DK1019374T3 - Polymorfe og Donepezil-hydrochlorid og fremstillingsfremgangsmåde - Google Patents
Polymorfe og Donepezil-hydrochlorid og fremstillingsfremgangsmådeInfo
- Publication number
- DK1019374T3 DK1019374T3 DK97924337T DK97924337T DK1019374T3 DK 1019374 T3 DK1019374 T3 DK 1019374T3 DK 97924337 T DK97924337 T DK 97924337T DK 97924337 T DK97924337 T DK 97924337T DK 1019374 T3 DK1019374 T3 DK 1019374T3
- Authority
- DK
- Denmark
- Prior art keywords
- polymorphic
- manufacturing process
- donepezil hydrochloride
- donepezil
- hydrochloride
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hospice & Palliative Care (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychiatry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14629396 | 1996-06-07 | ||
| PCT/JP1996/003881 WO1997046526A1 (en) | 1996-06-07 | 1996-12-27 | Stable polymorphs of donepezil (1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine) hydrochloride and process for production |
| US08/774,802 US6140321A (en) | 1996-06-07 | 1996-12-30 | Polymorphs of donepezil hydrochloride and process for production |
| PCT/JP1997/001932 WO1997046527A1 (en) | 1996-06-07 | 1997-06-06 | Polymorphs of donepezil hydrochloride and process for production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1019374T3 true DK1019374T3 (da) | 2003-04-07 |
Family
ID=27307991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97924337T DK1019374T3 (da) | 1996-06-07 | 1997-06-06 | Polymorfe og Donepezil-hydrochlorid og fremstillingsfremgangsmåde |
Country Status (12)
| Country | Link |
|---|---|
| EP (2) | EP1019374B1 (da) |
| AU (1) | AU731282B2 (da) |
| CA (1) | CA2252806C (da) |
| DK (1) | DK1019374T3 (da) |
| ES (1) | ES2188946T3 (da) |
| HK (1) | HK1020952A1 (da) |
| NO (1) | NO321267B1 (da) |
| NZ (1) | NZ333197A (da) |
| RU (1) | RU2190603C2 (da) |
| SI (1) | SI9720038B (da) |
| SK (1) | SK285312B6 (da) |
| WO (1) | WO1997046527A1 (da) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4095676B2 (ja) | 1997-03-03 | 2008-06-04 | エーザイ株式会社 | 注意障害を治療するためのコリンエステラーゼ阻害剤の使用 |
| GB9716879D0 (en) * | 1997-08-08 | 1997-10-15 | Shire Int Licensing Bv | Treatment of attention deficit disorders |
| EP1048653B1 (en) | 1997-12-05 | 2004-03-03 | Eisai Co., Ltd. | Donepezil polycrystals and process for producing the same |
| US6193993B1 (en) | 1998-03-03 | 2001-02-27 | Eisai Co., Ltd. | Suppository containing an antidementia medicament |
| IL138914A0 (en) * | 1998-06-16 | 2001-11-25 | Lilly Co Eli | Methods for increasing levels of acetylcholine |
| US6288108B1 (en) | 1998-06-16 | 2001-09-11 | Eli Lilly And Company | Methods for increasing levels of acetylcholine |
| KR20010052891A (ko) * | 1998-06-16 | 2001-06-25 | 피터 지. 스트링거 | 아세틸콜린 수치를 상승시키는 방법 |
| WO2001066114A1 (en) | 2000-03-03 | 2001-09-13 | Eisai Co., Ltd. | Novel methods using cholinesterase inhibitors |
| SI21223A (sl) * | 2002-06-19 | 2003-12-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Farmacevtska formulacija s stabiliziranim amorfnim donepezilijevim kloridom |
| IL150509A (en) | 2002-07-01 | 2007-07-04 | Joseph Kaspi | Pharmaceutical preparations containing donafazil hydrochloride |
| WO2004041281A1 (en) * | 2002-11-01 | 2004-05-21 | Oregon Health And Science University | Treatment of hyperkinetic movement disorder with donepezil |
| US20050288330A1 (en) * | 2004-06-29 | 2005-12-29 | Avinash Naidu | Process for producing a polymorphic form of (1-Benzyl-4-[(5,6-dimethoxy-1-indanone)-2-yl] methyl piperidine hydrochloride (donepezil hydrochloride) |
| WO2006011154A1 (en) * | 2004-07-28 | 2006-02-02 | Usv Limited | A novel polymorph of (1-benzyl-4-[(5,6-dimethoxy-1-indanone)-2-yl] methyl piperidine hydrochloride (donepezil hydrochloride) and a process for producing thereof |
| US7186842B2 (en) | 2003-02-12 | 2007-03-06 | Usv, Ltd. | Polymorph of (1-benzyl-4-[(5,6-dimethoxy-1-indanone)-2-y1] methyl piperidine hydrochloride (Donepezil hydrochloride) and a process for producing thereof |
| WO2004092137A1 (en) * | 2003-04-16 | 2004-10-28 | Hetero Drugs Limited | Novel crystalline forms of donepezil hydrochloride |
| WO2006015338A2 (en) * | 2004-07-30 | 2006-02-09 | Dr. Reddy's Laboratories Ltd. | Crystalline form of donepezil hydrochloride |
