CO4650039A1 - Benzotiofenos amorfos, procedimientos de preparacion y procedimientos de uso - Google Patents

Benzotiofenos amorfos, procedimientos de preparacion y procedimientos de uso

Info

Publication number
CO4650039A1
CO4650039A1 CO97049147A CO97049147A CO4650039A1 CO 4650039 A1 CO4650039 A1 CO 4650039A1 CO 97049147 A CO97049147 A CO 97049147A CO 97049147 A CO97049147 A CO 97049147A CO 4650039 A1 CO4650039 A1 CO 4650039A1
Authority
CO
Colombia
Prior art keywords
procedures
amorphos
benzothiophenes
preparation
preparation procedures
Prior art date
Application number
CO97049147A
Other languages
English (en)
Inventor
George William Cuff
Lavji Thakkar Arvind
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CO4650039A1 publication Critical patent/CO4650039A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

Un compuesto de fórmula Ien la que:R1 y R3 son independientemente hidrógeno, -CH3 , -CO- (alquilo C1 -C6 ), o -COAr, en el que Ar es fenilo opcionalmente sustituido;R2 se selecciona entre el grupo formado por pirrolidinilo, hexametilenimino y piperidinilo; o una de sus sales o solvatos farmacéuticamente aceptable, en una forma amorfa.
CO97049147A 1996-08-28 1997-08-26 Benzotiofenos amorfos, procedimientos de preparacion y procedimientos de uso CO4650039A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2483196P 1996-08-28 1996-08-28

Publications (1)

Publication Number Publication Date
CO4650039A1 true CO4650039A1 (es) 1998-09-03

Family

ID=21822611

Family Applications (1)

Application Number Title Priority Date Filing Date
CO97049147A CO4650039A1 (es) 1996-08-28 1997-08-26 Benzotiofenos amorfos, procedimientos de preparacion y procedimientos de uso

Country Status (25)

Country Link
EP (1) EP0826682B1 (es)
JP (1) JP2002514174A (es)
KR (1) KR20000035941A (es)
CN (1) CN1244124A (es)
AR (2) AR009333A1 (es)
AT (1) ATE234295T1 (es)
AU (1) AU723987B2 (es)
BR (1) BR9713176A (es)
CA (1) CA2263175A1 (es)
CO (1) CO4650039A1 (es)
CZ (1) CZ64399A3 (es)
DE (1) DE69719640T2 (es)
EA (1) EA002022B1 (es)
ES (1) ES2195089T3 (es)
HU (1) HUP0001172A3 (es)
IL (1) IL128641A (es)
IN (1) IN182940B (es)
NO (1) NO990914L (es)
NZ (1) NZ333839A (es)
PE (1) PE108598A1 (es)
PL (1) PL333356A1 (es)
TR (1) TR199900403T2 (es)
WO (1) WO1998008513A1 (es)
YU (1) YU10599A (es)
ZA (1) ZA977617B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR19980033284A (ko) * 1996-10-30 1998-07-25 피터지.스트링거 개선된 유방암 예방법
US6465445B1 (en) 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US7005428B1 (en) 1998-06-11 2006-02-28 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
FI982733A (fi) * 1998-12-17 2000-06-18 Orion Yhtymae Oyj Trifenyylietyleeniantiestrogeenien liukoisia koostumuksia
ATE541840T1 (de) * 2002-09-30 2012-02-15 Gea Farmaceutisk Fabrik As Raloxifene-l-lactat oder ein hemihydrat davon, deren verwendungen, pharmazeutischen zusammensetzungen und herstellungsverfahren
US20050008704A1 (en) * 2003-07-11 2005-01-13 Ray Anup Kumar Pharmaceutical composition for solubility enhancement of hydrophobic drugs
CN101304970A (zh) * 2005-12-21 2008-11-12 卫材R&D管理有限公司 1，2-二氢吡啶化合物的无定形物
GB2456096B (en) 2006-10-17 2011-08-17 Cipla Ltd Crystalline form of benzothiophene compound and process for preparation thereof
ES2437916T3 (es) 2009-07-02 2014-01-15 Synthon B.V. Composición de raloxifeno
WO2011099942A1 (en) 2010-02-09 2011-08-18 Silverstone Pharma New addition salts of raloxifene, process for the preparation thereof and use thereof in therapy
ITMI20121821A1 (it) * 2012-10-25 2014-04-26 Erregierre Spa Composizione farmaceutica solubile in acqua a base di un sale di raloxifene

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4230862A (en) * 1975-10-28 1980-10-28 Eli Lilly And Company Antifertility compounds
JP3157882B2 (ja) * 1991-11-15 2001-04-16 帝国臓器製薬株式会社 新規なベンゾチオフエン誘導体
TW366342B (en) * 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
US5482949A (en) * 1993-03-19 1996-01-09 Eli Lilly And Company Sulfonate derivatives of 3-aroylbenzo[b]thiophenes
US6756388B1 (en) * 1993-10-12 2004-06-29 Pfizer Inc. Benzothiophenes and related compounds as estrogen agonists
US5631369A (en) * 1994-08-31 1997-05-20 Eli Lilly And Company Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents

Also Published As

Publication number Publication date
ATE234295T1 (de) 2003-03-15
NO990914D0 (no) 1999-02-25
JP2002514174A (ja) 2002-05-14
YU10599A (sh) 2001-07-10
EA002022B1 (ru) 2001-12-24
PL333356A1 (en) 1999-12-06
DE69719640D1 (de) 2003-04-17
BR9713176A (pt) 2000-02-08
AR009333A1 (es) 2000-04-12
EP0826682B1 (en) 2003-03-12
AU723987B2 (en) 2000-09-07
AR009334A1 (es) 2000-04-12
IN182940B (es) 1999-08-14
NO990914L (no) 1999-02-25
EA199900235A1 (ru) 1999-08-26
IL128641A0 (en) 2000-01-31
PE108598A1 (es) 1999-01-13
HUP0001172A3 (en) 2002-01-28
ZA977617B (en) 1999-02-25
IL128641A (en) 2001-10-31
CZ64399A3 (cs) 1999-05-12
ES2195089T3 (es) 2003-12-01
EP0826682A1 (en) 1998-03-04
CN1244124A (zh) 2000-02-09
HUP0001172A2 (hu) 2001-06-28
DE69719640T2 (de) 2003-11-06
TR199900403T2 (xx) 2002-01-21
AU4233597A (en) 1998-03-19
NZ333839A (en) 2001-06-29
CA2263175A1 (en) 1998-03-05
KR20000035941A (ko) 2000-06-26
WO1998008513A1 (en) 1998-03-05

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