HK1020952A1 - Polymorphs (iii) of donepezil hydrochloride and preparation processe and use thereof. - Google Patents

Polymorphs (iii) of donepezil hydrochloride and preparation processe and use thereof.

Info

Publication number
HK1020952A1
HK1020952A1 HK99106107A HK99106107A HK1020952A1 HK 1020952 A1 HK1020952 A1 HK 1020952A1 HK 99106107 A HK99106107 A HK 99106107A HK 99106107 A HK99106107 A HK 99106107A HK 1020952 A1 HK1020952 A1 HK 1020952A1
Authority
HK
Hong Kong
Prior art keywords
processe
polymorphs
iii
preparation
donepezil hydrochloride
Prior art date
Application number
HK99106107A
Other languages
English (en)
Inventor
Akio Imai
Hideaki Watanabe
Takashi Kajima
Yasushi Ishihama
Akiyo Ohtsuka
Tomohide Tanaka
Yukio Narabu
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP1996/003881 external-priority patent/WO1997046526A1/en
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of HK1020952A1 publication Critical patent/HK1020952A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK99106107A 1996-06-07 1999-12-24 Polymorphs (iii) of donepezil hydrochloride and preparation processe and use thereof. HK1020952A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP14629396 1996-06-07
PCT/JP1996/003881 WO1997046526A1 (en) 1996-06-07 1996-12-27 Stable polymorphs of donepezil (1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine) hydrochloride and process for production
US08/774,802 US6140321A (en) 1996-06-07 1996-12-30 Polymorphs of donepezil hydrochloride and process for production
PCT/JP1997/001932 WO1997046527A1 (en) 1996-06-07 1997-06-06 Polymorphs of donepezil hydrochloride and process for production

Publications (1)

Publication Number Publication Date
HK1020952A1 true HK1020952A1 (en) 2000-05-26

Family

ID=27307991

Family Applications (1)

Application Number Title Priority Date Filing Date
HK99106107A HK1020952A1 (en) 1996-06-07 1999-12-24 Polymorphs (iii) of donepezil hydrochloride and preparation processe and use thereof.

Country Status (12)

Country Link
EP (2) EP1019374B1 (xx)
AU (1) AU731282B2 (xx)
CA (1) CA2252806C (xx)
DK (1) DK1019374T3 (xx)
ES (1) ES2188946T3 (xx)
HK (1) HK1020952A1 (xx)
NO (1) NO321267B1 (xx)
NZ (1) NZ333197A (xx)
RU (1) RU2190603C2 (xx)
SI (1) SI9720038B (xx)
SK (1) SK285312B6 (xx)
WO (1) WO1997046527A1 (xx)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4095676B2 (ja) 1997-03-03 2008-06-04 エーザイ株式会社 注意障害を治療するためのコリンエステラーゼ阻害剤の使用
GB9716879D0 (en) * 1997-08-08 1997-10-15 Shire Int Licensing Bv Treatment of attention deficit disorders
EP1048653B1 (en) 1997-12-05 2004-03-03 Eisai Co., Ltd. Donepezil polycrystals and process for producing the same
US6193993B1 (en) 1998-03-03 2001-02-27 Eisai Co., Ltd. Suppository containing an antidementia medicament
IL138914A0 (en) * 1998-06-16 2001-11-25 Lilly Co Eli Methods for increasing levels of acetylcholine
US6288108B1 (en) 1998-06-16 2001-09-11 Eli Lilly And Company Methods for increasing levels of acetylcholine
KR20010052891A (ko) * 1998-06-16 2001-06-25 피터 지. 스트링거 아세틸콜린 수치를 상승시키는 방법
WO2001066114A1 (en) 2000-03-03 2001-09-13 Eisai Co., Ltd. Novel methods using cholinesterase inhibitors
SI21223A (sl) * 2002-06-19 2003-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Farmacevtska formulacija s stabiliziranim amorfnim donepezilijevim kloridom
IL150509A (en) 2002-07-01 2007-07-04 Joseph Kaspi Pharmaceutical preparations containing donafazil hydrochloride
WO2004041281A1 (en) * 2002-11-01 2004-05-21 Oregon Health And Science University Treatment of hyperkinetic movement disorder with donepezil
US20050288330A1 (en) * 2004-06-29 2005-12-29 Avinash Naidu Process for producing a polymorphic form of (1-Benzyl-4-[(5,6-dimethoxy-1-indanone)-2-yl] methyl piperidine hydrochloride (donepezil hydrochloride)
WO2006011154A1 (en) * 2004-07-28 2006-02-02 Usv Limited A novel polymorph of (1-benzyl-4-[(5,6-dimethoxy-1-indanone)-2-yl] methyl piperidine hydrochloride (donepezil hydrochloride) and a process for producing thereof
US7186842B2 (en) 2003-02-12 2007-03-06 Usv, Ltd. Polymorph of (1-benzyl-4-[(5,6-dimethoxy-1-indanone)-2-y1] methyl piperidine hydrochloride (Donepezil hydrochloride) and a process for producing thereof
WO2004092137A1 (en) * 2003-04-16 2004-10-28 Hetero Drugs Limited Novel crystalline forms of donepezil hydrochloride
WO2006015338A2 (en) * 2004-07-30 2006-02-09 Dr. Reddy's Laboratories Ltd. Crystalline form of donepezil hydrochloride
CA2584547C (en) 2004-10-19 2014-07-08 Miha Vrbinc Solid pharmaceutical composition comprising donepezil hydrochloride
EP1858847A1 (en) * 2005-02-28 2007-11-28 Ranbaxy Laboratories Limited Stable form i donepezil hydrochloride and process for its preparation and use in pharmaceutical compositions
EP1858848A1 (en) * 2005-03-17 2007-11-28 Synthon B.V. Process for making crystalline donepezil hydrochloride monohydrate
WO2006111983A2 (en) * 2005-04-21 2006-10-26 Jubilant Organosys Limited NOVEL POLYMORPHIC FORM OF (l-BENZYL-4-[(5,6-DIMETHOXY-l- INDANONE)-2-YL]METHYL PIPERIDINE HYDROCHLORIDE AND PROCESS FOR PREPARING THE SAME
GB0515803D0 (en) * 2005-07-30 2005-09-07 Pliva Hrvatska D O O Intermediate compounds
HU227474B1 (en) * 2005-12-20 2011-07-28 Richter Gedeon Nyrt Process for industrial scale production of high purity donepezil hydrochloride polymorph i.
EP2032521B1 (en) 2006-06-27 2009-10-28 Sandoz AG New method for salt preparation
CA2672212A1 (en) * 2006-12-11 2008-06-19 Reviva Pharmaceuticals, Inc. Compositions, synthesis, and methods of using indanone based cholinesterase inhibitors
DE102007037932A1 (de) 2007-08-11 2009-02-12 Alfred E. Tiefenbacher Gmbh & Co.Kg Donepezilhydrochlorid in amorpher Form enthaltende Tablette
CN101397270B (zh) * 2007-09-28 2012-03-28 天津和美生物技术有限公司 多奈哌齐盐的多晶型物及其制备和应用
JP5562337B2 (ja) * 2008-12-17 2014-07-30 エーザイ・アール・アンド・ディー・マネジメント株式会社 ドネペジルの多形結晶及びその製造方法
DE102010010998A1 (de) 2010-03-10 2011-09-15 Stada Arzneimittel Ag Feste pharmazeutische Zusammensetzung, umfassend Donepezil-Hydrochlorid der kristallinen polymorphen Form I
WO2011151359A1 (en) 2010-06-02 2011-12-08 Noscira, S.A. Combined treatment with a cholinesterase inhibitor and a thiadiazolidinedione derivative
EP2502620A1 (en) 2011-03-24 2012-09-26 Krka Tovarna Zdravil, D.D., Novo Mesto Solid pharmaceutical composition comprising donepezil
CN110393440B (zh) * 2019-06-28 2021-08-13 顾美红 一种即热式烧水机
WO2024145323A1 (en) 2022-12-28 2024-07-04 Corium, Llc Pre-mixing method of preparing transdermal delivery system
WO2024145319A1 (en) 2022-12-28 2024-07-04 Corium, Llc Method of preparing transdermal delivery system

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI95572C (fi) * 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi

Also Published As

Publication number Publication date
CA2252806C (en) 2005-11-22
EP1019374B1 (en) 2003-01-02
SI9720038A (sl) 1999-06-30
SI9720038B (sl) 2010-06-30
EP1211243A1 (en) 2002-06-05
RU2190603C2 (ru) 2002-10-10
AU731282B2 (en) 2001-03-29
NZ333197A (en) 2001-03-30
SK167698A3 (en) 1999-06-11
CA2252806A1 (en) 1997-12-11
EP1019374A1 (en) 2000-07-19
SK285312B6 (sk) 2006-10-05
WO1997046527A1 (en) 1997-12-11
ES2188946T3 (es) 2003-07-01
DK1019374T3 (da) 2003-04-07
NO321267B1 (no) 2006-04-10
EP1211243B1 (en) 2009-10-14
NO985721L (no) 1999-01-28
NO985721D0 (no) 1998-12-07
AU2979297A (en) 1998-01-05

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Legal Events

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PE Patent expired

Effective date: 20170605