DE69505968D1 - Azolidindion-derivate und ihre anwendung als antihyperglykämika - Google Patents
Azolidindion-derivate und ihre anwendung als antihyperglykämikaInfo
- Publication number
- DE69505968D1 DE69505968D1 DE69505968T DE69505968T DE69505968D1 DE 69505968 D1 DE69505968 D1 DE 69505968D1 DE 69505968 T DE69505968 T DE 69505968T DE 69505968 T DE69505968 T DE 69505968T DE 69505968 D1 DE69505968 D1 DE 69505968D1
- Authority
- DE
- Germany
- Prior art keywords
- image
- hyperglycemas
- azolidindion
- derivatives
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/44—Two oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/245,734 US5468762A (en) | 1994-05-18 | 1994-05-18 | Azolidinediones as antihyperglycemic agents |
| PCT/US1995/004631 WO1995031454A1 (en) | 1994-05-18 | 1995-04-13 | New azolidinediones as antihyperglycemic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69505968D1 true DE69505968D1 (de) | 1998-12-17 |
| DE69505968T2 DE69505968T2 (de) | 1999-05-12 |
Family
ID=22927868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69505968T Expired - Fee Related DE69505968T2 (de) | 1994-05-18 | 1995-04-13 | Azolidindion-derivate und ihre anwendung als antihyperglykämika |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US5468762A (de) |
| EP (1) | EP0759919B1 (de) |
| JP (1) | JPH10500133A (de) |
| KR (1) | KR970703340A (de) |
| CN (1) | CN1152312A (de) |
| AT (1) | ATE173256T1 (de) |
| AU (1) | AU684357B2 (de) |
| CA (1) | CA2190015A1 (de) |
| DE (1) | DE69505968T2 (de) |
| DK (1) | DK0759919T3 (de) |
| ES (1) | ES2124545T3 (de) |
| GR (1) | GR3029355T3 (de) |
| HU (1) | HUT76823A (de) |
| NZ (1) | NZ284654A (de) |
| TW (1) | TW328089B (de) |
| WO (1) | WO1995031454A1 (de) |
| ZA (1) | ZA953981B (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5728720A (en) * | 1993-12-27 | 1998-03-17 | Japan Tobacco Inc. | Isoxazolidinedione compounds and use thereof |
| ATE235476T1 (de) * | 1994-08-10 | 2003-04-15 | Takeda Chemical Industries Ltd | Thiazolidindione derivate, ihre herstellung und verwendung |
| TW403748B (en) * | 1994-11-02 | 2000-09-01 | Takeda Chemical Industries Ltd | An oxazolidinedione derivative, its production and a pharmaceutical composition for lowering blood sugar and lipid in blood comprising the same |
| CA2171702A1 (en) * | 1995-03-14 | 1996-09-15 | Takashi Sohda | Benzofuran compounds and their use |
| US5925656A (en) * | 1995-04-10 | 1999-07-20 | Dr. Reddy's Research Foundation | Compounds having antidiabetic, hypolipidemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| ZA973850B (en) * | 1996-05-06 | 1997-12-02 | Reddy Research Foundation | Novel antidiabetic compounds having hypolipidaemic, anti-hypertensive properties, process for their preparation and pharmaceutical compositions containing them. |
| US5919782A (en) * | 1996-05-06 | 1999-07-06 | Dr. Reddy's Research Foundation | Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| US5801173A (en) * | 1996-05-06 | 1998-09-01 | Dr. Reddy's Research Foundation | Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| US5889032A (en) * | 1996-05-06 | 1999-03-30 | Dr. Reddy's Research Foundation | Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| US6372750B2 (en) * | 1996-07-01 | 2002-04-16 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases |
| US6114526A (en) * | 1996-07-01 | 2000-09-05 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
| USRE39266E1 (en) * | 1996-07-01 | 2006-09-05 | Dr. Reddy's Laboratories, Limited | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
| CA2258949C (en) | 1996-07-01 | 2008-05-06 | Dr. Reddy's Research Foundation | Novel heterocyclic compounds process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
| US6011036A (en) * | 1997-04-15 | 2000-01-04 | Dr. Reddy's Research Foundation | Heterocyclic compounds having antidiabetic hypolipidemic antihypertensive properties process for their preparation and pharmaceutical compositions containing them |
| US6011031A (en) * | 1997-05-30 | 2000-01-04 | Dr. Reddy's Research Foundation | Azolidinediones useful for the treatment of diabetes, dyslipidemia and hypertension: process for their preparation and pharmaceutical compositions containing them |
| AU6331199A (en) * | 1998-09-30 | 2000-04-17 | Roche Diagnostics Gmbh | Oxazolidine derivatives for the treatment and prevention of metabolic bone disorders |
