HUP0203316A2 - Amino-triazolopiridin-származékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents
Amino-triazolopiridin-származékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0203316A2 HUP0203316A2 HU0203316A HUP0203316A HUP0203316A2 HU P0203316 A2 HUP0203316 A2 HU P0203316A2 HU 0203316 A HU0203316 A HU 0203316A HU P0203316 A HUP0203316 A HU P0203316A HU P0203316 A2 HUP0203316 A2 HU P0203316A2
- Authority
- HU
- Hungary
- Prior art keywords
- phenyl
- group
- optionally
- substituted
- lower alkyl
- Prior art date
Links
- KGUHUVQIJHGHLX-UHFFFAOYSA-N 2h-triazolo[4,5-b]pyridin-5-amine Chemical class NC1=CC=C2NN=NC2=N1 KGUHUVQIJHGHLX-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- -1 or -O(CH2)n-phenyl Chemical group 0.000 abstract 9
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 125000004434 sulfur atom Chemical group 0.000 abstract 2
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 abstract 1
- XGXOQBWTDDSGKT-UHFFFAOYSA-N 2-(1,4,5,6-tetrahydropyrimidin-2-yl)benzoic acid Chemical compound OC(=O)C1=CC=CC=C1C1=NCCCN1 XGXOQBWTDDSGKT-UHFFFAOYSA-N 0.000 abstract 1
- DAFSXTNSQHDLLK-UHFFFAOYSA-N 2-(4,5,6,7-tetrahydro-1h-1,3-diazepin-2-yl)benzoic acid Chemical compound OC(=O)C1=CC=CC=C1C1=NCCCCN1 DAFSXTNSQHDLLK-UHFFFAOYSA-N 0.000 abstract 1
- HHCYLDWTHIPYMV-UHFFFAOYSA-N 2-(4,5-dihydro-1h-imidazol-2-yl)benzoic acid Chemical compound OC(=O)C1=CC=CC=C1C1=NCCN1 HHCYLDWTHIPYMV-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000004618 benzofuryl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 abstract 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000001041 indolyl group Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000002757 morpholinyl group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 125000003226 pyrazolyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Addiction (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
A találmány (I) általános képletű vegyületekre[mely képletben R1jelentése egy-három nitrogén-, oxigén- és/vagy kénatomot tartalmazóheteroarilcsoport, amely adott esetben helyettesítve lehet, és aheteroarilcsoport a pirazolgyűrűhöz adott esetben alkilén- vagyalkeniléncsoporton keresztül kapcsolódhat; vagy R1 jelentése adottesetben helyettesített fenilcsoport, vagy -O(CH2)n-fenil-,benzofuril-, indolil- vagy benzotiofenil- csoport, vagy -S- kisszénatomszámú alkilcsoport; R2 és R4 jelentése egymástól függetlenülhidrogénatom, ciano- vagy -S(O)2-fenil-csoport; R jelentésehidrogénatom, halogénatom, vagy egy- három nitrogén-, oxigén- és/vagykénatomot tartalmazó, 5- vagy 6-tagú heteroaril-csoport, amely adottesetben helyettesítve lehet vagy -NR'R< (ahol R' és R< jelentéseegymástól függetlenül hidrogénatom, - (CH2)n-fenil-csoport, mimelletta fenilport adott esetben helyettesítve lehet, -CH(kis szénatomszámúalkil)-fenil-, indán-1-il-, 1,2,3,4-tet<- >rahidro-naftalin- vagycikloalkilcsoport; vagy -O-fenilcsoport, mimellett a fenilgyűrű adottesetben helyettesítve lehet, vagy -O-tetrahidronaftalenil- vagy -O-CH2-6-metil-piridin-2-il- csoport; vagy benzo[1,3]dioxolil-, 1H-indol-5-il-, naftil-, benzofurán-2-i1-, 1,3,4,9-tetrahidro-b-karbolin-2-il-,piperidin-1-i1-, pirrolidin-l-il-, piperazin-4-il-metil- vagymorfolinilcsoport; R5 jelentése -NR2 (ahol R azonos vagy különbözőlehet és jelentése hidrogénatom, kis szénatomszámú alkil-, fenil-,benzil-, -CO-kis szénatomszámú alkil-, -CO-kis szénatomszámú alkoxi-,kis szén<- >atomszámú alkenil-, -CO(CH2)n-fenil- vagy -COO(CH2)n-fenilcsoport, mimellett a fenilgyűrű adott esetben helyettesítvelehet, -CO(CH2)3-NHCO-kis szénatomszámú alkoxi-, -(CH2)n-fenilcsoport,ahol a fenilgyűrű adott esetben helyettesítve lehet, vagy 4,5-dihidro-1H-imidazol-2- il-benzoesav, 1,4,5,6-tetrahidro-pirimidin-2-il-benzoesav vagy 4,5,6,7-tetrahidro- lH-[1,3]diazepin-2-il-benzoesav; nértéke 0-4 és gyógyászatilag alkalmas savaddíciós sóikra vonatkozik. Atalálmány kiterjed a vegyületek előállítására és ezeket tartalmazógyógyszerkészítményekre is. A találmány szerinti vegyületek azadenozin receptorral összefüggő betegségek kezelésére alkalmazhatók. Ó
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99117578 | 1999-09-06 | ||
PCT/EP2000/008372 WO2001017999A2 (en) | 1999-09-06 | 2000-08-28 | Amino-triazolopyridine derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0203316A2 true HUP0203316A2 (hu) | 2003-01-28 |
HUP0203316A3 HUP0203316A3 (en) | 2004-07-28 |
Family
ID=8238933
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0203316A HUP0203316A3 (en) | 1999-09-06 | 2000-08-28 | Amino-triazolopyridine derivatives, process for their preparation and pharmaceutical compositions containing them |
Country Status (22)
Country | Link |
---|---|
US (1) | US6355653B1 (hu) |
EP (1) | EP1214322A2 (hu) |
JP (1) | JP2003528811A (hu) |
KR (1) | KR20020027625A (hu) |
CN (1) | CN1379777A (hu) |
AR (1) | AR037484A1 (hu) |
AU (1) | AU7511000A (hu) |
BR (1) | BR0013792A (hu) |
CA (1) | CA2383998A1 (hu) |
CZ (1) | CZ20021220A3 (hu) |
HR (1) | HRP20020172A2 (hu) |
HU (1) | HUP0203316A3 (hu) |
IL (1) | IL148167A0 (hu) |
MA (1) | MA26816A1 (hu) |
MX (1) | MXPA02001748A (hu) |
NO (1) | NO20021077D0 (hu) |
PE (1) | PE20010629A1 (hu) |
PL (1) | PL354240A1 (hu) |
TR (1) | TR200200579T2 (hu) |
WO (1) | WO2001017999A2 (hu) |
YU (1) | YU13502A (hu) |
ZA (1) | ZA200201055B (hu) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
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US6506772B1 (en) | 2000-12-15 | 2003-01-14 | Hoffmann-La Roche Inc. | Substituted [1,2,4]triazolo[1,5a]pyridine derivatives with activity as adenosine receptor ligands |
US6514989B1 (en) * | 2001-07-20 | 2003-02-04 | Hoffmann-La Roche Inc. | Aromatic and heteroaromatic substituted 1,2,4-triazolo pyridine derivatives |
JP4101755B2 (ja) * | 2001-10-08 | 2008-06-18 | エフ.ホフマン−ラ ロシュ アーゲー | 8−アミノ−〔1,2,4〕トリアゾロ〔1,5−a〕ピリジン−6−カルボン酸アミド |
US6693116B2 (en) * | 2001-10-08 | 2004-02-17 | Hoffmann-La Roche Inc. | Adenosine receptor ligands |
MXPA04005158A (es) | 2001-11-30 | 2004-08-11 | Schering Corp | Antagonistas receptores de adenosina a2a biciclica de (1.2.4]- triazol. |
HUP0105407A3 (en) * | 2001-12-21 | 2004-04-28 | Sanofi Aventis | Triazolo[1,5-a]quinolin derivatives, process for their preparation, pharmaceutical compositions thereof and intermediates |
EA200400982A1 (ru) | 2002-01-28 | 2004-12-30 | Киова Хакко Когио Ко., Лтд. | Способы лечения пациентов, страдающих от нарушения движений |
BR0312123A (pt) * | 2002-06-13 | 2005-03-29 | Pfizer | Agentes de gnrh não peptìdicos, composições farmacêuticas e métodos para o seu uso |
WO2005070927A2 (en) * | 2004-01-26 | 2005-08-04 | Altana Pharma Ag | 1,2,4-triazolo[1,5-a] pyridines as gastric acid secretion inhibitors |
MX2007007604A (es) * | 2004-12-21 | 2007-08-02 | Schering Corp | Antagonistas del receptor de pirazolo[1,5-a]pirimidina adenosina a2a. |
ES2273599B1 (es) | 2005-10-14 | 2008-06-01 | Universidad De Barcelona | Compuestos para el tratamiento de la fibrilacion auricular. |
CA2657247A1 (en) * | 2006-07-28 | 2008-01-31 | Boehringer Ingelheim International Gmbh | Compounds which modulate the cb2 receptor |
JP5030114B2 (ja) * | 2006-09-25 | 2012-09-19 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Cb2受容体をモジュレートする化合物 |
KR20090094336A (ko) * | 2006-11-27 | 2009-09-04 | 하. 룬트벡 아크티에 셀스카브 | 헤테로아릴 아미드 유도체 |
EP2086540B8 (en) * | 2006-12-01 | 2011-03-02 | Galapagos N.V. | Triazolopyridine compounds useful for the treatment of degenerative & inflammatory diseases |
KR20090130109A (ko) * | 2007-04-10 | 2009-12-17 | 하. 룬트벡 아크티에 셀스카브 | P2x7 길항제로서의 헤테로아릴 아미드 유사체 |
WO2009017954A1 (en) * | 2007-08-01 | 2009-02-05 | Phenomix Corporation | Inhibitors of jak2 kinase |
GB0719803D0 (en) | 2007-10-10 | 2007-11-21 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
EP2217565B1 (en) * | 2007-11-07 | 2013-05-22 | Boehringer Ingelheim International GmbH | Compounds which modulate the cb2 receptor |
JP2011520884A (ja) * | 2008-05-13 | 2011-07-21 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Cb2受容体を変調するスルホン化合物 |
WO2009155551A1 (en) * | 2008-06-20 | 2009-12-23 | Genentech, Inc. | Triazolopyridine jak inhibitor compounds and methods |
BRPI0909945A2 (pt) * | 2008-06-20 | 2015-07-28 | Genentech Inc | "composto, composição farmacêutica, método para tratar ou atenuar a gravidade de uma doença ou condição responsiva à inibição da atividade jak2 quinase em um paciente, kit para o tratamento de uma doença ou distúrbio responsivo à inibição da jak quinase" |
WO2010005782A1 (en) * | 2008-07-10 | 2010-01-14 | Boehringer Ingelheim International Gmbh | Sulfone compounds which modulate the cb2 receptor |
TWI453207B (zh) * | 2008-09-08 | 2014-09-21 | Signal Pharm Llc | 胺基三唑并吡啶,其組合物及使用其之治療方法 |
JP5453437B2 (ja) | 2008-09-25 | 2014-03-26 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Cb2受容体を選択的に調節するスルホニル化合物 |
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JP5756800B2 (ja) | 2009-06-16 | 2015-07-29 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Cb2受容体を調節するアゼチジン2−カルボキサミド誘導体 |
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WO2011109324A1 (en) | 2010-03-05 | 2011-09-09 | Boehringer Ingelheim International Gmbh | Tetrazole compounds which selectively modulate the cb2 receptor |
WO2012012307A1 (en) | 2010-07-22 | 2012-01-26 | Boehringer Ingelheim International Gmbh | Sulfonyl compounds which modulate the cb2 rece |
EP2758396B1 (en) * | 2011-09-19 | 2017-03-29 | F. Hoffmann-La Roche AG | Triazolopyridine compounds as pde10a inhibitors |
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EP2803668A1 (en) | 2013-05-17 | 2014-11-19 | Boehringer Ingelheim International Gmbh | Novel (cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles |
JP2019513700A (ja) | 2016-03-16 | 2019-05-30 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | 殺有害生物剤及び植物保護剤としてのn−(シアノベンジル)−6−(シクロプロピル−カルボニルアミノ)−4−(フェニル)−ピリジン−2−カルボキサミド誘導体及び関連する化合物 |
CN106543175B (zh) * | 2016-10-28 | 2018-06-01 | 上海大学 | 三芳基[1,2,4]三氮唑[1,5-a]吡啶衍生物及其制备方法 |
EP3575301A4 (en) * | 2017-03-16 | 2020-08-05 | Jiangsu Hengrui Medicine Co., Ltd. | HETEROARYL [4,3-C] PYRIMIDINE-5-AMINE DERIVATIVE, PROCESS FOR PREPARATION AND MEDICAL USES |
CR20200441A (es) | 2018-02-27 | 2021-03-15 | Incyte Corp | Imidazopirimidinas y triazolopirimidinas como inhibidores de a2a / a2b |
