ATE541840T1 - Raloxifene-l-lactat oder ein hemihydrat davon, deren verwendungen, pharmazeutischen zusammensetzungen und herstellungsverfahren - Google Patents

Raloxifene-l-lactat oder ein hemihydrat davon, deren verwendungen, pharmazeutischen zusammensetzungen und herstellungsverfahren

Info

Publication number
ATE541840T1
ATE541840T1 AT03747847T AT03747847T ATE541840T1 AT E541840 T1 ATE541840 T1 AT E541840T1 AT 03747847 T AT03747847 T AT 03747847T AT 03747847 T AT03747847 T AT 03747847T AT E541840 T1 ATE541840 T1 AT E541840T1
Authority
AT
Austria
Prior art keywords
raloxifene
solvates
addition salts
acid addition
sulphuric acid
Prior art date
Application number
AT03747847T
Other languages
English (en)
Inventor
Gunnar Karup
Soren Pedersen
Original Assignee
Gea Farmaceutisk Fabrik As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gea Farmaceutisk Fabrik As filed Critical Gea Farmaceutisk Fabrik As
Application granted granted Critical
Publication of ATE541840T1 publication Critical patent/ATE541840T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT03747847T 2002-09-30 2003-09-30 Raloxifene-l-lactat oder ein hemihydrat davon, deren verwendungen, pharmazeutischen zusammensetzungen und herstellungsverfahren ATE541840T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200201450 2002-09-30
PCT/DK2003/000645 WO2004029046A2 (en) 2002-09-30 2003-09-30 Novel raloxifene acid addition salts and/or solvates thereof, improved method for purification of said raloxifene acid addition salts and/or solvates thereof and pharmaceutical compositions comprising these

Publications (1)

Publication Number Publication Date
ATE541840T1 true ATE541840T1 (de) 2012-02-15

Family

ID=32039058

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03747847T ATE541840T1 (de) 2002-09-30 2003-09-30 Raloxifene-l-lactat oder ein hemihydrat davon, deren verwendungen, pharmazeutischen zusammensetzungen und herstellungsverfahren

Country Status (7)

Country Link
US (1) US7964734B2 (de)
EP (4) EP1832583A1 (de)
AT (1) ATE541840T1 (de)
AU (1) AU2003266940B2 (de)
CA (1) CA2499819A1 (de)
NO (1) NO20052100L (de)
WO (1) WO2004029046A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004029046A2 (en) 2002-09-30 2004-04-08 A/S Gea Farmaceutisk Fabrik Novel raloxifene acid addition salts and/or solvates thereof, improved method for purification of said raloxifene acid addition salts and/or solvates thereof and pharmaceutical compositions comprising these
MXPA05011297A (es) 2003-04-25 2006-05-25 Gilead Sciences Inc Analogos antivirales de fosfonato.
ES2363160T3 (es) 2004-07-27 2011-07-22 Gilead Sciences, Inc. Conjugados de fosfonato nucelosidico como agentes anti-vih.
WO2008000042A1 (en) 2006-06-30 2008-01-03 Iceutica Pty Ltd Methods for the preparation of biologically active compounds in nanoparticulate form
GB2456096B (en) * 2006-10-17 2011-08-17 Cipla Ltd Crystalline form of benzothiophene compound and process for preparation thereof
JP4825697B2 (ja) 2007-01-25 2011-11-30 株式会社ミツトヨ デジタル式変位測定器
JP5620376B2 (ja) 2008-07-08 2014-11-05 ギリアード サイエンシーズ， インコーポレイテッド Ｈｉｖ阻害剤化合物の塩
AU2010239081C1 (en) 2009-04-24 2014-11-06 Iceutica Pty Ltd A novel formulation of indomethacin
WO2011099942A1 (en) 2010-02-09 2011-08-18 Silverstone Pharma New addition salts of raloxifene, process for the preparation thereof and use thereof in therapy
IN2013MU00665A (de) 2013-03-05 2015-07-03 Cipla Ltd
US9526734B2 (en) 2014-06-09 2016-12-27 Iceutica Pty Ltd. Formulation of meloxicam
US10851125B2 (en) 2017-08-01 2020-12-01 Gilead Sciences, Inc. Crystalline forms of ethyl ((S)-((((2R,5R)-5-(6-amino-9H-purin-9-yl)-4-fluoro-2,5-dihydrofuran-2-yl)oxy)methyl)(phenoxy)phosphoryl(-L-alaninate

