) 2017-09-14
JP6997095B2 (ja) 2022-02-03
CA3226824A1 (en) 2017-09-14
CA3016068A1 (en) 2017-09-14
ES2934785T3 (es) 2023-02-27
EP3426255B1 (en) 2022-11-30
CA3016068C (en) 2024-02-27
KR20220016279A (ko) 2022-02-08
JP2019507769A (ja) 2019-03-22
CN109069514B (zh) 2023-12-29
JP2024028841A (ja) 2024-03-05
BR112018067922A2 (pt) 2019-01-15
JP7453946B2 (ja) 2024-03-21
AU2022204071A1 (en) 2022-06-30

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