ITMI20031333A1 - Processo di preparazione di raloxifene cloridrato. - Google Patents

Processo di preparazione di raloxifene cloridrato.

Info

Publication number
ITMI20031333A1
ITMI20031333A1 IT001333A ITMI20031333A ITMI20031333A1 IT MI20031333 A1 ITMI20031333 A1 IT MI20031333A1 IT 001333 A IT001333 A IT 001333A IT MI20031333 A ITMI20031333 A IT MI20031333A IT MI20031333 A1 ITMI20031333 A1 IT MI20031333A1
Authority
IT
Italy
Prior art keywords
benzo
thiophene
acetoxy
piperidinoethoxy
raloxifene
Prior art date
Application number
IT001333A
Other languages
English (en)
Inventor
Paolo Belotti
Massimo Ferrari
Fabrizio Zinetti
Original Assignee
Erregierre Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erregierre Spa filed Critical Erregierre Spa
Priority to IT001333A priority Critical patent/ITMI20031333A1/it
Publication of ITMI20031333A0 publication Critical patent/ITMI20031333A0/it
Priority to US10/562,762 priority patent/US20070100147A1/en
Priority to PL04741907T priority patent/PL1641773T3/pl
Priority to PT04741907T priority patent/PT1641773E/pt
Priority to EP04741907A priority patent/EP1641773B1/en
Priority to CA2549354A priority patent/CA2549354C/en
Priority to AT04741907T priority patent/ATE402161T1/de
Priority to PCT/EP2004/051263 priority patent/WO2005003116A1/en
Priority to DE602004015290T priority patent/DE602004015290D1/de
Priority to ES04741907T priority patent/ES2311157T3/es
Publication of ITMI20031333A1 publication Critical patent/ITMI20031333A1/it
Priority to IL172801A priority patent/IL172801A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
IT001333A 2003-06-30 2003-06-30 Processo di preparazione di raloxifene cloridrato. ITMI20031333A1 (it)

Priority Applications (11)

Application Number Priority Date Filing Date Title
IT001333A ITMI20031333A1 (it) 2003-06-30 2003-06-30 Processo di preparazione di raloxifene cloridrato.
ES04741907T ES2311157T3 (es) 2003-06-30 2004-06-28 Procedimiento para la preparacion de clorhidrato de raloxifeno.
EP04741907A EP1641773B1 (en) 2003-06-30 2004-06-28 Process for preparing raloxifene hydrochloride
PL04741907T PL1641773T3 (pl) 2003-06-30 2004-06-28 Sposób wytwarzania chlorowodorku raloksyfenu
PT04741907T PT1641773E (pt) 2003-06-30 2004-06-28 Processo para preparar cloridrato de raloxifeno
US10/562,762 US20070100147A1 (en) 2003-06-30 2004-06-28 Process for preparing raloxifene hydrochloride
CA2549354A CA2549354C (en) 2003-06-30 2004-06-28 Process for preparing raloxifene hydrochloride
AT04741907T ATE402161T1 (de) 2003-06-30 2004-06-28 Verfahren zur herstellung von raloxifene- hydrochlorid
PCT/EP2004/051263 WO2005003116A1 (en) 2003-06-30 2004-06-28 Process for preparing raloxifene hydrochloride
DE602004015290T DE602004015290D1 (de) 2003-06-30 2004-06-28 Verfahren zur herstellung von raloxifene-hydrochlorid
IL172801A IL172801A (en) 2003-06-30 2005-12-25 Process for preparing raloxifene hydrochloride

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT001333A ITMI20031333A1 (it) 2003-06-30 2003-06-30 Processo di preparazione di raloxifene cloridrato.

Publications (2)

Publication Number Publication Date
ITMI20031333A0 ITMI20031333A0 (it) 2003-06-30
ITMI20031333A1 true ITMI20031333A1 (it) 2005-01-01

Family

ID=30131328

Family Applications (1)

Application Number Title Priority Date Filing Date
IT001333A ITMI20031333A1 (it) 2003-06-30 2003-06-30 Processo di preparazione di raloxifene cloridrato.

