DE60323529D1 - Rutheniumkomplexe mit antikrebswirkung - Google Patents

Rutheniumkomplexe mit antikrebswirkung

Info

Publication number
DE60323529D1
DE60323529D1 DE60323529T DE60323529T DE60323529D1 DE 60323529 D1 DE60323529 D1 DE 60323529D1 DE 60323529 T DE60323529 T DE 60323529T DE 60323529 T DE60323529 T DE 60323529T DE 60323529 D1 DE60323529 D1 DE 60323529D1
Authority
DE
Germany
Prior art keywords
ruthenium complexes
cancer effects
cancer
ruthenium
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60323529T
Other languages
English (en)
Inventor
Peter John Sadler
Lainez Rafael Fernandez
Abraba Habtemariam
Michael Melchart
Duncan Ian Jodrell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Edinburgh
Original Assignee
University of Edinburgh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Edinburgh filed Critical University of Edinburgh
Application granted granted Critical
Publication of DE60323529D1 publication Critical patent/DE60323529D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F17/00—Metallocenes
    • C07F17/02—Metallocenes of metals of Groups 8, 9 or 10 of the Periodic System
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60323529T 2002-07-05 2003-07-04 Rutheniumkomplexe mit antikrebswirkung Expired - Fee Related DE60323529D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0215526.5A GB0215526D0 (en) 2002-07-05 2002-07-05 Anticancer compounds
PCT/GB2003/002879 WO2004005304A1 (en) 2002-07-05 2003-07-04 Ruthenium anticancer complexes

Publications (1)

Publication Number Publication Date
DE60323529D1 true DE60323529D1 (de) 2008-10-23

Family

ID=9939861

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60323529T Expired - Fee Related DE60323529D1 (de) 2002-07-05 2003-07-04 Rutheniumkomplexe mit antikrebswirkung

Country Status (20)

Country Link
US (1) US20060058270A1 (de)
EP (1) EP1558620B1 (de)
JP (1) JP2005536487A (de)
KR (1) KR20050053589A (de)
CN (1) CN100362005C (de)
AT (1) ATE407937T1 (de)
AU (1) AU2003251159B2 (de)
BR (1) BR0312470A (de)
CA (1) CA2491640A1 (de)
DE (1) DE60323529D1 (de)
DK (1) DK1558620T3 (de)
ES (1) ES2314245T3 (de)
GB (1) GB0215526D0 (de)
MX (1) MXPA05000314A (de)
NO (1) NO20050640L (de)
NZ (1) NZ538005A (de)
PL (1) PL373049A1 (de)
PT (1) PT1558620E (de)
WO (1) WO2004005304A1 (de)
ZA (1) ZA200500908B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001030790A1 (en) * 1999-10-27 2001-05-03 The University Court, The University Of Edinburgh Half-sandwich ruthenium (ii) compounds comprising nitrogen containing ligands for treatment of cancer
US7241913B2 (en) 2003-04-30 2007-07-10 The University Court Of The University Of Edinburgh Ruthenium compounds
GB0418643D0 (en) * 2004-08-20 2004-09-22 Univ Edinburgh Ruthenium (II) compounds
GB0604602D0 (en) * 2006-03-07 2006-04-19 Univ Edinburgh Ruthenium (II) compounds
EP2016085B9 (de) 2006-05-09 2015-12-30 Ecole Polytechnique Fédérale de Lausanne (EPFL) Übergangsmetallkomplexe zum inhibieren von resistenz bei der behandlung von krebs und metastasen
GB0610062D0 (en) * 2006-05-19 2006-06-28 Univ Edinburgh Ruthenium (ll) compounds
DE102009053392A1 (de) * 2009-11-14 2011-06-22 Umicore AG & Co. KG, 63457 Verfahren zur Herstellung von Ru(0) Olefin-Komplexen
WO2013038395A1 (en) 2011-09-16 2013-03-21 Universidade De Lisboa Transition metal complexes for pharmaceutical applications
WO2013136296A2 (en) 2012-03-14 2013-09-19 Universidade De Lisboa Water-soluble organometallic ruthenium and iron compunds presenting heteroaromatic ligands
CN103360428A (zh) * 2012-04-09 2013-10-23 中国科学院化学研究所 抑制蛋白酪氨酸磷酸酶1b活性的含钌配合物及其制备方法和蛋白酪氨酸磷酸酶1b抑制剂
CN102964385B (zh) * 2012-11-30 2015-02-18 广西师范学院 一种有机金属钌化合物及其制备方法和用途
US9751081B2 (en) 2014-12-01 2017-09-05 Clemson University Self-regenerating antioxidant catalysts and methods of using the same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4980473A (en) * 1985-01-18 1990-12-25 The Trustees Of Columbia University In The City Of New York Chemical probes for left-handed DNA and chiral metal complexes as Z-specific anti-tumor agents
EP0916637B1 (de) * 1995-12-06 2005-04-20 Japan Science and Technology Agency Verfahren zur herstellung optische aktive verbindungen
WO2001030790A1 (en) * 1999-10-27 2001-05-03 The University Court, The University Of Edinburgh Half-sandwich ruthenium (ii) compounds comprising nitrogen containing ligands for treatment of cancer
GB0016052D0 (en) * 2000-06-30 2000-08-23 Univ Edinburgh Ruthenium (II) compounds

Also Published As

Publication number Publication date
ATE407937T1 (de) 2008-09-15
PL373049A1 (en) 2005-08-08
NZ538005A (en) 2007-08-31
NO20050640L (no) 2005-03-22
EP1558620B1 (de) 2008-09-10
AU2003251159B2 (en) 2008-11-06
EP1558620A1 (de) 2005-08-03
AU2003251159A1 (en) 2004-01-23
GB0215526D0 (en) 2002-08-14
ZA200500908B (en) 2006-03-29
BR0312470A (pt) 2005-04-26
ES2314245T3 (es) 2009-03-16
KR20050053589A (ko) 2005-06-08
US20060058270A1 (en) 2006-03-16
JP2005536487A (ja) 2005-12-02
WO2004005304A1 (en) 2004-01-15
CN1665826A (zh) 2005-09-07
PT1558620E (pt) 2008-12-03
CN100362005C (zh) 2008-01-16
DK1558620T3 (da) 2009-01-05
MXPA05000314A (es) 2005-09-20
CA2491640A1 (en) 2004-01-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee