ATE173256T1 - Azolidindion-derivate und ihre anwendung als antihyperglykämika - Google Patents
Azolidindion-derivate und ihre anwendung als antihyperglykämikaInfo
- Publication number
- ATE173256T1 ATE173256T1 AT95916989T AT95916989T ATE173256T1 AT E173256 T1 ATE173256 T1 AT E173256T1 AT 95916989 T AT95916989 T AT 95916989T AT 95916989 T AT95916989 T AT 95916989T AT E173256 T1 ATE173256 T1 AT E173256T1
- Authority
- AT
- Austria
- Prior art keywords
- image
- azolidindone
- antihyperglycemics
- derivatives
- alkyl
- Prior art date
Links
- 239000003472 antidiabetic agent Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 1
- 230000002058 anti-hyperglycaemic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/44—Two oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Indole Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Photoreceptors In Electrophotography (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/245,734 US5468762A (en) | 1994-05-18 | 1994-05-18 | Azolidinediones as antihyperglycemic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE173256T1 true ATE173256T1 (de) | 1998-11-15 |
Family
ID=22927868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95916989T ATE173256T1 (de) | 1994-05-18 | 1995-04-13 | Azolidindion-derivate und ihre anwendung als antihyperglykämika |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US5468762A (de) |
| EP (1) | EP0759919B1 (de) |
| JP (1) | JPH10500133A (de) |
| KR (1) | KR970703340A (de) |
| CN (1) | CN1152312A (de) |
| AT (1) | ATE173256T1 (de) |
| AU (1) | AU684357B2 (de) |
| CA (1) | CA2190015A1 (de) |
| DE (1) | DE69505968T2 (de) |
| DK (1) | DK0759919T3 (de) |
| ES (1) | ES2124545T3 (de) |
| GR (1) | GR3029355T3 (de) |
| HU (1) | HUT76823A (de) |
| NZ (1) | NZ284654A (de) |
| TW (1) | TW328089B (de) |
| WO (1) | WO1995031454A1 (de) |
| ZA (1) | ZA953981B (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE179709T1 (de) * | 1993-12-27 | 1999-05-15 | Japan Tobacco Inc | Isoxazolidindionderivate und deren verwendung |
| WO1996005186A1 (en) * | 1994-08-10 | 1996-02-22 | Takeda Chemical Industries, Ltd. | Thiazolidinedione derivatives, their production and use |
| TW403748B (en) * | 1994-11-02 | 2000-09-01 | Takeda Chemical Industries Ltd | An oxazolidinedione derivative, its production and a pharmaceutical composition for lowering blood sugar and lipid in blood comprising the same |
| CA2171702A1 (en) * | 1995-03-14 | 1996-09-15 | Takashi Sohda | Benzofuran compounds and their use |
| US5925656A (en) * | 1995-04-10 | 1999-07-20 | Dr. Reddy's Research Foundation | Compounds having antidiabetic, hypolipidemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| US5801173A (en) * | 1996-05-06 | 1998-09-01 | Dr. Reddy's Research Foundation | Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| US5919782A (en) * | 1996-05-06 | 1999-07-06 | Dr. Reddy's Research Foundation | Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| US5889032A (en) * | 1996-05-06 | 1999-03-30 | Dr. Reddy's Research Foundation | Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them |
| ZA973850B (en) * | 1996-05-06 | 1997-12-02 | Reddy Research Foundation | Novel antidiabetic compounds having hypolipidaemic, anti-hypertensive properties, process for their preparation and pharmaceutical compositions containing them. |
| USRE39266E1 (en) * | 1996-07-01 | 2006-09-05 | Dr. Reddy's Laboratories, Limited | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
