EA201892822A1 - Новые антибактериальные соединения - Google Patents
Новые антибактериальные соединенияInfo
- Publication number
- EA201892822A1 EA201892822A1 EA201892822A EA201892822A EA201892822A1 EA 201892822 A1 EA201892822 A1 EA 201892822A1 EA 201892822 A EA201892822 A EA 201892822A EA 201892822 A EA201892822 A EA 201892822A EA 201892822 A1 EA201892822 A1 EA 201892822A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- connections
- new antibacterial
- new
- antibacterial
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Cephalosporin Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Настоящее изобретение относится к новым антибактериальным соединениям, содержащим их фармацевтическим композициям и их применению в качестве противомикробных средств.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16173550 | 2016-06-08 | ||
| PCT/EP2017/063600 WO2017211759A1 (en) | 2016-06-08 | 2017-06-05 | New antibacterial compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201892822A1 true EA201892822A1 (ru) | 2019-06-28 |
Family
ID=56116327
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201892822A EA201892822A1 (ru) | 2016-06-08 | 2017-06-05 | Новые антибактериальные соединения |
| EA201892815A EA201892815A1 (ru) | 2016-06-08 | 2017-06-05 | Новые антибактериальные соединения |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201892815A EA201892815A1 (ru) | 2016-06-08 | 2017-06-05 | Новые антибактериальные соединения |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US10640488B2 (ru) |
| EP (2) | EP3468970A1 (ru) |
| JP (2) | JP2019517545A (ru) |
| KR (2) | KR20190019084A (ru) |
| CN (2) | CN109415373A (ru) |
| AR (2) | AR108777A1 (ru) |
| AU (2) | AU2017276627A1 (ru) |
| BR (2) | BR112018075297A2 (ru) |
| CA (2) | CA3025624A1 (ru) |
| CY (1) | CY1123194T1 (ru) |
| DK (1) | DK3468975T3 (ru) |
| EA (2) | EA201892822A1 (ru) |
| ES (1) | ES2802233T3 (ru) |
| HR (1) | HRP20200894T1 (ru) |
| HU (1) | HUE049547T2 (ru) |
| IL (2) | IL263285A (ru) |
| LT (1) | LT3468975T (ru) |
| MA (1) | MA45221A (ru) |
| MD (1) | MD3468975T2 (ru) |
| ME (1) | ME03738B (ru) |
| MX (2) | MX2018015125A (ru) |
| PL (1) | PL3468975T3 (ru) |
| PT (1) | PT3468975T (ru) |
| RS (1) | RS60511B1 (ru) |
| SG (2) | SG11201810352XA (ru) |
| SI (1) | SI3468975T1 (ru) |
| WO (2) | WO2017211760A1 (ru) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201810352XA (en) * | 2016-06-08 | 2018-12-28 | Acraf | New antibacterial compounds |
| US11976084B2 (en) | 2020-11-23 | 2024-05-07 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| US11970502B2 (en) | 2021-05-04 | 2024-04-30 | Enanta Pharmaceuticals, Inc. | Macrocyclic antiviral agents |
| CN113698412A (zh) * | 2021-09-01 | 2021-11-26 | 临沂大学 | 一种香豆素并[4,3-b]吡咯类衍生物及其合成方法和应用 |
| US11919910B2 (en) | 2021-11-12 | 2024-03-05 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| WO2023086350A1 (en) | 2021-11-12 | 2023-05-19 | Enanta Pharmaceuticals, Inc. | Alkyne-containing antiviral agents |
| WO2023086352A1 (en) | 2021-11-12 | 2023-05-19 | Enanta Pharmaceuticals, Inc. | Novel spiropyrrolidine derived antiviral agents |
| US11993600B2 (en) | 2021-12-08 | 2024-05-28 | Enanta Pharmaceuticals, Inc. | Saturated spirocyclics as antiviral agents |
| US12006291B2 (en) | 2022-01-11 | 2024-06-11 | Enanta Pharmaceuticals, Inc. | Processes for the preparation of 4,6,7-trifluoro-1H-indole-2-carboxylic acid |
| CN115850672B (zh) * | 2022-11-25 | 2024-07-19 | 浙江甬仑聚嘉新材料有限公司 | 一种液晶聚合物及其制备方法和应用 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2886570B2 (ja) * | 1989-09-29 | 1999-04-26 | エーザイ株式会社 | 縮合ヘテロ環を有する化合物 |
| AU645681B2 (en) * | 1991-05-02 | 1994-01-20 | John Wyeth & Brother Limited | Piperazine derivatives |
| US5607936A (en) | 1994-09-30 | 1997-03-04 | Merck & Co., Inc. | Substituted aryl piperazines as neurokinin antagonists |
| FR2822154B1 (fr) | 2001-03-13 | 2005-10-21 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, leur preparation et les compositions qui les contiennent |
| CA2488635C (en) * | 2002-06-12 | 2012-10-23 | Abbott Laboratories | Antagonists of melanin concentrating hormone receptor |
| DE102004041163A1 (de) | 2004-08-25 | 2006-03-02 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Neue Verbindungen mit antibakterieller Aktivität |
| WO2006046552A1 (ja) * | 2004-10-27 | 2006-05-04 | Toyama Chemical Co., Ltd. | 新規な含窒素複素環化合物およびその塩 |
| MX2007012234A (es) | 2005-03-31 | 2008-03-18 | Johnson & Johnson | Compuestos de pirazol biciclico como agentes antibacterianos. |
| CN101258157A (zh) * | 2005-05-24 | 2008-09-03 | 阿斯利康(瑞典)有限公司 | 具有抗菌活性的氨基哌啶喹啉及其氮杂等构类似物 |
| MY150958A (en) * | 2005-06-16 | 2014-03-31 | Astrazeneca Ab | Compounds for the treatment of multi-drug resistant bacterial infections |
| JP5398984B2 (ja) * | 2005-06-24 | 2014-01-29 | 富山化学工業株式会社 | 新規な含窒素複素環化合物およびその塩 |
| CN101346379A (zh) * | 2005-10-21 | 2009-01-14 | 葛兰素集团有限公司 | 用作抗菌剂的周环并合的三环化合物 |
| KR20090130347A (ko) * | 2007-05-09 | 2009-12-22 | 화이자 인코포레이티드 | 치환된 헤테로사이클릭 유도체 및 조성물 및 항균제로서의 이의 약학적 용도 |
| JP5620636B2 (ja) * | 2007-11-26 | 2014-11-05 | 富山化学工業株式会社 | 新規な複素環化合物またはその塩を含有する抗菌剤 |
| US20110071155A1 (en) * | 2008-05-23 | 2011-03-24 | Carlos Alemparte-Gallardo | Tricyclic Nitrogen Containing Compounds And Their Use As Antibacterials |
| CA2725726A1 (en) | 2008-05-23 | 2009-11-26 | Glaxo Group Limited | Tricyclic nitrogen containing compounds and their use as antibacterials |
| TW201022279A (en) * | 2008-11-14 | 2010-06-16 | Astrazeneca Ab | Chemical compounds |
| JP5653935B2 (ja) * | 2009-01-15 | 2015-01-14 | グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ | 抗菌薬として有用なナフチリジン―２（１ｈ）−オン化合物 |
| CA2750047A1 (en) | 2009-01-21 | 2010-07-29 | Basilea Pharmaceutica Ag | Novel bicyclic antibiotics |
| US9156822B2 (en) | 2010-07-02 | 2015-10-13 | The University Of North Carolina At Chapel Hill | Functionally selective ligands of dopamine D2 receptors |
| WO2012117421A1 (en) * | 2011-03-02 | 2012-09-07 | Orchid Research Laboratories Ltd | Histone deacetylase inhibitors |
| AU2012275499A1 (en) * | 2011-06-27 | 2013-12-19 | Kyorin Pharmaceutical Co., Ltd. | Bridged bicyclic compounds for the treatment of bacterial infections |
| BR112014011064A8 (pt) | 2011-11-08 | 2017-12-26 | Actelion Pharmaceuticals Ltd | derivados de antibióticos 2-oxo-oxazolidin-3,5-diila |
| JP2014533747A (ja) | 2011-11-30 | 2014-12-15 | アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | ３，７−二置換オクタヒドロ−２Ｈ−ピリド［４，３−ｅ］［１，３］オキサジン−２−オン抗生物質 |
| CN105218501A (zh) * | 2014-07-03 | 2016-01-06 | 南京大学 | 含哌嗪环的香豆素类衍生物及其制备与在抗菌药物中的应用 |
| KR20170043603A (ko) | 2014-08-22 | 2017-04-21 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | 네이세리아 고노레아에 감염을 치료하기 위한 트리시클릭 질소 함유 화합물 |
| MA41168A (fr) * | 2014-12-17 | 2017-10-24 | Acraf | Nouveaux composés antibactériens |
| MA41169A (fr) * | 2014-12-17 | 2017-10-24 | Acraf | Composés antibactériens à large spectre d'activité |
| SG11201810352XA (en) * | 2016-06-08 | 2018-12-28 | Acraf | New antibacterial compounds |
-
2017
- 2017-06-05 SG SG11201810352XA patent/SG11201810352XA/en unknown
- 2017-06-05 CN CN201780039687.1A patent/CN109415373A/zh active Pending
- 2017-06-05 JP JP2018564236A patent/JP2019517545A/ja active Pending
- 2017-06-05 MX MX2018015125A patent/MX2018015125A/es unknown
- 2017-06-05 WO PCT/EP2017/063601 patent/WO2017211760A1/en unknown
- 2017-06-05 EP EP17727595.5A patent/EP3468970A1/en not_active Withdrawn
- 2017-06-05 RS RS20200735A patent/RS60511B1/sr unknown
- 2017-06-05 AU AU2017276627A patent/AU2017276627A1/en not_active Abandoned
- 2017-06-05 ES ES17732775T patent/ES2802233T3/es active Active
- 2017-06-05 CN CN201780042649.1A patent/CN109790157A/zh active Pending
- 2017-06-05 MD MDE20190471T patent/MD3468975T2/ro not_active IP Right Cessation
- 2017-06-05 SG SG11201810389XA patent/SG11201810389XA/en unknown
- 2017-06-05 JP JP2018564240A patent/JP2019517546A/ja active Pending
- 2017-06-05 BR BR112018075297-5A patent/BR112018075297A2/pt not_active IP Right Cessation
- 2017-06-05 KR KR1020187036946A patent/KR20190019084A/ko not_active Application Discontinuation
- 2017-06-05 EP EP17732775.6A patent/EP3468975B1/en active Active
- 2017-06-05 US US16/307,193 patent/US10640488B2/en not_active Expired - Fee Related
- 2017-06-05 MX MX2018015126A patent/MX2018015126A/es unknown
- 2017-06-05 LT LTEP17732775.6T patent/LT3468975T/lt unknown
- 2017-06-05 AU AU2017276626A patent/AU2017276626A1/en not_active Abandoned
- 2017-06-05 DK DK17732775.6T patent/DK3468975T3/da active
- 2017-06-05 CA CA3025624A patent/CA3025624A1/en not_active Abandoned
- 2017-06-05 SI SI201730306T patent/SI3468975T1/sl unknown
- 2017-06-05 HU HUE17732775A patent/HUE049547T2/hu unknown
- 2017-06-05 ME MEP-2020-112A patent/ME03738B/me unknown
- 2017-06-05 PL PL17732775T patent/PL3468975T3/pl unknown
- 2017-06-05 MA MA045221A patent/MA45221A/fr unknown
- 2017-06-05 EA EA201892822A patent/EA201892822A1/ru unknown
- 2017-06-05 US US16/307,410 patent/US10633366B2/en not_active Expired - Fee Related
- 2017-06-05 CA CA3025270A patent/CA3025270A1/en not_active Abandoned
- 2017-06-05 WO PCT/EP2017/063600 patent/WO2017211759A1/en unknown
- 2017-06-05 PT PT177327756T patent/PT3468975T/pt unknown
- 2017-06-05 BR BR112018075334-3A patent/BR112018075334A2/pt not_active IP Right Cessation
- 2017-06-05 KR KR1020187036945A patent/KR20190019083A/ko not_active Application Discontinuation
- 2017-06-05 EA EA201892815A patent/EA201892815A1/ru unknown
- 2017-06-07 AR ARP170101554A patent/AR108777A1/es unknown
- 2017-06-07 AR ARP170101555A patent/AR108778A1/es unknown
-
2018
- 2018-11-26 IL IL263285A patent/IL263285A/en unknown
- 2018-11-26 IL IL263283A patent/IL263283A/en unknown
-
2020
- 2020-06-04 HR HRP20200894TT patent/HRP20200894T1/hr unknown
- 2020-06-29 CY CY20201100597T patent/CY1123194T1/el unknown
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