CO5150186A1 - Derivados de 3-bencil-ureido y 2-guanidino-tiazol y preparaciones farmaceuticas que los contienen - Google Patents
Derivados de 3-bencil-ureido y 2-guanidino-tiazol y preparaciones farmaceuticas que los contienenInfo
- Publication number
- CO5150186A1 CO5150186A1 CO99066263A CO99066263A CO5150186A1 CO 5150186 A1 CO5150186 A1 CO 5150186A1 CO 99066263 A CO99066263 A CO 99066263A CO 99066263 A CO99066263 A CO 99066263A CO 5150186 A1 CO5150186 A1 CO 5150186A1
- Authority
- CO
- Colombia
- Prior art keywords
- zero
- alkyl
- cycloalkyl
- hydrogen
- jpeg
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Compuestos de fórmula (I)<EMI FILE="99066263_1" ID="1" IMF=JPEG >en dondeR1 es <EMI FILE="99066263_2" ID="2" IMF=JPEG >R2 es<EMI FILE="99066263_3" ID="3" IMF=JPEG >R3 es hidrógeno, alquilo, cicloalquilo, arilo, aralquilo, heteroarilo, carboxilo, alquil-O-CO- ó aralquil-O-CO-;R4 es hidrógeno, alquilo, cicloalquilo, arilo, o heteroarilo;R5 y R6 independientemente entre sí, son hidrógeno, alquilo, cicloalquilo o heteroarilo;R7 y R8 independientemente entre sí, son hidrógeno, alquilo, cicloalquilo o heteroarilo óR7 y R8 juntamente con los átomos de N a los cuales están unidos, forman un anillo heterocíclico de 5 a 8 miembros, que pueden llevar uno o más substituyentes alquilo;R9 es hidrógeno, alquilo o cicloalquilo;R10 es hidrógeno, arilo, aralquilo, heteroarilo, heterociclilalquilo, carboxialquilo, alquilo, cicloalquilo, alquil-O-CO-, aralquil-O-CO, alquil-CO-, alquilsulfonilo, arilsulfonilo o heteroarilsulfonilo; A es oxígeno, azufre, -CH=CH- ó<EMI FILE="99066263_4" ID="4" IMF=JPEG >a a f son cero o números enteros positivos, con a siendo de cero a 2; b siendo de cero a 4; c y d siendo cero ó 1, con la condición de que c y d no son ambos simultáneamente cero;e es cero a 5, con la condición de que e es distinto de cero cuando d es cero y e es cero a 3 cuando A es igual a -CH=CH-;y f es cero a 3, con la condición de que f no es cero cuando A es oxígeno, azufre o <EMI FILE="99066263_5" ID="5" IMF=JPEG >y sus sales y ésteres farmacéuticamente aceptables.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98119985 | 1998-10-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5150186A1 true CO5150186A1 (es) | 2002-04-29 |
Family
ID=8232838
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO99066263A CO5150186A1 (es) | 1998-10-22 | 1999-10-20 | Derivados de 3-bencil-ureido y 2-guanidino-tiazol y preparaciones farmaceuticas que los contienen |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US6297266B1 (es) |
| EP (1) | EP1123283B1 (es) |
| JP (1) | JP3530137B2 (es) |
| KR (1) | KR100469219B1 (es) |
| CN (1) | CN1211375C (es) |
| AR (1) | AR023058A1 (es) |
| AT (1) | ATE266012T1 (es) |
| AU (1) | AU760219B2 (es) |
| BR (1) | BR9914666A (es) |
| CA (1) | CA2347741C (es) |
| CO (1) | CO5150186A1 (es) |
| CZ (1) | CZ20011395A3 (es) |
| DE (1) | DE69917058T2 (es) |
| DK (1) | DK1123283T3 (es) |
| ES (1) | ES2221482T3 (es) |
| HK (1) | HK1047281A1 (es) |
| HR (1) | HRP20010275A2 (es) |
| HU (1) | HUP0104202A3 (es) |
| ID (1) | ID28356A (es) |
| IL (1) | IL142090A0 (es) |
| MA (1) | MA26756A1 (es) |
| NO (1) | NO20011908L (es) |
| NZ (1) | NZ510676A (es) |
| PE (1) | PE20001116A1 (es) |
| PL (1) | PL347427A1 (es) |
| PT (1) | PT1123283E (es) |
| RU (1) | RU2214404C2 (es) |
| TR (1) | TR200101115T2 (es) |
| WO (1) | WO2000024724A1 (es) |
| YU (1) | YU29201A (es) |
| ZA (1) | ZA200102653B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2391550T3 (es) | 1999-04-15 | 2012-11-27 | Bristol-Myers Squibb Company | Inhibidores cíclicos de la proteína tirosina quinasa |
| US7125875B2 (en) | 1999-04-15 | 2006-10-24 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
| NZ520143A (en) * | 2000-01-19 | 2005-01-28 | Alteon Inc | Thiazole, imidazole and oxazole compounds and treatments of disorders associated with protein aging |
| ATE357444T1 (de) | 2000-08-17 | 2007-04-15 | Lumera Corp | Design und synthese von nlo-materialien für electro-optische anwendungen, die von thiophen abgeleitet sind |
| EP1347971B1 (en) | 2000-12-21 | 2006-03-01 | Bristol-Myers Squibb Company | Thiazolyl inhibitors of tec family tyrosine kinases |
| EA012607B1 (ru) * | 2004-09-20 | 2009-10-30 | 4Сц Аг | НОВЫЕ ГЕТЕРОЦИКЛИЧЕСКИЕ ИНГИБИТОРЫ NF-κB |
| UA103319C2 (en) | 2008-05-06 | 2013-10-10 | Глаксосмитклайн Ллк | Thiazole- and oxazole-benzene sulfonamide compounds |
| WO2010012793A1 (en) * | 2008-08-01 | 2010-02-04 | Bayer Cropscience Sa | Fungicide aminothiazole derivatives |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL95548A0 (en) * | 1989-09-15 | 1991-06-30 | Fujisawa Pharmaceutical Co | Thiazole derivatives,processes for the preparation thereof and pharmaceutical composition containing the same |
| CA2037153A1 (en) * | 1990-03-09 | 1991-09-10 | Leo Alig | Acetic acid derivatives |
| US5273982A (en) | 1990-03-09 | 1993-12-28 | Hoffmann-La Roche Inc. | Acetic acid derivatives |
| US6306840B1 (en) * | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
| JPH0987237A (ja) * | 1995-09-21 | 1997-03-31 | Kyowa Hakko Kogyo Co Ltd | 芳香族誘導体 |
| EP0928793B1 (en) * | 1998-01-02 | 2002-05-15 | F. Hoffmann-La Roche Ag | Thiazole derivatives |
| EP0928790B1 (en) * | 1998-01-02 | 2003-03-05 | F. Hoffmann-La Roche Ag | Thiazole derivatives |
-
1999
- 1999-10-15 CZ CZ20011395A patent/CZ20011395A3/cs unknown
- 1999-10-15 AT AT99970988T patent/ATE266012T1/de not_active IP Right Cessation
- 1999-10-15 DE DE69917058T patent/DE69917058T2/de not_active Expired - Fee Related
- 1999-10-15 TR TR2001/01115T patent/TR200101115T2/xx unknown
- 1999-10-15 DK DK99970988T patent/DK1123283T3/da active
- 1999-10-15 AU AU11519/00A patent/AU760219B2/en not_active Ceased
- 1999-10-15 NZ NZ510676A patent/NZ510676A/xx unknown
- 1999-10-15 PT PT99970988T patent/PT1123283E/pt unknown
- 1999-10-15 ID IDW20010863A patent/ID28356A/id unknown
- 1999-10-15 ES ES99970988T patent/ES2221482T3/es not_active Expired - Lifetime
- 1999-10-15 KR KR10-2001-7004899A patent/KR100469219B1/ko not_active IP Right Cessation
- 1999-10-15 PL PL99347427A patent/PL347427A1/xx not_active Application Discontinuation
- 1999-10-15 CN CNB998124265A patent/CN1211375C/zh not_active Expired - Fee Related
- 1999-10-15 RU RU2001113285/04A patent/RU2214404C2/ru not_active IP Right Cessation
- 1999-10-15 IL IL14209099A patent/IL142090A0/xx unknown
- 1999-10-15 JP JP2000578294A patent/JP3530137B2/ja not_active Expired - Fee Related
- 1999-10-15 EP EP99970988A patent/EP1123283B1/en not_active Expired - Lifetime
- 1999-10-15 HU HU0104202A patent/HUP0104202A3/hu unknown
- 1999-10-15 BR BR9914666-5A patent/BR9914666A/pt not_active IP Right Cessation
- 1999-10-15 WO PCT/EP1999/007824 patent/WO2000024724A1/en active IP Right Grant
- 1999-10-15 CA CA002347741A patent/CA2347741C/en not_active Expired - Fee Related
- 1999-10-15 YU YU29201A patent/YU29201A/sh unknown
- 1999-10-18 PE PE1999001048A patent/PE20001116A1/es not_active Application Discontinuation
- 1999-10-19 US US09/420,387 patent/US6297266B1/en not_active Expired - Fee Related
- 1999-10-20 CO CO99066263A patent/CO5150186A1/es unknown
- 1999-10-20 AR ARP990105306A patent/AR023058A1/es not_active Application Discontinuation
-
2001
- 2001-03-30 ZA ZA200102653A patent/ZA200102653B/en unknown
- 2001-04-12 HR HR20010275A patent/HRP20010275A2/hr not_active Application Discontinuation
- 2001-04-18 NO NO20011908A patent/NO20011908L/no not_active Application Discontinuation
- 2001-04-20 MA MA26171A patent/MA26756A1/fr unknown
-
2002
- 2002-12-09 HK HK02108922.4A patent/HK1047281A1/zh unknown
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