HUP0102383A2 - Benzotiofénszármazékok alkalmazása homocisztein és C-reaktív protein szint csökkentésére - Google Patents
Benzotiofénszármazékok alkalmazása homocisztein és C-reaktív protein szint csökkentéséreInfo
- Publication number
- HUP0102383A2 HUP0102383A2 HU0102383A HUP0102383A HUP0102383A2 HU P0102383 A2 HUP0102383 A2 HU P0102383A2 HU 0102383 A HU0102383 A HU 0102383A HU P0102383 A HUP0102383 A HU P0102383A HU P0102383 A2 HUP0102383 A2 HU P0102383A2
- Authority
- HU
- Hungary
- Prior art keywords
- reactive protein
- homocysteine
- reducing levels
- benzothiophene derivatives
- benzoyl
- Prior art date
Links
- 108010074051 C-Reactive Protein Proteins 0.000 title abstract 2
- 102100032752 C-reactive protein Human genes 0.000 title abstract 2
- FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical compound OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 title abstract 2
- FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical class C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 title 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Abstract
Jelen találmány a homocisztein és/vagy C-reaktív protein szintcsökkentést foganatosító alkalmazásra vonatkozik humán alanyokban, ésa magába foglalja egy hatékony mennyiség alkalmazását az (I) képletszerinti vegyületből vagy annak gyógyszerészetileg elfogadható sójábólvagy szolvátjából. Az (I) általános képletben R1 és R3 jelentéseegymástól függetlenül hidrogén, metil, benzoil, szubsztituált benzoilvagy C(O)-C1-C6 alkil) csoport, R2-t a pirrolidin-1-il, piperidin-1-ilés a hexametilénimin-1-il közül választják, ahol R2 jelentése kívántesetben N-oxid. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8960198P | 1998-06-17 | 1998-06-17 | |
| PCT/US1999/012604 WO1999065306A1 (en) | 1998-06-17 | 1999-06-04 | Methods for reducing levels of homocysteine and c-reactive protein |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0102383A2 true HUP0102383A2 (hu) | 2002-01-28 |
| HUP0102383A3 HUP0102383A3 (en) | 2003-01-28 |
Family
ID=22218549
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0102383A HUP0102383A3 (en) | 1998-06-17 | 1999-06-04 | The use of benzothiophene derivatives for reducing levels of homocysteine and c-reactive protein |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6353003B1 (hu) |
| EP (1) | EP0966965A1 (hu) |
| JP (1) | JP2002518296A (hu) |
| KR (1) | KR20010052947A (hu) |
| CN (1) | CN1305342A (hu) |
| AU (1) | AU753035B2 (hu) |
| BR (1) | BR9911224A (hu) |
| CA (1) | CA2333384A1 (hu) |
| EA (1) | EA200100049A1 (hu) |
| HR (1) | HRP20000860A2 (hu) |
| HU (1) | HUP0102383A3 (hu) |
| IL (1) | IL138915A0 (hu) |
| NO (1) | NO20006086L (hu) |
| PL (1) | PL344841A1 (hu) |
| SK (1) | SK18802000A3 (hu) |
| TR (1) | TR200003713T2 (hu) |
| WO (1) | WO1999065306A1 (hu) |
| ZA (1) | ZA200005884B (hu) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004204675A1 (en) * | 2003-01-06 | 2004-07-29 | Wyeth | The use of estrogen receptor alpha modulators for the treatment of multiphe sclerosis |
| US7517887B2 (en) * | 2003-04-09 | 2009-04-14 | General Atomics | Reversible inhibitors of S-adenosyl-L-homocysteine hydrolase and uses thereof |
| US7868011B2 (en) * | 2003-04-09 | 2011-01-11 | General Atomics | Use of reversible inhibitors of S-adenosyl-L-homocysteine hydrolase for treating lupus |
| US7196093B2 (en) * | 2003-04-09 | 2007-03-27 | General Atomics | Reversible inhibitors of SAH hydrolase and uses thereof |
| WO2004093882A1 (ja) * | 2003-04-18 | 2004-11-04 | Advanced Medicine Research Institute | 眼に適用する疾患治療剤 |
| US20070003600A1 (en) * | 2003-06-11 | 2007-01-04 | Carolyn Moore | Methods for reducing c-reactive protein |
| TWI386204B (zh) * | 2008-04-10 | 2013-02-21 | Mitsubishi Tanabe Pharma Corp | 高半胱胺酸合成酶抑制劑 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4133814A (en) | 1975-10-28 | 1979-01-09 | Eli Lilly And Company | 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents |
| US4380635A (en) | 1981-04-03 | 1983-04-19 | Eli Lilly And Company | Synthesis of acylated benzothiophenes |
| US4418068A (en) | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
| US5075321A (en) | 1987-03-24 | 1991-12-24 | University Of Pennsylvania | Methods of treating diseases characterized by interactions of IgG-containing immune complexes with macrophage Fc receptors using antiestrogenic benzothiophenes |
| US5395842A (en) | 1988-10-31 | 1995-03-07 | Endorecherche Inc. | Anti-estrogenic compounds and compositions |
| TW366342B (en) * | 1992-07-28 | 1999-08-11 | Lilly Co Eli | The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss |
| TW383306B (en) | 1992-12-22 | 2000-03-01 | Lilly Co Eli | New use of 2-phenyl-3-aroylbenzothiophenes in lowering serum cholesterol |
| US5482949A (en) | 1993-03-19 | 1996-01-09 | Eli Lilly And Company | Sulfonate derivatives of 3-aroylbenzo[b]thiophenes |
| US5445941A (en) | 1993-06-21 | 1995-08-29 | Eli Lilly And Company | Method for screening anti-osteoporosis agents |
| US5441947A (en) | 1993-08-25 | 1995-08-15 | Eli Lilly And Company | Methods of inhibiting vascular restenosis |
| US5476862A (en) | 1993-12-21 | 1995-12-19 | Eli Lilly And Company | Methods of increasing thrombomodulin expression |
| EP0664121B1 (en) | 1993-12-21 | 2001-10-31 | Eli Lilly And Company | Use of raloxifene and its analogs for the manufacture of a medicament for the treatment of atherosclerose and ischaemic heart disease |
| US5441965A (en) | 1993-12-21 | 1995-08-15 | Eli Lilly And Company | Methods of inhibiting thrombin |
| US5510357A (en) | 1995-02-28 | 1996-04-23 | Eli Lilly And Company | Benzothiophene compounds as anti-estrogenic agents |
| JP4111352B2 (ja) | 1996-05-21 | 2008-07-02 | 新日鐵住金ステンレス株式会社 | ステンレス鋼の高清浄化精錬法 |
| US6069175A (en) | 1996-11-15 | 2000-05-30 | Pfizer Inc. | Estrogen agonist/antagonists treatment of atherosclerosis |
| US6025373A (en) | 1997-04-22 | 2000-02-15 | Eli Lilly And Company | Methods for reducing fibrinogen |
| US6103740A (en) | 1997-08-21 | 2000-08-15 | Eli Lilly And Company | Methods for lowering platelet counts |
-
1999
- 1999-05-03 US US09/303,618 patent/US6353003B1/en not_active Expired - Fee Related
- 1999-06-04 EA EA200100049A patent/EA200100049A1/ru unknown
- 1999-06-04 BR BR9911224-8A patent/BR9911224A/pt not_active IP Right Cessation
- 1999-06-04 CN CN99807136A patent/CN1305342A/zh active Pending
- 1999-06-04 IL IL13891599A patent/IL138915A0/xx unknown
- 1999-06-04 AU AU48192/99A patent/AU753035B2/en not_active Ceased
- 1999-06-04 CA CA002333384A patent/CA2333384A1/en not_active Abandoned
- 1999-06-04 PL PL99344841A patent/PL344841A1/xx not_active Application Discontinuation
- 1999-06-04 EP EP99304364A patent/EP0966965A1/en not_active Withdrawn
- 1999-06-04 TR TR2000/03713T patent/TR200003713T2/xx unknown
- 1999-06-04 JP JP2000554197A patent/JP2002518296A/ja not_active Withdrawn
- 1999-06-04 KR KR1020007014326A patent/KR20010052947A/ko not_active Application Discontinuation
- 1999-06-04 HU HU0102383A patent/HUP0102383A3/hu unknown
- 1999-06-04 WO PCT/US1999/012604 patent/WO1999065306A1/en not_active Application Discontinuation
- 1999-06-04 SK SK1880-2000A patent/SK18802000A3/sk unknown
-
2000
- 2000-10-20 ZA ZA200005884A patent/ZA200005884B/en unknown
- 2000-11-30 NO NO20006086A patent/NO20006086L/no not_active Application Discontinuation
- 2000-12-14 HR HR20000860A patent/HRP20000860A2/hr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU753035B2 (en) | 2002-10-03 |
| CN1305342A (zh) | 2001-07-25 |
| CA2333384A1 (en) | 1999-12-23 |
| KR20010052947A (ko) | 2001-06-25 |
| NO20006086D0 (no) | 2000-11-30 |
| US6353003B1 (en) | 2002-03-05 |
| EP0966965A1 (en) | 1999-12-29 |
| EA200100049A1 (ru) | 2001-06-25 |
| NO20006086L (no) | 2000-11-30 |
| ZA200005884B (en) | 2001-10-22 |
| AU4819299A (en) | 2000-01-05 |
| TR200003713T2 (tr) | 2001-04-20 |
| HRP20000860A2 (en) | 2001-10-31 |
| WO1999065306A1 (en) | 1999-12-23 |
| BR9911224A (pt) | 2001-02-20 |
| PL344841A1 (en) | 2001-11-19 |
| HUP0102383A3 (en) | 2003-01-28 |
| JP2002518296A (ja) | 2002-06-25 |
| IL138915A0 (en) | 2001-11-25 |
| SK18802000A3 (sk) | 2001-09-11 |
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