| US6114526A (en) * | 1996-07-01 | 2000-09-05 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
| US6372750B2 (en) * | 1996-07-01 | 2002-04-16 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases |
| KR100579765B1 (ko) | 1996-07-01 | 2006-12-28 | 닥터 레디스 레보러터리즈 리미티드 | 신규헤테로고리형화합물의제조방법,이를함유하는약제조성물및당뇨병및이와관련된질병의치료에있어서그의용도 |
| US6011036A (en) * | 1997-04-15 | 2000-01-04 | Dr. Reddy's Research Foundation | Heterocyclic compounds having antidiabetic hypolipidemic antihypertensive properties process for their preparation and pharmaceutical compositions containing them |
| US6011031A (en) * | 1997-05-30 | 2000-01-04 | Dr. Reddy's Research Foundation | Azolidinediones useful for the treatment of diabetes, dyslipidemia and hypertension: process for their preparation and pharmaceutical compositions containing them |
| AU6331199A (en) * | 1998-09-30 | 2000-04-17 | Roche Diagnostics Gmbh | Oxazolidine derivatives for the treatment and prevention of metabolic bone disorders |
| US6756360B1 (en) * | 1998-12-24 | 2004-06-29 | Metabasis Therapeutics, Inc. | Combination of FBPase inhibitors and insulin sensitizers for the treatment of diabetes |
| AU6875800A (en) * | 1999-09-10 | 2001-04-17 | Takeda Chemical Industries Ltd. | Heterocyclic compounds and process for the preparation thereof |
| PL356525A1 (en) * | 1999-12-22 | 2004-06-28 | Metabasis Therapeutics, Inc. | Novel bisamidate phosphonate prodrugs |
| US7563774B2 (en) * | 2000-06-29 | 2009-07-21 | Metabasis Therapeutics, Inc. | Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes |
| WO2003040114A1 (en) * | 2001-11-06 | 2003-05-15 | Bristol-Myers Squibb Company | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method |
| US7148246B2 (en) * | 2003-02-27 | 2006-12-12 | Sanofi-Aventis Deutschland Gmbh | Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals |
| US7351726B2 (en) * | 2003-09-25 | 2008-04-01 | Wyeth | Substituted oxadiazolidinediones |
| US7141592B2 (en) * | 2003-09-25 | 2006-11-28 | Wyeth | Substituted oxadiazolidinediones |
| RU2007102288A (ru) * | 2004-08-18 | 2008-09-27 | Мебабазис Терапеутикс, Инк. (Us) | Новые тиазольные ингибиторы фруктозо-1,6-бисфосфатазы |
| WO2014068397A1 (en) | 2012-11-05 | 2014-05-08 | Commissariat A L'energie Atomique Et Aux Energies Atlternatives (Cea) | Combination of an anti-cancer agent such as a tyrosinekinase inhibitor and a stat5 antagonist, preferably a thiazolidinedione, for eliminating hematologic cancer stem cells in vivo and for preventing hematologic cancer relapse |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1003445B (zh) * | 1984-10-03 | 1989-03-01 | 武田药品工业株式会社 | 噻唑烷二酮衍生物，其制备方法和用途 |
| WO1991007107A1 (en) * | 1989-11-13 | 1991-05-30 | Pfizer Inc. | Oxazolidinedione hypoglycemic agents |
| EP0544696B1 (de) * | 1990-08-23 | 1995-01-11 | Pfizer Inc. | Hypoglykämische hydroxyharnstoffderivate |
| FR2673427B1 (fr) * | 1991-03-01 | 1993-06-18 | Sanofi Elf | Derives heterocycliques diazotes n-substitues par un groupement biphenylmethyle, leur preparation, les compositions pharmaceutiques en contenant. |
| TW268952B (de) * | 1993-02-26 | 1996-01-21 | Takeda Pharm Industry Co Ltd |
-
1994
- 1994-05-18 US US08/245,734 patent/US5468762A/en not_active Expired - Lifetime
-
1995
- 1995-04-13 WO PCT/US1995/004631 patent/WO1995031454A1/en not_active Ceased
- 1995-04-13 US US08/421,111 patent/US5510360A/en not_active Expired - Lifetime
- 1995-04-13 AU AU23842/95A patent/AU684357B2/en not_active Ceased
- 1995-04-13 AT AT95916989T patent/ATE173256T1/de not_active IP Right Cessation
- 1995-04-13 JP JP7529644A patent/JPH10500133A/ja active Pending
- 1995-04-13 ES ES95916989T patent/ES2124545T3/es not_active Expired - Lifetime
- 1995-04-13 CA CA002190015A patent/CA2190015A1/en not_active Abandoned
- 1995-04-13 DK DK95916989T patent/DK0759919T3/da active
- 1995-04-13 EP EP95916989A patent/EP0759919B1/de not_active Expired - Lifetime
- 1995-04-13 CN CN95194037A patent/CN1152312A/zh active Pending
- 1995-04-13 HU HU9603185A patent/HUT76823A/hu unknown
- 1995-04-13 NZ NZ284654A patent/NZ284654A/xx unknown
- 1995-04-13 DE DE69505968T patent/DE69505968T2/de not_active Expired - Fee Related
- 1995-04-13 KR KR1019960706490A patent/KR970703340A/ko not_active Withdrawn
- 1995-04-28 TW TW084104226A patent/TW328089B/zh active
- 1995-05-16 ZA ZA953981A patent/ZA953981B/xx unknown
-
1999
- 1999-02-10 GR GR990400442T patent/GR3029355T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69505968D1 (de) | 1998-12-17 |
| HUT76823A (en) | 1997-11-28 |
| GR3029355T3 (en) | 1999-05-28 |
| DE69505968T2 (de) | 1999-05-12 |
| NZ284654A (en) | 1998-12-23 |
| ES2124545T3 (es) | 1999-02-01 |
| US5468762A (en) | 1995-11-21 |
| AU2384295A (en) | 1995-12-05 |
| TW328089B (en) | 1998-03-11 |
| CA2190015A1 (en) | 1995-11-23 |
| AU684357B2 (en) | 1997-12-11 |
| ZA953981B (en) | 1996-11-18 |
| HU9603185D0 (en) | 1997-01-28 |
| EP0759919A1 (de) | 1997-03-05 |
| KR970703340A (ko) | 1997-07-03 |
| DK0759919T3 (da) | 1999-07-26 |
| WO1995031454A1 (en) | 1995-11-23 |
| US5510360A (en) | 1996-04-23 |
| EP0759919B1 (de) | 1998-11-11 |
| JPH10500133A (ja) | 1998-01-06 |
| CN1152312A (zh) | 1997-06-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE173256T1 (de) | Azolidindion-derivate und ihre anwendung als antihyperglykämika | |
| DE69331843D1 (de) | Xanthine-Derivate als Antidepressiva | |
| KR950701911A (ko) | 피페리딘 유도체를 유효성분으로 하는 말초혈관확장제(peripheral vaso-dilating agent containing piperidine derivative as active ingredient) | |
| NO953305D0 (no) | Antranilsyrederivat | |
| DK0590919T3 (da) | Terapeutiske midler mod Parkinsons sygdom | |
| DK0863136T3 (da) | Azetidin- og pyrrolidinderivater | |
| MX9702670A (es) | Derivado de azol. | |
| ATE175661T1 (de) | Benzamid-derivate als vasopressin-antagonisten | |
| CA2103590A1 (en) | Benzamide derivative | |
| CA2321188A1 (en) | Derivatives of azetidine and pyrrolidine | |
| KR960007592A (ko) | 신규한 피롤로카바졸 | |
| DE69222459D1 (de) | Thiazolidindionderivate, ihre Herstellung und Anwendung | |
| ES2191341T3 (es) | Derivados de la 2-fenoxianilina. | |
| ATE118770T1 (de) | Thiazolidinone und oxazolidenonederivate, ihre herstellung und ihre anwendung als vasodilatatoren. | |
| DE69512208D1 (de) | Aminosäurederivate und ihre verwendung als phospholipase-a2-inhibitoren | |
| DK0420224T3 (da) | Anthihepatopatisk middel | |
| ATE163649T1 (de) | Peptide, herstellung und deren verwendung | |
| ATE144900T1 (de) | Verwendung von xanthinderivaten gegen magengeschwüre | |
| ECSP951498A (es) | Nuevos derivados de pirrocarbazol case ran 4121/15 | |
| TW360630B (en) | A secoaporphine compounds on arrhythmia | |
| ATE44741T1 (de) | 2-(n-substituierte guanidino)-4heteroarylthiazole als mittel gegen geschwuere. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |