HUP0102506A2 - Benzotiofénszármazékok alkalmazása az acetil-kolin szint növelésére - Google Patents
Benzotiofénszármazékok alkalmazása az acetil-kolin szint növeléséreInfo
- Publication number
- HUP0102506A2 HUP0102506A2 HU0102506A HUP0102506A HUP0102506A2 HU P0102506 A2 HUP0102506 A2 HU P0102506A2 HU 0102506 A HU0102506 A HU 0102506A HU P0102506 A HUP0102506 A HU P0102506A HU P0102506 A2 HUP0102506 A2 HU P0102506A2
- Authority
- HU
- Hungary
- Prior art keywords
- acetylcholine
- increasing
- level
- benzothiophene derivatives
- optionally
- Prior art date
Links
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 title abstract 2
- 229960004373 acetylcholine Drugs 0.000 title abstract 2
- FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical class C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 title 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 2
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 229940124596 AChE inhibitor Drugs 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/618—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate
- A61K31/621—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate having the hydroxy group in position 2 esterified, e.g. benorylate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Abstract
A jelen találmány tárgyát az acetil-kolin-szint növelésére szolgálóalkalmazás eljárás képezi, melynek során az arra rászoruló emlősbe az(I) általános képletű vegyületet és opcionálisan egy AChE-inhibitorhatékony mennyiségét adják be. Az (I) általános képletben az R1 és azR3 jelentése egymástól függetlenül hidrogénatom, metil-, benzoil-,szubsztituált benzoil- vagy C(O)-(1-6 szénatomos alkil)-csoport; az R2jelentése pedig pirrolidin-1-il-, piperidin-1-il- vagy hexametilén-imin-1-il-csoport, és az R2-csoport opcionálisan az N-oxid. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8948998P | 1998-06-16 | 1998-06-16 | |
PCT/US1999/012525 WO1999065489A1 (en) | 1998-06-16 | 1999-06-04 | Methods for increasing levels of acetylcholine |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0102506A2 true HUP0102506A2 (hu) | 2002-01-28 |
HUP0102506A3 HUP0102506A3 (en) | 2003-01-28 |
Family
ID=22217929
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0102506A HUP0102506A3 (en) | 1998-06-16 | 1999-06-04 | The use of benzothiophene derivatives for increasing the level of acetylcholine |
Country Status (18)
Country | Link |
---|---|
US (1) | US6395719B1 (hu) |
EP (1) | EP0970695A1 (hu) |
JP (1) | JP2002518329A (hu) |
KR (1) | KR20010052891A (hu) |
CN (1) | CN1305377A (hu) |
AU (1) | AU751158B2 (hu) |
BR (1) | BR9911220A (hu) |
CA (1) | CA2335295A1 (hu) |
EA (1) | EA200100039A1 (hu) |
HR (1) | HRP20000862A2 (hu) |
HU (1) | HUP0102506A3 (hu) |
IL (1) | IL139015A0 (hu) |
NO (1) | NO20006087L (hu) |
PL (1) | PL344785A1 (hu) |
SK (1) | SK18792000A3 (hu) |
TR (1) | TR200003704T2 (hu) |
WO (1) | WO1999065489A1 (hu) |
ZA (1) | ZA200005887B (hu) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6288108B1 (en) | 1998-06-16 | 2001-09-11 | Eli Lilly And Company | Methods for increasing levels of acetylcholine |
CA2335295A1 (en) | 1998-06-16 | 1999-12-23 | Eli Lilly And Company | Methods for increasing levels of acetylcholine |
EP0976404A3 (en) * | 1998-07-30 | 2001-06-27 | Pfizer Products Inc. | A pharmaceutical composition for the prevention and treatment of diseases of cognitive dysfunction in a mammal |
WO2005065645A2 (en) * | 2003-12-31 | 2005-07-21 | Actavis Group Hf | Donepezil formulations |
GB0511003D0 (en) * | 2005-05-28 | 2005-07-06 | Univ Cardiff | Screening and treatment of alzheimer's disease |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0002097B1 (en) | 1977-08-22 | 1981-08-05 | Imperial Chemical Industries Plc | Triphenylalkene derivatives, process for their preparation and pharmaceutical compositions containing them |
TW366342B (en) | 1992-07-28 | 1999-08-11 | Lilly Co Eli | The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss |
US5554601A (en) | 1993-11-05 | 1996-09-10 | University Of Florida | Methods for neuroprotection |
US6489355B2 (en) | 1993-12-01 | 2002-12-03 | Eli Lilly And Company | Methods of inhibiting the effects of amyloidogenic proteins |
US5462950A (en) | 1993-12-21 | 1995-10-31 | Eli Lilly And Company | Methods of treating menstrual symptoms and compositions therefore |
US5389670A (en) | 1993-12-21 | 1995-02-14 | Eli Lilly Company | Methods of inhibiting the symptoms of premenstrual syndrome/late luteal phase dysphoric disorder |
US5552415A (en) | 1993-12-21 | 1996-09-03 | Eli Lilly And Company | Method of inhibiting Alzheimer's Disease |
US5441965A (en) | 1993-12-21 | 1995-08-15 | Eli Lilly And Company | Methods of inhibiting thrombin |
US5578613A (en) | 1993-12-21 | 1996-11-26 | Eli Lilly And Company | Methods for inhibiting weight gain or inducing weight loss |
EP0735821A4 (en) | 1993-12-21 | 1998-04-01 | Lilly Co Eli | METHODS FOR TREATING OR PREVENTING CONDITIONS ASSOCIATED WITH AMYLO DOGEN PEPTIDES |
US5534526A (en) | 1993-12-21 | 1996-07-09 | Eli Lilly And Company | Methods for inhibiting vasomotor symptoms and attending psychological disturbances surrounding post-menopausal syndrome |
US5604248A (en) | 1994-05-05 | 1997-02-18 | Eli Lilly And Company | Method for minimizing the uterotrophic effect of tamoxifen and tamoxifen analogs |
US5512296A (en) | 1994-08-22 | 1996-04-30 | Eli Lilly And Company | Methods for inhibiting neuronal damage |
US5510357A (en) | 1995-02-28 | 1996-04-23 | Eli Lilly And Company | Benzothiophene compounds as anti-estrogenic agents |
SG90193A1 (en) | 1995-02-28 | 2002-07-23 | Lilly Co Eli | Benzothiophene compounds, intermediates, compositions, and methods |
US5731342A (en) * | 1996-02-22 | 1998-03-24 | Eli Lilly And Company | Benzothiophenes, formulations containing same, and methods |
IL120269A0 (en) | 1996-02-28 | 1997-06-10 | Pfizer | 1,1,2-triphenylbut-1-ene derivatives for treating Alzheimer's disease |
SK285312B6 (sk) | 1996-06-07 | 2006-10-05 | Eisai Co., Ltd. | Polymorf (III) donepezil hydrochloridu, spôsob jeho výroby a terapeutický prostriedok s jeho obsahom |
ZA982877B (en) | 1997-04-09 | 1999-10-04 | Lilly Co Eli | Treatment of central nervous system disorders with selective estrogen receptor modulators. |
KR20010052892A (ko) | 1998-06-16 | 2001-06-25 | 피터 지. 스트링거 | 아세틸콜린 수치를 상승시키는 방법 |
CA2335295A1 (en) | 1998-06-16 | 1999-12-23 | Eli Lilly And Company | Methods for increasing levels of acetylcholine |
-
1999
- 1999-06-04 CA CA002335295A patent/CA2335295A1/en not_active Abandoned
- 1999-06-04 WO PCT/US1999/012525 patent/WO1999065489A1/en not_active Application Discontinuation
- 1999-06-04 IL IL13901599A patent/IL139015A0/xx unknown
- 1999-06-04 PL PL99344785A patent/PL344785A1/xx unknown
- 1999-06-04 TR TR2000/03704T patent/TR200003704T2/xx unknown
- 1999-06-04 HU HU0102506A patent/HUP0102506A3/hu unknown
- 1999-06-04 SK SK1879-2000A patent/SK18792000A3/sk unknown
- 1999-06-04 EA EA200100039A patent/EA200100039A1/ru unknown
- 1999-06-04 US US09/700,506 patent/US6395719B1/en not_active Expired - Fee Related
- 1999-06-04 CN CN99807285A patent/CN1305377A/zh active Pending
- 1999-06-04 KR KR1020007014236A patent/KR20010052891A/ko not_active Application Discontinuation
- 1999-06-04 AU AU43338/99A patent/AU751158B2/en not_active Ceased
- 1999-06-04 JP JP2000554369A patent/JP2002518329A/ja not_active Withdrawn
- 1999-06-04 BR BR9911220-5A patent/BR9911220A/pt not_active IP Right Cessation
- 1999-06-11 EP EP99304587A patent/EP0970695A1/en not_active Withdrawn
-
2000
- 2000-10-20 ZA ZA200005887A patent/ZA200005887B/en unknown
- 2000-11-30 NO NO20006087A patent/NO20006087L/no not_active Application Discontinuation
- 2000-12-14 HR HR20000862A patent/HRP20000862A2/hr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
HRP20000862A2 (en) | 2001-10-31 |
AU4333899A (en) | 2000-01-05 |
TR200003704T2 (tr) | 2001-06-21 |
AU751158B2 (en) | 2002-08-08 |
CA2335295A1 (en) | 1999-12-23 |
EP0970695A1 (en) | 2000-01-12 |
NO20006087D0 (no) | 2000-11-30 |
BR9911220A (pt) | 2001-03-06 |
CN1305377A (zh) | 2001-07-25 |
HUP0102506A3 (en) | 2003-01-28 |
ZA200005887B (en) | 2002-07-22 |
US6395719B1 (en) | 2002-05-28 |
PL344785A1 (en) | 2001-11-19 |
JP2002518329A (ja) | 2002-06-25 |
IL139015A0 (en) | 2001-11-25 |
SK18792000A3 (sk) | 2001-07-10 |
KR20010052891A (ko) | 2001-06-25 |
EA200100039A1 (ru) | 2001-06-25 |
NO20006087L (no) | 2000-11-30 |
WO1999065489A1 (en) | 1999-12-23 |
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