NO20052100D0 - Raloksifensalt I - Google Patents

Raloksifensalt I

Info

Publication number
NO20052100D0
NO20052100D0 NO20052100A NO20052100A NO20052100D0 NO 20052100 D0 NO20052100 D0 NO 20052100D0 NO 20052100 A NO20052100 A NO 20052100A NO 20052100 A NO20052100 A NO 20052100A NO 20052100 D0 NO20052100 D0 NO 20052100D0
Authority
NO
Norway
Prior art keywords
raloxifene
solvates
addition salts
acid addition
sulphuric acid
Prior art date
Application number
NO20052100A
Other languages
English (en)
Other versions
NO20052100L (no
Inventor
Gunnar Leo Karup
Soren Bols Pedersen
Original Assignee
Gea Farmaceutisk Fabrik As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gea Farmaceutisk Fabrik As filed Critical Gea Farmaceutisk Fabrik As
Publication of NO20052100D0 publication Critical patent/NO20052100D0/no
Publication of NO20052100L publication Critical patent/NO20052100L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO20052100A 2002-09-30 2005-04-29 Raloksifensalt I NO20052100L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200201450 2002-09-30
PCT/DK2003/000645 WO2004029046A2 (en) 2002-09-30 2003-09-30 Novel raloxifene acid addition salts and/or solvates thereof, improved method for purification of said raloxifene acid addition salts and/or solvates thereof and pharmaceutical compositions comprising these

Publications (2)

Publication Number Publication Date
NO20052100D0 true NO20052100D0 (no) 2005-04-29
NO20052100L NO20052100L (no) 2005-06-29

Family

ID=32039058

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20052100A NO20052100L (no) 2002-09-30 2005-04-29 Raloksifensalt I

Country Status (7)

Country Link
US (1) US7964734B2 (no)
EP (4) EP1832582A1 (no)
AT (1) ATE541840T1 (no)
AU (1) AU2003266940B2 (no)
CA (1) CA2499819A1 (no)
NO (1) NO20052100L (no)
WO (1) WO2004029046A2 (no)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1832582A1 (en) 2002-09-30 2007-09-12 A/S GEA Farmaceutisk Fabrik Novel raloxifene malonic acid addition salts and/or solvates thereof, and pharmaceutical compositions comprising these
NZ542342A (en) 2003-04-25 2009-05-31 Gilead Sciences Inc Antiviral phosphonate analogs
DK1778251T3 (da) 2004-07-27 2011-07-18 Gilead Sciences Inc Nukleosidphosphatkonjugater som anti-HIV-midler
IN2014MN00380A (no) 2006-06-30 2015-06-19 Iceutica Pty Ltd
GB2456096B (en) * 2006-10-17 2011-08-17 Cipla Ltd Crystalline form of benzothiophene compound and process for preparation thereof
JP4825697B2 (ja) 2007-01-25 2011-11-30 株式会社ミツトヨ デジタル式変位測定器
WO2010005986A1 (en) 2008-07-08 2010-01-14 Gilead Sciences, Inc. Salts of hiv inhibitor compounds
EP2421513B1 (en) 2009-04-24 2017-12-13 Iceutica Pty Ltd. A novel formulation of indomethacin
WO2011099942A1 (en) 2010-02-09 2011-08-18 Silverstone Pharma New addition salts of raloxifene, process for the preparation thereof and use thereof in therapy
IN2013MU00665A (no) 2013-03-05 2015-07-03 Cipla Ltd
US9526734B2 (en) 2014-06-09 2016-12-27 Iceutica Pty Ltd. Formulation of meloxicam
PT3661937T (pt) 2017-08-01 2021-09-24 Gilead Sciences Inc Formas cristalinas de ((s)-((((2r,5r)-5-(6-amino-9h-purin-9-il)-4-fluoro-2,5-dihidrofurano-2-il)oxi)metil)(fenoxi)fosforil)-l-alaninato de etil (gs-9131) para tratamento de infeções virais

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
IL65379A0 (en) 1981-04-03 1982-05-31 Lilly Co Eli Process for preparing acylated benzothiophenes
AU555658B2 (en) 1981-04-03 1986-10-02 Eli Lilly And Company Benzothiophene compounds
IL65378A (en) 1981-04-03 1986-02-28 Lilly Co Eli Process for preparing 3-(4-aminoethoxybenzoyl)benzo-(b)thiophenes
TW366342B (en) * 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
US5418252A (en) * 1993-10-15 1995-05-23 Eli Lilly And Company Method for inhibiting cartilage degradation
US5478847A (en) 1994-03-02 1995-12-26 Eli Lilly And Company Methods of use for inhibiting bone loss and lowering serum cholesterol
CA2143263C (en) 1994-03-02 2002-01-08 Kerry John Hartauer Orally administrable raloxifene formulations
CA2145614A1 (en) 1994-03-31 1995-10-01 Jeffrey A. Dodge Intermediates and processes for preparing benzothiophene compounds
US5420349A (en) 1994-06-10 1995-05-30 Eli Lilly And Company 2-amino-3-aroyl-benzo[β]thiophenes and methods for preparing and using same to produce 6-hydroxy-2-(4-hydroxyphenyl)-3-]benzo[4-(2-aminoethoxy)-benzoyl[β]thiophenes
US5523416A (en) 1994-07-22 1996-06-04 Eli Lilly And Company Process for preparing 3-(4-aminoethoxy-benzoyl) benzo (B)-thiophenes
US5731436A (en) 1994-08-31 1998-03-24 Eli Lilly And Company Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents
US5631369A (en) 1994-08-31 1997-05-20 Eli Lilly And Company Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceutical agents
CO4410190A1 (es) 1994-09-19 1997-01-09 Lilly Co Eli 3-[4-(2-AMINOETOXI)-BENZOIL]-2-ARIL-6-HIDROXIBENZO [b] TIOFENO CRISTALINO
US5606075A (en) 1995-06-07 1997-02-25 Eli Lilly And Company Process for the synthesis of benzo[b]thiophenes
EP0830362A4 (en) 1995-06-07 1998-09-02 Lilly Co Eli METHOD FOR SYNTHESISING VINYLSULFENIC ACID DERIVATIVES
US5569772A (en) 1995-06-07 1996-10-29 Eli Lilly And Company Process for the synthesis of benzo[b]thiophenes
CN1192741A (zh) 1995-06-07 1998-09-09 伊莱利利公司 乙烯亚砜类化合物及其合成方法
US5606076A (en) 1995-06-07 1997-02-25 Eli Lilly And Company Process for the synthesis of benzo[b]thiophenes
PL328832A1 (en) 1996-02-22 1999-02-15 Lilly Co Eli Benzothiophenes, pharmaceutic agents and methods
WO1997034888A1 (en) 1996-03-19 1997-09-25 Eli Lilly And Company SYNTHESIS OF 3-[4-(2-AMINOETHOXY)-BENZOYL]-2-ARYL-6-HYDROXY-BENZO[b]THIOPHENES
MEP18308A (en) * 1996-03-26 2010-06-10 Lilly Co Eli Benzothiophenes, formulations containing same, and methods
JP2002514174A (ja) * 1996-08-28 2002-05-14 イーライ・リリー・アンド・カンパニー 非晶質ベンゾチオフェン類、製造方法および使用方法
US6046195A (en) 1996-09-25 2000-04-04 Merck Sharp & Dohme Ltd. Spiro-azacyclic derivatives, their preparation and their use as tachykinin antagonists
ZA9710262B (en) 1996-11-19 1999-05-13 Lilly Co Eli Process for the synthesis of benzothiophenes
EP0979076A4 (en) 1997-04-30 2003-03-19 Lilly Co Eli INTERMEDIATES AND PROCESSES FOR THE PREPARATION OF BENZO b] THIOPHENES
CN1252717A (zh) 1997-04-30 2000-05-10 伊莱利利公司 制备苯并[b]噻吩的中间体和方法
CN1253556A (zh) 1997-04-30 2000-05-17 伊莱利利公司 制备苯并噻吩的方法
CA2236254A1 (en) * 1997-04-30 1998-10-30 David Warren Hoard Process for preparing benzo¬b|thiophenes
CA2287918A1 (en) 1997-04-30 1998-11-05 John Mcneill Mcgill Iii A regioselective alkylation process for preparing substituted benzo¬b|thiophenes
CA2231013A1 (en) * 1997-04-30 1998-10-30 Eli Lilly And Company Process for preparing benzoic acid derivative intermediates and benzothiophene pharmaceuticals
EP1098636A1 (en) 1998-07-23 2001-05-16 Novo Nordisk A/S A wet granulation method for preparing a stable pharmaceutical formulation
FI982733A (fi) * 1998-12-17 2000-06-18 Orion Yhtymae Oyj Trifenyylietyleeniantiestrogeenien liukoisia koostumuksia
US6294192B1 (en) 1999-02-26 2001-09-25 Lipocine, Inc. Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents
JP2003510313A (ja) 1999-09-27 2003-03-18 イーライ・リリー・アンド・カンパニー 安息香酸の製造方法
AU2002230409A1 (en) 2000-11-27 2002-06-03 Eli Lilly And Company Process for preparing 3-aryl-benzo(b)thiophenes
WO2002042261A2 (en) 2000-11-27 2002-05-30 Eli Lilly And Company PROCESS FOR PREPARING α-(3-ARYLTHIO)-ACETOPHENONES
EP1832582A1 (en) 2002-09-30 2007-09-12 A/S GEA Farmaceutisk Fabrik Novel raloxifene malonic acid addition salts and/or solvates thereof, and pharmaceutical compositions comprising these
ITMI20031333A1 (it) 2003-06-30 2005-01-01 Erregierre Spa Processo di preparazione di raloxifene cloridrato.

Also Published As

Publication number Publication date
EP1546138B1 (en) 2012-01-18
AU2003266940B9 (en) 2004-04-19
EP1546138A2 (en) 2005-06-29
AU2003266940A1 (en) 2004-04-19
US20060154966A1 (en) 2006-07-13
EP1832583A1 (en) 2007-09-12
WO2004029046A3 (en) 2004-10-14
NO20052100L (no) 2005-06-29
WO2004029046A2 (en) 2004-04-08
ATE541840T1 (de) 2012-02-15
EP1826205A1 (en) 2007-08-29
EP1832582A1 (en) 2007-09-12
CA2499819A1 (en) 2004-04-08
US7964734B2 (en) 2011-06-21
AU2003266940C1 (en) 2004-04-19
AU2003266940B2 (en) 2007-02-08

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