| US6756360B1 (en) | 1998-12-24 | 2004-06-29 | Metabasis Therapeutics, Inc. | Combination of FBPase inhibitors and insulin sensitizers for the treatment of diabetes |
| AU6875800A (en) * | 1999-09-10 | 2001-04-17 | Takeda Chemical Industries Ltd. | Heterocyclic compounds and process for the preparation thereof |
| WO2001047935A2 (en) * | 1999-12-22 | 2001-07-05 | Metabasis Therapeutics, Inc. | Novel bisamidate phosphonate prodrugs |
| US7563774B2 (en) * | 2000-06-29 | 2009-07-21 | Metabasis Therapeutics, Inc. | Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes |
| EP1442028A4 (de) * | 2001-11-06 | 2009-11-04 | Bristol Myers Squibb Co | Substituierte säurederivate, die sich als antidiabetika und mittel gegen obesitas eignen, und verfahren |
| US7148246B2 (en) * | 2003-02-27 | 2006-12-12 | Sanofi-Aventis Deutschland Gmbh | Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals |
| US7351726B2 (en) * | 2003-09-25 | 2008-04-01 | Wyeth | Substituted oxadiazolidinediones |
| US7141592B2 (en) * | 2003-09-25 | 2006-11-28 | Wyeth | Substituted oxadiazolidinediones |
| CN101005847A (zh) * | 2004-08-18 | 2007-07-25 | 症变治疗公司 | 果糖1,6－双磷酸酶的新颖噻唑类抑制剂 |
| AU2013340478B2 (en) | 2012-11-05 | 2018-08-23 | Commissariat A L'energie Atomique Et Aux Energies Alternatives (Cea) | Combination of an anti-cancer agent such as a tyrosinekinase inhibitor and a STAT5 antagonist, preferably a thiazolidinedione, for eliminating hematologic cancer stem cells in vivo and for preventing hematologic cancer relapse |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1003445B (zh) * | 1984-10-03 | 1989-03-01 | 武田药品工业株式会社 | 噻唑烷二酮衍生物，其制备方法和用途 |
| WO1991007107A1 (en) * | 1989-11-13 | 1991-05-30 | Pfizer Inc. | Oxazolidinedione hypoglycemic agents |
| US5334604A (en) * | 1990-08-23 | 1994-08-02 | Pfizer Inc. | Hypoglycemic hydroxyurea derivatives |
| FR2673427B1 (fr) * | 1991-03-01 | 1993-06-18 | Sanofi Elf | Derives heterocycliques diazotes n-substitues par un groupement biphenylmethyle, leur preparation, les compositions pharmaceutiques en contenant. |
| TW268952B (de) * | 1993-02-26 | 1996-01-21 | Takeda Pharm Industry Co Ltd |
-
1994
- 1994-05-18 US US08/245,734 patent/US5468762A/en not_active Expired - Lifetime
-
1995
- 1995-04-13 ES ES95916989T patent/ES2124545T3/es not_active Expired - Lifetime
- 1995-04-13 US US08/421,111 patent/US5510360A/en not_active Expired - Lifetime
- 1995-04-13 DK DK95916989T patent/DK0759919T3/da active
- 1995-04-13 DE DE69505968T patent/DE69505968T2/de not_active Expired - Fee Related
- 1995-04-13 KR KR1019960706490A patent/KR970703340A/ko not_active Application Discontinuation
- 1995-04-13 AT AT95916989T patent/ATE173256T1/de not_active IP Right Cessation
- 1995-04-13 NZ NZ284654A patent/NZ284654A/xx unknown
- 1995-04-13 AU AU23842/95A patent/AU684357B2/en not_active Ceased
- 1995-04-13 EP EP95916989A patent/EP0759919B1/de not_active Expired - Lifetime
- 1995-04-13 JP JP7529644A patent/JPH10500133A/ja active Pending
- 1995-04-13 CA CA002190015A patent/CA2190015A1/en not_active Abandoned
- 1995-04-13 CN CN95194037A patent/CN1152312A/zh active Pending
- 1995-04-13 WO PCT/US1995/004631 patent/WO1995031454A1/en active IP Right Grant
- 1995-04-13 HU HU9603185A patent/HUT76823A/hu unknown
- 1995-04-28 TW TW084104226A patent/TW328089B/zh active
- 1995-05-16 ZA ZA953981A patent/ZA953981B/xx unknown
-
1999
- 1999-02-10 GR GR990400442T patent/GR3029355T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0759919B1 (de) | 1998-11-11 |
| DK0759919T3 (da) | 1999-07-26 |
| AU2384295A (en) | 1995-12-05 |
| EP0759919A1 (de) | 1997-03-05 |
| HUT76823A (en) | 1997-11-28 |
| NZ284654A (en) | 1998-12-23 |
| CN1152312A (zh) | 1997-06-18 |
| US5468762A (en) | 1995-11-21 |
| ATE173256T1 (de) | 1998-11-15 |
| KR970703340A (ko) | 1997-07-03 |
| JPH10500133A (ja) | 1998-01-06 |
| ZA953981B (en) | 1996-11-18 |
| ES2124545T3 (es) | 1999-02-01 |
| WO1995031454A1 (en) | 1995-11-23 |
| HU9603185D0 (en) | 1997-01-28 |
| GR3029355T3 (en) | 1999-05-28 |
| TW328089B (en) | 1998-03-11 |
| DE69505968T2 (de) | 1999-05-12 |
| CA2190015A1 (en) | 1995-11-23 |
| AU684357B2 (en) | 1997-12-11 |
| US5510360A (en) | 1996-04-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |