HUP9802290A2 - Pirrolszármazékok és az azokat tartalmazó gyógyászati kompozíciók - Google Patents

Pirrolszármazékok és az azokat tartalmazó gyógyászati kompozíciók

Info

Publication number
HUP9802290A2
HUP9802290A2 HU9802290A HUP9802290A HUP9802290A2 HU P9802290 A2 HUP9802290 A2 HU P9802290A2 HU 9802290 A HU9802290 A HU 9802290A HU P9802290 A HUP9802290 A HU P9802290A HU P9802290 A2 HUP9802290 A2 HU P9802290A2
Authority
HU
Hungary
Prior art keywords
optionally
substituted
amino
powder
hydrogen atom
Prior art date
Application number
HU9802290A
Other languages
English (en)
Inventor
Ayatsugu Nakamura
Mitsushi Tanaka
Masami Tsuda
Original Assignee
Nippon Shinyaku Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co., Ltd. filed Critical Nippon Shinyaku Co., Ltd.
Publication of HUP9802290A2 publication Critical patent/HUP9802290A2/hu
Publication of HUP9802290A3 publication Critical patent/HUP9802290A3/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/50—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

A találmány tárgya az (I) általánős képletű pirrőlszármazékőkat, vagyazők gyógyászatilag elfőgadható sóit, vagy azők szőlvátjait tartalmazógyógyászati készítmények, ahől az alábbi képletben R1 jelentésehidrőgénatőm, vagy alkőxi-karbőnil-aminő-csőpőrt; R2 jelentése alkil-,adőtt esetben szűbsztitűált arilcsőpőrt, adőtt esetben szűbsztitűáltarőmás heterőciklűs, szűbsztitűálatlan aminőcsőpőrt, adőtt esetbenszűbsztitűált mőnő-alkil-aminő-, dialkil-aminő- vagy ciklikűsaminőcsőpőrt, R3 cianő vagy karbamőilcsőpőrt; R4 hidrőgénatőmőt vagyalkilcsőpőrtőt jelent; E jelentése alkiléncsőpőrt; q jelentése 0 vagy1; A jelentése pedig metil-, szűbsztitűált aril- vagy szűbsztitűáltheterőciklűsős csőpőrt. A találmány szerinti gyógyászati készítményeka pőllakiűria és űrinális inkőntinencia kezelésében hatékőnyak. (I) ŕ
HU9802290A 1995-06-07 1996-06-06 Pyrrole derivatives and pharmaceutical compositions containing them HUP9802290A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14069895 1995-06-07

Publications (2)

Publication Number Publication Date
HUP9802290A2 true HUP9802290A2 (hu) 1999-10-28
HUP9802290A3 HUP9802290A3 (en) 2002-02-28

Family

ID=15274666

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9802290A HUP9802290A3 (en) 1995-06-07 1996-06-06 Pyrrole derivatives and pharmaceutical compositions containing them

Country Status (20)

