DE60009868T2 - Anti-tumor dihydrochinazolindervate - Google Patents

Anti-tumor dihydrochinazolindervate Download PDF

Info

Publication number
DE60009868T2
DE60009868T2 DE60009868T DE60009868T DE60009868T2 DE 60009868 T2 DE60009868 T2 DE 60009868T2 DE 60009868 T DE60009868 T DE 60009868T DE 60009868 T DE60009868 T DE 60009868T DE 60009868 T2 DE60009868 T2 DE 60009868T2
Authority
DE
Germany
Prior art keywords
dihydrochinazoline
dervate
tumor
formulawhere
membered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60009868T
Other languages
English (en)
Other versions
DE60009868D1 (en
Inventor
Lorraine Skelton
Vassilis Bavetsias
Ann Jackman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cancer Research Technology Ltd
Original Assignee
Cancer Research Technology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Research Technology Ltd filed Critical Cancer Research Technology Ltd
Application granted granted Critical
Publication of DE60009868D1 publication Critical patent/DE60009868D1/de
Publication of DE60009868T2 publication Critical patent/DE60009868T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE60009868T 1999-02-24 2000-02-24 Anti-tumor dihydrochinazolindervate Expired - Fee Related DE60009868T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9904275.6A GB9904275D0 (en) 1999-02-24 1999-02-24 Anti-cancer compounds
PCT/GB2000/000655 WO2000050417A1 (en) 1999-02-24 2000-02-24 Anti-cancer dihydroquinazoline derivatives

Publications (2)

Publication Number Publication Date
DE60009868D1 DE60009868D1 (en) 2004-05-19
DE60009868T2 true DE60009868T2 (de) 2005-04-21

Family

ID=10848434

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60009868T Expired - Fee Related DE60009868T2 (de) 1999-02-24 2000-02-24 Anti-tumor dihydrochinazolindervate

Country Status (11)

Country Link
US (1) US6699861B1 (de)
EP (1) EP1155012B1 (de)
JP (1) JP2002537391A (de)
AT (1) ATE264322T1 (de)
AU (1) AU772670B2 (de)
CA (1) CA2364708A1 (de)
DE (1) DE60009868T2 (de)
DK (1) DK1155012T3 (de)
ES (1) ES2219308T3 (de)
GB (1) GB9904275D0 (de)
WO (1) WO2000050417A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0121214D0 (en) 2001-08-31 2001-10-24 Btg Int Ltd Synthetic method
JP4328202B2 (ja) 2001-08-31 2009-09-09 ビーティージー・インターナショナル・リミテッド 抗癌シクロペンタ［ｇ］キナゾリン化合物
ES2373644T3 (es) 2001-08-31 2012-02-07 Btg International Limited Uso de derivados de ciclopenta[g]quinazolina para el tratamiento del c�?ncer.
CA2459584A1 (en) * 2001-09-05 2003-03-13 Cynthia C. Bamdad Compositions and use thereof in the treatment of cancer
WO2007110868A2 (en) 2006-03-28 2007-10-04 Atir Holding S.A. Heterocyclic compounds and uses thereof in the treatment of sexual disorders
WO2010151711A1 (en) 2009-06-25 2010-12-29 Alkermes, Inc. Prodrugs of nh-acidic compounds
WO2012011939A2 (en) 2010-07-19 2012-01-26 Onyx Pharmaceuticals, Inc. Synthesis of cyclopentaquinazolines
KR20130114653A (ko) * 2010-09-03 2013-10-17 포르마 티엠, 엘엘씨. 암과 같은 질환의 치료를 위한 ｎａｍｐｔ 억제제로서의 4-｛［（피리딘-3-일-메틸）아미노카르보닐］아미노｝벤젠-술폰 유도체
EP2697206B1 (de) 2011-04-10 2019-04-03 Atir Holding S.A. Heterocyclische verbindungen und ihre verwendung bei der behandlung von sexuellen funktionsstörungen
IN2015MN00002A (de) 2012-07-09 2015-10-16 Lupin Ltd
JP7384812B2 (ja) 2018-03-05 2023-11-21 アルカームス ファーマ アイルランド リミテッド アリピプラゾール投与戦略

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2065653B (en) 1979-12-19 1983-03-09 Nat Res Dev Anti-cancer quinazoline derivatives
GB8607683D0 (en) 1986-03-27 1986-04-30 Ici Plc Anti-tumor agents
GB8707053D0 (en) 1987-03-25 1987-04-29 Ici Plc Anti-tumour agents
GB8809978D0 (en) 1988-04-27 1988-06-02 Ici Plc Anti-tumour agents
GB8829296D0 (en) 1988-12-15 1989-01-25 Ici Plc Anti-tumour compounds
AU640016B2 (en) 1990-05-30 1993-08-12 Imperial Chemical Industries Plc Hydroquinazoline derivatives
GB9105771D0 (en) 1991-03-19 1991-05-01 Cancer Res Inst Royal Anti-cancer compounds
GB9205320D0 (en) 1992-03-11 1992-04-22 Ici Plc Anti-tumour compounds
GB9220571D0 (en) 1992-09-30 1992-11-11 Ici Plc Quinazoline derivatives
GB9223352D0 (en) 1992-11-06 1992-12-23 Ici Plc Tricyclic compounds

Also Published As

Publication number Publication date
ATE264322T1 (de) 2004-04-15
DK1155012T3 (da) 2004-08-09
AU772670B2 (en) 2004-05-06
AU2683800A (en) 2000-09-14
EP1155012A1 (de) 2001-11-21
GB9904275D0 (en) 1999-04-21
WO2000050417A1 (en) 2000-08-31
JP2002537391A (ja) 2002-11-05
DE60009868D1 (en) 2004-05-19
CA2364708A1 (en) 2000-08-31
EP1155012B1 (de) 2004-04-14
US6699861B1 (en) 2004-03-02
ES2219308T3 (es) 2004-12-01

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Legal Events

Date Code Title Description
8332 No legal effect for de
8370 Indication related to discontinuation of the patent is to be deleted
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee