PE20030063A1 - Derivados de 1-(3-feniloxipropil) piperidina - Google Patents

Derivados de 1-(3-feniloxipropil) piperidina

Info

Publication number
PE20030063A1
PE20030063A1 PE2002000504A PE2002000504A PE20030063A1 PE 20030063 A1 PE20030063 A1 PE 20030063A1 PE 2002000504 A PE2002000504 A PE 2002000504A PE 2002000504 A PE2002000504 A PE 2002000504A PE 20030063 A1 PE20030063 A1 PE 20030063A1
Authority
PE
Peru
Prior art keywords
alkyl
alkyloxy
halogen
phenyloxypropyl
piperidine
Prior art date
Application number
PE2002000504A
Other languages
English (en)
Inventor
David Raeburn Barn
Jean Cottney
Ronald Palin
Simon James Anthony Grove
Richard Morphy
Phillip Martin Cowley
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of PE20030063A1 publication Critical patent/PE20030063A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A DERIVADOS DE 1-(3-FENILOXIPROPIL) PIPERIDINA DE FORMULA I DONDE R1 ES ALQUILO C1-C8, CICLOALQUILO, FENILO CON ALQUILO C1-C6, ALQUILOXI C1-C6, HALOGENO; R2 ES H, ALQUILO C1-C6; R1 Y R2 JUNTOS CON C FORMAN CICLOALQUILO C4-C8 CON ALQUILO C1-C8, ENTRE OTROS; R3 ES H, OH, ALQUILOXI C1-C6,, ALQUILCARBONILOXI C1-C6; R4 ES H, ALQUILO C1-C8, ALQUILOXI C1-C6, HALOGENO; Y ES EL GRUPO (A) Y Z ES H; R6 ES H, ALQUILO C1-C8; R7 ES H, ALQUILO C1-C6, ALQUILOXI C1-C6, HALOGENO. SON COMPUESTOS PREFERIDOS 1-{1-[3-(2,5-DIMETILFENOXI)-4-METILPENTIL]-4-PIPERIDINIL}-1,3-DIHIDRO-2H-BENZIMIDAZOL-2-ONA; 1-{1-[3-(5-METOXI-2-METILFENOXI)-4-METILPENTIL]-4-PIPERIDINIL}-1,3-DIHIDRO-2H-BENZIMIDAZOL-2-ONA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. LOS COMPUESTOS MENCIONADOS SON AGENTES ANALGESICOS, SEDANTES, ANTIINFLAMATORIOS, NEUROPROTECTORES
PE2002000504A 2001-06-13 2002-06-12 Derivados de 1-(3-feniloxipropil) piperidina PE20030063A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01202271 2001-06-13

Publications (1)

Publication Number Publication Date
PE20030063A1 true PE20030063A1 (es) 2003-02-08

Family

ID=8180471

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002000504A PE20030063A1 (es) 2001-06-13 2002-06-12 Derivados de 1-(3-feniloxipropil) piperidina

Country Status (3)

Country Link
AR (1) AR034470A1 (es)
PE (1) PE20030063A1 (es)
WO (1) WO2002100861A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8067603B2 (en) 2003-09-25 2011-11-29 Solvay Pharmaceuticals B.V. Benzimidazolone and quinazolinone derivatives as agonists on human ORL1 receptors
US7723360B2 (en) * 2004-08-06 2010-05-25 Boehringer Ingelheim International Gmbh Alkyl-and piperidine-substituted benzimidazole derivatives
WO2006080519A1 (ja) * 2005-01-31 2006-08-03 Kyowa Hakko Kogyo Co., Ltd. ジアミン誘導体
AU2016204605B2 (en) * 2009-06-25 2017-11-23 Alkermes Pharma Ireland Limited Prodrugs of nh-acidic compounds
JP5732453B2 (ja) 2009-06-25 2015-06-10 アルカーメス ファーマ アイルランド リミテッド Ｎｈ酸性化合物のプロドラッグ
US11273158B2 (en) 2018-03-05 2022-03-15 Alkermes Pharma Ireland Limited Aripiprazole dosing strategy

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002515503A (ja) * 1998-05-18 2002-05-28 ノボ ノルディスク アクティーゼルスカブ オピオイド受容体のサブタイプへの高い親和性を有する新規１，３，８−トリアザスピロ〔４，５〕デカノン
ID29137A (id) * 1998-07-27 2001-08-02 Schering Corp Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1
US6262066B1 (en) * 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1

Also Published As

Publication number Publication date
WO2002100861A1 (en) 2002-12-19
AR034470A1 (es) 2004-02-25

Similar Documents

Publication Publication Date Title
NO20003671L (no) 4-(2-keto-1-benzimidazolinyl)piperidin-forbindelser som orl1- reseptor agonister
PE2799A1 (es) Lactamas e imidas heterociclicas de aralquilo y aralquilideno
NO20032252D0 (no) Piperazinylpyrazinforbindelser som agonist eller antagonist av serotonin 5HT-2-reseptor
DE3868301D1 (de) 2-(methyl(4-piperidinyl))-1,2,3,4-tetrahydro-9h-pyrido(3,4-b)indolderivate, ihre herstellung und therapeutische verwendung.
PE20040526A1 (es) Amidas de 4-alquenil piperidina de indol, azaindol y relacionadas con heterociclicos
PE20021004A1 (es) Derivados de piperidina como inhibidores de la ccr5
KR940005609A (ko) 벤즈이미다졸의 피페리딘 유도체
PE20060977A1 (es) Derivados de piperidinilo como bloqueantes de canales de calcio
NO20015365L (no) Piperidinderivater som er anvendbare som CCR5-antagonister
ES2193990T3 (es) Derivados de purina.
PE20040720A1 (es) Derivados de benzodioxol
PE20020544A1 (es) Derivados de indolilmaleimida
CO5570660A2 (es) Indazolilpirrolotriazinas c-6 modificadas
PE20011081A1 (es) Derivados de piperazina y piperidina
CO5050296A1 (es) Derivados de 1-arenosulfonil-2-arilo-pirrolidina y de piperidina
AR017019A1 (es) Compuestos derivados del 2-(4-aril o heteroarilpiperazin-1-ilmetil)-1h-indol, composiciones y su uso en la manufactura de medicamentos
ES2062425T3 (es) Piridinas, procedimientos de preparacion y medicamentos que las contienen.
PE20030063A1 (es) Derivados de 1-(3-feniloxipropil) piperidina
PE20020676A1 (es) Compuestos de mutilina como antibacterianos
PE20050442A1 (es) Derivados de 8-azoniabiciclo[3.2.1]octano como antagonistas de receptores muscarinicos de la acetilcolina
CO4650039A1 (es) Benzotiofenos amorfos, procedimientos de preparacion y procedimientos de uso
CO5160255A1 (es) DERIVADOS DE 4-OXO-3,5-DIHIDRO-4H-PIRIDAZINO[4,5-b]INDOL-1- CARBOXAMIDA Y COMPOSICIONES QUE LOS COMPRENDEN
DK0511222T3 (da) Disubstituerede piperidiner og pyrrolidiner som anticholinergiske midler
AR029858A1 (es) Derivados de indol
RU2342363C2 (ru) Бензоилпиперидиновые соединения

Legal Events

Date Code Title Description
FD Application declared void or lapsed