Country Link
US (2) US5998459A (hu)
EP (1) EP0842923B1 (hu)
JP (1) JP3160910B2 (hu)
KR (1) KR100275222B1 (hu)
CN (2) CN1090617C (hu)
AT (1) ATE318799T1 (hu)
AU (1) AU710683B2 (hu)
BR (1) BR9608502A (hu)
CA (1) CA2223918C (hu)
DE (1) DE69635857T2 (hu)
DK (1) DK0842923T3 (hu)
ES (1) ES2259795T3 (hu)
HU (1) HUP9802290A3 (hu)
MX (1) MX9709475A (hu)
NO (1) NO321606B1 (hu)
NZ (1) NZ309151A (hu)
PT (1) PT842923E (hu)
RU (1) RU2166941C2 (hu)
TW (1) TW504503B (hu)
WO (1) WO1996040634A1 (hu)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2166941C2 (ru) * 1995-06-07 2001-05-20 Ниппон Синяку Ко., Лтд. Производные пиррола и фармацевтическая композиция на их основе
HUP9902645A3 (en) * 1996-03-18 1999-12-28 Eisai Co Ltd Fused-ring carboxylic acid derivatives
CA2316853A1 (en) * 1998-01-14 1999-07-22 Ayatsugu Nakamura Potassium channel activators
WO1999061016A1 (en) * 1998-05-27 1999-12-02 Nippon Shinyaku Co., Ltd. Cyclooxygenase-2 inhibitors
EP1283040A4 (en) * 2000-03-21 2008-05-14 Nippon Shinyaku Co Ltd ORAL PREPARATIONS WITH PROLONGED RELEASE
CA2415815A1 (en) * 2000-07-06 2002-01-17 Nigel H. Greig Tetrahydrobenzothiazole analogues as neuroprotective agents
TWI239952B (en) * 2001-03-14 2005-09-21 Nippon Shinyaku Co Ltd Stable crystals of pyrrole compound
HUP0303829A3 (en) * 2001-04-16 2006-02-28 Tanabe Seiyaku Co Large conductance calcium-acitvated k channel opener compounds, use thereof and pharmaceutical compositions containing them
TWI271402B (en) 2002-10-15 2007-01-21 Tanabe Seiyaku Co Large conductance calcium-activated K channel opener
JP4808154B2 (ja) * 2003-03-13 2011-11-02 バーテックス ファーマシューティカルズ インコーポレイテッド プロテインキナーゼインヒビターとして有用な組成物
US20050075359A1 (en) * 2003-03-14 2005-04-07 Rikako Kono Large conductance calcium-activated K channel opener
GB0321509D0 (en) * 2003-09-13 2003-10-15 Astrazeneca Ab Chemical compounds
WO2005037271A2 (en) * 2003-10-17 2005-04-28 Tanabe Seiyaku Co., Ltd. Large conductance calcium-activated k channel opener
US7118801B2 (en) * 2003-11-10 2006-10-10 Gore Enterprise Holdings, Inc. Aerogel/PTFE composite insulating material
ITTO20040125A1 (it) * 2004-03-01 2004-06-01 Rotta Research Lab Nuove amidine eterocicliche inibitrici la produzione di ossido d'azoto (no) ad attivita' antinfiammatoria ed analgesica
JP2005325103A (ja) * 2004-04-13 2005-11-24 Tanabe Seiyaku Co Ltd 医薬組成物
WO2006130493A2 (en) * 2005-05-31 2006-12-07 Vertex Pharmaceuticals Incorporated Heterocycles useful as modulators of ion channels
PE20070341A1 (es) * 2005-07-29 2007-04-13 Wyeth Corp Derivados de pirrol como moduladores del receptor de progesterona
PE20070404A1 (es) * 2005-07-29 2007-05-10 Wyeth Corp Compuestos derivados de cianopirrol-sulfonamida como moduladores del receptor de progesterona
EP2280948A1 (en) 2008-04-09 2011-02-09 Mitsubishi Tanabe Pharma Corporation Pyrimidine, pyridine and triazine derivatives as maxi-k channel openers.
US9994559B2 (en) 2014-12-17 2018-06-12 King's College London Bicycloheteroaryl-heteroaryl-benzoic acid compounds as retinoic acid receptor beta (RARβ) agonists
GB201610867D0 (en) 2016-06-22 2016-08-03 King's College London Crystalline forms of a therapeutic compound and processes for their preparation

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DD143426A1 (de) * 1979-05-07 1980-08-20 Karl Gewald Verfahren zur herstellung von 5,6-kondensierten 4-amino-3-cyan-pyridonen-(2)
US4431823A (en) * 1981-07-23 1984-02-14 Hoffmann-La Roche Inc. 1H-Pyrrole-3-carbonitrile-4(2-benzoyl)phenyl derivatives as intermediates for pyrrolo[3,4-D][2]benzazepines
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Also Published As

Publication number Publication date
TW504503B (en) 2002-10-01
WO1996040634A1 (fr) 1996-12-19
ES2259795T3 (es) 2006-10-16
US5998459A (en) 1999-12-07
JP3160910B2 (ja) 2001-04-25
KR19990022329A (ko) 1999-03-25
NO975666L (no) 1998-02-09
HUP9802290A3 (en) 2002-02-28
CA2223918C (en) 2006-01-10
NO975666D0 (no) 1997-12-05
CA2223918A1 (en) 1996-12-19
CN1349796A (zh) 2002-05-22
DE69635857D1 (de) 2006-04-27
NO321606B1 (no) 2006-06-12
CN1186485A (zh) 1998-07-01
AU710683B2 (en) 1999-09-30
US6172102B1 (en) 2001-01-09
PT842923E (pt) 2006-07-31
EP0842923B1 (en) 2006-03-01
CN1090617C (zh) 2002-09-11
EP0842923A1 (en) 1998-05-20
EP0842923A4 (en) 1999-12-29
DE69635857T2 (de) 2006-10-19
RU2166941C2 (ru) 2001-05-20
DK0842923T3 (da) 2006-06-19
BR9608502A (pt) 1999-07-06
NZ309151A (en) 2000-01-28
KR100275222B1 (ko) 2001-02-01
AU5910996A (en) 1996-12-30
MX9709475A (es) 1998-02-28
ATE318799T1 (de) 2006-03-15

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