| CA2584547C (en) | 2004-10-19 | 2014-07-08 | Miha Vrbinc | Solid pharmaceutical composition comprising donepezil hydrochloride |
| EP1858847A1 (en) * | 2005-02-28 | 2007-11-28 | Ranbaxy Laboratories Limited | Stable form i donepezil hydrochloride and process for its preparation and use in pharmaceutical compositions |
| EP1858848A1 (en) * | 2005-03-17 | 2007-11-28 | Synthon B.V. | Process for making crystalline donepezil hydrochloride monohydrate |
| WO2006111983A2 (en) * | 2005-04-21 | 2006-10-26 | Jubilant Organosys Limited | NOVEL POLYMORPHIC FORM OF (l-BENZYL-4-[(5,6-DIMETHOXY-l- INDANONE)-2-YL]METHYL PIPERIDINE HYDROCHLORIDE AND PROCESS FOR PREPARING THE SAME |
| GB0515803D0 (en) * | 2005-07-30 | 2005-09-07 | Pliva Hrvatska D O O | Intermediate compounds |
| HU227474B1 (en) * | 2005-12-20 | 2011-07-28 | Richter Gedeon Nyrt | Process for industrial scale production of high purity donepezil hydrochloride polymorph i. |
| EP2032521B1 (en) | 2006-06-27 | 2009-10-28 | Sandoz AG | New method for salt preparation |
| CA2672212A1 (en) * | 2006-12-11 | 2008-06-19 | Reviva Pharmaceuticals, Inc. | Compositions, synthesis, and methods of using indanone based cholinesterase inhibitors |
| DE102007037932A1 (de) | 2007-08-11 | 2009-02-12 | Alfred E. Tiefenbacher Gmbh & Co.Kg | Donepezilhydrochlorid in amorpher Form enthaltende Tablette |
| CN101397270B (zh) * | 2007-09-28 | 2012-03-28 | 天津和美生物技术有限公司 | 多奈哌齐盐的多晶型物及其制备和应用 |
| JP5562337B2 (ja) * | 2008-12-17 | 2014-07-30 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ドネペジルの多形結晶及びその製造方法 |
| DE102010010998A1 (de) | 2010-03-10 | 2011-09-15 | Stada Arzneimittel Ag | Feste pharmazeutische Zusammensetzung, umfassend Donepezil-Hydrochlorid der kristallinen polymorphen Form I |
| WO2011151359A1 (en) | 2010-06-02 | 2011-12-08 | Noscira, S.A. | Combined treatment with a cholinesterase inhibitor and a thiadiazolidinedione derivative |
| EP2502620A1 (en) | 2011-03-24 | 2012-09-26 | Krka Tovarna Zdravil, D.D., Novo Mesto | Solid pharmaceutical composition comprising donepezil |
| CN110393440B (zh) * | 2019-06-28 | 2021-08-13 | 顾美红 | 一种即热式烧水机 |
| WO2024145323A1 (en) | 2022-12-28 | 2024-07-04 | Corium, Llc | Pre-mixing method of preparing transdermal delivery system |
| WO2024145319A1 (en) | 2022-12-28 | 2024-07-04 | Corium, Llc | Method of preparing transdermal delivery system |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI95572C (fi) * | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi |
-
1997
- 1997-06-06 NZ NZ333197A patent/NZ333197A/en not_active IP Right Cessation
- 1997-06-06 RU RU99100325/04A patent/RU2190603C2/ru active
- 1997-06-06 EP EP97924337A patent/EP1019374B1/en not_active Expired - Lifetime
- 1997-06-06 AU AU29792/97A patent/AU731282B2/en not_active Expired
- 1997-06-06 ES ES97924337T patent/ES2188946T3/es not_active Expired - Lifetime
- 1997-06-06 EP EP02005248A patent/EP1211243B1/en not_active Expired - Lifetime
- 1997-06-06 WO PCT/JP1997/001932 patent/WO1997046527A1/en not_active Application Discontinuation
- 1997-06-06 DK DK97924337T patent/DK1019374T3/da active
- 1997-06-06 CA CA002252806A patent/CA2252806C/en not_active Expired - Lifetime
- 1997-06-06 SK SK1676-98A patent/SK285312B6/sk not_active IP Right Cessation
- 1997-06-06 SI SI9720038A patent/SI9720038B/sl active Search and Examination
-
1998
- 1998-12-07 NO NO19985721A patent/NO321267B1/no not_active IP Right Cessation
-
1999
- 1999-12-24 HK HK99106107A patent/HK1020952A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2252806C (en) | 2005-11-22 |
| EP1019374B1 (en) | 2003-01-02 |
| SI9720038A (sl) | 1999-06-30 |
| SI9720038B (sl) | 2010-06-30 |
| EP1211243A1 (en) | 2002-06-05 |
| RU2190603C2 (ru) | 2002-10-10 |
| AU731282B2 (en) | 2001-03-29 |
| NZ333197A (en) | 2001-03-30 |
| SK167698A3 (en) | 1999-06-11 |
| CA2252806A1 (en) | 1997-12-11 |
| EP1019374A1 (en) | 2000-07-19 |
| SK285312B6 (sk) | 2006-10-05 |
| WO1997046527A1 (en) | 1997-12-11 |
| ES2188946T3 (es) | 2003-07-01 |
| HK1020952A1 (en) | 2000-05-26 |
| NO321267B1 (no) | 2006-04-10 |
| EP1211243B1 (en) | 2009-10-14 |
| NO985721L (no) | 1999-01-28 |
| NO985721D0 (no) | 1998-12-07 |
| AU2979297A (en) | 1998-01-05 |
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