HUP0204149A2 - Új szulfoniloxazolamin-származékok, ezeket tartalmazó gyógyszerkészítmények és eljárás a vegyületek előállítására - Google Patents
Új szulfoniloxazolamin-származékok, ezeket tartalmazó gyógyszerkészítmények és eljárás a vegyületek előállításáraInfo
- Publication number
- HUP0204149A2 HUP0204149A2 HU0204149A HUP0204149A HUP0204149A2 HU P0204149 A2 HUP0204149 A2 HU P0204149A2 HU 0204149 A HU0204149 A HU 0204149A HU P0204149 A HUP0204149 A HU P0204149A HU P0204149 A2 HUP0204149 A2 HU P0204149A2
- Authority
- HU
- Hungary
- Prior art keywords
- compounds
- preparation
- general formula
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
- -1 sulfonyl oxazole amine Chemical class 0.000 title abstract 10
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 125000004434 sulfur atom Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Surgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
A találmány az (I) általános képletű vegyületekre, valamintgyógyászatilag elfogadható sóikra és szolvátjaikra vonatkozik. Az (I)általános képletben R1 és R2 egymástól függetlenül hidrogénatomot, -R6, cikloalkil-, -(CH2)n-R7, -(CH2)n-O-R6, -(CH2)n-NH2, -(CH2)n-NHR6,-(CH2)n-N(R6)2 vagy alkenilcsoportot jelent, vagy pedig R1 és R2együtt egygyűrűs heterociklusos csoportot alkot, mely heterociklusoscsoport egy vagy kettő nitrogén-, oxigén- és/vagy kénatomot tartalmaz;R3 és R4 egymástól függetlenül hidrogén- vagy halogénatomot, vagy -R6,trifluormetil-, nitro-, hidroxi-, -O-R6, amino-, -NH-R6 vagy -N(R6)2csoportot jelent, R5 jelentése 5- vagy 6-tagú, telített vagytelítetlen heterociklusos csoport, amely egy vagy kettő nitrogén-,oxigén- és/vagy kénatomot tartalmaz, továbbá adott esetben mono- vagydiszubsztituált lehet halogénatommal vagy -R6, trifluormetil-, nitro-,hidroxi-, -O-R6, amino-, -NH-R6 vagy -N(R6)2 csoporttal; R6 jelentésealkilcsoport; R7 jelentése R3 és/vagy R4 helyettesítőkkelszubsztituált fenilcsoport; n értéke 0, 1 vagy 2. A találmány továbbáaz (1) általános képletű vegyületeknek gyógyászati készítményekelőállítására történő alkalmazására vonatkozik. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19956791A DE19956791A1 (de) | 1999-11-25 | 1999-11-25 | Neue Sulfonyloxazolamine |
| PCT/EP2000/011734 WO2001038316A2 (de) | 1999-11-25 | 2000-11-24 | Sulfonyloxazolamine und deren verwendung als 5-ht6 rezeptorliganden |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0204149A2 true HUP0204149A2 (hu) | 2003-04-28 |
| HUP0204149A3 HUP0204149A3 (en) | 2005-04-28 |
Family
ID=7930321
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0204149A HUP0204149A3 (en) | 1999-11-25 | 2000-11-24 | New sulfonyl oxazole amine derivatives, pharmaceutical compositions containing them and process for preparation the compounds |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6737426B1 (hu) |
| EP (1) | EP1233963A2 (hu) |
| JP (1) | JP2003514902A (hu) |
| KR (1) | KR20020058020A (hu) |
| CN (1) | CN1423649A (hu) |
| AR (1) | AR026589A1 (hu) |
| AU (1) | AU3004201A (hu) |
| BR (1) | BR0015814A (hu) |
| CA (1) | CA2389679A1 (hu) |
| CZ (1) | CZ20021687A3 (hu) |
| DE (1) | DE19956791A1 (hu) |
| HU (1) | HUP0204149A3 (hu) |
| MX (1) | MXPA02005092A (hu) |
| NO (1) | NO20022455D0 (hu) |
| PL (1) | PL355152A1 (hu) |
| SK (1) | SK6942002A3 (hu) |
| WO (1) | WO2001038316A2 (hu) |
| ZA (1) | ZA200203365B (hu) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10129940A1 (de) * | 2001-06-13 | 2002-12-19 | Merck Patent Gmbh | Sulfonyloxazolamine als therapeutische Wirkstoffe |
| WO2008061248A2 (en) * | 2006-11-16 | 2008-05-22 | The Regents Of The University Of California | Phenylsulfoxyoxazole compound inhibitors of urea transporters |
| ATE499099T1 (de) * | 2007-07-19 | 2011-03-15 | Esteve Labor Dr | Substituierte tetrahydro- chinolinsulfonamidverbindungen, ihre herstellung und ihre verwendung als medikamente |
| RU2443697C1 (ru) | 2010-12-21 | 2012-02-27 | Александр Васильевич Иващенко | Замещенные метил-амины, антагонисты серотониновых 5-ht6 рецепторов, способы получения и применения |
| KR102533605B1 (ko) * | 2018-01-10 | 2023-05-17 | 주식회사 라이조테크 | 신규한 페닐설포닐 옥사졸 유도체 및 이의 용도 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0930302B1 (en) | 1998-01-16 | 2003-04-02 | F.Hoffmann-La Roche Ag | Benzosulfone derivatives |
| US6194410B1 (en) | 1998-03-11 | 2001-02-27 | Hoffman-La Roche Inc. | Pyrazolopyrimidine and pyrazolines and process for preparation thereof |
| DE19858593A1 (de) * | 1998-12-18 | 2000-06-21 | Merck Patent Gmbh | Sulfonyloxazolamine als therapeutische Wirkstoffe |
-
1999
- 1999-11-25 DE DE19956791A patent/DE19956791A1/de not_active Withdrawn
-
2000
- 2000-11-23 AR ARP000106186A patent/AR026589A1/es unknown
- 2000-11-24 KR KR1020027006349A patent/KR20020058020A/ko not_active Application Discontinuation
- 2000-11-24 PL PL00355152A patent/PL355152A1/xx unknown
- 2000-11-24 SK SK694-2002A patent/SK6942002A3/sk unknown
- 2000-11-24 CN CN00816010A patent/CN1423649A/zh active Pending
- 2000-11-24 JP JP2001540079A patent/JP2003514902A/ja active Pending
- 2000-11-24 MX MXPA02005092A patent/MXPA02005092A/es unknown
- 2000-11-24 BR BR0015814-3A patent/BR0015814A/pt not_active Application Discontinuation
- 2000-11-24 CZ CZ20021687A patent/CZ20021687A3/cs unknown
- 2000-11-24 CA CA002389679A patent/CA2389679A1/en not_active Abandoned
- 2000-11-24 AU AU30042/01A patent/AU3004201A/en not_active Abandoned
- 2000-11-24 WO PCT/EP2000/011734 patent/WO2001038316A2/de not_active Application Discontinuation
- 2000-11-24 US US10/148,078 patent/US6737426B1/en not_active Expired - Fee Related
- 2000-11-24 HU HU0204149A patent/HUP0204149A3/hu unknown
- 2000-11-24 EP EP00990614A patent/EP1233963A2/de not_active Withdrawn
-
2002
- 2002-04-26 ZA ZA200203365A patent/ZA200203365B/en unknown
- 2002-05-24 NO NO20022455A patent/NO20022455D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001038316A2 (de) | 2001-05-31 |
| AR026589A1 (es) | 2003-02-19 |
| JP2003514902A (ja) | 2003-04-22 |
| CZ20021687A3 (cs) | 2002-08-14 |
| HUP0204149A3 (en) | 2005-04-28 |
| MXPA02005092A (es) | 2002-11-07 |
| NO20022455L (no) | 2002-05-24 |
| BR0015814A (pt) | 2002-07-23 |
| CA2389679A1 (en) | 2001-05-31 |
| DE19956791A1 (de) | 2001-05-31 |
| EP1233963A2 (de) | 2002-08-28 |
| CN1423649A (zh) | 2003-06-11 |
| WO2001038316A3 (de) | 2001-10-18 |
| PL355152A1 (en) | 2004-04-05 |
| KR20020058020A (ko) | 2002-07-12 |
| AU3004201A (en) | 2001-06-04 |
| NO20022455D0 (no) | 2002-05-24 |
| ZA200203365B (en) | 2003-10-07 |
| SK6942002A3 (en) | 2002-12-03 |
| US6737426B1 (en) | 2004-05-18 |
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