DE602004015290D1 - Verfahren zur herstellung von raloxifene-hydrochlorid - Google Patents

Verfahren zur herstellung von raloxifene-hydrochlorid

Info

Publication number
DE602004015290D1
DE602004015290D1 DE602004015290T DE602004015290T DE602004015290D1 DE 602004015290 D1 DE602004015290 D1 DE 602004015290D1 DE 602004015290 T DE602004015290 T DE 602004015290T DE 602004015290 T DE602004015290 T DE 602004015290T DE 602004015290 D1 DE602004015290 D1 DE 602004015290D1
Authority
DE
Germany
Prior art keywords
benzo
thiophene
acetoxy
piperidinoethoxy
hydrochloride
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602004015290T
Other languages
English (en)
Inventor
Massimo Ferrari
Fabrizio Zinetti
Paolo Belotti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Erregierre SpA
Original Assignee
Erregierre SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erregierre SpA filed Critical Erregierre SpA
Publication of DE602004015290D1 publication Critical patent/DE602004015290D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
DE602004015290T 2003-06-30 2004-06-28 Verfahren zur herstellung von raloxifene-hydrochlorid Active DE602004015290D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT001333A ITMI20031333A1 (it) 2003-06-30 2003-06-30 Processo di preparazione di raloxifene cloridrato.
PCT/EP2004/051263 WO2005003116A1 (en) 2003-06-30 2004-06-28 Process for preparing raloxifene hydrochloride

Publications (1)

Publication Number Publication Date
DE602004015290D1 true DE602004015290D1 (de) 2008-09-04

Family

ID=30131328

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602004015290T Active DE602004015290D1 (de) 2003-06-30 2004-06-28 Verfahren zur herstellung von raloxifene-hydrochlorid

Country Status (11)

Country Link
US (1) US20070100147A1 (de)
EP (1) EP1641773B1 (de)
AT (1) ATE402161T1 (de)
CA (1) CA2549354C (de)
DE (1) DE602004015290D1 (de)
ES (1) ES2311157T3 (de)
IL (1) IL172801A (de)
IT (1) ITMI20031333A1 (de)
PL (1) PL1641773T3 (de)
PT (1) PT1641773E (de)
WO (1) WO2005003116A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1832583A1 (de) 2002-09-30 2007-09-12 A/S GEA Farmaceutisk Fabrik Neue Schwefelsäureadditionssalze aus Raloxifen und/oder Solvate daraus sowie pharmazeutische Zusammensetzungen damit
US8367105B2 (en) * 2004-11-10 2013-02-05 Teva Pharmaceutical Industries, Ltd. Compressed solid dosage form manufacturing process well-suited for use with drugs of low aqueous solubility and compressed solid dosage forms made thereby
WO2008047105A1 (en) 2006-10-17 2008-04-24 Cipla Limited Crystalline form of benzothiophene compound and process for preparation thereof
CN101663260B (zh) * 2007-04-25 2013-02-13 弗·哈夫曼-拉罗切有限公司 制备酰基氯的方法
WO2009121788A1 (en) 2008-04-04 2009-10-08 F. Hoffmann-La Roche Ag New process for the preparatiion of cyclohexanecarboxylic acid dericatives
JP5526120B2 (ja) 2008-04-04 2014-06-18 エフ．ホフマン−ラ ロシュ アーゲー 対応するシクロヘキサンカルボキシアミド誘導体を経るシクロヘキサンカルボン酸誘導体の新規な製造方法
US20110088613A1 (en) * 2008-06-09 2011-04-21 Massimo Ferrari Process for controlling the growth of a raloxifene hydrochloride crystal
CA2726931C (en) 2008-06-17 2016-03-22 F.Hoffmann-La Roche Ag 1-(2-ethyl-butyl) -cyclohexanecarboxylic acid ester as an intermediate in the preparation of pharmaceutically active amides
GB2469647B (en) 2009-04-21 2014-03-05 Linde Ag Lasers
WO2011099942A1 (en) 2010-02-09 2011-08-18 Silverstone Pharma New addition salts of raloxifene, process for the preparation thereof and use thereof in therapy
IT1403083B1 (it) * 2010-10-25 2013-10-04 Fidia Farmaceutici Nuova forma polimorfa di raloxifene cloridrato
CN105753836A (zh) * 2016-02-03 2016-07-13 上海天慈生物谷生物工程有限公司 一种预防骨质疏松症药物的制备方法
CN111138409B (zh) * 2020-01-03 2021-02-02 江苏美迪克化学品有限公司 一种盐酸雷洛昔芬及其中间体的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4358593A (en) * 1981-04-03 1982-11-09 Eli Lilly And Company Process for preparing 3-(4-aminoethoxybenzoyl)benzo[b]thiophenes
PH18628A (en) * 1981-04-03 1985-08-23 Lilly Co Eli "6-hydroxy-2-(4-hydroxyphenyl)-3 4-(2- piperidine or 3-methylpyrollidine -benzo b thiophene compounds
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
EP0233228A1 (de) * 1985-08-06 1987-08-26 Boehringer Mannheim Italia S.P.A. Pharmazeutisch wirkzame 2-thiomethyl substituierte 1,4-dihydropyridine
US5523416A (en) * 1994-07-22 1996-06-04 Eli Lilly And Company Process for preparing 3-(4-aminoethoxy-benzoyl) benzo (B)-thiophenes
US5629425A (en) * 1994-09-19 1997-05-13 Eli Lilly And Company Haloalkyl hemisolvates of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-piperidinoethoxy)-benzoyl]benzo[b]thiophene

Also Published As

Publication number Publication date
ES2311157T3 (es) 2009-02-01
CA2549354A1 (en) 2005-01-13
ITMI20031333A0 (it) 2003-06-30
WO2005003116A9 (en) 2008-09-25
ITMI20031333A1 (it) 2005-01-01
PT1641773E (pt) 2008-10-31
CA2549354C (en) 2013-03-12
IL172801A0 (en) 2006-06-11
EP1641773A1 (de) 2006-04-05
ATE402161T1 (de) 2008-08-15
EP1641773B1 (de) 2008-07-23
US20070100147A1 (en) 2007-05-03
PL1641773T3 (pl) 2009-04-30
WO2005003116A1 (en) 2005-01-13
IL172801A (en) 2011-08-31

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