BR0015821A - Derivados de pirimidina - Google Patents
Derivados de pirimidinaInfo
- Publication number
- BR0015821A BR0015821A BR0015821-6A BR0015821A BR0015821A BR 0015821 A BR0015821 A BR 0015821A BR 0015821 A BR0015821 A BR 0015821A BR 0015821 A BR0015821 A BR 0015821A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- pyrimidine derivatives
- cyclo
- compounds
- formula
- Prior art date
Links
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title abstract 2
- 150000003230 pyrimidines Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 206010037660 Pyrexia Diseases 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 229940111134 coxibs Drugs 0.000 abstract 1
- 150000001924 cycloalkanes Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
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- A—HUMAN NECESSITIES
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- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Communicable Diseases (AREA)
- Reproductive Health (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Pregnancy & Childbirth (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
Abstract
"DERIVADOS DE PIRIMIDINA". A invenção fornece os compostos da fórmula (I) e seus derivados de uso farmacêutico, nos quais: R^ 1^ e R^ 2^ são independentemente selecionados entre H, alquila de C~ 1-6~, alquenila de C~ 2-6~, alquinila de C~ 3-6~, ciclo-alquil (C~ 3-10~) alquila(C~ 0-6~), ou ciclo-alcano com ponte de C~ 4-12~; e R^ 3^ é alquila de C~ 1-6~ ou NH~ 2~. Os compostos da fórmula (I) são inibidores potentes e seletivos de COX-2 e têm uso no tratamento de dor, febre, e inflamação de uma série de condições e doenças.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9927844.2A GB9927844D0 (en) | 1999-11-26 | 1999-11-26 | Chemical compounds |
PCT/EP2000/011673 WO2001038311A2 (en) | 1999-11-26 | 2000-11-23 | Pyrimidine derivatives as selective inhibitors of cox-2 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0015821A true BR0015821A (pt) | 2002-07-30 |
Family
ID=10865107
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0015821-6A BR0015821A (pt) | 1999-11-26 | 2000-11-23 | Derivados de pirimidina |
Country Status (21)
Country | Link |
---|---|
US (1) | US6780869B1 (pt) |
EP (1) | EP1235812B1 (pt) |
JP (1) | JP2003514898A (pt) |
KR (1) | KR20020063899A (pt) |
CN (1) | CN1399633A (pt) |
AT (1) | ATE316962T1 (pt) |
AU (1) | AU2508401A (pt) |
BR (1) | BR0015821A (pt) |
CA (1) | CA2395049A1 (pt) |
CO (1) | CO5271666A1 (pt) |
CZ (1) | CZ20021802A3 (pt) |
DE (1) | DE60025848T2 (pt) |
ES (1) | ES2256086T3 (pt) |
GB (1) | GB9927844D0 (pt) |
HU (1) | HUP0203385A3 (pt) |
IL (1) | IL149586A0 (pt) |
MX (1) | MXPA02005231A (pt) |
NO (1) | NO20022470L (pt) |
PE (1) | PE20011008A1 (pt) |
PL (1) | PL356237A1 (pt) |
WO (1) | WO2001038311A2 (pt) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9927844D0 (en) | 1999-11-26 | 2000-01-26 | Glaxo Group Ltd | Chemical compounds |
GB0003224D0 (en) | 2000-02-11 | 2000-04-05 | Glaxo Group Ltd | Chemical compounds |
GB0021494D0 (en) * | 2000-09-01 | 2000-10-18 | Glaxo Group Ltd | Chemical comkpounds |
GB0112803D0 (en) * | 2001-05-25 | 2001-07-18 | Glaxo Group Ltd | Pyrimidine derivatives |
GB0112802D0 (en) * | 2001-05-25 | 2001-07-18 | Glaxo Group Ltd | Pyrimidine derivatives |
GB0112810D0 (en) * | 2001-05-25 | 2001-07-18 | Glaxo Group Ltd | Pyrimidine derivatives |
GB0119477D0 (en) * | 2001-08-09 | 2001-10-03 | Glaxo Group Ltd | Pyrimidine derivatives |
EP1437338B1 (en) * | 2001-10-10 | 2009-09-16 | Hitachi High-Technologies Corporation | Luminous compounds and labeling reagents using the same |
IL162932A0 (en) * | 2002-02-22 | 2005-11-20 | Warner Lambert Co | Combinations of an alpha-2-delta ligand with a selective inhibitor of cyclooxygenase-2 |
DE60305053T2 (de) * | 2002-08-19 | 2006-08-31 | Glaxo Group Ltd., Greenford | Pyrimidinderivate als selektive cox-2-inhibitoren |
UY27939A1 (es) * | 2002-08-21 | 2004-03-31 | Glaxo Group Ltd | Compuestos |
GB0221443D0 (en) * | 2002-09-16 | 2002-10-23 | Glaxo Group Ltd | Pyridine derivates |
GB0227443D0 (en) * | 2002-11-25 | 2002-12-31 | Glaxo Group Ltd | Pyrimidine derivatives |
WO2005000227A2 (en) * | 2003-06-06 | 2005-01-06 | Intermune, Inc. | Methods of treating tnf-mediated disorders |
GB0319037D0 (en) * | 2003-08-13 | 2003-09-17 | Glaxo Group Ltd | 7-Azaindole Derivatives |
GB0813142D0 (en) | 2008-07-17 | 2008-08-27 | Glaxo Group Ltd | Novel compounds |
US8759356B2 (en) * | 2009-05-19 | 2014-06-24 | Dow Agrosciences, Llc. | Compounds and methods for controlling fungi |
US9133123B2 (en) | 2010-04-23 | 2015-09-15 | Cytokinetics, Inc. | Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use |
AR081331A1 (es) | 2010-04-23 | 2012-08-08 | Cytokinetics Inc | Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos |
AR081626A1 (es) | 2010-04-23 | 2012-10-10 | Cytokinetics Inc | Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos |
US9115132B2 (en) | 2010-07-09 | 2015-08-25 | Convergence Pharmaceuticals Limited | Tetrazole compounds as calcium channel blockers |
RS63426B1 (sr) | 2015-02-25 | 2022-08-31 | Univ California | 5ht agonisti za lečenje poremećaja epilepsije |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6020343A (en) | 1995-10-13 | 2000-02-01 | Merck Frosst Canada, Inc. | (Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors |
DE69724788T2 (de) * | 1996-07-18 | 2004-08-05 | Merck Frosst Canada & Co., Halifax | Substituierte pyridine als selektive cyclooxygenase inhibitoren |
AR038955A1 (es) * | 1996-12-05 | 2005-02-02 | Amgen Inc | Compuestos de pirimidinona y piridona sustituidos y metodos para su uso |
GB9927844D0 (en) | 1999-11-26 | 2000-01-26 | Glaxo Group Ltd | Chemical compounds |
GB0003224D0 (en) | 2000-02-11 | 2000-04-05 | Glaxo Group Ltd | Chemical compounds |
-
1999
- 1999-11-26 GB GBGB9927844.2A patent/GB9927844D0/en not_active Ceased
-
2000
- 2000-11-23 IL IL14958600A patent/IL149586A0/xx unknown
- 2000-11-23 BR BR0015821-6A patent/BR0015821A/pt not_active Application Discontinuation
- 2000-11-23 AT AT00988751T patent/ATE316962T1/de not_active IP Right Cessation
- 2000-11-23 EP EP00988751A patent/EP1235812B1/en not_active Expired - Lifetime
- 2000-11-23 WO PCT/EP2000/011673 patent/WO2001038311A2/en active IP Right Grant
- 2000-11-23 KR KR1020027006732A patent/KR20020063899A/ko not_active Application Discontinuation
- 2000-11-23 ES ES00988751T patent/ES2256086T3/es not_active Expired - Lifetime
- 2000-11-23 MX MXPA02005231A patent/MXPA02005231A/es unknown
- 2000-11-23 JP JP2001540074A patent/JP2003514898A/ja active Pending
- 2000-11-23 CA CA002395049A patent/CA2395049A1/en not_active Abandoned
- 2000-11-23 CZ CZ20021802A patent/CZ20021802A3/cs unknown
- 2000-11-23 US US10/130,516 patent/US6780869B1/en not_active Expired - Fee Related
- 2000-11-23 DE DE60025848T patent/DE60025848T2/de not_active Expired - Fee Related
- 2000-11-23 HU HU0203385A patent/HUP0203385A3/hu unknown
- 2000-11-23 AU AU25084/01A patent/AU2508401A/en not_active Abandoned
- 2000-11-23 CN CN00816293A patent/CN1399633A/zh active Pending
- 2000-11-23 PL PL00356237A patent/PL356237A1/xx not_active Application Discontinuation
- 2000-11-23 PE PE2000001249A patent/PE20011008A1/es not_active Application Discontinuation
- 2000-11-24 CO CO00090138A patent/CO5271666A1/es not_active Application Discontinuation
-
2002
- 2002-05-24 NO NO20022470A patent/NO20022470L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ES2256086T3 (es) | 2006-07-16 |
KR20020063899A (ko) | 2002-08-05 |
WO2001038311A2 (en) | 2001-05-31 |
CA2395049A1 (en) | 2001-05-31 |
HUP0203385A2 (en) | 2003-05-28 |
NO20022470D0 (no) | 2002-05-24 |
CZ20021802A3 (cs) | 2002-10-16 |
DE60025848D1 (en) | 2006-04-13 |
GB9927844D0 (en) | 2000-01-26 |
CO5271666A1 (es) | 2003-04-30 |
NO20022470L (no) | 2002-07-18 |
DE60025848T2 (de) | 2006-08-03 |
EP1235812B1 (en) | 2006-02-01 |
AU2508401A (en) | 2001-06-04 |
EP1235812A2 (en) | 2002-09-04 |
MXPA02005231A (es) | 2002-11-07 |
IL149586A0 (en) | 2002-11-10 |
JP2003514898A (ja) | 2003-04-22 |
CN1399633A (zh) | 2003-02-26 |
ATE316962T1 (de) | 2006-02-15 |
HUP0203385A3 (en) | 2003-07-28 |
PL356237A1 (en) | 2004-06-28 |
WO2001038311A3 (en) | 2001-11-01 |
PE20011008A1 (es) | 2001-10-15 |
US6780869B1 (en) | 2004-08-24 |
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