Country Status (11)

Country Link
US (1) US20070100147A1 (it)
EP (1) EP1641773B1 (it)
AT (1) ATE402161T1 (it)
CA (1) CA2549354C (it)
DE (1) DE602004015290D1 (it)
ES (1) ES2311157T3 (it)
IL (1) IL172801A (it)
IT (1) ITMI20031333A1 (it)
PL (1) PL1641773T3 (it)
PT (1) PT1641773E (it)
WO (1) WO2005003116A1 (it)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004029046A2 (en) 2002-09-30 2004-04-08 A/S Gea Farmaceutisk Fabrik Novel raloxifene acid addition salts and/or solvates thereof, improved method for purification of said raloxifene acid addition salts and/or solvates thereof and pharmaceutical compositions comprising these
US8367105B2 (en) * 2004-11-10 2013-02-05 Teva Pharmaceutical Industries, Ltd. Compressed solid dosage form manufacturing process well-suited for use with drugs of low aqueous solubility and compressed solid dosage forms made thereby
GB2456096B (en) * 2006-10-17 2011-08-17 Cipla Ltd Crystalline form of benzothiophene compound and process for preparation thereof
EP2150520B1 (en) * 2007-04-25 2012-10-31 F. Hoffmann-La Roche AG Novel process for the preparation of acid chlorides
BRPI0909813B1 (pt) 2008-04-04 2018-01-02 F. Hoffmann-La Roche Ag "processos para preparação de derivados de ácido ciclo-hexanocarboxílico, e intermediário"
AU2009231424B2 (en) 2008-04-04 2014-01-30 F. Hoffmann-La Roche Ag New process for the preparation of cyclohexanecarboxylic acid derivatives via the corresponding cyclohexanecarboxamide derivative
WO2009150669A1 (en) * 2008-06-09 2009-12-17 Erregierre S.P.A. Process for controlling the growth of a raloxifene hydrochloride crystal
JP5325980B2 (ja) 2008-06-17 2013-10-23 エフ．ホフマン−ラ ロシュ アーゲー 薬学的に活性なアミドの製造における中間体としての１−（２−エチル−ブチル）−シクロヘキサンカルボン酸エステル
GB2469647B (en) 2009-04-21 2014-03-05 Linde Ag Lasers
WO2011099942A1 (en) 2010-02-09 2011-08-18 Silverstone Pharma New addition salts of raloxifene, process for the preparation thereof and use thereof in therapy
IT1403083B1 (it) * 2010-10-25 2013-10-04 Fidia Farmaceutici Nuova forma polimorfa di raloxifene cloridrato
CN105753836A (zh) * 2016-02-03 2016-07-13 上海天慈生物谷生物工程有限公司 一种预防骨质疏松症药物的制备方法
CN112851634B (zh) * 2020-01-03 2021-11-16 江苏美迪克化学品有限公司 一种盐酸雷洛昔芬的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
PH18628A (en) * 1981-04-03 1985-08-23 Lilly Co Eli "6-hydroxy-2-(4-hydroxyphenyl)-3 4-(2- piperidine or 3-methylpyrollidine -benzo b thiophene compounds
US4358593A (en) * 1981-04-03 1982-11-09 Eli Lilly And Company Process for preparing 3-(4-aminoethoxybenzoyl)benzo[b]thiophenes
EP0233228A1 (en) * 1985-08-06 1987-08-26 Boehringer Mannheim Italia S.P.A. Pharmaceutically active 2-thiomethyl-substituted-1,4-dihydropyridines
US5523416A (en) * 1994-07-22 1996-06-04 Eli Lilly And Company Process for preparing 3-(4-aminoethoxy-benzoyl) benzo (B)-thiophenes
US5629425A (en) * 1994-09-19 1997-05-13 Eli Lilly And Company Haloalkyl hemisolvates of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-piperidinoethoxy)-benzoyl]benzo[b]thiophene

Also Published As

Publication number Publication date
DE602004015290D1 (de) 2008-09-04
WO2005003116A9 (en) 2008-09-25
PL1641773T3 (pl) 2009-04-30
EP1641773A1 (en) 2006-04-05
WO2005003116A1 (en) 2005-01-13
IL172801A (en) 2011-08-31
ATE402161T1 (de) 2008-08-15
IL172801A0 (en) 2006-06-11
CA2549354A1 (en) 2005-01-13
ES2311157T3 (es) 2009-02-01
EP1641773B1 (en) 2008-07-23
ITMI20031333A0 (it) 2003-06-30
US20070100147A1 (en) 2007-05-03
PT1641773E (pt) 2008-10-31
CA2549354C (en) 2013-03-12

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