MX2020012376A (es) * | 2018-05-18 | 2021-03-09 | Incyte Corp | Derivados de pirimidina fusionados como inhibidores de los receptores de adenosina a2a/a2b. |
JP7399589B2 (ja) * | 2018-09-12 | 2023-12-18 | 日本化薬株式会社 | 有害生物防除剤 |
TWI829857B (zh) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶 |
EP4121431A1 (en) * | 2021-01-09 | 2023-01-25 | Bugworks Research, Inc. | Diaminopyrazolo[1,5-a]pyrimidine-6-carbonitrile compounds as adenosine 2a receptor and adenosine 2b receptor antagonist |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
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GB9226735D0 (en) | 1992-12-22 | 1993-02-17 | Ici Plc | Azole derivatives |
WO1999043678A1 (fr) | 1998-02-24 | 1999-09-02 | Kyowa Hakko Kogyo Co., Ltd. | Medicaments et prophylaxie contre la maladie de parkinson |
-
2000
- 2000-08-24 US US09/645,127 patent/US6355653B1/en not_active Expired - Fee Related
- 2000-08-28 CN CN00812501A patent/CN1379777A/zh active Pending
- 2000-08-28 WO PCT/EP2000/008372 patent/WO2001017999A2/en not_active Application Discontinuation
- 2000-08-28 TR TR2002/00579T patent/TR200200579T2/xx unknown
- 2000-08-28 IL IL14816700A patent/IL148167A0/xx unknown
- 2000-08-28 BR BR0013792-8A patent/BR0013792A/pt not_active IP Right Cessation
- 2000-08-28 CZ CZ20021220A patent/CZ20021220A3/cs unknown
- 2000-08-28 YU YU13502A patent/YU13502A/sh unknown
- 2000-08-28 EP EP00964043A patent/EP1214322A2/en not_active Withdrawn
- 2000-08-28 AU AU75110/00A patent/AU7511000A/en not_active Abandoned
- 2000-08-28 HU HU0203316A patent/HUP0203316A3/hu unknown
- 2000-08-28 KR KR1020027002990A patent/KR20020027625A/ko not_active Application Discontinuation
- 2000-08-28 CA CA002383998A patent/CA2383998A1/en not_active Abandoned
- 2000-08-28 MX MXPA02001748A patent/MXPA02001748A/es unknown
- 2000-08-28 PL PL00354240A patent/PL354240A1/xx not_active Application Discontinuation
- 2000-08-28 JP JP2001522222A patent/JP2003528811A/ja active Pending
- 2000-09-04 PE PE2000000903A patent/PE20010629A1/es not_active Application Discontinuation
- 2000-09-04 AR ARP000104612A patent/AR037484A1/es not_active Application Discontinuation
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2002
- 2002-02-06 ZA ZA200201055A patent/ZA200201055B/xx unknown
- 2002-02-26 HR HR20020172A patent/HRP20020172A2/hr not_active Application Discontinuation
- 2002-03-05 NO NO20021077A patent/NO20021077D0/no not_active Application Discontinuation
- 2002-03-06 MA MA26540A patent/MA26816A1/fr unknown
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CA2383998A1 (en) | 2001-03-15 |
YU13502A (sh) | 2004-11-25 |
CZ20021220A3 (cs) | 2002-10-16 |
TR200200579T2 (tr) | 2002-12-23 |
KR20020027625A (ko) | 2002-04-13 |
AU7511000A (en) | 2001-04-10 |
NO20021077L (no) | 2002-03-05 |
HRP20020172A2 (en) | 2003-10-31 |
JP2003528811A (ja) | 2003-09-30 |
BR0013792A (pt) | 2002-05-14 |
PE20010629A1 (es) | 2001-05-30 |
MXPA02001748A (es) | 2002-08-06 |
AR037484A1 (es) | 2004-11-17 |
PL354240A1 (en) | 2003-12-29 |
CN1379777A (zh) | 2002-11-13 |
WO2001017999A3 (en) | 2001-12-06 |
EP1214322A2 (en) | 2002-06-19 |
IL148167A0 (en) | 2002-09-12 |
HUP0203316A3 (en) | 2004-07-28 |
MA26816A1 (fr) | 2004-12-20 |
NO20021077D0 (no) | 2002-03-05 |
WO2001017999A2 (en) | 2001-03-15 |
US6355653B1 (en) | 2002-03-12 |
ZA200201055B (en) | 2003-07-30 |
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