DE60305053D1 - Pyrimidinderivate als selektive cox-2-inhibitoren - Google Patents

Pyrimidinderivate als selektive cox-2-inhibitoren

Info

Publication number
DE60305053D1
DE60305053D1 DE60305053T DE60305053T DE60305053D1 DE 60305053 D1 DE60305053 D1 DE 60305053D1 DE 60305053 T DE60305053 T DE 60305053T DE 60305053 T DE60305053 T DE 60305053T DE 60305053 D1 DE60305053 D1 DE 60305053D1
Authority
DE
Germany
Prior art keywords
inhibitors
pyrimidine derivatives
selective cox
compounds
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60305053T
Other languages
English (en)
Other versions
DE60305053T2 (de
Inventor
Gordon Weingarten
Gianpaolo Bravi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0219305A external-priority patent/GB0219305D0/en
Priority claimed from GB0219304A external-priority patent/GB0219304D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of DE60305053D1 publication Critical patent/DE60305053D1/de
Application granted granted Critical
Publication of DE60305053T2 publication Critical patent/DE60305053T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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DE60305053T 2002-08-19 2003-08-15 Pyrimidinderivate als selektive cox-2-inhibitoren Expired - Fee Related DE60305053T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0219305A GB0219305D0 (en) 2002-08-19 2002-08-19 Pyrimidine derivatives
GB0219304A GB0219304D0 (en) 2002-08-19 2002-08-19 Pyrimidine derivatives
GB0219305 2002-08-19
GB0219304 2002-08-19
PCT/EP2003/009153 WO2004018452A1 (en) 2002-08-19 2003-08-15 Pyrimidine derivatives as selective cox-2 inhibitors

Publications (2)

Publication Number Publication Date
DE60305053D1 true DE60305053D1 (de) 2006-06-08
DE60305053T2 DE60305053T2 (de) 2006-08-31

Family

ID=31948026

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60305053T Expired - Fee Related DE60305053T2 (de) 2002-08-19 2003-08-15 Pyrimidinderivate als selektive cox-2-inhibitoren

Country Status (8)

Country Link
US (1) US7235560B2 (de)
EP (1) EP1546128B1 (de)
JP (1) JP2006500372A (de)
AT (1) ATE325115T1 (de)
AU (1) AU2003258630A1 (de)
DE (1) DE60305053T2 (de)
ES (1) ES2263058T3 (de)
WO (1) WO2004018452A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1546128B1 (de) 2002-08-19 2006-05-03 Glaxo Group Limited Pyrimidinderivate als selektive cox-2-inhibitoren
GB0221443D0 (en) 2002-09-16 2002-10-23 Glaxo Group Ltd Pyridine derivates
DE14172398T1 (de) 2004-10-08 2015-01-08 Forward Pharma A/S Gesteuerte Freisetzung von pharmazeutischen Zusammensetzungen mit Fumarinsäureester
EP1931642A4 (de) * 2005-09-15 2011-06-01 Orchid Res Lab Ltd Neue pyrimidincarboxamide
WO2007042035A2 (en) * 2005-10-07 2007-04-19 Aditech Pharma Ab Combination therapy with fumaric acid esters for the treatment of autoimmune and/or inflammatory disorders
PT2564839T (pt) 2009-01-09 2016-07-14 Forward Pharma As Formulação farmacêutica compreendendo um ou mais ésteres de ácido fumárico numa matriz de erosão
EP2547662A4 (de) * 2010-03-17 2013-10-02 Glaxo Group Ltd Pyrimidinderivate zur verwendung als sphingosin-1-phosphat-1 (s1p1)-rezeptoragonisten
CA3026149A1 (en) * 2016-06-02 2017-12-07 Cadent Therapeutics, Inc. Potassium channel modulators
EP3571193B1 (de) 2017-01-23 2021-12-01 Cadent Therapeutics, Inc. Kaliumkanalmodulatoren
MA53978A (fr) 2018-10-22 2021-09-01 Cadent Therapeutics Inc Formes cristallines de modulateurs des canaux potassiques
WO2021050700A1 (en) * 2019-09-13 2021-03-18 The Broad Institute, Inc. Cyclooxygenase-2 inhibitors and uses thereof

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3149109A (en) 1962-02-20 1964-09-15 Searle & Co Certain 4-trifluoromethyl-2-(oxy/thio) pyrimidines
GB1121922A (en) 1966-06-17 1968-07-31 Ici Ltd Pyrimidine derivatives
US5474995A (en) 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
DK0923933T3 (da) 1993-11-30 2002-10-21 Searle & Co Substituerede pyrazolyl-benzensulfonamider til anvendelse ved behandling af inflammation
US5418254A (en) * 1994-05-04 1995-05-23 G. D. Searle & Co. Substituted cyclopentadienyl compounds for the treatment of inflammation
JP3036079B2 (ja) 1994-09-09 2000-04-24 日本新薬株式会社 複素環誘導体及び医薬
EP0723960B1 (de) 1995-01-26 2003-04-02 Basf Aktiengesellschaft Herbizide 2,6-disubstituierte Pyridine und 2,4-disubstituierte Pyrimidine
US5849758A (en) 1995-05-30 1998-12-15 American Cyanamid Company Herbicidal 2, 6-disubstituted pyridines and 2, 4-disubstituted pyrimidines
US5596008A (en) 1995-02-10 1997-01-21 G. D. Searle & Co. 3,4-Diaryl substituted pyridines for the treatment of inflammation
US5700816A (en) 1995-06-12 1997-12-23 Isakson; Peter C. Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitor and a leukotriene A4 hydrolase inhibitor
AU6269496A (en) 1995-06-12 1997-01-09 G.D. Searle & Co. Combination of a cyclooxygenase-2 inhibitor and a leukotrien e b4 receptor antagonist for the treatment of infla mmations
DE69616364T2 (de) 1995-08-02 2002-07-11 Smithkline Beecham Corp Endothelinrezeptorantagonisten
US6020343A (en) 1995-10-13 2000-02-01 Merck Frosst Canada, Inc. (Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors
JPH09241161A (ja) 1996-03-08 1997-09-16 Nippon Shinyaku Co Ltd 医 薬
DE19614858A1 (de) 1996-04-16 1997-10-23 Basf Ag Herbizide heterocyclisch substituierte Benzoylisothiazole
CZ292843B6 (cs) 1996-07-18 2003-12-17 Merck Frosst Canada & Co. Derivát pyridinu a farmaceutický prostředek s jeho obsahem
EP0820996A1 (de) 1996-07-24 1998-01-28 American Cyanamid Company Cyanopyridine mit herbizider Wirkung
WO1998016227A1 (en) 1996-10-15 1998-04-23 G.D. Searle & Co. Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of neoplasia
JP2002514195A (ja) 1996-12-05 2002-05-14 アムジエン・インコーポレーテツド 置換ピリミジン化合物およびそれの使用
DE19651099A1 (de) 1996-12-09 1998-06-10 Consortium Elektrochem Ind Mehrkomponentensystem zum Verändern, Abbau oder Bleichen von Lignin, ligninhaltigen Materialien oder ähnlichen Stoffen sowie Verfahren zu seiner Anwendung
US5972842A (en) 1996-12-12 1999-10-26 American Cyanamid Company Herbicidal cyanopyridines
DE19708928A1 (de) 1997-03-05 1998-09-10 Bayer Ag Substituierte aromatische Aminoverbindungen
US6103737A (en) 1997-07-03 2000-08-15 Dupont Pharmaceuticals Company Aryl- and arylamino- substituted heterocycles as corticotropin releasing hormone antagonists
DE69833464T2 (de) 1997-09-05 2006-08-24 Glaxo Group Ltd., Greenford Pharmazeutische Zusammensetzung, enthaltend 2,3-Diaryl-PyrazoloÄ1,5-bÜPyridazin Derivate
US5972986A (en) 1997-10-14 1999-10-26 G.D. Searle & Co. Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of neoplasia
US6355799B1 (en) 1997-10-27 2002-03-12 Isk Americas Incorporated Substituted benzene compounds, process for their preparation, and herbicidal and defoliant compositions containing them
US6121202A (en) 1997-11-07 2000-09-19 American Cyanamid Company Thienyloxypyridines and-pyrimidines useful as herbicidal agents
JP2000026421A (ja) 1998-01-29 2000-01-25 Kumiai Chem Ind Co Ltd ジアリ―ルスルフィド誘導体及び有害生物防除剤
DE19909541A1 (de) 1998-03-06 1999-10-14 American Cyanamid Co Herbizide 2-Aryloxy- bzw. 2-Arylthio-6-arylpyrimidine
US6306866B1 (en) 1998-03-06 2001-10-23 American Cyanamid Company Use of aryl-substituted pyrimidines as insecticidal and acaricidal agents
AU3536699A (en) 1998-04-27 1999-11-16 Ihara Chemical Industry Co. Ltd. 3-arylphenyl sulfide derivatives and insecticides and miticides
DE19831246A1 (de) 1998-07-11 2000-01-13 Clariant Gmbh Verfahren zur Herstellung von Arylpyridinen
KR20010075673A (ko) 1998-11-03 2001-08-09 그레이엄 브레레톤, 레슬리 에드워즈 선택적 ｃｏｘ-2 억제제로서의 피라졸로피리딘 유도체
US6545054B1 (en) 1999-02-11 2003-04-08 Millennium Pharmaceuticals, Inc. Alkenyl and alkynyl compounds as inhibitors of factor Xa
US6313072B1 (en) 1999-02-18 2001-11-06 American Cyanamid Company Herbicidal 2-aryloxy-or 2-arylthio-6-arylpyrimidines
US6498166B1 (en) 1999-02-27 2002-12-24 Smithkline Beecham Corporation Pyrazolopyridines
JP4570057B2 (ja) 1999-09-09 2010-10-27 三菱レイヨン株式会社 アリールピリジン誘導体の製造法
GB9927844D0 (en) * 1999-11-26 2000-01-26 Glaxo Group Ltd Chemical compounds
ES2193921T3 (es) * 1999-12-03 2003-11-16 Pfizer Prod Inc Compuestos de sulfamoilheteroaril-pirazol como agentes antinflamatorios/analgesicos.
CO5261556A1 (es) 1999-12-08 2003-03-31 Pharmacia Corp Composiciones inhibidoras de ciclooxigenasa-2 que tiene rapido acceso de efecto terapeutico
GB9930358D0 (en) 1999-12-22 2000-02-09 Glaxo Group Ltd Process for the preparation of chemical compounds
EP1246621A4 (de) 1999-12-23 2004-11-24 Nitromed Inc Nitrosierte und nitrosylierte cyclooxygenase-2-inhibitoren, zusammensetzungen und methoden für deren verwendung
GB0002336D0 (en) 2000-02-01 2000-03-22 Glaxo Group Ltd Medicaments
GB0002312D0 (en) 2000-02-01 2000-03-22 Glaxo Group Ltd Medicaments
GB0003224D0 (en) 2000-02-11 2000-04-05 Glaxo Group Ltd Chemical compounds
ATE293962T1 (de) 2000-02-25 2005-05-15 Hoffmann La Roche Adenosin-rezeptor modulatoren
BR0108908A (pt) * 2000-03-03 2002-12-24 Pfizer Prod Inc Derivados de éteres de pirazol como agentes antiinflamatórios/analgésicos
JP2001252044A (ja) 2000-03-15 2001-09-18 Healthy Shokuhin Kk 五大栄養素調合食品薬膳
DE60103752T2 (de) 2000-04-28 2005-07-14 Glaxo Group Ltd., Greenford Verfahren zur herstellung von pyrazolopyridinderivaten
WO2002000647A1 (en) 2000-06-23 2002-01-03 Bristol-Myers Squibb Pharma Company Heteroaryl-phenyl substituted factor xa inhibitors
NZ523184A (en) 2000-06-23 2004-06-25 Bristol Myers Squibb Pharma Co 1 - (heteroaryl-phenyl) - condensed pyrazol derivatives as factor Xa inhibitors
GB0021494D0 (en) 2000-09-01 2000-10-18 Glaxo Group Ltd Chemical comkpounds
DE10059418A1 (de) 2000-11-30 2002-06-20 Aventis Pharma Gmbh Ortho, meta-substituierte Bisarylverbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
WO2002055484A1 (fr) 2001-01-12 2002-07-18 Takeda Chemical Industries, Ltd. Compose biaryle, procede de production de ce compose, et principe actif
JP2004518678A (ja) 2001-01-24 2004-06-24 オークランド ユニサーヴィスィズ リミテッド 抗癌剤２，３−ジヒドロ−１Ｈ−ピロロ［３，２−ｆ］キノリンのコバルトおよびクロムとの錯体
US6960595B2 (en) 2001-03-23 2005-11-01 Bristol-Myers Squibb Pharma Company 5-6 to 5-7 Heterobicycles as factor Xa inhibitors
US6756498B2 (en) 2001-04-27 2004-06-29 Smithkline Beecham Corporation Process for the preparation of chemical compounds
GB0112803D0 (en) 2001-05-25 2001-07-18 Glaxo Group Ltd Pyrimidine derivatives
GB0112810D0 (en) 2001-05-25 2001-07-18 Glaxo Group Ltd Pyrimidine derivatives
GB0112802D0 (en) 2001-05-25 2001-07-18 Glaxo Group Ltd Pyrimidine derivatives
IL159058A0 (en) 2001-06-12 2004-05-12 Neurogen Corp 2,5-diarylpyrazines, 2,5-diarylpyridines and 2,5-diarylpyrimidines as crf1 receptor modulators
SE0102439D0 (sv) 2001-07-05 2001-07-05 Astrazeneca Ab New compounds
GB0119472D0 (en) 2001-08-09 2001-10-03 Astrazeneca Ab Compounds
GB0119477D0 (en) 2001-08-09 2001-10-03 Glaxo Group Ltd Pyrimidine derivatives
US6667311B2 (en) 2001-09-11 2003-12-23 Albany Molecular Research, Inc. Nitrogen substituted biaryl purine derivatives as potent antiproliferative agents
GB0206200D0 (en) 2002-03-15 2002-05-01 Glaxo Group Ltd Pharmaceutical compositions
US6861249B1 (en) 2002-04-09 2005-03-01 David Kent Microbial spray for animal waste
EP1546128B1 (de) 2002-08-19 2006-05-03 Glaxo Group Limited Pyrimidinderivate als selektive cox-2-inhibitoren
GB0221443D0 (en) 2002-09-16 2002-10-23 Glaxo Group Ltd Pyridine derivates
GB0227443D0 (en) 2002-11-25 2002-12-31 Glaxo Group Ltd Pyrimidine derivatives
GB0319037D0 (en) 2003-08-13 2003-09-17 Glaxo Group Ltd 7-Azaindole Derivatives

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ES2263058T3 (es) 2006-12-01
JP2006500372A (ja) 2006-01-05
ATE325115T1 (de) 2006-06-15
AU2003258630A1 (en) 2004-03-11
EP1546128B1 (de) 2006-05-03
EP1546128A1 (de) 2005-06-29

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