YU13502A - Derivati amino-triazolopiridina - Google Patents

Derivati amino-triazolopiridina

Info

Publication number
YU13502A
YU13502A YU13502A YUP13502A YU13502A YU 13502 A YU13502 A YU 13502A YU 13502 A YU13502 A YU 13502A YU P13502 A YUP13502 A YU P13502A YU 13502 A YU13502 A YU 13502A
Authority
YU
Yugoslavia
Prior art keywords
phenyl
optionally substituted
hydrogen
compounds
amino
Prior art date
Application number
YU13502A
Other languages
English (en)
Inventor
Trottmann Gerda Huber
Walter Hunkeler
Roland Jakob-Roetne
Gavin John Kilpatrick
Matthias Heinrich Nettekoven
Claus Riemer
Original Assignee
F. Hoffmann-La Roche Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag. filed Critical F. Hoffmann-La Roche Ag.
Publication of YU13502A publication Critical patent/YU13502A/sh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Immunology (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Pronalazak se odnosi na jedinjenja formule I, naznacena time sto R1 perdstavlja 5-to ili 6-toclanu heteroarilnu grupu, koja sadrzi 1 do 3 heteroatoma, izabrana izmedju N, O ili S, i cije su grupe opciono supstituisane jednim ili sa dva supstituenta, koji su nizi alkil, -(CH2)nOH, halogen ili nizi alkoksi, i naznacena time sto heteroarilne grupe mogu biti opciono vezane za pirazolski prsten preko nekog alkilena ili alkenil grupe ili je to fenil, opciono supstituisan jednim ili sa dva supstituenta, koji su nizi alkil, hidroksi-nizi alkil, halogen, hidroksi ili nizi alkoksi ili je -O(CH2)nfenil, benzofuril, indolil ili benzotiofenil ili je -S-nizi alkil; R2 i R4 su nezavisno jedan od drugog, vodonik, cijano ili -S(O)2-fenil; R3 je vodonik, halogen ili 5-to ili 6-toclana heteroarilna grupa, koja sadrzi 1 do 3 heteroatoma, izabrana izmedju N, O ili S i gde su grupe opciono supstituisane jednim ili sa dva supstituenta, koji su nizi alkil, -(CH2)n-aril, hldroksi, halogen, nizi alkoksi, morfolinil, amino, nizi alkilamino ili -C(O)NR'2, naznaceno time sto je R* nizi alkil ili vodonik ili je fenil, opciono supstituisan jednim ili sa dva supstituenta koji su halogen, nizi alkoksi, amino, di-nizi alkil amino, CF3, -OCF3, -NHC(O)nizi alkil cijano, -C(O)-nizi alkil, -C(O)O-nizi alkil, -S-nizi alkil, -S(O)2NH-fenil, -S(O)2metilpiperazinil; ili je NR'R", naznacen time sto su R' i R", nezavisno jedan od drugog, vodonik, -(CH2)nfenil, koji je opciono supstituisan halogenom ili nizom alkoksi grupom, -CH(nizi alkil)-fenil, indan-1-il, 1,2,3,4-tetrahidro-naftalen ili cikloalkil; ili je O-fenil, ciji je fenilni prsten opciono supstituisan halogenom, nizom alkil ili nizom alkoksi grupom, -O-tetraidronaftalenil ili -O-CH2-6-metil-piridin-2-il; ili je -benzol[1,3]dioksolil, -1H-indol-5-il, naftil, benzofuran-2-il, 1,3,4,9-tetrahidro-b-karbolin-2-il, piperidin-1-il, pirolidin-1-il, piperazin-4-il-metil ili morfolinil; R5 je -NR2, pri cemu R moze ili ne mora biti vodonik, nizi alkil, fenil, benzil, -CO-nizi alkil, -CO-nizi alkoksi, -nizi alkenil, -CO(CH2)n-fenil ili -COO(CH2)n-fenil, naznacen time sto je fenilni prsten opciono supstituisan sa CF3 nizom alkoksi, halogen ili nizom alkil grupom, -CO(CH2)3-NHCO-nizi alkoksi, -(CH2)n-fenil, naznacen time, sto je fenilni prsten opciono supstituisan nizom alkoksi, CF3 ili halogenom ili je 4,5-dihidro-1H-imidazol-2-il-benzojeva kiselina, 1,4,5,6-tetrahidro-pirimidin-2-il-benzojeva kiselina ili 4,5,6,7-tetrahidro-1H-[1,3]diazepin-2-il-benzojeva kiselina; n je 0-4, i njihove farmaceutski prihvatljive soli.
YU13502A 1999-09-06 2000-08-28 Derivati amino-triazolopiridina YU13502A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99117578 1999-09-06

Publications (1)

Publication Number Publication Date
YU13502A true YU13502A (sh) 2004-11-25

Family

ID=8238933

Family Applications (1)

Application Number Title Priority Date Filing Date
YU13502A YU13502A (sh) 1999-09-06 2000-08-28 Derivati amino-triazolopiridina

Country Status (22)

Country Link
US (1) US6355653B1 (sh)
EP (1) EP1214322A2 (sh)
JP (1) JP2003528811A (sh)
KR (1) KR20020027625A (sh)
CN (1) CN1379777A (sh)
AR (1) AR037484A1 (sh)
AU (1) AU7511000A (sh)
BR (1) BR0013792A (sh)
CA (1) CA2383998A1 (sh)
CZ (1) CZ20021220A3 (sh)
HR (1) HRP20020172A2 (sh)
HU (1) HUP0203316A3 (sh)
IL (1) IL148167A0 (sh)
MA (1) MA26816A1 (sh)
MX (1) MXPA02001748A (sh)
NO (1) NO20021077L (sh)
PE (1) PE20010629A1 (sh)
PL (1) PL354240A1 (sh)
TR (1) TR200200579T2 (sh)
WO (1) WO2001017999A2 (sh)
YU (1) YU13502A (sh)
ZA (1) ZA200201055B (sh)

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KR20110063438A (ko) * 2008-09-25 2011-06-10 베링거 인겔하임 인터내셔날 게엠베하 Ｃｂ2 수용체를 선택적으로 조절하는 설포닐 화합물
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Also Published As

Publication number Publication date
MA26816A1 (fr) 2004-12-20
IL148167A0 (en) 2002-09-12
PE20010629A1 (es) 2001-05-30
PL354240A1 (en) 2003-12-29
US6355653B1 (en) 2002-03-12
WO2001017999A2 (en) 2001-03-15
ZA200201055B (en) 2003-07-30
CA2383998A1 (en) 2001-03-15
BR0013792A (pt) 2002-05-14
MXPA02001748A (es) 2002-08-06
CZ20021220A3 (cs) 2002-10-16
CN1379777A (zh) 2002-11-13
NO20021077D0 (no) 2002-03-05
KR20020027625A (ko) 2002-04-13
HUP0203316A3 (en) 2004-07-28
EP1214322A2 (en) 2002-06-19
WO2001017999A3 (en) 2001-12-06
TR200200579T2 (tr) 2002-12-23
NO20021077L (no) 2002-03-05
HRP20020172A2 (en) 2003-10-31
HUP0203316A2 (hu) 2003-01-28
AR037484A1 (es) 2004-11-17
JP2003528811A (ja) 2003-09-30
AU7511000A (en) 2001-04-10

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