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4133814A (en) 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4418068A (en) 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
IL65379A0 (en) 1981-04-03 1982-05-31 Lilly Co Eli Process for preparing acylated benzothiophenes
IL65378A (en) 1981-04-03 1986-02-28 Lilly Co Eli Process for preparing 3-(4-aminoethoxybenzoyl)benzo-(b)thiophenes
PH18628A (en) * 1981-04-03 1985-08-23 Lilly Co Eli "6-hydroxy-2-(4-hydroxyphenyl)-3 4-(2- piperidine or 3-methylpyrollidine -benzo b thiophene compounds
TW366342B (en) 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
US5418252A (en) * 1993-10-15 1995-05-23 Eli Lilly And Company Method for inhibiting cartilage degradation
US5478847A (en) 1994-03-02 1995-12-26 Eli Lilly And Company Methods of use for inhibiting bone loss and lowering serum cholesterol
BR9500758A (pt) 1994-03-02 1995-10-24 Lilly Co Eli Formulaçoes farmacêuticas para administraçao oral
CA2145614A1 (en) 1994-03-31 1995-10-01 Jeffrey A. Dodge Intermediates and processes for preparing benzothiophene compounds
US5420349A (en) 1994-06-10 1995-05-30 Eli Lilly And Company 2-amino-3-aroyl-benzo[β]thiophenes and methods for preparing and using same to produce 6-hydroxy-2-(4-hydroxyphenyl)-3-]benzo[4-(2-aminoethoxy)-benzoyl[β]thiophenes
US5523416A (en) 1994-07-22 1996-06-04 Eli Lilly And Company Process for preparing 3-(4-aminoethoxy-benzoyl) benzo (B)-thiophenes
US5731436A (en) 1994-08-31 1998-03-24 Eli Lilly And Company Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents
US5631369A (en) 1994-08-31 1997-05-20 Eli Lilly And Company Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents
CO4410191A1 (es) 1994-09-19 1997-01-09 Lilly Co Eli SINTESIS DE 3-[4-(2-AMINOETOXI)BENZOIL]-2-ARIL-6- HIDROXIBENZO [b] TIOFENOS
US5606076A (en) 1995-06-07 1997-02-25 Eli Lilly And Company Process for the synthesis of benzo[b]thiophenes
WO1996040691A1 (en) 1995-06-07 1996-12-19 Eli Lilly And Company Vinyl sulfoxides and a process for their synthesis
US5606075A (en) 1995-06-07 1997-02-25 Eli Lilly And Company Process for the synthesis of benzo[b]thiophenes
US5569772A (en) 1995-06-07 1996-10-29 Eli Lilly And Company Process for the synthesis of benzo[b]thiophenes
PL323907A1 (en) 1995-06-07 1998-04-27 Lilly Co Eli Method of synthesising derivatives of vinylsulphenic acids
IL125863A (en) 1996-02-22 2000-10-31 Lilly Co Eli Benzothiophenes and formulations containing same
AU5258696A (en) 1996-03-19 1997-10-10 Eli Lilly And Company Synthesis of 3-{4-(2-aminoethoxy)-benzoyl}-2-aryl-6-hydroxy-benzo{b}thiop henes
IL126320A (en) 1996-03-26 2001-08-08 Lilly Co Eli Reloxifen and pharmaceuticals containing it
PE108598A1 (es) * 1996-08-28 1999-01-13 Lilly Co Eli Benzotiofenos amorfos, procedimientos de preparacion y procedimientos de uso
EP0929554B1 (de) 1996-09-25 2006-03-15 MERCK SHARP & DOHME LTD. Spiro-azacyclische derivate, deren herstellung und verwendung als tachykinin-antagonisten
ZA9710262B (en) 1996-11-19 1999-05-13 Lilly Co Eli Process for the synthesis of benzothiophenes
EP0979075A4 (de) 1997-04-30 2002-07-24 Lilly Co Eli VERFAHREN DER REGIOSELEKTIVEN ALKYLIERUNG ZUR HERSTELLUNG VON SUBSTITUIERTEN BENZO[b]THIOPHENEN
CA2236254A1 (en) * 1997-04-30 1998-10-30 David Warren Hoard Process for preparing benzo¬b|thiophenes
AU7261498A (en) 1997-04-30 1998-11-24 Eli Lilly And Company Intermediates and processes for preparing benzo{b}thiophenes
CA2231013A1 (en) 1997-04-30 1998-10-30 Eli Lilly And Company Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceuticals
AU7261598A (en) 1997-04-30 1998-11-24 Eli Lilly And Company Intermediates and a process for preparing benzo{b}thiophenes
WO1998049156A1 (en) 1997-04-30 1998-11-05 Eli Lilly And Company Processes for preparing benzothiophenes
JP2002521322A (ja) 1998-07-23 2002-07-16 ノボ ノルディスク アクティーゼルスカブ 安定な医薬製剤の製造のための湿式顆粒化方法
FI982733A (fi) * 1998-12-17 2000-06-18 Orion Yhtymae Oyj Trifenyylietyleeniantiestrogeenien liukoisia koostumuksia
US6294192B1 (en) 1999-02-26 2001-09-25 Lipocine, Inc. Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents
EP1220847A2 (de) 1999-09-27 2002-07-10 Eli Lilly And Company Verfahren zur herstellung von benzoesäuren
WO2002042289A2 (en) 2000-11-27 2002-05-30 Eli Lilly And Company Process for preparing 3-aryl-benzo[b]thiophenes
AU2002228593A1 (en) 2000-11-27 2002-06-03 Eli Lilly And Company Process for preparing alpha-(3-arylthio)-acetophenones
WO2004029046A2 (en) 2002-09-30 2004-04-08 A/S Gea Farmaceutisk Fabrik Novel raloxifene acid addition salts and/or solvates thereof, improved method for purification of said raloxifene acid addition salts and/or solvates thereof and pharmaceutical compositions comprising these
ITMI20031333A1 (it) 2003-06-30 2005-01-01 Erregierre Spa Processo di preparazione di raloxifene cloridrato.

Also Published As

Publication number Publication date
US7964734B2 (en) 2011-06-21
NO20052100L (no) 2005-06-29
EP1832583A1 (de) 2007-09-12
CA2499819A1 (en) 2004-04-08
AU2003266940B9 (en) 2004-04-19
AU2003266940A1 (en) 2004-04-19
WO2004029046A3 (en) 2004-10-14
US20060154966A1 (en) 2006-07-13
WO2004029046A2 (en) 2004-04-08
EP1546138A2 (de) 2005-06-29
AU2003266940B2 (en) 2007-02-08
EP1826205A1 (de) 2007-08-29
EP1546138B1 (de) 2012-01-18
AU2003266940C1 (en) 2004-04-19
NO20052100D0 (no) 2005-04-29
EP1832582A1 (de) 2007-09-12

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