MX2018015126A - Nuevos compuestos antibacterianos. - Google Patents
Nuevos compuestos antibacterianos.Info
- Publication number
- MX2018015126A MX2018015126A MX2018015126A MX2018015126A MX2018015126A MX 2018015126 A MX2018015126 A MX 2018015126A MX 2018015126 A MX2018015126 A MX 2018015126A MX 2018015126 A MX2018015126 A MX 2018015126A MX 2018015126 A MX2018015126 A MX 2018015126A
- Authority
- MX
- Mexico
- Prior art keywords
- antibacterial compounds
- new antibacterial
- cyclic group
- following formulae
- new
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
La presente invención se refiere a nuevos compuestos antibacterianos (I) como se definen a continuación, a composiciones farmacéuticas que los contienen, y a su uso como agentes antimicrobianos. Un compuesto de fórmula (I) A-L1-Y-L2-R-B, en donde A es un grupo cíclico que tiene una de las fórmulas siguientes (I), (II) y (III), en donde B es un grupo cíclico que tiene una de las siguientes fórmulas (IV) a (IX). (ver Fórmulas).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16173550 | 2016-06-08 | ||
| PCT/EP2017/063601 WO2017211760A1 (en) | 2016-06-08 | 2017-06-05 | New antibacterial compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2018015126A true MX2018015126A (es) | 2019-09-02 |
Family
ID=56116327
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018015126A MX2018015126A (es) | 2016-06-08 | 2017-06-05 | Nuevos compuestos antibacterianos. |
| MX2018015125A MX2018015125A (es) | 2016-06-08 | 2017-06-05 | Nuevos compuestos antibacterianos. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018015125A MX2018015125A (es) | 2016-06-08 | 2017-06-05 | Nuevos compuestos antibacterianos. |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US10640488B2 (es) |
| EP (2) | EP3468970A1 (es) |
| JP (2) | JP2019517546A (es) |
| KR (2) | KR20190019083A (es) |
| CN (2) | CN109790157A (es) |
| AR (2) | AR108778A1 (es) |
| AU (2) | AU2017276627A1 (es) |
| BR (2) | BR112018075297A2 (es) |
| CA (2) | CA3025624A1 (es) |
| CY (1) | CY1123194T1 (es) |
| DK (1) | DK3468975T3 (es) |
| EA (2) | EA201892822A1 (es) |
| ES (1) | ES2802233T3 (es) |
| HR (1) | HRP20200894T1 (es) |
| HU (1) | HUE049547T2 (es) |
| IL (2) | IL263283A (es) |
| LT (1) | LT3468975T (es) |
| MA (1) | MA45221A (es) |
| MD (1) | MD3468975T2 (es) |
| ME (1) | ME03738B (es) |
| MX (2) | MX2018015126A (es) |
| PL (1) | PL3468975T3 (es) |
| PT (1) | PT3468975T (es) |
| RS (1) | RS60511B1 (es) |
| SG (2) | SG11201810389XA (es) |
| SI (1) | SI3468975T1 (es) |
| WO (2) | WO2017211759A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112018075297A2 (pt) * | 2016-06-08 | 2019-03-19 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A | composto, composição farmacêutica, e, método para tratar uma infecção bacteriana |
| CA3202764A1 (en) | 2020-11-23 | 2022-05-27 | Enanta Pharmaceuticals, Inc. | Novel spiropyrrolidine derived antiviral agents |
| WO2022235605A1 (en) | 2021-05-04 | 2022-11-10 | Enanta Pharmaceuticals, Inc. | Novel macrocyclic antiviral agents |
| CN113698412A (zh) * | 2021-09-01 | 2021-11-26 | 临沂大学 | 一种香豆素并[4,3-b]吡咯类衍生物及其合成方法和应用 |
| US11858945B2 (en) | 2021-11-12 | 2024-01-02 | Enanta Pharmaceuticals, Inc. | Alkyne-containing antiviral agents |
| US11912714B2 (en) | 2021-11-12 | 2024-02-27 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| WO2023086400A1 (en) | 2021-11-12 | 2023-05-19 | Enanta Pharmaceuticals, Inc. | Novel spiropyrrolidine derived antiviral agents |
| WO2023107419A1 (en) | 2021-12-08 | 2023-06-15 | Enanta Pharmaceuticals, Inc. | Saturated spirocyclics as antiviral agents |
| WO2023137007A1 (en) * | 2022-01-11 | 2023-07-20 | Enanta Pharmaceuticals, Inc. | Processes for the preparation of 4,6,7-trifluoro-1h-indole-2-carboxylic acid |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2886570B2 (ja) | 1989-09-29 | 1999-04-26 | エーザイ株式会社 | 縮合ヘテロ環を有する化合物 |
| IL101722A (en) * | 1991-05-02 | 1996-05-14 | Wyeth John & Brother Ltd | History of piperazine, their preparation and pharmaceutical preparations containing them |
| US5607936A (en) | 1994-09-30 | 1997-03-04 | Merck & Co., Inc. | Substituted aryl piperazines as neurokinin antagonists |
| FR2822154B1 (fr) | 2001-03-13 | 2005-10-21 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, leur preparation et les compositions qui les contiennent |
| WO2003106452A2 (en) * | 2002-06-12 | 2003-12-24 | Millennium Pharmaceuticals, Inc. | Antagonists of melanin concentrating hormone receptor |
| DE102004041163A1 (de) | 2004-08-25 | 2006-03-02 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Neue Verbindungen mit antibakterieller Aktivität |
| WO2006046552A1 (ja) * | 2004-10-27 | 2006-05-04 | Toyama Chemical Co., Ltd. | 新規な含窒素複素環化合物およびその塩 |
| JP5023054B2 (ja) | 2005-03-31 | 2012-09-12 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 抗バクテリア剤としての二環式ピラゾール化合物 |
| CA2608072A1 (en) * | 2005-05-24 | 2006-11-30 | Astrazeneca Ab | Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity |
| MY150958A (en) * | 2005-06-16 | 2014-03-31 | Astrazeneca Ab | Compounds for the treatment of multi-drug resistant bacterial infections |
| US8329694B2 (en) * | 2005-06-24 | 2012-12-11 | Toyama Chemical Co., Ltd. | Quinoxalinones as antibacterial composition |
| CN101346379A (zh) * | 2005-10-21 | 2009-01-14 | 葛兰素集团有限公司 | 用作抗菌剂的周环并合的三环化合物 |
| JP2010526130A (ja) | 2007-05-09 | 2010-07-29 | ファイザー・インク | 置換ヘテロ環式誘導体ならびにそれらの医薬使用および組成物 |
| JP5620636B2 (ja) * | 2007-11-26 | 2014-11-05 | 富山化学工業株式会社 | 新規な複素環化合物またはその塩を含有する抗菌剤 |
| MX2010012732A (es) | 2008-05-23 | 2010-12-07 | Glaxo Group Ltd | Compuestos que contienen nitrogeno triciclico y su uso como antibacterianos. |
| JP2011520944A (ja) * | 2008-05-23 | 2011-07-21 | グラクソ グループ リミテッド | 窒素含有三環式化合物および抗菌剤としてのその使用 |
| TW201022279A (en) * | 2008-11-14 | 2010-06-16 | Astrazeneca Ab | Chemical compounds |
| US8318940B2 (en) | 2009-01-15 | 2012-11-27 | Glaxo Group Limited | Naphthyridin-2 (1 H)-one compounds useful as antibacterials |
| WO2010084152A1 (en) | 2009-01-21 | 2010-07-29 | Basilea Pharmaceutica Ag | Novel bicyclic antibiotics |
| US9156822B2 (en) | 2010-07-02 | 2015-10-13 | The University Of North Carolina At Chapel Hill | Functionally selective ligands of dopamine D2 receptors |
| WO2012117421A1 (en) * | 2011-03-02 | 2012-09-07 | Orchid Research Laboratories Ltd | Histone deacetylase inhibitors |
| AU2012275499A1 (en) * | 2011-06-27 | 2013-12-19 | Kyorin Pharmaceutical Co., Ltd. | Bridged bicyclic compounds for the treatment of bacterial infections |
| IN2014CN04126A (es) | 2011-11-08 | 2015-07-10 | Actelion Pharmaceuticals Ltd | |
| CA2854266A1 (en) | 2011-11-30 | 2013-06-06 | Actelion Pharmaceuticals Ltd | 3,7-disubstituted octahydro-2h-pyrido[4,3-e][1,3]oxazin-2-one antibiotics |
| CN105218501A (zh) * | 2014-07-03 | 2016-01-06 | 南京大学 | 含哌嗪环的香豆素类衍生物及其制备与在抗菌药物中的应用 |
| KR20170043603A (ko) | 2014-08-22 | 2017-04-21 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | 네이세리아 고노레아에 감염을 치료하기 위한 트리시클릭 질소 함유 화합물 |
| MA41168A (fr) | 2014-12-17 | 2017-10-24 | Acraf | Nouveaux composés antibactériens |
| MA41169A (fr) * | 2014-12-17 | 2017-10-24 | Acraf | Composés antibactériens à large spectre d'activité |
| BR112018075297A2 (pt) * | 2016-06-08 | 2019-03-19 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A | composto, composição farmacêutica, e, método para tratar uma infecção bacteriana |
-
2017
- 2017-06-05 BR BR112018075297-5A patent/BR112018075297A2/pt not_active IP Right Cessation
- 2017-06-05 EP EP17727595.5A patent/EP3468970A1/en not_active Withdrawn
- 2017-06-05 CN CN201780042649.1A patent/CN109790157A/zh active Pending
- 2017-06-05 SG SG11201810389XA patent/SG11201810389XA/en unknown
- 2017-06-05 AU AU2017276627A patent/AU2017276627A1/en not_active Abandoned
- 2017-06-05 WO PCT/EP2017/063600 patent/WO2017211759A1/en unknown
- 2017-06-05 MD MDE20190471T patent/MD3468975T2/ro not_active IP Right Cessation
- 2017-06-05 AU AU2017276626A patent/AU2017276626A1/en not_active Abandoned
- 2017-06-05 MX MX2018015126A patent/MX2018015126A/es unknown
- 2017-06-05 JP JP2018564240A patent/JP2019517546A/ja active Pending
- 2017-06-05 US US16/307,193 patent/US10640488B2/en active Active
- 2017-06-05 PL PL17732775T patent/PL3468975T3/pl unknown
- 2017-06-05 SI SI201730306T patent/SI3468975T1/sl unknown
- 2017-06-05 WO PCT/EP2017/063601 patent/WO2017211760A1/en unknown
- 2017-06-05 HU HUE17732775A patent/HUE049547T2/hu unknown
- 2017-06-05 MA MA045221A patent/MA45221A/fr unknown
- 2017-06-05 SG SG11201810352XA patent/SG11201810352XA/en unknown
- 2017-06-05 KR KR1020187036945A patent/KR20190019083A/ko not_active Application Discontinuation
- 2017-06-05 CN CN201780039687.1A patent/CN109415373A/zh active Pending
- 2017-06-05 KR KR1020187036946A patent/KR20190019084A/ko not_active Application Discontinuation
- 2017-06-05 EP EP17732775.6A patent/EP3468975B1/en active Active
- 2017-06-05 RS RS20200735A patent/RS60511B1/sr unknown
- 2017-06-05 JP JP2018564236A patent/JP2019517545A/ja active Pending
- 2017-06-05 PT PT177327756T patent/PT3468975T/pt unknown
- 2017-06-05 EA EA201892822A patent/EA201892822A1/ru unknown
- 2017-06-05 ME MEP-2020-112A patent/ME03738B/me unknown
- 2017-06-05 CA CA3025624A patent/CA3025624A1/en not_active Abandoned
- 2017-06-05 LT LTEP17732775.6T patent/LT3468975T/lt unknown
- 2017-06-05 EA EA201892815A patent/EA201892815A1/ru unknown
- 2017-06-05 ES ES17732775T patent/ES2802233T3/es active Active
- 2017-06-05 US US16/307,410 patent/US10633366B2/en not_active Expired - Fee Related
- 2017-06-05 MX MX2018015125A patent/MX2018015125A/es unknown
- 2017-06-05 DK DK17732775.6T patent/DK3468975T3/da active
- 2017-06-05 CA CA3025270A patent/CA3025270A1/en not_active Abandoned
- 2017-06-05 BR BR112018075334-3A patent/BR112018075334A2/pt not_active IP Right Cessation
- 2017-06-07 AR ARP170101555A patent/AR108778A1/es unknown
- 2017-06-07 AR ARP170101554A patent/AR108777A1/es unknown
-
2018
- 2018-11-26 IL IL263283A patent/IL263283A/en unknown
- 2018-11-26 IL IL263285A patent/IL263285A/en unknown
-
2020
- 2020-06-04 HR HRP20200894TT patent/HRP20200894T1/hr unknown
- 2020-06-29 CY CY20201100597T patent/CY1123194T1/el unknown
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