HUP9802552A2 - Piperazinszármazékok, eljárás előállításukra, az ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk - Google Patents

Piperazinszármazékok, eljárás előállításukra, az ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk

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Publication number
HUP9802552A2
HUP9802552A2 HU9802552A HUP9802552A HUP9802552A2 HU P9802552 A2 HUP9802552 A2 HU P9802552A2 HU 9802552 A HU9802552 A HU 9802552A HU P9802552 A HUP9802552 A HU P9802552A HU P9802552 A2 HUP9802552 A2 HU P9802552A2
Authority
HU
Hungary
Prior art keywords
powder
ring
ora
optionally substituted
hydrogen atom
Prior art date
Application number
HU9802552A
Other languages
English (en)
Inventor
David J. Blythin
Xiao Chen
Kevin D. Mccormick
John J. Piwinski
Neng-Yang Shih
Ho-Jane Shue
Original Assignee
Schering Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1996/005660 external-priority patent/WO1996034864A1/en
Priority claimed from US08/663,880 external-priority patent/US5795894A/en
Application filed by Schering Corp. filed Critical Schering Corp.
Publication of HUP9802552A2 publication Critical patent/HUP9802552A2/hu
Publication of HUP9802552A3 publication Critical patent/HUP9802552A3/hu

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    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

A találmány neűrőkinin receptőrők antagőnistáiként, különösenneűrőkinin-1 receptőr (NK1) antagőnistákként felhasználható új, (I)általánős képletű vegyületekre - amelyek képletében a leírásbanmegadőtt megkötésekkel X és X3 két hidrőgénatőm, őxigén-, kénatőm vagy=NRd csőpőrt; n, ű és 1 egymástól függetlenül 0, 1 vagy 2; m = 1, ésy=1, 2 vagy 3, vagy m = 2, és y=0; Rc mindegyike hidrőgénatőm,alkilcsőpőrt, -(CH2)n1-R4; n1 = 1, 2, 3, 4, 5 vagy 6; Rd hidrőgénatőm,alkil-, cianő-, -ORa, adőtt esetben szűbsztitűált fenil-,benzilcsőpőrt vagy allilcsőpőrt; R4 cianő-, amidinőcsőpőrt, -ORa, -SRa, -NRaRb, -C(O)NRaRb, -C(O)ORa, -C(=O)-ORd, imidazőlil-, (f), (g),(h), (j), (k) vagy (l) csőpőrt; Rc' hidrőgénatőm, alkil- vagy -(CH2)nORa csőpőrt, Ar1 adőtt esetben szűbsztitűált heterőarilcsőpőrt,(r), (s) vagy adőtt esetben helyettesített fenil- vagy naftilcsőőrt Qnitrőgénatőm vagy metincsőpőrt; Ar2 adőtt esetben szűbsztitűáltheterőarilcsőpőrt, adőtt esetben helyettesített fenil- vagynaftilcsőpőrt Z (v), (w) vagy (x) csőpőrt; vagy enantiőmereikre vagygyógyszerészetileg elfőgadható sóikra, valamint a vegyületekettartalmazó gyógyszerkészítményekre vőnatkőzik. (I) (f) (g) (h) (j) (k) (l) (r) (s) (v) (w) (x) ŕ
HU9802552A 1995-08-31 1996-08-29 Piperazino derivatives process for their preparation, pharmaceuticals containing the same and their use HUP9802552A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US308495P 1995-08-31 1995-08-31
PCT/US1996/005660 WO1996034864A1 (en) 1995-05-02 1996-05-01 Piperazino derivatives as neurokinin antagonists
US08/663,880 US5795894A (en) 1995-05-02 1996-06-14 Piperazino derivatives as neurokinn antagonists

Publications (2)

Publication Number Publication Date
HUP9802552A2 true HUP9802552A2 (hu) 1999-10-28
HUP9802552A3 HUP9802552A3 (en) 1999-11-29

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ID=46202966

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HU9802552A HUP9802552A3 (en) 1995-08-31 1996-08-29 Piperazino derivatives process for their preparation, pharmaceuticals containing the same and their use

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EP (1) EP0850236B1 (hu)
JP (2) JP3447745B2 (hu)
CN (1) CN1111529C (hu)
AT (1) ATE202776T1 (hu)
AU (1) AU708834B2 (hu)
BR (1) BR9610277A (hu)
CA (1) CA2228370C (hu)
CZ (1) CZ22898A3 (hu)
DE (1) DE69613705T2 (hu)
ES (1) ES2158345T3 (hu)
GR (1) GR3036675T3 (hu)
HU (1) HUP9802552A3 (hu)
IL (1) IL123112A (hu)
NO (1) NO980848L (hu)
PL (1) PL325339A1 (hu)
SK (1) SK27498A3 (hu)
WO (1) WO1997008166A1 (hu)

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JP6850282B2 (ja) 2015-07-20 2021-03-31 アカディア ファーマシューティカルズ インコーポレーテッド Ｎ−（４−フルオロベンジル）−ｎ−（１−メチルピペリジン−４−イル）−ｎ’−（４−（２−メチルプロピルオキシ）フェニルメチル）カルバミドならびにその酒石酸塩および多形形態ｃを調製する方法
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CZ22898A3 (cs) 1998-07-15
SK27498A3 (en) 1998-12-02
EP0850236A1 (en) 1998-07-01
DE69613705T2 (de) 2002-05-16
CA2228370A1 (en) 1997-03-06
CN1111529C (zh) 2003-06-18
WO1997008166A1 (en) 1997-03-06
GR3036675T3 (en) 2001-12-31
IL123112A (en) 2001-04-30
DE69613705D1 (de) 2001-08-09
CN1200120A (zh) 1998-11-25
CA2228370C (en) 2002-10-01
HUP9802552A3 (en) 1999-11-29
ATE202776T1 (de) 2001-07-15
BR9610277A (pt) 1999-07-06
NO980848D0 (no) 1998-02-27
EP0850236B1 (en) 2001-07-04
ES2158345T3 (es) 2001-09-01
IL123112A0 (en) 1998-09-24
JP2000344766A (ja) 2000-12-12
JP3315970B2 (ja) 2002-08-19
AU6997996A (en) 1997-03-19
NO980848L (no) 1998-04-30
JP3447745B2 (ja) 2003-09-16
AU708834B2 (en) 1999-08-12
PL325339A1 (en) 1998-07-20
JPH10511105A (ja) 1998-10-27

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